Full-Length Isoforms of Kaposi's Sarcoma-Associated Herpesvirus Latency-Associated Nuclear Antigen Accumulate in the Cytoplasm of Cells Undergoing the Lytic Cycle of Replication

scientific article published on 4 October 2017

Full-Length Isoforms of Kaposi's Sarcoma-Associated Herpesvirus Latency-Associated Nuclear Antigen Accumulate in the Cytoplasm of Cells Undergoing the Lytic Cycle of Replication is …
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P356DOI10.1128/JVI.01532-17
P932PMC publication ID5709576
P698PubMed publication ID28978712

P50authorAshlee V MosesQ95982764
P2093author name stringTimothy M Rose
David Wu
Serge Barcy
Gail H Deutsch
H Jacques Garrigues
Keiji Ueda
Kellie Howard
Minako Ikoma
P2860cites workDetermination of the wound healing effect of Calendula extracts using the scratch assay with 3T3 fibroblasts.Q42833621
Microsequencing of proteins electrotransferred onto immobilizing matrices from polyacrylamide gel electrophoresis: application to an insoluble proteinQ43618989
Human herpesvirus-8 (HHV-8) gene expression in Kaposi's sarcoma (KS) primary lesions: an in situ hybridization studyQ44210720
A naturally occurring C-terminal truncated isoform of the latent nuclear antigen of Kaposi's sarcoma-associated herpesvirus does not associate with viral episomal DNA.Q44913048
Human beta-defensin-2 production in keratinocytes is regulated by interleukin-1, bacteria, and the state of differentiationQ46167434
Switch from p53 to MDM2 as differentiating human keratinocytes lose their proliferative potential and increase in cellular sizeQ47231411
Regulation of nuclear import by phosphorylation adjacent to nuclear localization signalsQ48004807
Lymph Nodes Involved by Multicentric Castleman Disease Among HIV-positive Individuals are Often Involved by Kaposi SarcomaQ59621846
Expression of human herpesvirus-8 (HHV-8) encoded pathogenic genes in Kaposi's Sarcoma (KS) primary lesionsQ59647836
Distinct expression of Kaposi's sarcoma-associated herpesvirus-encoded proteins in Kaposi's sarcoma and multicentric Castleman's diseaseQ61776908
Differential detergent fractionation of isolated hepatocytes: biochemical, immunochemical and two-dimensional gel electrophoresis characterization of cytoskeletal and noncytoskeletal compartmentsQ72048900
Changes in keratin gene expression during terminal differentiation of the keratinocyteQ72609330
Morphogenesis of HHV8 in primary human dermal microvascular endothelium and primary effusion lymphomasQ73172582
The latency-associated nuclear antigen tethers the Kaposi's sarcoma-associated herpesvirus genome to host chromosomes in body cavity-based lymphoma cellsQ73184792
Expression and localization of human herpesvirus 8-encoded proteins in primary effusion lymphoma, Kaposi's sarcoma, and multicentric Castleman's diseaseQ73642658
Reactivation of Kaposi's sarcoma-associated herpesvirus infection from latency by expression of the ORF 50 transactivator, a homolog of the EBV R proteinQ77760836
The lytic activation of KSHV during keratinocyte differentiation is dependent upon a suprabasal position, the loss of integrin engagement, and calcium, but not the interaction of cadherinsQ82486710
Mesenchymal stem cell-conditioned medium accelerates skin wound healing: an in vitro study of fibroblast and keratinocyte scratch assaysQ83142880
Differential Detergent Fractionation of Eukaryotic CellsQ83506633
KSHV attachment and entry are dependent on αVβ3 integrin localized to specific cell surface microdomains and do not correlate with the presence of heparan sulfateQ24301376
Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathwayQ24306635
Human herpesvirus 8 LANA interacts with proteins of the mSin3 corepressor complex and negatively regulates Epstein-Barr virus gene expression in dually infected PEL cellsQ24527215
Carboxy terminus of human herpesvirus 8 latency-associated nuclear antigen mediates dimerization, transcriptional repression, and targeting to nuclear bodies.Q24531182
Identification of the gene encoding the major latency-associated nuclear antigen of the Kaposi's sarcoma-associated herpesvirusQ24561400
Nucleotide sequence of the Kaposi sarcoma-associated herpesvirus (HHV8)Q24650427
The 222- to 234-kilodalton latent nuclear protein (LNA) of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) is encoded by orf73 and is a component of the latency-associated nuclear antigenQ24672438
CRM1 is an export receptor for leucine-rich nuclear export signalsQ27860453
Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNAQ28118718
KSHV reactivation from latency requires Pim-1 and Pim-3 kinases to inactivate the latency-associated nuclear antigen LANAQ28474913
Oncogenic herpesvirus KSHV Hijacks BMP-Smad1-Id signaling to promote tumorigenesisQ28540651
LANA binds to multiple active viral and cellular promoters and associates with the H3K4methyltransferase hSET1 complexQ28540872
In vitro scratch assay: a convenient and inexpensive method for analysis of cell migration in vitroQ29617927
Complex alternative cytoplasmic protein isoforms of the Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen 1 generated through noncanonical translation initiationQ30535717
Identification of a major latent nuclear antigen, LNA-1, in the human herpesvirus 8 genomeQ30668836
A viral gene that activates lytic cycle expression of Kaposi’s sarcoma-associated herpesvirusQ33559699
Kaposi Sarcoma Herpesvirus (KSHV) Latency-Associated Nuclear Antigen (LANA) recruits components of the MRN (Mre11-Rad50-NBS1) repair complex to modulate an innate immune signaling pathway and viral latencyQ33632932
A cluster of latently expressed genes in Kaposi's sarcoma-associated herpesvirusQ33784966
Characterization of monoclonal antibodies raised against the latent nuclear antigen of human herpesvirus 8Q33814510
Long-term infection and transformation of dermal microvascular endothelial cells by human herpesvirus 8.Q33817882
Latent nuclear antigen of Kaposi's sarcoma-associated herpesvirus interacts with RING3, a homolog of the Drosophila female sterile homeotic (fsh) geneQ33824419
Origin-independent assembly of Kaposi's sarcoma-associated herpesvirus DNA replication compartments in transient cotransfection assays and association with the ORF-K8 protein and cellular PML.Q33836726
Induction of Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen by the lytic transactivator RTA: a novel mechanism for establishment of latencyQ33843211
Close but distinct regions of human herpesvirus 8 latency-associated nuclear antigen 1 are responsible for nuclear targeting and binding to human mitotic chromosomesQ33851443
Efficient persistence of extrachromosomal KSHV DNA mediated by latency-associated nuclear antigenQ33859518
p53 inhibition by the LANA protein of KSHV protects against cell deathQ33885642
Conservation of Complex Nuclear Localization Signals Utilizing Classical and Non-Classical Nuclear Import Pathways in LANA Homologs of KSHV and RFHVQ33895240
Cell size correlates with phenotype and proliferative capacity in human corneal epithelial cellsQ34004236
Latency-associated nuclear antigen (LANA) cooperatively binds to two sites within the terminal repeat, and both sites contribute to the ability of LANA to suppress transcription and to facilitate DNA replicationQ34128791
Kaposi's sarcoma-associated herpesvirus-encoded latency-associated nuclear antigen inhibits lytic replication by targeting Rta: a potential mechanism for virus-mediated control of latencyQ34194120
Calcium regulation of growth and differentiation of mouse epidermal cells in cultureQ34248695
Kaposi's sarcoma-associated herpesvirus ORF18 and ORF30 are essential for late gene expression during lytic replicationQ34261905
Nuclear import of Epstein-Barr virus nuclear antigen 1 mediated by NPI-1 (Importin alpha5) is up- and down-regulated by phosphorylation of the nuclear localization signal for which Lys379 and Arg380 are essentialQ34353280
The latency-associated nuclear antigen of Kaposi sarcoma-associated herpesvirus induces B cell hyperplasia and lymphomaQ34391203
Phosphorylation of the chromatin binding domain of KSHV LANAQ34456086
cGAS-mediated stabilization of IFI16 promotes innate signaling during herpes simplex virus infectionQ34469746
The latent nuclear antigen of Kaposi sarcoma-associated herpesvirus targets the retinoblastoma-E2F pathway and with the oncogene Hras transforms primary rat cellsQ34511161
Modulation of Kaposi's sarcoma-associated herpesvirus infection and replication by MEK/ERK, JNK, and p38 multiple mitogen-activated protein kinase pathways during primary infectionQ34648384
Kaposi's Sarcoma-Associated Herpesvirus Latency-Associated Nuclear Antigen Prolongs the Life Span of Primary Human Umbilical Vein Endothelial CellsQ34997083
The Single RBP-Jκ Site within the LANA Promoter Is Crucial for Establishing Kaposi's Sarcoma-Associated Herpesvirus Latency during Primary InfectionQ35077558
Recruitment of the de novo DNA methyltransferase Dnmt3a by Kaposi's sarcoma-associated herpesvirus LANAQ35080754
Five-parameter fluorescence imaging: wound healing of living Swiss 3T3 cellsQ35085825
Identification of Caspase Cleavage Sites in KSHV Latency-Associated Nuclear Antigen and Their Effects on Caspase-Related Host Defense ResponsesQ35720026
Post-Translational Modifications of Kaposi’s Sarcoma-Associated Herpesvirus Regulatory Proteins – SUMO and KSHVQ35755464
Expression of a virus-derived cytokine, KSHV vIL-6, in HIV-seronegative Castleman's diseaseQ35764989
Protein arginine methyltransferase 1-directed methylation of Kaposi sarcoma-associated herpesvirus latency-associated nuclear antigenQ35774091
High expression of HHV-8-encoded ORF73 protein in spindle-shaped cells of Kaposi's sarcomaQ35787282
Differential viral protein expression in Kaposi's sarcoma-associated herpesvirus-infected diseases: Kaposi's sarcoma, primary effusion lymphoma, and multicentric Castleman's disease.Q35809792
MAP kinases and cell migrationQ35889220
The Kaposi's sarcoma-associated herpesvirus LANA protein stabilizes and activates c-MycQ36099076
Involucrin synthesis is correlated with cell size in human epidermal culturesQ36205249
Expression of murine epidermal differentiation markers is tightly regulated by restricted extracellular calcium concentrations in vitroQ36221429
Reactivation of Kaposi's sarcoma-associated herpesvirus from latency requires MEK/ERK, JNK and p38 multiple mitogen-activated protein kinase pathwaysQ36454456
KSHV LANA inhibits TGF-beta signaling through epigenetic silencing of the TGF-beta type II receptorQ36591375
Cytoplasmic isoforms of Kaposi sarcoma herpesvirus LANA recruit and antagonize the innate immune DNA sensor cGASQ36646579
Kaposi's sarcoma-associated herpesvirus (KSHV) latency-associated nuclear antigen regulates the KSHV epigenome by association with the histone demethylase KDM3A.Q36911800
Phosphorylation of Kaposi's sarcoma-associated herpesvirus processivity factor ORF59 by a viral kinase modulates its ability to associate with RTA and oriLytQ36978654
Concurrent expression of latent and a limited number of lytic genes with immune modulation and antiapoptotic function by Kaposi's sarcoma-associated herpesvirus early during infection of primary endothelial and fibroblast cells and subsequent declinQ37010247
Genetic disruption of KSHV major latent nuclear antigen LANA enhances viral lytic transcriptional programQ37060535
The ORF59 DNA polymerase processivity factor homologs of Old World primate RV2 rhadinoviruses are highly conserved nuclear antigens expressed in differentiated epithelium in infected macaquesQ37448524
A critical Sp1 element in the rhesus rhadinovirus (RRV) Rta promoter confers high-level activity that correlates with cellular permissivity for viral replicationQ37523519
Cell size as a determinant of the clone-forming ability of human keratinocytesQ37528349
Restricted expression of Kaposi sarcoma-associated herpesvirus (human herpesvirus 8) genes in Kaposi sarcomaQ37535731
KSHV cell attachment sites revealed by ultra sensitive tyramide signal amplification (TSA) localize to membrane microdomains that are up-regulated on mitotic cellsQ37638617
Quantitative Analysis of the KSHV Transcriptome Following Primary Infection of Blood and Lymphatic Endothelial CellsQ37727998
Kaposi Sarcoma-associated Herpesvirus: mechanisms of oncogenesisQ38597909
Consequences of exposure to initiating levels of carcinogens in vitro and in vivo: altered differentiation and growth, mutations, and transformationQ38663082
Expression of the Peptide Antibiotic Human β-Defensin 1 in Cultured Gingival Epithelial Cells and Gingival TissueQ39572822
Limited Transmission of Kaposi’s Sarcoma-Associated Herpesvirus in Cultured CellsQ39580911
Cloning and Functional Analysis of Kaposi’s Sarcoma-Associated Herpesvirus DNA Polymerase and Its Processivity FactorQ39582755
Transcriptional activation by the product of open reading frame 50 of Kaposi's sarcoma-associated herpesvirus is required for lytic viral reactivation in B cellsQ39596534
DNA-PK/Ku complex binds to latency-associated nuclear antigen and negatively regulates Kaposi's sarcoma-associated herpesvirus latent replication.Q39725564
De novo infection and serial transmission of Kaposi's sarcoma-associated herpesvirus in cultured endothelial cellsQ39748116
Host Range of Kaposi's Sarcoma-Associated Herpesvirus in Cultured CellsQ39752549
Latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus (KSHV) upregulates survivin expression in KSHV-Associated B-lymphoma cells and contributes to their proliferationQ39852047
The size and conformation of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) DNA in infected cells and virionsQ39877021
Kaposi's sarcoma-associated herpesvirus gene expression in endothelial (spindle) tumor cellsQ39877852
Transcriptional activation by the Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen is facilitated by an N-terminal chromatin-binding motif.Q39960021
Latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus up-regulates transcription of human telomerase reverse transcriptase promoter through interaction with transcription factor Sp1.Q39992257
Productive lytic replication of a recombinant Kaposi's sarcoma-associated herpesvirus in efficient primary infection of primary human endothelial cellsQ39996542
AGS and other tissue culture cells can unknowingly be persistently infected with PIV5; a virus that blocks interferon signalling by degrading STAT1.Q40131626
Deregulation of c-Myc in primary effusion lymphoma by Kaposi's sarcoma herpesvirus latency-associated nuclear antigenQ40169138
KSHV encoded LANA upregulates Pim-1 and is a substrate for its kinase activityQ40286016
The latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus modulates cellular gene expression and protects lymphoid cells from p16 INK4A-induced cell cycle arrestQ40496132
Use of the red fluorescent protein as a marker of Kaposi's sarcoma-associated herpesvirus lytic gene expressionQ40537413
The restricted cellular host range of human herpesvirus 8.Q40868542
Molecular polymorphism of Kaposi's sarcoma-associated herpesvirus (Human herpesvirus 8) latent nuclear antigen: evidence for a large repertoire of viral genotypes and dual infection with different viral genotypes.Q40923894
Transcriptional analysis of human herpesvirus-8 open reading frames 71, 72, 73, K14, and 74 in a primary effusion lymphoma cell lineQ40959840
Antibodies to butyrate-inducible antigens of Kaposi's sarcoma-associated herpesvirus in patients with HIV-1 infection.Q41198290
Lytic growth of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) in cultureQ41225141
The latency-associated nuclear antigen interacts with MeCP2 and nucleosomes through separate domainsQ41860564
The induction of epidermal transglutaminase and terminal differentiation by tumor promoters in cultured epidermal cellsQ42242068
Association of p63 with proliferative potential in normal and neoplastic human keratinocytesQ42481013
Activation of Kaposi's sarcoma-associated herpesvirus lytic gene expression during epithelial differentiationQ42584376
Expression of p53 and human herpesvirus-8 (HHV-8)-encoded latency-associated nuclear antigen with inhibition of apoptosis in HHV-8-associated malignanciesQ42665921
Identification and Characterization of Human Herpesvirus-8 Lytic Cycle-Associated ORF 59 Protein and the Encoding cDNA by Monoclonal AntibodyQ42671697
Infection of primary human tonsillar lymphoid cells by KSHV reveals frequent but abortive infection of T cellsQ42710003
P433issue24
P407language of work or nameEnglishQ1860
P921main subjectcytoplasmQ79899
P577publication date2017-11-30
P1433published inJournal of VirologyQ1251128
P1476titleFull-Length Isoforms of Kaposi's Sarcoma-Associated Herpesvirus Latency-Associated Nuclear Antigen Accumulate in the Cytoplasm of Cells Undergoing the Lytic Cycle of Replication
P478volume91