Phosphorylation of the chromatin binding domain of KSHV LANA

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Phosphorylation of the chromatin binding domain of KSHV LANA is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1371/JOURNAL.PPAT.1002972
P932PMC publication ID3475679
P698PubMed publication ID23093938
P5875ResearchGate publication ID232649571

P2093author name stringHeng Zhu
Jianfei Hu
Jiang Qian
Jun Wan
Jian Zhu
Gangling Liao
Meir Shamay
S Diane Hayward
Renfeng Li
Hee-Sool Rho
Crystal Woodard
Ai Na Ng
Rob Newman
P2860cites workPhysical and functional interactions between STAT3 and Kaposi's sarcoma-associated herpesvirus-encoded LANAQ24299259
Human herpesvirus 8 LANA interacts with proteins of the mSin3 corepressor complex and negatively regulates Epstein-Barr virus gene expression in dually infected PEL cellsQ24527215
Protein interactions targeting the latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus to cell chromosomesQ24538878
Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen interacts with bromodomain protein Brd4 on host mitotic chromosomesQ24673761
Diverse protein kinase interactions identified by protein microarrays reveal novel connections between cellular processesQ27939657
KSHV reactivation from latency requires Pim-1 and Pim-3 kinases to inactivate the latency-associated nuclear antigen LANAQ28474913
Global analysis of protein phosphorylation in yeastQ29615057
Identification of the first specific inhibitor of p90 ribosomal S6 kinase (RSK) reveals an unexpected role for RSK in cancer cell proliferationQ30435905
The serine/threonine protein kinase, p90 ribosomal S6 kinase, is an important regulator of prostate cancer cell proliferationQ30436561
Activation of p90 ribosomal S6 kinase by ORF45 of Kaposi's sarcoma-associated herpesvirus and its role in viral lytic replicationQ30441657
A novel KRAB-Zinc finger protein interacts with latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus and activates transcription via terminal repeat sequencesQ33265370
KSHV-induced notch components render endothelial and mural cell characteristics and cell survivalQ33627013
Kaposi's sarcoma-associated herpesvirus reactivation is regulated by interaction of latency-associated nuclear antigen with recombination signal sequence-binding protein Jkappa, the major downstream effector of the Notch signaling pathwayQ33737793
Characterization of the minimal replicator of Kaposi's sarcoma-associated herpesvirus latent originQ33781363
The latency-associated nuclear antigen of rhesus monkey rhadinovirus inhibits viral replication through repression of Orf50/Rta transcriptional activationQ33834414
Close but distinct regions of human herpesvirus 8 latency-associated nuclear antigen 1 are responsible for nuclear targeting and binding to human mitotic chromosomesQ33851443
Efficient persistence of extrachromosomal KSHV DNA mediated by latency-associated nuclear antigenQ33859518
p53 inhibition by the LANA protein of KSHV protects against cell deathQ33885642
The RBP-Jκ binding sites within the RTA promoter regulate KSHV latent infection and cell proliferationQ34130213
Kaposi's sarcoma-associated herpesvirus-encoded latency-associated nuclear antigen inhibits lytic replication by targeting Rta: a potential mechanism for virus-mediated control of latencyQ34194120
The latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus supports latent DNA replication in dividing cellsQ34355092
The latent nuclear antigen of Kaposi sarcoma-associated herpesvirus targets the retinoblastoma-E2F pathway and with the oncogene Hras transforms primary rat cellsQ34511161
A novel viral mechanism for dysregulation of beta-catenin in Kaposi's sarcoma-associated herpesvirus latency.Q34531461
Acetylation of the latency-associated nuclear antigen regulates repression of Kaposi's sarcoma-associated herpesvirus lytic transcription.Q34648229
The nucleosomal surface as a docking station for Kaposi's sarcoma herpesvirus LANA.Q40318272
The latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus modulates cellular gene expression and protects lymphoid cells from p16 INK4A-induced cell cycle arrestQ40496132
Transcriptional coactivation of c-Jun by the KSHV-encoded LANA.Q40635358
The latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus interacts preferentially with the terminal repeats of the genome in vivo and this complex is sufficient for episomal DNA replicationQ40644381
Latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus functionally interacts with heterochromatin protein 1.Q40682995
Kaposi's sarcoma-associated herpesvirus LANA protein downregulates nuclear glycogen synthase kinase 3 activity and consequently blocks differentiationQ41846091
Regulation of the interaction between glycogen synthase kinase 3 and the Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigenQ41849965
The latency-associated nuclear antigen interacts with MeCP2 and nucleosomes through separate domainsQ41860564
Disruption of LANA in rhesus rhadinovirus generates a highly lytic recombinant virusQ41891421
Kaposi's sarcoma-associated herpesvirus latent protein LANA interacts with HIF-1 alpha to upregulate RTA expression during hypoxia: Latency control under low oxygen conditionsQ42049779
Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen induces a strong bend on binding to terminal repeat DNA.Q42584460
Expression of p53 and human herpesvirus-8 (HHV-8)-encoded latency-associated nuclear antigen with inhibition of apoptosis in HHV-8-associated malignanciesQ42665921
ERK1/2 and MEK1/2 induced by Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) early during infection of target cells are essential for expression of viral genes and for establishment of infectionQ42931199
The Transcriptional Activity of cAMP Response Element-binding Protein-binding Protein Is Modulated by the Latency Associated Nuclear Antigen of Kaposi's Sarcoma-associated HerpesvirusQ57662902
The manipulation of miRNA-gene regulatory networks by KSHV induces endothelial cell motilityQ84470156
Modulation of Kaposi's sarcoma-associated herpesvirus infection and replication by MEK/ERK, JNK, and p38 multiple mitogen-activated protein kinase pathways during primary infectionQ34648384
Mutational analysis of the latency-associated nuclear antigen DNA-binding domain of Kaposi's sarcoma-associated herpesvirus reveals structural conservation among gammaherpesvirus origin-binding proteinsQ34734774
Kaposi's Sarcoma-Associated Herpesvirus Latency-Associated Nuclear Antigen Induces Expression of the Helix-Loop-Helix Protein Id-1 in Human Endothelial CellsQ34976840
Recruitment of the de novo DNA methyltransferase Dnmt3a by Kaposi's sarcoma-associated herpesvirus LANAQ35080754
Kaposi's sarcoma-associated herpesvirus LANA-1 interacts with the short variant of BRD4 and releases cells from a BRD4- and BRD2/RING3-induced G1 cell cycle arrestQ35139294
The internal Kaposi's sarcoma-associated herpesvirus LANA regions exert a critical role on episome persistenceQ35140238
Phosphorylation of Tip60 by GSK-3 determines the induction of PUMA and apoptosis by p53Q35252479
Functional p53 signaling in Kaposi's sarcoma-associated herpesvirus lymphomas: implications for therapy.Q35635426
Conserved herpesvirus kinases target the DNA damage response pathway and TIP60 histone acetyltransferase to promote virus replication.Q35660314
Reactivation of the p53 pathway as a treatment modality for KSHV-induced lymphomas.Q35664106
Determination of Kaposi's sarcoma-associated herpesvirus C-terminal latency-associated nuclear antigen residues mediating chromosome association and DNA bindingQ35785433
Nutlin-3 induces apoptosis, disrupts viral latency and inhibits expression of angiopoietin-2 in Kaposi sarcoma tumor cells.Q35954902
Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen interacts with multifunctional angiogenin to utilize its antiapoptotic functions.Q36023151
The Kaposi's sarcoma-associated herpesvirus LANA protein stabilizes and activates c-MycQ36099076
Reactivation of Kaposi's sarcoma-associated herpesvirus from latency requires MEK/ERK, JNK and p38 multiple mitogen-activated protein kinase pathwaysQ36454456
KSHV LANA inhibits TGF-beta signaling through epigenetic silencing of the TGF-beta type II receptorQ36591375
The MEK/ERK cascade: from signaling specificity to diverse functionsQ36656631
Genetic disruption of KSHV major latent nuclear antigen LANA enhances viral lytic transcriptional programQ37060535
Role of Kaposi's sarcoma-associated herpesvirus C-terminal LANA chromosome binding in episome persistenceQ37157253
Protein array identification of substrates of the Epstein-Barr virus protein kinase BGLF4Q37192108
Profiling the human protein-DNA interactome reveals ERK2 as a transcriptional repressor of interferon signalingQ37415666
Kaposi's sarcoma-associated herpesvirus induces the phosphatidylinositol 3-kinase-PKC-zeta-MEK-ERK signaling pathway in target cells early during infection: implications for infectivityQ38359214
Bub1 and CENP-F can contribute to Kaposi's sarcoma-associated herpesvirus genome persistence by targeting LANA to kinetochoresQ39675686
The latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus permits replication of terminal repeat-containing plasmids.Q39700420
Human I-mfa domain proteins specifically interact with KSHV LANA and affect its regulation of Wnt signaling-dependent transcriptionQ39711148
DNA-PK/Ku complex binds to latency-associated nuclear antigen and negatively regulates Kaposi's sarcoma-associated herpesvirus latent replication.Q39725564
Distinct p53, p53:LANA, and LANA complexes in Kaposi's Sarcoma--associated Herpesvirus LymphomasQ39744147
Kaposi's sarcoma-associated herpesvirus Lana-1 is a major activator of the serum response element and mitogen-activated protein kinase pathways via interactions with the Mediator complexQ39749787
A Domain in the C-terminal region of latency-associated nuclear antigen 1 of Kaposi's sarcoma-associated Herpesvirus affects transcriptional activation and binding to nuclear heterochromatinQ39756815
Inhibition of KSHV-infected primary effusion lymphomas in NOD/SCID mice by gamma-secretase inhibitor.Q39794624
Latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus (KSHV) upregulates survivin expression in KSHV-Associated B-lymphoma cells and contributes to their proliferationQ39852047
Transcriptional activation by the Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen is facilitated by an N-terminal chromatin-binding motif.Q39960021
Latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus up-regulates transcription of human telomerase reverse transcriptase promoter through interaction with transcription factor Sp1.Q39992257
ORF73-null murine gammaherpesvirus 68 reveals roles for mLANA and p53 in virus replicationQ40094006
Deregulation of c-Myc in primary effusion lymphoma by Kaposi's sarcoma herpesvirus latency-associated nuclear antigenQ40169138
Herpesvirus saimiri episomal persistence is maintained via interaction between open reading frame 73 and the cellular chromosome-associated protein MeCP2.Q40176573
KSHV encoded LANA upregulates Pim-1 and is a substrate for its kinase activityQ40286016
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue10
P921main subjectphosphorylationQ242736
P304page(s)e1002972
P577publication date2012-10-18
P1433published inPLOS PathogensQ283209
P1476titlePhosphorylation of the chromatin binding domain of KSHV LANA
P478volume8

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cites work (P2860)
Q38721370A Human Proteome Array Approach to Identifying Key Host Proteins Targeted by Toxoplasma Kinase ROP18.
Q35973676A Screen for Extracellular Signal-Regulated Kinase-Primed Glycogen Synthase Kinase 3 Substrates Identifies the p53 Inhibitor iASPP.
Q30398275Assay Development and High-Throughput Screening for Inhibitors of Kaposi's Sarcoma-Associated Herpesvirus N-Terminal Latency-Associated Nuclear Antigen Binding to Nucleosomes
Q30535717Complex alternative cytoplasmic protein isoforms of the Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen 1 generated through noncanonical translation initiation
Q37030691Current understanding of the role of the Brd4 protein in the papillomavirus lifecycle
Q64128205Development of an ORF45-Derived Peptide To Inhibit the Sustained RSK Activation and Lytic Replication of Kaposi's Sarcoma-Associated Herpesvirus
Q38100381Epigenetic regulation of EBV and KSHV latency
Q41924146Full-Length Isoforms of Kaposi's Sarcoma-Associated Herpesvirus Latency-Associated Nuclear Antigen Accumulate in the Cytoplasm of Cells Undergoing the Lytic Cycle of Replication
Q35720026Identification of Caspase Cleavage Sites in KSHV Latency-Associated Nuclear Antigen and Their Effects on Caspase-Related Host Defense Responses
Q92137391Infection-induced epigenetic changes and their impact on the pathogenesis of diseases
Q34717723Interaction of gamma-herpesvirus genome maintenance proteins with cellular chromatin.
Q26738483Kaposi's Sarcoma Herpesvirus Genome Persistence
Q27680411Molecular Basis for Oligomeric-DNA Binding and Episome Maintenance by KSHV LANA
Q35014918Molecular biology of KSHV lytic reactivation
Q55437554Murine leukemia virus p12 tethers the capsid-containing pre-integration complex to chromatin by binding directly to host nucleosomes in mitosis.
Q31040119PMD: A Resource for Archiving and Analyzing Protein Microarray data
Q35680401Phosphoproteomic Analysis of KSHV-Infected Cells Reveals Roles of ORF45-Activated RSK during Lytic Replication
Q38100859Potential of protein kinase inhibitors for treating herpesvirus-associated disease.
Q99591124Regulation of KSHV Latency and Lytic Reactivation
Q21129297The CK1 Family: Contribution to Cellular Stress Response and Its Role in Carcinogenesis
Q38108700The chromatin landscape of Kaposi's sarcoma-associated herpesvirus
Q64247511Towards Better Understanding of KSHV Life Cycle: from Transcription and Posttranscriptional Regulations to Pathogenesis