Epigenetic regulation of EBV and KSHV latency

scientific article published on 16 April 2013

Epigenetic regulation of EBV and KSHV latency is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.COVIRO.2013.03.004
P932PMC publication ID3947873
P698PubMed publication ID23601957

P2093author name stringPaul M Lieberman
Fang Lu
Horng-Shen Chen
P2860cites workThe EBV lytic switch protein, Z, preferentially binds to and activates the methylated viral genomeQ40516561
Infection of HHV-8+ primary effusion lymphoma cells with a recombinant Epstein-Barr virus leads to restricted EBV latency, altered phenotype, and increased tumorigenicity without affecting TCL1 expression.Q40635375
Epstein-Barr virus-associated Burkitt lymphomagenesis selects for downregulation of the nuclear antigen EBNA2.Q40705440
Methylation of the Epstein-Barr virus genome in normal lymphocytesQ41075320
CpG methylation of the major Epstein-Barr virus latency promoter in Burkitt's lymphoma and Hodgkin's diseaseQ41158549
Mitotic chromosome interactions of Epstein-Barr nuclear antigen 1 (EBNA1) and human EBNA1-binding protein 2 (EBP2)Q41370670
The latency-associated nuclear antigen interacts with MeCP2 and nucleosomes through separate domainsQ41860564
Chromatin profiling of Epstein-Barr virus latency control regionQ41867337
Cohesins repress Kaposi's sarcoma-associated herpesvirus immediate early gene transcription during latencyQ41947834
Unexpected structure of Epstein-Barr virus lytic cycle activator Zta.Q42160761
Expression of Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor monocistronic and bicistronic transcripts in primary effusion lymphomasQ42656894
EBNA1 efficiently assembles on chromatin containing the Epstein-Barr virus latent origin of replicationQ43505203
Molecular profile of Epstein-Barr virus infection in HHV-8-positive primary effusion lymphomaQ43813156
Pheno- and genotypic features of Epstein-Barr virus associated B-cell lymphoproliferations in peripheral T-cell lymphomas.Q54449917
Transcription profile of Kaposi's sarcoma-associated herpesvirus in primary Kaposi's sarcoma lesions as determined by real-time PCR arraysQ73344152
Inhibition of Epstein-Barr virus OriP function by tankyrase, a telomere-associated poly-ADP ribose polymerase that binds and modifies EBNA1Q24520598
Protein interactions targeting the latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus to cell chromosomesQ24538878
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CTCF: master weaver of the genomeQ24621388
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Structure of the p53 binding domain of HAUSP/USP7 bound to Epstein-Barr nuclear antigen 1 implications for EBV-mediated immortalizationQ28243346
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The double bromodomain-containing chromatin adaptor Brd4 and transcriptional regulationQ28290625
Methylated DNA recognition during the reversal of epigenetic silencing is regulated by cysteine and serine residues in the Epstein-Barr virus lytic switch proteinQ28472387
KSHV reactivation from latency requires Pim-1 and Pim-3 kinases to inactivate the latency-associated nuclear antigen LANAQ28474913
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Nucleophosmin phosphorylation by v-cyclin-CDK6 controls KSHV latencyQ33545232
The epigenetic landscape of latent Kaposi sarcoma-associated herpesvirus genomes.Q33598569
AP-1 homolog BZLF1 of Epstein-Barr virus has two essential functions dependent on the epigenetic state of the viral genomeQ33640163
Epigenetic analysis of KSHV latent and lytic genomesQ33641399
Mechanisms that regulate Epstein-Barr virus EBNA-1 gene transcription during restricted latency are conserved among lymphocryptoviruses of Old World primates.Q33653017
CTCF Prevents the Epigenetic Drift of EBV Latency Promoter QpQ33668727
CpG-methylation regulates a class of Epstein-Barr virus promotersQ33707736
Kaposi's sarcoma-associated herpesvirus reactivation is regulated by interaction of latency-associated nuclear antigen with recombination signal sequence-binding protein Jkappa, the major downstream effector of the Notch signaling pathwayQ33737793
DNA methylation and the Epstein-Barr virusQ33765683
Roscovitine inhibits EBNA1 serine 393 phosphorylation, nuclear localization, transcription, and episome maintenanceQ33786506
The herpesvirus associated ubiquitin specific protease, USP7, is a negative regulator of PML proteins and PML nuclear bodiesQ33815705
Regulation of Epstein-Barr virus OriP replication by poly(ADP-ribose) polymerase 1.Q33826947
Transcription program of human herpesvirus 8 (kaposi's sarcoma-associated herpesvirus).Q33841257
BZLF1 activation of the methylated form of the BRLF1 immediate-early promoter is regulated by BZLF1 residue 186.Q33843046
Protein-DNA binding and CpG methylation at nucleotide resolution of latency-associated promoters Qp, Cp, and LMP1p of Epstein-Barr virusQ33865166
Epstein-Barr nuclear antigen 1 binds and destabilizes nucleosomes at the viral origin of latent DNA replicationQ33941808
EBV latency types adopt alternative chromatin conformationsQ33987454
Coordination of KSHV latent and lytic gene control by CTCF-cohesin mediated chromosome conformationQ34005284
Epigenetic regulation of Kaposi's sarcoma-associated herpesvirus latency by virus-encoded microRNAs that target Rta and the cellular Rbl2-DNMT pathwayQ34092628
Brd2/RING3 interacts with a chromatin-binding domain in the Kaposi's Sarcoma-associated herpesvirus latency-associated nuclear antigen 1 (LANA-1) that is required for multiple functions of LANA-1.Q34092739
Coupled transcriptome and proteome analysis of human lymphotropic tumor viruses: insights on the detection and discovery of viral genesQ34106764
The RBP-Jκ binding sites within the RTA promoter regulate KSHV latent infection and cell proliferationQ34130213
A protein array screen for Kaposi's sarcoma-associated herpesvirus LANA interactors links LANA to TIP60, PP2A activity, and telomere shortening.Q34179693
Charting latency transcripts in Kaposi's sarcoma-associated herpesvirus by whole-genome real-time quantitative PCRQ34340317
The Kaposi's sarcoma-associated herpesvirus K12 transcript from a primary effusion lymphoma contains complex repeat elements, is spliced, and initiates from a novel promoterQ34359380
Phosphorylation of the chromatin binding domain of KSHV LANAQ34456086
The importance of epigenetic alterations in the development of epstein-barr virus-related lymphomasQ34549462
Acetylation of the latency-associated nuclear antigen regulates repression of Kaposi's sarcoma-associated herpesvirus lytic transcription.Q34648229
Cohesin: genomic insights into controlling gene transcription and developmentQ34762370
The single RBP-Jkappa site within the LANA promoter is crucial for establishing Kaposi's sarcoma-associated herpesvirus latency during primary infectionQ35077558
Transcriptional activation by EBV nuclear antigen 1 is essential for the expression of EBV's transforming genesQ35080523
Recruitment of the de novo DNA methyltransferase Dnmt3a by Kaposi's sarcoma-associated herpesvirus LANAQ35080754
Brd4 is required for e2-mediated transcriptional activation but not genome partitioning of all papillomavirusesQ35101324
Kaposi's sarcoma-associated herpesvirus LANA-1 interacts with the short variant of BRD4 and releases cells from a BRD4- and BRD2/RING3-induced G1 cell cycle arrestQ35139294
The lytic phase of epstein-barr virus requires a viral genome with 5-methylcytosine residues in CpG sitesQ35666071
Persistence of the Epstein-Barr virus and the origins of associated lymphomasQ35715171
Protein arginine methyltransferase 1-directed methylation of Kaposi sarcoma-associated herpesvirus latency-associated nuclear antigenQ35774091
Methylation status of the Epstein-Barr virus major latent promoter C in iatrogenic B cell lymphoproliferative disease. Application of PCR-based analysis.Q35787708
Identification of host-chromosome binding sites and candidate gene targets for Kaposi's sarcoma-associated herpesvirus LANAQ35943531
Carboxyl-terminal amino acids 1052 to 1082 of the latency-associated nuclear antigen (LANA) interact with RBP-Jκ and are responsible for LANA-mediated RTA repression.Q35943718
The ubiquitin-specific protease USP7 modulates the replication of Kaposi's sarcoma-associated herpesvirus latent episomal DNAQ36086767
Chromatin remodeling of the Kaposi's sarcoma-associated herpesvirus ORF50 promoter correlates with reactivation from latencyQ36538689
Transcriptional activation of the Epstein-Barr virus latency C promoter after 5-azacytidine treatment: evidence that demethylation at a single CpG site is crucial.Q36555784
Host-cell-determined methylation of specific Epstein-Barr virus promoters regulates the choice between distinct viral latency programsQ36564877
Cohesin regulation: fashionable ways to wear a ringQ36749404
Lytic cycle switches of oncogenic human gammaherpesvirusesQ36786043
The EBNA1 protein of Epstein-Barr virus functionally interacts with Brd4Q36994613
The Epstein-Barr virus nuclear antigen-1 promotes genomic instability via induction of reactive oxygen species.Q37114836
Identifying sites bound by Epstein-Barr virus nuclear antigen 1 (EBNA1) in the human genome: defining a position-weighted matrix to predict sites bound by EBNA1 in viral genomesQ37127891
The latency-associated nuclear antigen, a multifunctional protein central to Kaposi's sarcoma-associated herpesvirus latencyQ37380228
Epigenetic regulation of Kaposi's sarcoma-associated herpesvirus replicationQ37476243
The amino terminus of Epstein-Barr Virus (EBV) nuclear antigen 1 contains AT hooks that facilitate the replication and partitioning of latent EBV genomes by tethering them to cellular chromosomesQ37583383
Does CTCF mediate between nuclear organization and gene expression?Q37658609
Epigenetic reprogramming of host genes in viral and microbial pathogenesisQ37781197
Why do viruses cause cancer? Highlights of the first century of human tumour virologyQ37811898
Cohesin: a critical chromatin organizer in mammalian gene regulationQ37919509
The bromodomain interaction moduleQ38019699
Kaposi's sarcoma-associated herpesvirus latent and lytic gene expression as revealed by DNA arraysQ38305362
Timeless-dependent DNA replication-coupled recombination promotes Kaposi's Sarcoma-associated herpesvirus episome maintenance and terminal repeat stabilityQ38318452
Genome-wide analyses of Zta binding to the Epstein-Barr virus genome reveals interactions in both early and late lytic cycles and an epigenetic switch leading to an altered binding profileQ38321333
Kaposi's sarcoma-associated herpesvirus-encoded LANA recruits topoisomerase IIβ for latent DNA replication of the terminal repeatsQ39320195
BRD4 jump-starts transcription after mitotic silencingQ39435811
Evidence that protein binding specifies sites of DNA demethylationQ39444301
The replisome pausing factor Timeless is required for episomal maintenance of latent Epstein-Barr virusQ39559198
Rep*: a viral element that can partially replace the origin of plasmid DNA synthesis of Epstein-Barr virus.Q39580375
Differential methylation of Epstein-Barr virus latency promoters facilitates viral persistence in healthy seropositive individuals.Q39596964
Transcripts encoding K12, v-FLIP, v-cyclin, and the microRNA cluster of Kaposi's sarcoma-associated herpesvirus originate from a common promoter.Q39612221
Genome-wide analysis of host-chromosome binding sites for Epstein-Barr Virus Nuclear Antigen 1 (EBNA1).Q39647281
Epstein-Barr virus nuclear antigen 1 Hijacks the host kinase CK2 to disrupt PML nuclear bodiesQ39666008
Bub1 and CENP-F can contribute to Kaposi's sarcoma-associated herpesvirus genome persistence by targeting LANA to kinetochoresQ39675686
The de novo methyltransferases DNMT3a and DNMT3b target the murine gammaherpesvirus immediate-early gene 50 promoter during establishment of latencyQ39732626
The CBP bromodomain and nucleosome targeting are required for Zta-directed nucleosome acetylation and transcription activationQ39743627
Distinct p53, p53:LANA, and LANA complexes in Kaposi's Sarcoma--associated Herpesvirus LymphomasQ39744147
Differential hyperacetylation of histones H3 and H4 upon promoter-specific recruitment of EBNA2 in Epstein-Barr virus chromatin.Q39776571
Nucleosome assembly proteins bind to Epstein-Barr virus nuclear antigen 1 and affect its functions in DNA replication and transcriptional activationQ39804470
The reversal of epigenetic silencing of the EBV genome is regulated by viral bZIP proteinQ39960898
Latency type-specific distribution of epigenetic marks at the alternative promoters Cp and Qp of Epstein-Barr virusQ39983012
Cohesins localize with CTCF at the KSHV latency control region and at cellular c-myc and H19/Igf2 insulatorsQ40020777
Three pathways of Epstein-Barr virus gene activation from EBNA1-positive latency in B lymphocytesQ40048949
High-resolution analysis of CpG methylation and in vivo protein-DNA interactions at the alternative Epstein-Barr virus latency promoters Qp and Cp in the nasopharyngeal carcinoma cell line C666-1.Q40131153
KSHV encoded LANA upregulates Pim-1 and is a substrate for its kinase activityQ40286016
The nucleosomal surface as a docking station for Kaposi's sarcoma herpesvirus LANA.Q40318272
P433issue3
P304page(s)251-259
P577publication date2013-04-16
P1433published inCurrent opinion in virologyQ26842394
P1476titleEpigenetic regulation of EBV and KSHV latency
P478volume3