The de novo methyltransferases DNMT3a and DNMT3b target the murine gammaherpesvirus immediate-early gene 50 promoter during establishment of latency

scientific article

The de novo methyltransferases DNMT3a and DNMT3b target the murine gammaherpesvirus immediate-early gene 50 promoter during establishment of latency is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1128/JVI.00060-10
P932PMC publication ID2863815
P698PubMed publication ID20200245

P50authorSamuel H SpeckQ94468728
P2093author name stringJ Craig Forrest
Kathleen S Gray
P2860cites workDNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian developmentQ22010765
Natural history of murine  -herpesvirus infectionQ27469488
Methylated DNA recognition during the reversal of epigenetic silencing is regulated by cysteine and serine residues in the Epstein-Barr virus lytic switch proteinQ28472387
Essential role for de novo DNA methyltransferase Dnmt3a in paternal and maternal imprintingQ28508038
Molecular enzymology of mammalian DNA methyltransferasesQ28646064
Linking DNA methylation and histone modification: patterns and paradigmsQ29617801
Chromatin modification and epigenetic reprogramming in mammalian developmentQ29617802
RTA promoter demethylation and histone acetylation regulation of murine gammaherpesvirus 68 reactivationQ33411313
A viral gene that activates lytic cycle expression of Kaposi's sarcoma-associated herpesvirusQ33559699
Three distinct regions of the murine gammaherpesvirus 68 genome are transcriptionally active in latently infected miceQ33653581
Forced lytic replication impairs host colonization by a latency-deficient mutant of murine gammaherpesvirus-68.Q40600121
Methylation of the EBV genome and establishment of restricted latency in low-passage EBV-infected 293 epithelial cellsQ40712238
Kaposi's Sarcoma-associated herpesvirus open reading frame 50 stimulates the transcriptional activity of STAT3.Q40763723
Role for MyD88 signaling in murine gammaherpesvirus 68 latencyQ42156204
De novo DNA methyltransferase is essential for self-renewal, but not for differentiation, in hematopoietic stem cellsQ42688131
Limiting dilution analysis of virus-specific memory B cells by an ELISPOT assayQ44465948
Activation of the epstein-barr virus genome by 5-aza-cytidine in latently infected human lymphoid linesQ45805408
Defective de novo methylation of viral and cellular DNA sequences in ICF syndrome cellsQ74633165
Reactivation of Kaposi's sarcoma-associated herpesvirus infection from latency by expression of the ORF 50 transactivator, a homolog of the EBV R proteinQ77760836
Functional analysis of promoter CpG methylation using a CpG-free luciferase reporter vectorQ81509934
Kaposi's sarcoma-associated herpesvirus reactivation is regulated by interaction of latency-associated nuclear antigen with recombination signal sequence-binding protein Jkappa, the major downstream effector of the Notch signaling pathwayQ33737793
Activation of the BRLF1 promoter and lytic cycle of Epstein-Barr virus by histone acetylationQ33786869
Characterization of gammaherpesvirus 68 gene 50 transcriptionQ33798175
Rta of murine gammaherpesvirus 68 reactivates the complete lytic cycle from latency.Q33802415
BZLF1 activation of the methylated form of the BRLF1 immediate-early promoter is regulated by BZLF1 residue 186.Q33843046
CREB-binding protein and histone deacetylase regulate the transcriptional activity of Kaposi's sarcoma-associated herpesvirus open reading frame 50Q33854980
The Epstein-Barr virus lytic cycle activator Zta interacts with methylated ZRE in the promoter of host target gene egr1.Q33910725
Kinetic analysis of the specific host response to a murine gammaherpesvirusQ34068985
Murine gammaherpesvirus 68 infection is associated with lymphoproliferative disease and lymphoma in BALB beta2 microglobulin-deficient miceQ34142912
Kaposi's sarcoma-associated herpesvirus-encoded latency-associated nuclear antigen inhibits lytic replication by targeting Rta: a potential mechanism for virus-mediated control of latencyQ34194120
Identification of spliced gammaherpesvirus 68 LANA and v-cyclin transcripts and analysis of their expression in vivo during latent infectionQ34353305
B cells and herpesviruses: a model of lymphoproliferation.Q34717891
Disruption of gammaherpesvirus 68 gene 50 demonstrates that Rta is essential for virus replicationQ34977295
Activation of latent Kaposi's sarcoma-associated herpesvirus by demethylation of the promoter of the lytic transactivator.Q35056440
Long-term latent murine Gammaherpesvirus 68 infection is preferentially found within the surface immunoglobulin D-negative subset of splenic B cells in vivoQ35155237
Regulation of activation and recombination of the murine Igkappa locusQ35830435
CD4(+) T cell-mediated control of a gamma-herpesvirus in B cell-deficient mice is mediated by IFN-gammaQ36338436
Histone hyperacetylation occurs on promoters of lytic cycle regulatory genes in Epstein-Barr virus-infected cell lines which are refractory to disruption of latency by histone deacetylase inhibitorsQ36594092
The Rta/Orf50 transactivator proteins of the gamma-herpesviridae.Q36647077
Establishment of B-cell lines latently infected with reactivation-competent murine gammaherpesvirus 68 provides evidence for viral alteration of a DNA damage-signaling cascadeQ36804603
Alternatively initiated gene 50/RTA transcripts expressed during murine and human gammaherpesvirus reactivation from latencyQ37033176
Identification of infected B-cell populations by using a recombinant murine gammaherpesvirus 68 expressing a fluorescent proteinQ37232914
Identification of an Rta responsive promoter involved in driving gammaHV68 v-cyclin expression during virus replicationQ37383464
Epigenetic dysregulation of the host cell genome in Epstein-Barr virus-associated neoplasiaQ37476248
Cellular and viral DNA hypomethylation associated with induction of Epstein-Barr virus lytic cycleQ37557036
Variable methylation of the Epstein-Barr virus Wp EBNA gene promoter in B-lymphoblastoid cell linesQ37683015
B cells regulate murine gammaherpesvirus 68 latencyQ39593978
Differential methylation of Epstein-Barr virus latency promoters facilitates viral persistence in healthy seropositive individuals.Q39596964
Function of Rta is essential for lytic replication of murine gammaherpesvirus 68.Q39604125
Antibody to a lytic cycle viral protein decreases gammaherpesvirus latency in B-cell-deficient miceQ39685855
B lymphocyte-specific, Cre-mediated mutagenesis in miceQ39719513
Mature B cells are required for acute splenic infection, but not for establishment of latency, by murine gammaherpesvirus 68.Q39876421
Pathological changes in the spleens of gamma interferon receptor-deficient mice infected with murine gammaherpesvirus: a role for CD8 T cells.Q39879816
Germinal center B-cell-associated DNA hypomethylation at transcriptional regions of the AID geneQ40053298
Induction of the Epstein-Barr virus (EBV) cycle in latently infected cells by n-butyrateQ40227712
Inactivation of Dnmt3b in mouse embryonic fibroblasts results in DNA hypomethylation, chromosomal instability, and spontaneous immortalization.Q40448471
P433issue10
P407language of work or nameEnglishQ1860
P921main subjectimmediate early geneQ409638
P304page(s)4946-4959
P577publication date2010-03-03
P1433published inJournal of VirologyQ1251128
P1476titleThe de novo methyltransferases DNMT3a and DNMT3b target the murine gammaherpesvirus immediate-early gene 50 promoter during establishment of latency
P478volume84

Reverse relations

cites work (P2860)
Q33605765An in vitro system for studying murid herpesvirus-4 latency and reactivation
Q40852419De novo DNA Methyltransferases Dnmt3a and Dnmt3b regulate the onset of Igκ light chain rearrangement during early B-cell development
Q59356545Emerging Proviral Roles of Caspases during Lytic Replication of Gammaherpesviruses
Q38100381Epigenetic regulation of EBV and KSHV latency
Q36079181Epigenetic silencing of tumor suppressor genes during in vitro Epstein-Barr virus infection.
Q47550358Interferon regulatory factor 8 regulates caspase-1 expression to facilitate Epstein-Barr virus reactivation in response to B cell receptor stimulation and chemical induction.
Q34774797KSHV LANA--the master regulator of KSHV latency
Q37634460Pervasive transcription of a herpesvirus genome generates functionally important RNAs
Q99616354Role of DNA methylation and CpG sites in the viral telomerase RNA promoter during Gallid herpesvirus 2 pathogenesis
Q26852963The Interplay between Chromatin and Transcription Factor Networks during B Cell Development: Who Pulls the Trigger First?
Q26767186The Role of Gammaherpesviruses in Cancer Pathogenesis
Q35867993Tiled microarray identification of novel viral transcript structures and distinct transcriptional profiles during two modes of productive murine gammaherpesvirus 68 infection

Search more.