Recruitment of the tumour suppressor protein p73 by Kaposi’s Sarcoma Herpesvirus latent nuclear antigen contributes to the survival of primary effusion lymphoma cells

scientific article published on September 10, 2012

Recruitment of the tumour suppressor protein p73 by Kaposi’s Sarcoma Herpesvirus latent nuclear antigen contributes to the survival of primary effusion lymphoma cells is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1004882735
P356DOI10.1038/ONC.2012.385
P8608Fatcat IDrelease_s2cullb555d37h53cqln75k4pi
P953full work available at URLhttps://www.nature.com/articles/onc2012385
https://www.nature.com/articles/onc2012385.pdf
P698PubMed publication ID22964633

P50authorPäivi M OjalaQ56112086
Christina B KarstenQ56525462
Thomas F SchulzQ61072935
P2093author name stringW. Jäger
D. Steinemann
G. Sarek
M. Pietrek
S. Kati
S. Santag
P2860cites workTAp73 knockout shows genomic instability with infertility and tumor suppressor functionsQ36919913
The jury is in: p73 is a tumor suppressor after all.Q37285304
Skin human papillomavirus type 38 alters p53 functions by accumulation of deltaNp73.Q38317007
Distinct regulation of p53 and p73 activity by adenovirus E1A, E1B, and E4orf6 proteinsQ39446048
Viral oncoproteins discriminate between p53 and the p53 homolog p73.Q39576424
Persistent Infection of Epstein-Barr Virus-Positive B Lymphocytes by Human Herpesvirus 8Q39581248
Distinct p53, p53:LANA, and LANA complexes in Kaposi's Sarcoma--associated Herpesvirus LymphomasQ39744147
A Domain in the C-terminal region of latency-associated nuclear antigen 1 of Kaposi's sarcoma-associated Herpesvirus affects transcriptional activation and binding to nuclear heterochromatinQ39756815
An essential role for p73 in regulating mitotic cell deathQ39763275
Accumulation of LANA at nuclear matrix fraction is important for Kaposi's sarcoma-associated herpesvirus replication in latencyQ39913167
Transcriptional activation by the Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen is facilitated by an N-terminal chromatin-binding motif.Q39960021
Identification and characterization of the product encoded by ORF69 of Kaposi's sarcoma-associated herpesvirusQ40008314
The viral interferon-regulatory factor-3 is required for the survival of KSHV-infected primary effusion lymphoma cellsQ40077157
A novel role for p73 in the regulation of Akt-Foxo1a-Bim signaling and apoptosis induced by the plant lectin, Concanavalin A.Q40118545
Kaposi's sarcoma-associated herpesvirus-encoded latency-associated nuclear antigen induces chromosomal instability through inhibition of p53 functionQ40335991
Inhibiting primary effusion lymphoma by lentiviral vectors encoding short hairpin RNA.Q40486158
The latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus modulates cellular gene expression and protects lymphoid cells from p16 INK4A-induced cell cycle arrestQ40496132
Characterization of a novel HHV-8-positive cell line reveals implications for the pathogenesis and cell cycle control of primary effusion lymphomaQ40865709
Kaposi's sarcoma-associated herpesvirus confers a survival advantage to endothelial cellsQ42141115
Kaposi's sarcoma-associated herpesvirus induction of chromosome instability in primary human endothelial cellsQ42328529
Expression of p53 and human herpesvirus-8 (HHV-8)-encoded latency-associated nuclear antigen with inhibition of apoptosis in HHV-8-associated malignanciesQ42665921
Kaposi's sarcoma herpesvirus lytic replication compromises apoptotic response to p53 reactivation in virus-induced lymphomas.Q45358610
Functional impairment of p73 and p51, the p53-related proteins, by the human T-cell leukemia virus type 1 Tax oncoproteinQ45744096
c-Abl tyrosine kinase selectively regulates p73 nuclear matrix associationQ47807561
HDM2 antagonist Nutlin-3 disrupts p73-HDM2 binding and enhances p73 function.Q52581241
Human delta Np73 regulates a dominant negative feedback loop for TAp73 and p53.Q53393697
Functional inactivation of p73, a homolog of p53 tumor suppressor protein, by human papillomavirus E6 proteinsQ24290998
Mdm2 promotes the rapid degradation of p53Q24322597
Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53Q24328775
MDM2 suppresses p73 function without promoting p73 degradationQ24554510
In vivo activation of the p53 pathway by small-molecule antagonists of MDM2Q27642888
Regulation of p53 stability by Mdm2Q27860744
Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcomaQ28242984
Kaposi's sarcoma-associated herpesvirus-like DNA sequences in AIDS-related body-cavity-based lymphomasQ28299069
p53 mutations in human cancersQ28302973
Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53Q29615851
EC5S ubiquitin complex is recruited by KSHV latent antigen LANA for degradation of the VHL and p53 tumor suppressorsQ33261811
Small-molecule RETRA suppresses mutant p53-bearing cancer cells through a p73-dependent salvage pathway.Q33329474
The K-bZIP protein from Kaposi's sarcoma-associated herpesvirus interacts with p53 and represses its transcriptional activity.Q33813261
Kaposi's sarcoma-associated herpesvirus LANA2 is a B-cell-specific latent viral protein that inhibits p53Q33834993
Modulation of cellular and viral gene expression by the latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirusQ33835021
Viral interferon regulatory factor 1 of Kaposi's sarcoma-associated herpesvirus binds to p53 and represses p53-dependent transcription and apoptosis.Q33842636
Kaposi's sarcoma-associated herpesvirus open reading frame 50 represses p53-induced transcriptional activity and apoptosisQ33842738
p53 inhibition by the LANA protein of KSHV protects against cell deathQ33885642
Brd2/RING3 interacts with a chromatin-binding domain in the Kaposi's Sarcoma-associated herpesvirus latency-associated nuclear antigen 1 (LANA-1) that is required for multiple functions of LANA-1.Q34092739
NF-kappaB inhibits T-cell activation-induced, p73-dependent cell death by induction of MDM2Q34241420
Functional regulation of p73 and p63: development and cancerQ35601815
Functional p53 signaling in Kaposi's sarcoma-associated herpesvirus lymphomas: implications for therapy.Q35635426
Reactivation of the p53 pathway as a treatment modality for KSHV-induced lymphomas.Q35664106
KSHV vFLIP is essential for the survival of infected lymphoma cellsQ36399405
P433issue32
P407language of work or nameEnglishQ1860
P921main subjectprimary effusion lymphomaQ3832899
Kaposi's sarcomaQ725345
P304page(s)3676-3685
P577publication date2012-09-10
P1433published inOncogeneQ1568657
P1476titleRecruitment of the tumour suppressor protein p73 by Kaposi's Sarcoma Herpesvirus latent nuclear antigen contributes to the survival of primary effusion lymphoma cells
Recruitment of the tumour suppressor protein p73 by Kaposi’s Sarcoma Herpesvirus latent nuclear antigen contributes to the survival of primary effusion lymphoma cells
P478volume32

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cites work (P2860)
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