LIM domains-containing protein 1 (LIMD1), a tumor suppressor encoded at chromosome 3p21.3, binds pRB and represses E2F-driven transcription

scientific article

LIM domains-containing protein 1 (LIMD1), a tumor suppressor encoded at chromosome 3p21.3, binds pRB and represses E2F-driven transcription is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2004PNAS..10116531S
P356DOI10.1073/PNAS.0407123101
P932PMC publication ID534532
P698PubMed publication ID15542589
P5875ResearchGate publication ID8183599

P2093author name stringTyson V Sharp
Hsei-Wei Wang
George Klein
Andrew G Nicholson
Chris Boshoff
Nadege Presneau
Dimitra Bourboulia
Eva Darai
Mark Cannon
David N Butcher
Fernando Munoz
Stephan Imreh
P2860cites workInteraction of Hic-5, A senescence-related protein, with focal adhesion kinaseQ22003881
A novel gene containing LIM domains (LIMD1) is located within the common eliminated region 1 (C3CER1) in 3p21.3Q22011160
Retinoblastoma: a prototypic hereditary neoplasmQ67312912
Nonrandom loss of human chromosome 3 fragments from mouse-human microcell hybrids following progressive growth in SCID miceQ71678476
Tumor suppressor genesQ72455787
Molecular biology of lung cancerQ77224978
Two genetic hits (more or less) to cancerQ22251289
Purification and biochemical heterogeneity of the mammalian SWI-SNF complexQ24316969
The human TRIP6 gene encodes a LIM domain protein and maps to chromosome 7q22, a region associated with tumorigenesisQ24318876
Ajuba, a novel LIM protein, interacts with Grb2, augments mitogen-activated protein kinase activity in fibroblasts, and promotes meiotic maturation of Xenopus oocytes in a Grb2- and Ras-dependent mannerQ24517774
Interaction of the tau2 transcriptional activation domain of glucocorticoid receptor with a novel steroid receptor coactivator, Hic-5, which localizes to both focal adhesions and the nuclear matrixQ24549599
Ajuba, a cytosolic LIM protein, shuttles into the nucleus and affects embryonal cell proliferation and fate decisionsQ24550770
Mutation and cancer: statistical study of retinoblastomaQ24618185
CRM1 is an export receptor for leucine-rich nuclear export signalsQ27860453
Genomic libraries and a host strain designed for highly efficient two-hybrid selection in yeastQ28131604
The LIM domain: regulation by associationQ28137861
The mouse ortholog of the human SMARCB1 gene encodes two splice formsQ28141915
LIM domain protein Trip6 has a conserved nuclear export signal, nuclear targeting sequences, and multiple transactivation domainsQ28187236
LIM domains: multiple roles as adapters and functional modifiers in protein interactionsQ28271283
LPP, the preferred fusion partner gene of HMGIC in lipomas, is a novel member of the LIM protein gene familyQ28290227
Characterization of a focal adhesion protein, Hic-5, that shares extensive homology with paxillinQ28291872
Disruption of Ini1 leads to peri-implantation lethality and tumorigenesis in miceQ28592343
In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vectorQ29547503
Real time quantitative PCRQ29616373
Functional interactions of the retinoblastoma protein with mammalian D-type cyclinsQ29618856
Adenovirus E1a prevents the retinoblastoma gene product from repressing the activity of a cellular transcription factorQ33938069
The latent nuclear antigen of Kaposi sarcoma-associated herpesvirus targets the retinoblastoma-E2F pathway and with the oncogene Hras transforms primary rat cellsQ34511161
Kaposi sarcoma herpesvirus-induced cellular reprogramming contributes to the lymphatic endothelial gene expression in Kaposi sarcoma.Q34548882
The transcriptional map of the common eliminated region 1 (C3CER1) in 3p21.3.Q34647531
Tumor suppressor genes on chromosome 3p involved in the pathogenesis of lung and other cancersQ34935968
Zyxin and paxillin proteins: focal adhesion plaque LIM domain proteins go nuclearQ35064603
Search for unknown tumor‐antagonizing genesQ35563102
A new bacteriophage P1-derived vector for the propagation of large human DNA fragmentsQ36745476
Definition of a tumor suppressor locus within human chromosome 3p21-p22Q37299935
Molecular changes in the bronchial epithelium of patients with small cell lung cancerQ37511952
Identification of novel E2F1-regulated genes by microarrayQ38291297
K15 protein of Kaposi's sarcoma-associated herpesvirus is latently expressed and binds to HAX-1, a protein with antiapoptotic functionQ39685961
Interstitial deletions including chromosome 3 common eliminated region 1 (C3CER1) prevail in human solid tumors from 10 different tissuesQ40521433
E2F-1 gene transfer enhances invasiveness of human head and neck carcinoma cell linesQ40841477
Zyxin: zinc fingers at sites of cell adhesionQ41658428
Human lactoferrin inhibits growth of solid tumors and development of experimental metastases in mice.Q42799210
Levels of E2F-1 expression are higher in lung metastasis of colon cancer as compared with hepatic metastasis and correlate with levels of thymidylate synthase.Q54051499
P433issue47
P407language of work or nameEnglishQ1860
P921main subjectnegative regulation of transcription, DNA-templatedQ14633919
LIM domains containing 1Q21122306
P304page(s)16531-6
P577publication date2004-11-23
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleLIM domains-containing protein 1 (LIMD1), a tumor suppressor encoded at chromosome 3p21.3, binds pRB and represses E2F-driven transcription
P478volume101

Reverse relations

cites work (P2860)
Q89181309A HIF-LIMD1 negative feedback mechanism mitigates the pro-tumorigenic effects of hypoxia
Q35692123A Phosphoproteomic Comparison of B-RAFV600E and MKK1/2 Inhibitors in Melanoma Cells
Q24309249Ajuba LIM proteins are snail/slug corepressors required for neural crest development in Xenopus
Q35598545Caloric restriction induces heat shock response and inhibits B16F10 cell tumorigenesis both in vitro and in vivo
Q24329205Cell cycle regulated phosphorylation of LIMD1 in cell lines and expression in human breast cancers
Q57799063Communication of prostate cancer cells with bone cells via extracellular vesicle RNA; a potential mechanism of metastasis
Q43093361Computational analysis of prolyl hydroxylase domain-containing protein 2 (PHD2) mutations promoting polycythemia insurgence in humans.
Q37952876Defining the role of TRIP6 in cell physiology and cancer.
Q42074603Drug resistance reversed by silencing LIM domain-containing protein 1 expression in colorectal carcinoma
Q35245799Gene expression profiling identifies IRF4-associated molecular signatures in hematological malignancies
Q35569017Identification and validation of a two-gene expression index for subtype classification and prognosis in Diffuse Large B-Cell Lymphoma
Q92645565JUB induces epithelial-mesenchymal transition via the Wnt/β-catenin signaling pathway in hepatocellular carcinoma cells
Q42117777LIM protein JUB promotes epithelial-mesenchymal transition in colorectal cancer
Q24338307LIM-domain proteins, LIMD1, Ajuba, and WTIP are required for microRNA-mediated gene silencing
Q39024351LIMD1 antagonizes E2F1 activity and cell cycle progression by enhancing Rb function in cancer cells
Q57816463LIMD1 is a survival prognostic marker of gastric cancer and hinders tumor progression by suppressing activation of YAP1
Q49787520LIMD1 is induced by and required for LMP1 signaling, and protects EBV-transformed cells from DNA damage-induced cell death
Q33765893LIMD1 is more frequently altered than RB1 in head and neck squamous cell carcinoma: clinical and prognostic implications
Q34778717Landscape of transcriptional deregulations in the preeclamptic placenta
Q34508726Microenvironmental control of malignancy exerted by RNASET2, a widely conserved extracellular RNase
Q35640277Molecular signature induced by RNASET2, a tumor antagonizing gene, in ovarian cancer cells
Q36140441Novel BRCA2-Interacting Protein, LIMD1, Is Essential for the Centrosome Localization of BRCA2 in Esophageal Cancer Cell
Q39884402PDLIM4, an actin binding protein, suppresses prostate cancer cell growth
Q39576404PU.1 is a major transcriptional activator of the tumour suppressor gene LIMD1.
Q99712015RB1 Germline Variant Predisposing to a Rare Ovarian Germ Cell Tumor: A Case Report
Q36026989RHOBTB3 promotes proteasomal degradation of HIFα through facilitating hydroxylation and suppresses the Warburg effect
Q34718092The LIM domain protein LPP is a coactivator for the ETS domain transcription factor PEA3.
Q28512132The LIM protein, Limd1, regulates AP-1 activation through an interaction with Traf6 to influence osteoclast development
Q24303868The LIMD1 protein bridges an association between the prolyl hydroxylases and VHL to repress HIF-1 activity
Q37018751The chromosome 3p21.3-encoded gene, LIMD1, is a critical tumor suppressor involved in human lung cancer development
Q34341807The conserved LIM domain-containing focal adhesion protein ZYX-1 regulates synapse maintenance in Caenorhabditis elegans
Q36245347The manipulation of chromosomes by mankind: the uses of microcell-mediated chromosome transfer.
Q33723622Transcriptional profile of primary astrocytes expressing ALS-linked mutant SOD1.
Q40441327WT1-interacting protein and ZO-1 translocate into podocyte nuclei after puromycin aminonucleoside treatment
Q64113600WT1-interacting protein inhibits cell proliferation and tumorigenicity in non-small-cell lung cancer via the AKT/FOXO1 axis
Q36791515Why do we not all die of cancer at an early age?

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