KSHV and the Role of Notch Receptor Dysregulation in Disease Progression

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KSHV and the Role of Notch Receptor Dysregulation in Disease Progression is …
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P356DOI10.3390/PATHOGENS6030034
P932PMC publication ID5617991
P698PubMed publication ID28777778

P50authorDavid M. LukacQ42383802
P2093author name stringJennifer L DeCotiis
P2860cites workPYM binds the cytoplasmic exon-junction complex and ribosomes to enhance translation of spliced mRNAsQ24301026
Kaposi's sarcoma-associated herpesvirus ORF57 protein interacts with PYM to enhance translation of viral intronless mRNAsQ24309306
Herpes simplex virus nucleocapsids mature to progeny virions by an envelopment --> deenvelopment --> reenvelopment pathwayQ24529141
Egress of alphaherpesviruses: comparative ultrastructural studyQ24529503
Notch1 and Notch2 inhibit myeloid differentiation in response to different cytokinesQ24533662
SEL-10 is an inhibitor of notch signaling that targets notch for ubiquitin-mediated protein degradationQ24548288
Identification of direct transcriptional targets of the Kaposi's sarcoma-associated herpesvirus Rta lytic switch protein by conditional nuclear localizationQ24648127
Nucleotide sequence of the Kaposi sarcoma-associated herpesvirus (HHV8)Q24650427
Truncated mammalian Notch1 activates CBF1/RBPJk-repressed genes by a mechanism resembling that of Epstein-Barr virus EBNA2Q24650743
KSHV: pathways to tumorigenesis and persistent infectionQ27026000
Structure and Function of the CSL-KyoT2 Corepressor Complex: A Negative Regulator of Notch SignalingQ27680715
KSHV reactivation and novel implications of protein isomerization on lytic switch controlQ28080937
Notch signal transduction induces a novel profile of Kaposi's sarcoma-associated herpesvirus gene expression.Q53620977
The Theory of the GeneQ56456417
Cancer incidence in the African population of Harare, Zimbabwe: second results from the cancer registry 1993-1995Q62489954
Detection of human herpesvirus 8 DNA in semen from HIV-infected individuals but not healthy semen donorsQ73067198
Valproic acid induces human herpesvirus 8 lytic gene expression in BCBL-1 cellsQ73854104
Amplification of the Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8 lytic origin of DNA replication is dependent upon a cis-acting AT-rich region and an ORF50 response element and the trans-acting factors ORF50 (K-Rta) and K8 (K-bZIP)Q76368260
HHV-8 infection is specific for cell lines derived from primary effusion (body cavity-based) lymphomasQ77585009
Reactivation of Kaposi's sarcoma-associated herpesvirus infection from latency by expression of the ORF 50 transactivator, a homolog of the EBV R proteinQ77760836
Endothelial infection with KSHV genes in vivo reveals that vGPCR initiates Kaposi's sarcomagenesis and can promote the tumorigenic potential of viral latent genesQ78860218
Influence of HLA alleles on shedding of Kaposi sarcoma-associated herpesvirus in saliva in an African populationQ79772673
The KSHV immediate-early transcription factor RTA encodes ubiquitin E3 ligase activity that targets IRF7 for proteosome-mediated degradationQ81304838
Carboxyl-terminal amino acids 1052 to 1082 of the latency-associated nuclear antigen (LANA) interact with RBP-Jκ and are responsible for LANA-mediated RTA repression.Q35943718
Regulation of growth signalling and cell cycle by Kaposi's sarcoma-associated herpesvirus genes.Q35964857
Kaposi's sarcoma-associated herpesvirus interacts with EphrinA2 receptor to amplify signaling essential for productive infectionQ35983048
Kaposi's sarcoma herpesvirus-encoded latency-associated nuclear antigen stabilizes intracellular activated Notch by targeting the Sel10 proteinQ36019173
The Kaposi's sarcoma-associated herpesvirus LANA protein stabilizes and activates c-MycQ36099076
Fine-Tuning of the Kaposi's Sarcoma-Associated Herpesvirus Life Cycle in Neighboring Cells through the RTA-JAG1-Notch Pathway.Q36167973
KSHV viral cyclin interferes with T-cell development and induces lymphoma through Cdk6 and Notch activation in vivoQ36185745
Promoter- and cell-specific transcriptional transactivation by the Kaposi's sarcoma-associated herpesvirus ORF57/Mta proteinQ36315189
MicroRNAs and unusual small RNAs discovered in Kaposi's sarcoma-associated herpesvirus virionsQ36397498
The interaction between KSHV RTA and cellular RBP-Jkappa and their subsequent DNA binding are not sufficient for activation of RBP-JkappaQ36427142
Kaposi sarcoma herpesvirus promotes endothelial-to-mesenchymal transition through Notch-dependent signaling.Q36439695
Kaposi's sarcoma-associated herpesvirus ORF57 functions as a viral splicing factor and promotes expression of intron-containing viral lytic genes in spliceosome-mediated RNA splicingQ36484026
Chromatin remodeling of the Kaposi's sarcoma-associated herpesvirus ORF50 promoter correlates with reactivation from latencyQ36538689
Virion-wide protein interactions of Kaposi's sarcoma-associated herpesvirusQ36594106
Non-HIV-associated Kaposi's sarcoma of the tongue. Case report and review of the literatureQ36871904
Phosphorylation of Kaposi's sarcoma-associated herpesvirus processivity factor ORF59 by a viral kinase modulates its ability to associate with RTA and oriLytQ36978654
Concurrent expression of latent and a limited number of lytic genes with immune modulation and antiapoptotic function by Kaposi's sarcoma-associated herpesvirus early during infection of primary endothelial and fibroblast cells and subsequent declinQ37010247
Toll-like receptor signaling controls reactivation of KSHV from latencyQ37261693
The malignant potential of HIV-associated Kaposi sarcomaQ37314351
The Notch signaling pathway: transcriptional regulation at Notch target genesQ37376057
KSHV 2.0: a comprehensive annotation of the Kaposi's sarcoma-associated herpesvirus genome using next-generation sequencing reveals novel genomic and functional featuresQ37488130
Efficient infection of a human B cell line with cell-free Kaposi's sarcoma-associated herpesvirusQ37547223
Herpesvirus assembly: an updateQ37570980
Early events in Kaposi's sarcoma-associated herpesvirus infection of target cellsQ37634746
AIDS-related Kaposi's sarcoma: state of the art and therapeutic strategiesQ37636208
Virion proteins of Kaposi's sarcoma-associated herpesvirusQ37744006
Canonical and non-canonical Notch ligandsQ37785194
Castleman disease: the great mimic.Q37945564
Tegument Proteins of Kaposi's Sarcoma-Associated Herpesvirus and Related Gamma-HerpesvirusesQ37995595
Kaposi sarcoma: review and medical management updateQ38017050
Interaction of KSHV with host cell surface receptors and cell entryQ38262354
Cell surface heparan sulfate is a receptor for human herpesvirus 8 and interacts with envelope glycoprotein K8.1.Q38295126
Activation of the B cell antigen receptor triggers reactivation of latent Kaposi's sarcoma-associated herpesvirus in B cells.Q38315444
Role of Notch signal transduction in Kaposi's sarcoma-associated herpesvirus gene expressionQ38319392
Notch signaling: from the outside inQ28139768
Glycogen synthase kinase-3beta modulates notch signaling and stabilityQ28215000
Risk factors for classical Kaposi's sarcomaQ28215448
Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcomaQ28242984
High-level coexpression of JAG1 and NOTCH1 is observed in human breast cancer and is associated with poor overall survivalQ28272536
Physical interaction between a novel domain of the receptor Notch and the transcription factor RBP-J kappa/Su(H)Q28286560
Kaposi's sarcoma-associated herpesvirus-like DNA sequences in AIDS-related body-cavity-based lymphomasQ28299069
Primary effusion lymphomaQ28303700
Mind bomb 1 is required for pancreatic β-cell formationQ28585145
The canonical Notch signaling pathway: unfolding the activation mechanismQ29547725
Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemiaQ29614269
Kaposi's sarcoma-associated herpesvirus-like DNA sequences in multicentric Castleman's diseaseQ29619158
Distinct and essential roles of transcription factors IRF-3 and IRF-7 in response to viruses for IFN-alpha/beta gene inductionQ29620054
Kaposi's sarcoma-associated herpesvirus-encoded LANA can interact with the nuclear mitotic apparatus protein to regulate genome maintenance and segregationQ30482603
Binding of the Kaposi's sarcoma-associated herpesvirus to the ephrin binding surface of the EphA2 receptor and its inhibition by a small moleculeQ31162666
EC5S ubiquitin complex is recruited by KSHV latent antigen LANA for degradation of the VHL and p53 tumor suppressorsQ33261811
Intriguing interplay between viral proteins during herpesvirus assembly or: the herpesvirus assembly puzzleQ33341874
A comprehensive analysis of recruitment and transactivation potential of K-Rta and K-bZIP during reactivation of Kaposi's sarcoma-associated herpesvirusQ33415884
Non-human primate model of Kaposi's sarcoma-associated herpesvirus infectionQ33508240
KSHV manipulates Notch signaling by DLL4 and JAG1 to alter cell cycle genes in lymphatic endotheliaQ33509506
Antagonism of host antiviral responses by Kaposi's sarcoma-associated herpesvirus tegument protein ORF45.Q33582093
KSHV-induced notch components render endothelial and mural cell characteristics and cell survivalQ33627013
Kinetics of Kaposi's sarcoma-associated herpesvirus gene expressionQ33653424
Binding of RBP-Jkappa (CSL) protein to the promoter of the Kaposi's sarcoma-associated herpesvirus ORF47 (gL) gene is a critical but not sufficient determinant of transactivation by ORF50 protein.Q33664758
Thermodynamic analysis of the CSL x Notch interaction: distribution of binding energy of the Notch RAM region to the CSL beta-trefoil domain and the mode of competition with the viral transactivator EBNA2.Q33673817
Kaposi's sarcoma-associated herpesvirus reactivation is regulated by interaction of latency-associated nuclear antigen with recombination signal sequence-binding protein Jkappa, the major downstream effector of the Notch signaling pathwayQ33737793
Inhibition of KAP1 enhances hypoxia-induced Kaposi's sarcoma-associated herpesvirus reactivation through RBP-Jκ.Q33743831
A cluster of latently expressed genes in Kaposi's sarcoma-associated herpesvirusQ33784966
Three-dimensional structure of the human herpesvirus 8 capsidQ33811735
Identification of the immediate-early transcripts of Kaposi's sarcoma-associated herpesvirusQ33815257
A complex translational program generates multiple novel proteins from the latently expressed kaposin (K12) locus of Kaposi's sarcoma-associated herpesvirus.Q33815534
Notch1IC partially replaces EBNA2 function in B cells immortalized by Epstein-Barr virusQ33842309
Induction of Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen by the lytic transactivator RTA: a novel mechanism for establishment of latencyQ33843211
DNA binding by Kaposi's sarcoma-associated herpesvirus lytic switch protein is necessary for transcriptional activation of two viral delayed early promotersQ33844093
Oral ganciclovir for patients with cytomegalovirus retinitis treated with a ganciclovir implant. Roche Ganciclovir Study GroupQ33857954
Lipid rafts of primary endothelial cells are essential for Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8-induced phosphatidylinositol 3-kinase and RhoA-GTPases critical for microtubule dynamics and nuclear delivery of viral DNA but disQ41788529
In vivo-restricted and reversible malignancy induced by human herpesvirus-8 KSHV: a cell and animal model of virally induced Kaposi's sarcoma.Q41839438
Notch-Jagged complex structure implicates a catch bond in tuning ligand sensitivity.Q42220831
Latency-associated nuclear antigen of Kaposi sarcoma-associated herpesvirus promotes angiogenesis through targeting notch signaling effector Hey1.Q42237356
Interaction of Kaposi's sarcoma-associated herpesvirus ORF59 with oriLyt is dependent on binding with K-RtaQ42779536
Specific EGF repeats of Notch mediate interactions with Delta and serrate: Implications for notch as a multifunctional receptorQ42806879
FLIP-mediated autophagy regulation in cell death controlQ42832950
Herpes-like sequences in HIV-infected and uninfected Kaposi's sarcoma patientsQ43823829
Use of a claims database to characterize and estimate the incidence rate for Castleman diseaseQ43956973
Infectious human herpesvirus 8 in a healthy North American blood donorQ44132374
Prevalence, incidence and correlates of HHV-8/KSHV infection and Kaposi's sarcoma in renal and liver transplant recipients.Q44448784
KSHV vFLIP binds to IKK-gamma to activate IKK.Q44532483
Restricted tissue distribution of extralesional Kaposi's sarcoma-associated herpesvirus-like DNA sequences in AIDS patients with Kaposi's sarcoma.Q44677526
Localization of the delta-like-1-binding site in human Notch-1 and its modulation by calcium affinityQ45345841
Salivary shedding of HHV-8 in people infected or not by human immunodeficiency virus 1Q45372146
Active intranuclear movement of herpesvirus capsidsQ46415497
Gamma secretase inhibitor blocks Notch activation and induces apoptosis in Kaposi's sarcoma tumor cellsQ46531701
Notch Inhibitor PF-03084014 Inhibits Hepatocellular Carcinoma Growth and Metastasis via Suppression of Cancer Stemness due to Reduced Activation of Notch1-Stat3.Q46659674
Subversion of autophagy by Kaposi's sarcoma-associated herpesvirus impairs oncogene-induced senescenceQ46798265
Kaposi[apos ]s sarcoma in rheumatic diseasesQ35109810
KSHV RTA abolishes NFκB responsive gene expression during lytic reactivation by targeting vFLIP for degradation via the proteasomeQ35116456
Lytic but not latent infection by Kaposi's sarcoma-associated herpesvirus requires host CSL protein, the mediator of Notch signalingQ35168476
Kaposi's sarcoma-associated herpesvirus ORF6 gene is essential in viral lytic replicationQ35183996
HIV-associated multicentric Castleman diseaseQ35226470
Chromatinization of the KSHV Genome During the KSHV Life CycleQ35237492
Inhibition of RIG-I-mediated signaling by Kaposi's sarcoma-associated herpesvirus-encoded deubiquitinase ORF64.Q35275001
Stability of a long noncoding viral RNA depends on a 9-nt core element at the RNA 5' end to interact with viral ORF57 and cellular PABPC1.Q35479911
Targeted disruption of Kaposi's sarcoma-associated herpesvirus ORF57 in the viral genome is detrimental for the expression of ORF59, K8alpha, and K8.1 and the production of infectious virusQ35635202
Notch Transmembrane Domain: Secondary Structure and TopologyQ35755025
Clinical Manifestations of Kaposi Sarcoma Herpesvirus Lytic Activation: Multicentric Castleman Disease (KSHV-MCD) and the KSHV Inflammatory Cytokine SyndromeQ35795414
Insights into Autoregulation of Notch3 from Structural and Functional Studies of Its Negative Regulatory RegionQ35836383
Viral interactions with the Notch pathwayQ35853119
Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8 ORF50/Rta lytic switch protein functions as a tetramerQ35857736
Essential role of RBP-Jkappa in activation of the K8 delayed-early promoter of Kaposi's sarcoma-associated herpesvirus by ORF50/RTA.Q35867478
Treatment of Kaposi sarcoma-associated herpesvirus-associated cancersQ35895560
Efficient persistence of extrachromosomal KSHV DNA mediated by latency-associated nuclear antigenQ33859518
Reactive oxygen species hydrogen peroxide mediates Kaposi's sarcoma-associated herpesvirus reactivation from latencyQ33916507
Bone marrow failure associated with human herpesvirus 8 infection after transplantationQ33924650
Crystal structure of the nuclear effector of Notch signaling, CSL, bound to DNAQ33980474
Activation of Notch1 signaling is required for beta-catenin-mediated human primary melanoma progressionQ34084509
Establishment and maintenance of Kaposi's sarcoma-associated herpesvirus latency in B cellsQ34124015
The RBP-Jκ binding sites within the RTA promoter regulate KSHV latent infection and cell proliferationQ34130213
An interleukin-6-related systemic inflammatory syndrome in patients co-infected with Kaposi sarcoma-associated herpesvirus and HIV but without Multicentric Castleman diseaseQ34157797
Kaposi's sarcoma-associated herpesvirus-encoded latency-associated nuclear antigen inhibits lytic replication by targeting Rta: a potential mechanism for virus-mediated control of latencyQ34194120
Nucleotide sequence from the neurogenic locus notch implies a gene product that shares homology with proteins containing EGF-like repeatsQ34195800
KSHV PAN RNA associates with demethylases UTX and JMJD3 to activate lytic replication through a physical interaction with the virus genomeQ34270407
Characterization of interactions between RTA and the promoter of polyadenylated nuclear RNA in Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8.Q34338900
Immune escape of γ-herpesviruses from adaptive immunityQ34345549
The latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus supports latent DNA replication in dividing cellsQ34355092
KSHV miRNAs decrease expression of lytic genes in latently infected PEL and endothelial cells by targeting host transcription factorsQ34423454
Transcriptional origin of Kaposi's sarcoma-associated herpesvirus microRNAsQ34434808
Target selectivity of vertebrate notch proteins. Collaboration between discrete domains and CSL-binding site architecture determines activation probabilityQ34478018
Herpesvirus assembly and egressQ34499618
An essential role of ERK signalling in TPA-induced reactivation of Kaposi's sarcoma-associated herpesvirusQ34501055
Crystal structure of the CSL-Notch-Mastermind ternary complex bound to DNA.Q34501252
The latent nuclear antigen of Kaposi sarcoma-associated herpesvirus targets the retinoblastoma-E2F pathway and with the oncogene Hras transforms primary rat cellsQ34511161
Highly active antiretroviral therapy in AIDS-associated Kaposi's sarcoma: implications for the design of therapeutic trials in patients with advanced, symptomatic Kaposi's sarcomaQ34544861
Transmission of human herpesvirus 8 by blood transfusion.Q34569442
Acetylation of the latency-associated nuclear antigen regulates repression of Kaposi's sarcoma-associated herpesvirus lytic transcription.Q34648229
Abortive lytic reactivation of KSHV in CBF1/CSL deficient human B cell linesQ34733560
Kaposi's sarcoma-associated herpesvirus ORF57 promotes escape of viral and human interleukin-6 from microRNA-mediated suppressionQ34742851
Growth suppression of pre-T acute lymphoblastic leukemia cells by inhibition of notch signalingQ34811698
Mechanisms of Kaposi's Sarcoma-Associated Herpesvirus Latency and ReactivationQ35010647
Molecular biology of KSHV lytic reactivationQ35014918
Biphasic euchromatin-to-heterochromatin transition on the KSHV genome following de novo infection.Q35075128
The single RBP-Jkappa site within the LANA promoter is crucial for establishing Kaposi's sarcoma-associated herpesvirus latency during primary infectionQ35077558
KSHV microRNAs mediate cellular transformation and tumorigenesis by redundantly targeting cell growth and survival pathwaysQ35079842
Recruitment of the de novo DNA methyltransferase Dnmt3a by Kaposi's sarcoma-associated herpesvirus LANAQ35080754
Notch signaling and inherited disease syndromesQ35095915
Processivity factor of KSHV contains a nuclear localization signal and binding domains for transporting viral DNA polymerase into the nucleusQ38323238
Kaposi's sarcoma-associated herpesvirus viral interferon regulatory factor 4 (vIRF4/K10) is a novel interaction partner of CSL/CBF1, the major downstream effector of Notch signaling.Q38340693
Wide-scale use of Notch signaling factor CSL/RBP-Jkappa in RTA-mediated activation of Kaposi's sarcoma-associated herpesvirus lytic genesQ38348963
Kaposi's sarcoma-associated herpesvirus induces the phosphatidylinositol 3-kinase-PKC-zeta-MEK-ERK signaling pathway in target cells early during infection: implications for infectivityQ38359214
Kaposi's sarcoma-associated herpesvirus K-bZIP is a coregulator of K-Rta: physical association and promoter-dependent transcriptional repression.Q38359222
An easily transfectable cell line that produces an infectious reporter virus for routine and robust quantitation of Kaposi's sarcoma-associated herpesvirus reactivation.Q38700640
Kaposi's Sarcoma-associated herpesvirus lytic switch protein stimulates DNA binding of RBP-Jk/CSL to activate the Notch pathwayQ38761166
The emerging role of Notch pathway in ageing: Focus on the related mechanisms in age-related diseases.Q38872194
Generation of high-titre virus stocks using BrK.219, a B-cell line infected stably with recombinant Kaposi's sarcoma-associated herpesvirusQ38904066
PEST domain mutations in Notch receptors comprise an oncogenic driver segment in triple-negative breast cancer sensitive to a γ-secretase inhibitorQ38922595
Epstein Barr virus - a tumor virus that needs cytotoxic lymphocytes to persist asymptomaticallyQ38945578
Kaposi's sarcoma-associated herpesvirus Rta tetramers make high-affinity interactions with repetitive DNA elements in the Mta promoter to stimulate DNA binding of RBP-Jk/CSL.Q38959859
RhoA-GTPase facilitates entry of Kaposi's sarcoma-associated herpesvirus into adherent target cells in a Src-dependent mannerQ39321282
KSHV-initiated notch activation leads to membrane-type-1 matrix metalloproteinase-dependent lymphatic endothelial-to-mesenchymal transition.Q39426922
Valproic acid antagonizes the capacity of other histone deacetylase inhibitors to activate the Epstein-barr virus lytic cycle.Q39575256
Transcriptional activation by the product of open reading frame 50 of Kaposi's sarcoma-associated herpesvirus is required for lytic viral reactivation in B cellsQ39596534
Discovery of a viral NLR homolog that inhibits the inflammasomeQ39604966
Human herpesvirus 8 envelope glycoprotein K8.1A interaction with the target cells involves heparan sulfateQ39606465
Notch3 gene amplification in ovarian cancerQ39759149
Inhibition of KSHV-infected primary effusion lymphomas in NOD/SCID mice by gamma-secretase inhibitor.Q39794624
Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8 K-bZIP modulates latency-associated nuclear protein-mediated suppression of lytic origin-dependent DNA synthesisQ39833695
The lytic switch protein of KSHV activates gene expression via functional interaction with RBP-Jkappa (CSL), the target of the Notch signaling pathway.Q39860135
Kaposi's sarcoma-associated herpesvirus RTA promotes degradation of the Hey1 repressor protein through the ubiquitin proteasome pathwayQ39860632
The size and conformation of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) DNA in infected cells and virionsQ39877021
A systems biology approach to identify the combination effects of human herpesvirus 8 genes on NF-kappaB activationQ39897858
Kaposi's sarcoma-associated herpesvirus gH/gL: glycoprotein export and interaction with cellular receptors.Q39926353
Human herpesvirus 8 infects and replicates in primary cultures of activated B lymphocytes through DC-SIGN.Q40002946
Kaposi's sarcoma-associated herpesvirus transactivator RTA promotes degradation of the repressors to regulate viral lytic replicationQ40021229
Intracellular transport of newly synthesized varicella-zoster virus: final envelopment in the trans-Golgi networkQ40041837
Direct interactions of Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8 ORF50/Rta protein with the cellular protein octamer-1 and DNA are critical for specifying transactivation of a delayed-early promoter and stimulating viral reactivatiQ40126113
Intracellular activated Notch1 is critical for proliferation of Kaposi's sarcoma-associated herpesvirus-associated B-lymphoma cell lines in vitroQ40267803
Intracellular-activated Notch1 can reactivate Kaposi's sarcoma-associated herpesvirus from latencyQ40279784
KSHV RTA induces a transcriptional repressor, HEY1 that represses rta promoterQ40283008
Constitutively active K-cyclin/cdk6 kinase in Kaposi sarcoma-associated herpesvirus-infected cellsQ40426996
The kaposin B protein of KSHV activates the p38/MK2 pathway and stabilizes cytokine mRNAs.Q40461940
A posttranscriptional regulator of Kaposi's sarcoma-associated herpesvirus interacts with RNA-binding protein PCBP1 and controls gene expression through the IRES.Q40537403
RBP-J (CSL) is essential for activation of the K14/vGPCR promoter of Kaposi's sarcoma-associated herpesvirus by the lytic switch protein RTAQ40546002
Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8 envelope glycoprotein gB induces the integrin-dependent focal adhesion kinase-Src-phosphatidylinositol 3-kinase-rho GTPase signal pathways and cytoskeletal rearrangementsQ40572745
Host gene induction and transcriptional reprogramming in Kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8)-infected endothelial, fibroblast, and B cells: insights into modulation events early during infectionQ40598301
The latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus interacts preferentially with the terminal repeats of the genome in vivo and this complex is sufficient for episomal DNA replicationQ40644381
Kaposi's sarcoma-associated herpesvirus modulates microtubule dynamics via RhoA-GTP-diaphanous 2 signaling and utilizes the dynein motors to deliver its DNA to the nucleusQ40721382
Integrin alpha3beta1 (CD 49c/29) is a cellular receptor for Kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8) entry into the target cellsQ40749885
Human herpesvirus 8 envelope-associated glycoprotein B interacts with heparan sulfate-like moietiesQ40802330
Inflammatory cytokines and the reactivation of Kaposi's sarcoma-associated herpesvirus lytic replicationQ40909738
Detection of Kaposi sarcoma associated herpesvirus in peripheral blood of HIV-infected individuals and progression to Kaposi's sarcomaQ40972068
Kaposi's sarcoma in organ transplant recipients: report of 20 casesQ41593468
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue3
P407language of work or nameEnglishQ1860
P577publication date2017-08-04
P1433published inPathogensQ27724554
P1476titleKSHV and the Role of Notch Receptor Dysregulation in Disease Progression
P478volume6

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cites work (P2860)
Q49637887BioMuta and BioXpress: mutation and expression knowledgebases for cancer biomarker discovery.
Q90089117Oncolytic HSV-Infected Glioma Cells Activate NOTCH in Adjacent Tumor Cells Sensitizing Tumors to Gamma Secretase Inhibition
Q55518093Primary effusion lymphoma: current perspectives.
Q92257146Transcriptional and post-transcriptional regulation of viral gene expression in the gamma-herpesvirus Kaposi's sarcoma-associated herpesvirus

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