KSHV PAN RNA associates with demethylases UTX and JMJD3 to activate lytic replication through a physical interaction with the virus genome

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KSHV PAN RNA associates with demethylases UTX and JMJD3 to activate lytic replication through a physical interaction with the virus genome is …
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scholarly articleQ13442814

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P356DOI10.1371/JOURNAL.PPAT.1002680
P932PMC publication ID3349751
P698PubMed publication ID22589717
P5875ResearchGate publication ID224966916

P50authorCyprian RossettoQ56754394
Gregory S. PariQ66712656
P2860cites workLong noncoding RNA as modular scaffold of histone modification complexesQ22065890
Knockdown of ALR (MLL2) reveals ALR target genes and leads to alterations in cell adhesion and growthQ24337427
Identification of direct transcriptional targets of the Kaposi's sarcoma-associated herpesvirus Rta lytic switch protein by conditional nuclear localizationQ24648127
Many human large intergenic noncoding RNAs associate with chromatin-modifying complexes and affect gene expressionQ24654249
UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and developmentQ28241669
A large intergenic noncoding RNA induced by p53 mediates global gene repression in the p53 responseQ28592069
A long noncoding RNA maintains active chromatin to coordinate homeotic gene expressionQ29614326
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Genomic maps of long noncoding RNA occupancy reveal principles of RNA-chromatin interactionsQ29617830
Long noncoding RNA HOTAIR regulates polycomb-dependent chromatin modification and is associated with poor prognosis in colorectal cancers.Q51856604
A viral gene that activates lytic cycle expression of Kaposi's sarcoma-associated herpesvirusQ33559699
Epigenetic analysis of KSHV latent and lytic genomesQ33641399
A viral nuclear noncoding RNA binds re-localized poly(A) binding protein and is required for late KSHV gene expressionQ34055296
Characterization of an anti-apoptotic glycoprotein encoded by Kaposi's sarcoma-associated herpesvirus which resembles a spliced variant of human survivinQ34088693
Update on KSHV epidemiology, Kaposi Sarcoma pathogenesis, and treatment of Kaposi SarcomaQ34168712
Characterization of interactions between RTA and the promoter of polyadenylated nuclear RNA in Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8.Q34338900
Viruses and human cancer: from detection to causalityQ34567612
Demethylation of H3K27 regulates polycomb recruitment and H2A ubiquitinationQ34673352
Long intergenic noncoding RNAs: new links in cancer progressionQ34676547
Stability of a long noncoding viral RNA depends on a 9-nt core element at the RNA 5' end to interact with viral ORF57 and cellular PABPC1.Q35479911
Kaposi's sarcoma-associated herpesvirus noncoding polyadenylated nuclear RNA interacts with virus- and host cell-encoded proteins and suppresses expression of genes involved in immune modulationQ35599368
Targeted disruption of Kaposi's sarcoma-associated herpesvirus ORF57 in the viral genome is detrimental for the expression of ORF59, K8alpha, and K8.1 and the production of infectious virusQ35635202
Genome-wide identification of binding sites for Kaposi's sarcoma-associated herpesvirus lytic switch protein, RTA.Q37144643
Long noncoding RNAs as enhancers of gene expressionQ37187785
Polyadenylylated nuclear RNA encoded by Kaposi sarcoma-associated herpesvirusQ37273424
Kaposi sarcoma-associated herpesvirus/human herpesvirus 8 and Kaposi sarcomaQ37858314
Castleman's disease. Update on pathogenesisQ37873746
Open reading frame 50 protein of Kaposi's sarcoma-associated herpesvirus directly activates the viral PAN and K12 genes by binding to related response elementsQ38291376
Evaluation of the lytic origins of replication of Kaposi's sarcoma-associated virus/human herpesvirus 8 in the context of the viral genomeQ38760706
Kaposi's sarcoma-associated herpesvirus open reading frame 57 encodes a posttranscriptional regulator with multiple distinct activitiesQ39590466
Octamer-binding sequence is a key element for the autoregulation of Kaposi's sarcoma-associated herpesvirus ORF50/Lyta gene expressionQ39603733
Efficient infection by a recombinant Kaposi's sarcoma-associated herpesvirus cloned in a bacterial artificial chromosome: application for genetic analysisQ39683622
Overexpression of the kaposi's sarcoma-associated herpesvirus transactivator K-Rta can complement a K-bZIP deletion BACmid and yields an enhanced growth phenotypeQ40072559
Two subclasses of Kaposi's sarcoma-associated herpesvirus lytic cycle promoters distinguished by open reading frame 50 mutant proteins that are deficient in binding to DNAQ40402402
Lytic growth of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) in cultureQ41225141
Kaposi's sarcoma-associated herpesvirus bacterial artificial chromosome contains a duplication of a long unique-region fragment within the terminal repeat region.Q42141541
A Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8 ORF50 deletion mutant is defective for reactivation of latent virus and DNA replicationQ42150768
Long noncoding RNA high expression in hepatocellular carcinoma facilitates tumor growth through enhancer of zeste homolog 2 in humansQ45334856
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue5
P304page(s)e1002680
P577publication date2012-05-10
P1433published inPLOS PathogensQ283209
P1476titleKSHV PAN RNA associates with demethylases UTX and JMJD3 to activate lytic replication through a physical interaction with the virus genome
P478volume8

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