Epigenetic factor siRNA screen during primary KSHV infection identifies novel host restriction factors for the lytic cycle of KSHV

scientific article published on 10 January 2020

Epigenetic factor siRNA screen during primary KSHV infection identifies novel host restriction factors for the lytic cycle of KSHV is …
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scholarly articleQ13442814

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P356DOI10.1371/JOURNAL.PPAT.1008268
P932PMC publication ID6977772
P698PubMed publication ID31923286

P50authorLauren RobertsQ92553816
Luke Todd FischerQ92553819
Zsolt TothQ92553824
P2093author name stringBernadett Papp
Nenavath Gopal Naik
Gavin Golas
Katherine Glickman
Thomas Hong Nguyen
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Histone acetyl transferase TIP60 inhibits the replication of influenza a virus by activation the TBK1-IRF3 pathwayQ58590992
Chromatin remodeling controls Kaposi's sarcoma-associated herpesvirus reactivation from latencyQ58744047
KDM2B is a histone H3K79 demethylase and induces transcriptional repression via sirtuin-1-mediated chromatin silencingQ88679097
Genome-Wide Identification of Direct RTA Targets Reveals Key Host Factors for Kaposi's Sarcoma-Associated Herpesvirus Lytic ReactivationQ90434397
A comparative epigenome analysis of gammaherpesviruses suggests cis-acting sequence features as critical mediators of rapid polycomb recruitmentQ91035239
Sirtuin 6 Attenuates Kaposi's Sarcoma-Associated Herpesvirus Reactivation by Suppressing Ori-Lyt Activity and Expression of RTAQ91080371
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KDM2B in polycomb repressive complex 1.1 functions as a tumor suppressor in the initiation of T-cell leukemogenesisQ93021282
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RBP1 recruits the mSIN3-histone deacetylase complex to the pocket of retinoblastoma tumor suppressor family proteins found in limited discrete regions of the nucleus at growth arrestQ24291072
The human L(3)MBT polycomb group protein is a transcriptional repressor and interacts physically and functionally with TEL (ETV6)Q24294810
FOXP3 interactions with histone acetyltransferase and class II histone deacetylases are required for repressionQ24300168
Histone H2A deubiquitinase activity of the Polycomb repressive complex PR-DUBQ24309403
The acetyltransferase 60 kDa trans-acting regulatory protein of HIV type 1-interacting protein (Tip60) interacts with the translocation E26 transforming-specific leukaemia gene (TEL) and functions as a transcriptional co-repressorQ24530158
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Tip60 acetylates six lysines of a specific class in core histones in vitroQ28140015
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Human cytomegalovirus UL29/28 protein interacts with components of the NuRD complex which promote accumulation of immediate-early RNAQ28474716
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The E7 oncoprotein associates with Mi2 and histone deacetylase activity to promote cell growthQ33292242
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Coordination of KSHV latent and lytic gene control by CTCF-cohesin mediated chromosome conformationQ34005284
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A protein array screen for Kaposi's sarcoma-associated herpesvirus LANA interactors links LANA to TIP60, PP2A activity, and telomere shortening.Q34179693
KSHV PAN RNA associates with demethylases UTX and JMJD3 to activate lytic replication through a physical interaction with the virus genomeQ34270407
The H3K4me3 histone demethylase Fbxl10 is a regulator of chemokine expression, cellular morphology, and the metabolome of fibroblastsQ34289868
Histone demethylase JMJD2A regulates Kaposi's sarcoma-associated herpesvirus replication and is targeted by a viral transcriptional factor.Q34742661
KDM2b/JHDM1b, an H3K36me2-specific demethylase, is required for initiation and maintenance of acute myeloid leukemiaQ34870589
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Genome-wide RNAi screen identifies broadly-acting host factors that inhibit arbovirus infectionQ35097100
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LANA-Mediated Recruitment of Host Polycomb Repressive Complexes onto the KSHV Genome during De Novo InfectionQ36126100
KDM2B links the Polycomb Repressive Complex 1 (PRC1) to recognition of CpG islands.Q36474376
Chromatin remodeling of the Kaposi's sarcoma-associated herpesvirus ORF50 promoter correlates with reactivation from latencyQ36538689
The nucleosome remodeling and deacetylase complex in development and diseaseQ36692354
Kaposi's sarcoma-associated herpesvirus (KSHV) latency-associated nuclear antigen regulates the KSHV epigenome by association with the histone demethylase KDM3A.Q36911800
Concurrent expression of latent and a limited number of lytic genes with immune modulation and antiapoptotic function by Kaposi's sarcoma-associated herpesvirus early during infection of primary endothelial and fibroblast cells and subsequent declinQ37010247
Wild-type Kaposi's sarcoma-associated herpesvirus isolated from the oropharynx of immune-competent individuals has tropism for cultured oral epithelial cellsQ37092875
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Control of genetic stability by a new heterochromatin compaction pathway involving the Tip60 histone acetyltransferase.Q38370055
Structure and function insights into the NuRD chromatin remodeling complexQ38386331
KSHV encoded ORF59 modulates histone arginine methylation of the viral genome to promote viral reactivationQ38692823
Fbxl10/Kdm2b recruits polycomb repressive complex 1 to CpG islands and regulates H2A ubiquitylationQ39197334
Reactivation and Lytic Replication of Kaposi's Sarcoma-Associated Herpesvirus: An UpdateQ39284842
Negative elongation factor-mediated suppression of RNA polymerase II elongation of Kaposi's sarcoma-associated herpesvirus lytic gene expressionQ39323907
Construction and manipulation of a new Kaposi's sarcoma-associated herpesvirus bacterial artificial chromosome cloneQ39323923
Inhibition of the lytic cycle of Kaposi's sarcoma-associated herpesvirus by cohesin factors following de novo infectionQ40045381
ORC, MCM, and histone hyperacetylation at the Kaposi's sarcoma-associated herpesvirus latent replication originQ40276488
CTCF and Rad21 act as host cell restriction factors for Kaposi's sarcoma-associated herpesvirus (KSHV) lytic replication by modulating viral gene transcriptionQ41863211
Cohesins repress Kaposi's sarcoma-associated herpesvirus immediate early gene transcription during latencyQ41947834
MBD5 and MBD6 interact with the human PR-DUB complex through their methyl-CpG-binding domainQ42648708
KSHV episomes reveal dynamic chromatin loop formation with domain-specific gene regulationQ47557988
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue1
P407language of work or nameEnglishQ1860
P304page(s)e1008268
P577publication date2020-01-10
P1433published inPLOS PathogensQ283209
P1476titleEpigenetic factor siRNA screen during primary KSHV infection identifies novel host restriction factors for the lytic cycle of KSHV
P478volume16

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