Fine-Tuning of the Kaposi's Sarcoma-Associated Herpesvirus Life Cycle in Neighboring Cells through the RTA-JAG1-Notch Pathway.

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Fine-Tuning of the Kaposi's Sarcoma-Associated Herpesvirus Life Cycle in Neighboring Cells through the RTA-JAG1-Notch Pathway. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1371/JOURNAL.PPAT.1005900
P932PMC publication ID5070770
P698PubMed publication ID27760204

P50authorHao HuQ55908235
Zhiheng HeQ56502950
P2093author name stringShasha Li
Deguang Liang
Ke Lan
Rui Sun
P2860cites workRel/NF-kappaB can trigger the Notch signaling pathway by inducing the expression of Jagged1, a ligand for Notch receptorsQ22010043
Hallmarks of Cancer: The Next GenerationQ22252312
Human Sir2-related protein SIRT1 associates with the bHLH repressors HES1 and HEY2 and is involved in HES1- and HEY2-mediated transcriptional repressionQ24292887
A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctionsQ24294366
Mutations in NOTCH1 cause aortic valve diseaseQ24307999
Transcriptional repression by AML1 and LEF-1 is mediated by the TLE/Groucho corepressorsQ24316983
Notch signalling and the control of cell fate choices in vertebrates.Q52180338
Notch ligand, JAG1, is evolutionarily conserved target of canonical WNT signaling pathway in progenitor cells.Q52841003
Expression and localization of human herpesvirus 8-encoded proteins in primary effusion lymphoma, Kaposi's sarcoma, and multicentric Castleman's diseaseQ73642658
All Tcf HMG box transcription factors interact with Groucho-related co-repressorsQ24599779
Functional interaction of beta-catenin with the transcription factor LEF-1Q28286884
The Hes gene family: repressors and oscillators that orchestrate embryogenesisQ28290634
miR-K12-7-5p encoded by Kaposi's sarcoma-associated herpesvirus stabilizes the latent state by targeting viral ORF50/RTAQ28476790
Notch signalling controls pancreatic cell differentiationQ28504686
Oncogenic herpesvirus KSHV Hijacks BMP-Smad1-Id signaling to promote tumorigenesisQ28540651
Latent KSHV Infected Endothelial Cells Are Glutamine Addicted and Require Glutaminolysis for SurvivalQ28546705
rax, Hes1, and notch1 promote the formation of Müller glia by postnatal retinal progenitor cellsQ28572535
The canonical Notch signaling pathway: unfolding the activation mechanismQ29547725
Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemiaQ29614269
Cellular corepressor TLE2 inhibits replication-and-transcription- activator-mediated transactivation and lytic reactivation of Kaposi's sarcoma-associated herpesvirus.Q30919397
KSHV manipulates Notch signaling by DLL4 and JAG1 to alter cell cycle genes in lymphatic endotheliaQ33509506
KSHV-induced notch components render endothelial and mural cell characteristics and cell survivalQ33627013
Kaposi's sarcoma-associated herpesvirus reactivation is regulated by interaction of latency-associated nuclear antigen with recombination signal sequence-binding protein Jkappa, the major downstream effector of the Notch signaling pathwayQ33737793
Inhibition of KAP1 enhances hypoxia-induced Kaposi's sarcoma-associated herpesvirus reactivation through RBP-Jκ.Q33743831
Induction of Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen by the lytic transactivator RTA: a novel mechanism for establishment of latencyQ33843211
Efficient persistence of extrachromosomal KSHV DNA mediated by latency-associated nuclear antigenQ33859518
Activation of Kaposi's sarcoma-associated herpesvirus (KSHV) by inhibitors of class III histone deacetylases: identification of sirtuin 1 as a regulator of the KSHV life cycleQ33887681
Reactive oxygen species hydrogen peroxide mediates Kaposi's sarcoma-associated herpesvirus reactivation from latencyQ33916507
Induction of the Warburg effect by Kaposi's sarcoma herpesvirus is required for the maintenance of latently infected endothelial cellsQ33934809
Kaposi's sarcoma-associated herpesvirus K3 and K5 ubiquitin E3 ligases have stage-specific immune evasion roles during lytic replicationQ34059252
Biology of Kaposi's sarcomaQ34292002
Opposing regulation of PROX1 by interleukin-3 receptor and NOTCH directs differential host cell fate reprogramming by Kaposi sarcoma herpes virus.Q34311582
Global metabolic profiling of infection by an oncogenic virus: KSHV induces and requires lipogenesis for survival of latent infectionQ34390540
Global changes in Kaposi's sarcoma-associated virus gene expression patterns following expression of a tetracycline-inducible Rta transactivatorQ34782463
Noncyclic Notch activity in the presomitic mesoderm demonstrates uncoupling of somite compartmentalization and boundary formationQ34809773
Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) contains hypoxia response elements: relevance to lytic induction by hypoxiaQ35019982
Human herpesvirus 6 activates lytic cycle replication of Kaposi's sarcoma-associated herpesvirusQ35083522
Salinomycin inhibits Wnt signaling and selectively induces apoptosis in chronic lymphocytic leukemia cellsQ35164584
Intracellular Tat of human immunodeficiency virus type 1 activates lytic cycle replication of Kaposi's sarcoma-associated herpesvirus: role of JAK/STAT signaling.Q35784760
Differential viral protein expression in Kaposi's sarcoma-associated herpesvirus-infected diseases: Kaposi's sarcoma, primary effusion lymphoma, and multicentric Castleman's disease.Q35809792
The viral interferon regulatory factors of KSHV: immunosuppressors or oncogenes?Q35927496
Kaposi's sarcoma herpesvirus-encoded latency-associated nuclear antigen stabilizes intracellular activated Notch by targeting the Sel10 proteinQ36019173
KSHV induces aerobic glycolysis and angiogenesis through HIF-1-dependent upregulation of pyruvate kinase 2 in Kaposi's sarcomaQ36318661
KSHV infection and the pathogenesis of Kaposi's sarcomaQ37014777
Jagged1 is the pathological link between Wnt and Notch pathways in colorectal cancerQ37158989
Toll-like receptor signaling controls reactivation of KSHV from latencyQ37261693
The Drosophila Numb protein inhibits signaling of the Notch receptor during cell-cell interaction in sensory organ lineageQ37275107
The inflammatory kinase MAP4K4 promotes reactivation of Kaposi's sarcoma herpesvirus and enhances the invasiveness of infected endothelial cellsQ37288834
Notch signaling is required for lateral induction of Jagged1 during FGF-induced lens fiber differentiationQ37315216
KSHV 2.0: a comprehensive annotation of the Kaposi's sarcoma-associated herpesvirus genome using next-generation sequencing reveals novel genomic and functional featuresQ37488130
The role of Kaposi sarcoma-associated herpesvirus in the pathogenesis of Kaposi sarcomaQ38248404
Activation of the B cell antigen receptor triggers reactivation of latent Kaposi's sarcoma-associated herpesvirus in B cells.Q38315444
Stem cell and progenitor fate in the mammalian intestine: Notch and lateral inhibition in homeostasis and diseaseQ38412355
The Groucho/TLE/Grg family of transcriptional co-repressorsQ38610837
Lateral inhibition of Notch signaling in neoplastic cellsQ38923462
KSHV-initiated notch activation leads to membrane-type-1 matrix metalloproteinase-dependent lymphatic endothelial-to-mesenchymal transition.Q39426922
Activation of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) lytic replication by human cytomegalovirusQ39601922
X-box binding protein 1 contributes to induction of the Kaposi's sarcoma-associated herpesvirus lytic cycle under hypoxic conditionsQ39858771
The lytic switch protein of KSHV activates gene expression via functional interaction with RBP-Jkappa (CSL), the target of the Notch signaling pathway.Q39860135
Kaposi's sarcoma-associated herpesvirus gene expression in endothelial (spindle) tumor cellsQ39877852
Kaposi's sarcoma-associated herpesvirus RTA activates the processivity factor ORF59 through interaction with RBP-Jkappa and a cis-acting RTA responsive element.Q39940851
Induction of lytic cycle replication of Kaposi's sarcoma-associated herpesvirus by herpes simplex virus type 1: involvement of IL-10 and IL-4.Q40044014
Inefficient establishment of KSHV latency suggests an additional role for continued lytic replication in Kaposi sarcoma pathogenesis.Q40364647
Notch activation of Jagged1 contributes to the assembly of the arterial wall.Q40473882
Proteolytic processing of low density lipoprotein receptor-related protein mediates regulated release of its intracellular domainQ40743382
HIV-1 infection of primary effusion lymphoma cell line triggers Kaposi's sarcoma-associated herpesvirus (KSHV) reactivationQ40749286
Presenilin-dependent gamma-secretase-like intramembrane cleavage of ErbB4.Q40763743
Hypoxia induces lytic replication of Kaposi sarcoma-associated herpesvirusQ40807418
Kaposi's sarcoma-associated herpesvirus latent protein LANA interacts with HIF-1 alpha to upregulate RTA expression during hypoxia: Latency control under low oxygen conditionsQ42049779
Oxidative Stress Induces Reactivation of Kaposi's Sarcoma-Associated Herpesvirus and Death of Primary Effusion Lymphoma CellsQ42166459
Latency-associated nuclear antigen of Kaposi sarcoma-associated herpesvirus promotes angiogenesis through targeting notch signaling effector Hey1.Q42237356
A unique herpesviral transcriptional program in KSHV-infected lymphatic endothelial cells leads to mTORC1 activation and rapamycin sensitivityQ42624833
Human immunodeficiency virus type-1 activates lytic cycle replication of Kaposi's sarcoma-associated herpesvirus through induction of KSHV Rta.Q45731998
Gamma secretase inhibitor blocks Notch activation and induces apoptosis in Kaposi's sarcoma tumor cellsQ46531701
Beta-catenin directly displaces Groucho/TLE repressors from Tcf/Lef in Wnt-mediated transcription activationQ46952924
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue10
P304page(s)e1005900
P577publication date2016-10-19
P1433published inPLOS PathogensQ283209
P1476titleFine-Tuning of the Kaposi's Sarcoma-Associated Herpesvirus Life Cycle in Neighboring Cells through the RTA-JAG1-Notch Pathway
P478volume12

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cites work (P2860)
Q47559788Antitumor activity of Notch‑1 inhibition in human colorectal carcinoma cells
Q90434397Genome-Wide Identification of Direct RTA Targets Reveals Key Host Factors for Kaposi's Sarcoma-Associated Herpesvirus Lytic Reactivation
Q41662283KSHV and the Role of Notch Receptor Dysregulation in Disease Progression
Q47606321Kaposi's Sarcoma-Associated Herpesvirus: Epidemiology and Molecular Biology
Q92270413Latency-associated nuclear antigen inhibits lytic replication of Kaposi's sarcoma-associated herpesvirus by regulating let-7a/RBPJ signaling
Q99591124Regulation of KSHV Latency and Lytic Reactivation
Q92156491The Zebrafish Xenograft Platform-A Novel Tool for Modeling KSHV-Associated Diseases
Q58789756The crystal structure of KSHV ORF57 reveals dimeric active sites important for protein stability and function
Q54216669Transactivation of human endogenous retrovirus K (HERV-K) by KSHV promotes Kaposi's sarcoma development.
Q59357569Upregulation of MicroRNA 711 Mediates HIV-1 Vpr Promotion of Kaposi's Sarcoma-Associated Herpesvirus Latency and Induction of Pro-proliferation and Pro-survival Cytokines by Targeting the Notch/NF-κB-Signaling Axis
Q47571734Viral Oncology: Molecular Biology and Pathogenesis
Q89709144Whitefly HES1 binds to the intergenic region of Tomato yellow leaf curl China virus and promotes viral gene transcription

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