The lytic switch protein of KSHV activates gene expression via functional interaction with RBP-Jkappa (CSL), the target of the Notch signaling pathway.

scientific article published on August 2002

The lytic switch protein of KSHV activates gene expression via functional interaction with RBP-Jkappa (CSL), the target of the Notch signaling pathway. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1101/GAD.996502
P932PMC publication ID186409
P698PubMed publication ID12154127
P5875ResearchGate publication ID11229052

P50authorDavid M. LukacQ42383802
P2093author name stringJean Chang
Yuying Liang
Don Ganem
Stephen J Lynch
P2860cites workCIR, a corepressor linking the DNA binding factor CBF1 to the histone deacetylase complexQ22008610
p300 acts as a transcriptional coactivator for mammalian Notch-1Q24548267
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Nucleotide sequence of the Kaposi sarcoma-associated herpesvirus (HHV8)Q24650427
Truncated mammalian Notch1 activates CBF1/RBPJk-repressed genes by a mechanism resembling that of Epstein-Barr virus EBNA2Q24650743
Epstein-Barr virus immortalization: Notch2 interacts with CBF1 and blocks differentiationQ24678677
A conserved domain of the Epstein-Barr virus nuclear antigens 3A and 3C binds to a discrete domain of JkappaQ24682619
Notch signaling: from the outside inQ28139768
Functional interaction between the mouse notch1 intracellular region and histone acetyltransferases PCAF and GCN5Q28140561
Disruption of the mouse RBP-J kappa gene results in early embryonic deathQ28610816
Solubilization and purification of enzymatically active glutathione S-transferase (pGEX) fusion proteinsQ29615167
A viral gene that activates lytic cycle expression of Kaposi's sarcoma-associated herpesvirusQ33559699
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Kaposi's sarcoma: a result of the interplay among inflammatory cytokines, angiogenic factors and viral agentsQ61641140
Kaposi's sarcoma-associated herpesvirus infects endothelial and spindle cellsQ71563744
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Kaposi's sarcoma-associated herpesvirus: epidemiology, virology, and molecular biologyQ33671160
Kaposi's sarcoma-associated herpesvirus open reading frame 50/Rta protein activates the entire viral lytic cycle in the HH-B2 primary effusion lymphoma cell lineQ33807199
Transcription activation of polyadenylated nuclear rna by rta in human herpesvirus 8/Kaposi's sarcoma-associated herpesvirusQ33837983
Herpesvirus lytic replication and the cell cycle: arresting new developmentsQ33840180
DNA binding by Kaposi's sarcoma-associated herpesvirus lytic switch protein is necessary for transcriptional activation of two viral delayed early promotersQ33844093
Oral ganciclovir for patients with cytomegalovirus retinitis treated with a ganciclovir implant. Roche Ganciclovir Study GroupQ33857954
Notch signal transduction: a real rip and moreQ33964063
Molecular mimicry of human cytokine and cytokine response pathway genes by KSHV.Q34408877
Direct BRLF1 binding is required for cooperative BZLF1/BRLF1 activation of the Epstein-Barr virus early promoter, BMRF1.Q34981036
The Epstein-Barr virus nuclear antigen 2 transactivator is directed to response elements by the J kappa recombination signal binding proteinQ35648541
Epstein-Barr virus nuclear protein 2 transactivation of the latent membrane protein 1 promoter is mediated by J kappa and PU.1.Q35829475
EBNA-2 and EBNA-3C extensively and mutually exclusively associate with RBPJkappa in Epstein-Barr virus-transformed B lymphocytesQ35862488
Human herpesvirus 8 encodes a homolog of interleukin-6.Q35876140
A Bcl-2 homolog encoded by Kaposi sarcoma-associated virus, human herpesvirus 8, inhibits apoptosis but does not heterodimerize with Bax or BakQ35960931
Neoplastic transformation by truncated alleles of human NOTCH1/TAN1 and NOTCH2.Q36573355
Epstein-Barr viral latency is disrupted by the immediate-early BRLF1 protein through a cell-specific mechanismQ37389141
EBNA-2 upregulation of Epstein-Barr virus latency promoters and the cellular CD23 promoter utilizes a common targeting intermediate, CBF1.Q38304806
Recognition sequence of a highly conserved DNA binding protein RBP-J kappaQ38309890
The Epstein-Barr virus Rta protein activates lytic cycle genes and can disrupt latency in B lymphocytesQ38333495
Epstein-Barr virus EBNA3A and EBNA3C proteins both repress RBP-J kappa-EBNA2-activated transcription by inhibiting the binding of RBP-J kappa to DNA.Q38353695
The N- and C-terminal regions of RBP-J interact with the ankyrin repeats of Notch1 RAMIC to activate transcriptionQ38660700
Transcriptional activation by the product of open reading frame 50 of Kaposi's sarcoma-associated herpesvirus is required for lytic viral reactivation in B cellsQ39596534
Identification of a cellular protein that interacts and synergizes with the RTA (ORF50) protein of Kaposi's sarcoma-associated herpesvirus in transcriptional activationQ39611074
Kaposi's sarcoma-associated herpesvirus gene expression in endothelial (spindle) tumor cellsQ39877852
Activation of the Notch-regulated transcription factor CBF1/RBP-Jkappa through the 13SE1A oncoproteinQ40423684
Notch signaling in leukemiaQ40686107
Cell cycle arrest and apoptosis induced by Notch1 in B cellsQ40857740
The restricted cellular host range of human herpesvirus 8.Q40868542
Gene expression from the ORF50/K8 region of Kaposi's sarcoma-associated herpesvirusQ40920505
Angiogenic and HIV-inhibitory functions of KSHV-encoded chemokinesQ41088030
Kaposi's sarcoma-associated human herpesvirus-8 encodes homologues of macrophage inflammatory protein-1 and interleukin-6.Q41125455
G-protein-coupled receptor of Kaposi's sarcoma-associated herpesvirus is a viral oncogene and angiogenesis activatorQ42833351
Herpes-like sequences in HIV-infected and uninfected Kaposi's sarcoma patientsQ43823829
Masking of the CBF1/RBPJ kappa transcriptional repression domain by Epstein-Barr virus EBNA2.Q44697821
Mediation of Epstein-Barr virus EBNA2 transactivation by recombination signal-binding protein J kappaQ45781476
Modulators of Notch signaling.Q52567848
Kaposi's sarcoma-associated herpesvirus.Q53947567
Kaposi's sarcoma-associated herpesvirus encodes a functional Bcl-2 homologueQ56999807
P433issue15
P407language of work or nameEnglishQ1860
P304page(s)1977-1989
P577publication date2002-08-01
P1433published inGenes & DevelopmentQ1524533
P1476titleThe lytic switch protein of KSHV activates gene expression via functional interaction with RBP-Jkappa (CSL), the target of the Notch signaling pathway
P478volume16