CIR, a corepressor linking the DNA binding factor CBF1 to the histone deacetylase complex

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CIR, a corepressor linking the DNA binding factor CBF1 to the histone deacetylase complex is …
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scholarly articleQ13442814

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P819ADS bibcode1999PNAS...96...23H
P356DOI10.1073/PNAS.96.1.23
P3181OpenCitations bibliographic resource ID2301094
P932PMC publication ID15086
P698PubMed publication ID9874765
P5875ResearchGate publication ID13413221

P2093author name stringL Chen
S Zhou
D B Young
S D Hayward
J J Hsieh
P2860cites workSAP30, a novel protein conserved between human and yeast, is a component of a histone deacetylase complexQ24311791
Alagille syndrome is caused by mutations in human Jagged1, which encodes a ligand for Notch1Q24314766
Human Jk recombination signal binding protein gene (IGKJRB): comparison with its mouse homologueQ24318408
TAN-1, the human homolog of the Drosophila Notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasmsQ24320364
Histone deacetylases and SAP18, a novel polypeptide, are components of a human Sin3 complexQ24320470
The Epstein-Barr virus oncogene product latent membrane protein 1 engages the tumor necrosis factor receptor-associated death domain protein to mediate B lymphocyte growth transformation and activate NF-kappaBQ24646694
Transcriptional repression by YY1 is mediated by interaction with a mammalian homolog of the yeast global regulator RPD3Q24648290
Truncated mammalian Notch1 activates CBF1/RBPJk-repressed genes by a mechanism resembling that of Epstein-Barr virus EBNA2Q24650743
Epstein-Barr virus immortalization: Notch2 interacts with CBF1 and blocks differentiationQ24678677
A conserved domain of the Epstein-Barr virus nuclear antigens 3A and 3C binds to a discrete domain of JkappaQ24682619
The retinoblastoma protein associates with the protein phosphatase type 1 catalytic subunitQ27860669
Transcriptional control. Sinful repressionQ28237278
Histone deacetylase activity is required for full transcriptional repression by mSin3AQ28238079
Histone deacetylases associated with the mSin3 corepressor mediate mad transcriptional repressionQ28238089
Retinoblastoma protein recruits histone deacetylase to repress transcriptionQ28262144
Retinoblastoma protein represses transcription by recruiting a histone deacetylaseQ28262155
Rb interacts with histone deacetylase to repress transcriptionQ28263985
Notch-1 signalling requires ligand-induced proteolytic release of intracellular domainQ28273268
SAP30, a component of the mSin3 corepressor complex involved in N-CoR-mediated repression by specific transcription factorsQ28279441
Signalling downstream of activated mammalian NotchQ28289832
Notch3 mutations in CADASIL, a hereditary adult-onset condition causing stroke and dementiaQ28294011
The Epstein-Barr virus transforming protein LMP1 engages signaling proteins for the tumor necrosis factor receptor familyQ28307399
Role for N-CoR and histone deacetylase in Sin3-mediated transcriptional repressionQ28513708
A complex containing N-CoR, mSin3 and histone deacetylase mediates transcriptional repressionQ28578229
Disruption of the mouse RBP-J kappa gene results in early embryonic deathQ28610816
Histone acetylation and transcriptional regulatory mechanismsQ29547707
2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegansQ29547793
Nuclear receptor repression mediated by a complex containing SMRT, mSin3A, and histone deacetylaseQ29547913
Notch signalingQ29618190
Macromolecular domains within the cell nucleusQ29618685
Overlapping positive and negative regulatory domains of the human beta-interferon geneQ33556282
Alterations in Notch signaling in neoplastic lesions of the human cervixQ34124673
The human J kappa recombination signal sequence binding protein (RBP-J kappa) targets the Epstein-Barr virus EBNA2 protein to its DNA responsive elements.Q34327455
The mammalian transcriptional repressor RBP (CBF1) targets TFIID and TFIIA to prevent activated transcriptionQ35201509
The Epstein-Barr virus nuclear antigen 2 transactivator is directed to response elements by the J kappa recombination signal binding proteinQ35648541
Epstein-Barr virus nuclear protein 3C modulates transcription through interaction with the sequence-specific DNA-binding protein J kappaQ35839108
EBNA-2 and EBNA-3C extensively and mutually exclusively associate with RBPJkappa in Epstein-Barr virus-transformed B lymphocytesQ35862488
Epstein-Barr virus nuclear protein LP stimulates EBNA-2 acidic domain-mediated transcriptional activationQ35891360
The Epstein-Barr virus LMP1 amino acid sequence that engages tumor necrosis factor receptor associated factors is critical for primary B lymphocyte growth transformationQ35997566
glp-1 and lin-12, genes implicated in distinct cell-cell interactions in C. elegans, encode similar transmembrane proteinsQ36120142
Exclusive development of T cell neoplasms in mice transplanted with bone marrow expressing activated Notch allelesQ36366728
Association of TRAF1, TRAF2, and TRAF3 with an Epstein-Barr virus LMP1 domain important for B-lymphocyte transformation: role in NF-kappaB activationQ36564433
The mammalian transcriptional repressor RBP (CBF1) regulates interleukin-6 gene expressionQ36564525
Recombination signal sequence binding protein Jkappa is constitutively bound to the NF-kappaB site of the interleukin-6 promoter and acts as a negative regulatory factorQ36569110
The Epstein-Barr virus immortalizing protein EBNA-2 is targeted to DNA by a cellular enhancer-binding proteinQ36581891
The recombination signal sequence-binding protein RBP-2N functions as a transcriptional repressorQ36652805
EBNA-2 upregulation of Epstein-Barr virus latency promoters and the cellular CD23 promoter utilizes a common targeting intermediate, CBF1.Q38304806
Recognition sequence of a highly conserved DNA binding protein RBP-J kappaQ38309890
Purification of a novel MHC class I element binding activity from thymus nuclear extracts reveals that thymic RBP-Jkappa/CBF1 binds to NF-kappaB-like elementsQ38356552
Transduction of Notch2 in feline leukemia virus-induced thymic lymphomaQ39876976
RBP-J kappa repression activity is mediated by a co-repressor and antagonized by the Epstein-Barr virus transcription factor EBNA2.Q40397055
Epstein-Barr virus nuclear antigen 2 exerts its transactivating function through interaction with recombination signal binding protein RBP-J kappa, the homologue of Drosophila Suppressor of Hairless.Q40793575
Notch-related genes in animal development.Q40995572
Involvement of RBP-J in biological functions of mouse Notch1 and its derivatives.Q41078359
Comparative aspects of Notch signaling in lower and higher eukaryotes.Q41488242
Notch in vertebratesQ41601034
Compartmentalization of eukaryotic gene expression: causes and effectsQ41639481
The LIN-12/Notch signaling pathway and its regulationQ41689370
Transcriptional roles of CCAAT/enhancer binding protein-beta, nuclear factor-kappaB, and C-promoter binding factor 1 in interleukin (IL)-1beta-induced IL-6 synthesis by human rheumatoid fibroblast-like synoviocytesQ42452643
Suppressor of Hairless, the Drosophila homolog of the mouse recombination signal-binding protein gene, controls sensory organ cell fatesQ43575150
Masking of the CBF1/RBPJ kappa transcriptional repression domain by Epstein-Barr virus EBNA2.Q44697821
Expression of an activated Notch-related int-3 transgene interferes with cell differentiation and induces neoplastic transformation in mammary and salivary glandsQ45182928
Mediation of Epstein-Barr virus EBNA2 transactivation by recombination signal-binding protein J kappaQ45781476
lag-1, a gene required for lin-12 and glp-1 signaling in Caenorhabditis elegans, is homologous to human CBF1 and Drosophila Su(H).Q47069543
The neurogenic suppressor of hairless DNA-binding protein mediates the transcriptional activation of the enhancer of split complex genes triggered by Notch signaling.Q47072129
Inhibition of the DNA-binding activity of Drosophila suppressor of hairless and of its human homolog, KBF2/RBP-J kappa, by direct protein-protein interaction with Drosophila hairlessQ47072311
The suppressor of hairless protein participates in notch receptor signalingQ47072502
The Drosophila homolog of the immunoglobulin recombination signal-binding protein regulates peripheral nervous system development.Q52444074
Frequent provirus insertional mutagenesis of Notch1 in thymomas of MMTVD/myc transgenic mice suggests a collaboration of c-myc and Notch1 for oncogenesisQ59285746
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectCorepressor interacting with RBPJ, CIR1Q21114115
Mastermind like transcriptional coactivator 1Q21119393
recombination signal binding protein for immunoglobulin kappa J regionQ21201732
P304page(s)23-8
P577publication date1999-01-05
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleCIR, a corepressor linking the DNA binding factor CBF1 to the histone deacetylase complex
P478volume96

Reverse relations

cites work (P2860)
Q37081815A TAG on to the neurogenic functions of APP
Q28344636A genome-wide survey of RS domain proteins
Q24291301A human protein with sequence similarity to Drosophila mastermind coordinates the nuclear form of notch and a CSL protein to build a transcriptional activator complex on target promoters
Q52141250A model Notch response element detects Suppressor of Hairless-dependent molecular switch.
Q46703801A notch-independent activity of suppressor of hairless is required for normal mechanoreceptor physiology
Q40171091A proline repeat domain in the Notch co-activator MAML1 is important for the p300-mediated acetylation of MAML1.
Q24524363A role for SKIP in EBNA2 activation of CBF1-repressed promoters
Q40811596A site in the complement receptor 2 (CR2/CD21) silencer is necessary for lineage specific transcriptional regulation
Q33884014A somatic knockout of CBF1 in a human B-cell line reveals that induction of CD21 and CCR7 by EBNA-2 is strictly CBF1 dependent and that downregulation of immunoglobulin M is partially CBF1 independent
Q36315750Acetylated histone H3 and H4 mark the upregulated LMP2A promoter of Epstein-Barr virus in lymphoid cells
Q40423684Activation of the Notch-regulated transcription factor CBF1/RBP-Jkappa through the 13SE1A oncoprotein
Q52054027Activation of the rat renin promoter by HOXD10.PBX1b.PREP1, Ets-1, and the intracellular domain of notch.
Q36710879Activator-to-repressor conversion of T-box transcription factors by the Ripply family of Groucho/TLE-associated mediators
Q39002185Alterations in NF-kappaB and RBP-Jkappa by arenavirus infection of macrophages in vitro and in vivo
Q39601084Amino acids of Epstein-Barr virus nuclear antigen 3A essential for repression of Jkappa-mediated transcription and their evolutionary conservation
Q52599088An EGFR/Ebi/Sno pathway promotes delta expression by inactivating Su(H)/SMRTER repression during inductive notch signaling.
Q28244672An essential role of Pak1 phosphorylation of SHARP in Notch signaling
Q35541244Analyzing the nuclear complexes of Notch signaling by electrophoretic mobility shift assay
Q48162917Arabidopsis MAS2, an Essential Gene That Encodes a Homolog of Animal NF-κ B Activating Protein, Is Involved in 45S Ribosomal DNA Silencing.
Q33755151Arbiter of differentiation and death: Notch signaling meets apoptosis
Q28200963Association of transcription factor YY1 with the high molecular weight Notch complex suppresses the transactivation activity of Notch
Q24338176BEND6 is a nuclear antagonist of Notch signaling during self-renewal of neural stem cells
Q42439904Basal Expression of IκBα Is Controlled by the Mammalian Transcriptional Repressor RBP-J (CBF1) and Its Activator Notch1
Q38363498Binding of C/EBP and RBP (CBF1) to overlapping sites regulates interleukin-6 gene expression
Q42573954CBF-1 promotes transcriptional silencing during the establishment of HIV-1 latency
Q24338153CIR, a corepressor of CBF1, binds to PAP-1 and effects alternative splicing
Q35943718Carboxyl-terminal amino acids 1052 to 1082 of the latency-associated nuclear antigen (LANA) interact with RBP-Jκ and are responsible for LANA-mediated RTA repression.
Q28580975Characterization of a high-molecular-weight Notch complex in the nucleus of Notch(ic)-transformed RKE cells and in a human T-cell leukemia cell line
Q48318063Chromosomal Imbalances in Patients with Congenital Cardiac Defects: A Meta-analysis Reveals Novel Potential Critical Regions Involved in Heart Development
Q42828884Consequences of Notch-mediated induction of Jagged1.
Q33449310Construction and clarification of dynamic gene regulatory network of cancer cell cycle via microarray data.
Q47073624Coordination of symmetric cyclic gene expression during somitogenesis by Suppressor of Hairless involves regulation of retinoic acid catabolism
Q33980474Crystal structure of the nuclear effector of Notch signaling, CSL, bound to DNA
Q24655211DNA-binding and -bending activities of SAP30L and SAP30 are mediated by a zinc-dependent module and monophosphoinositides
Q22254582DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci
Q34547205Deciphering the role of Notch signaling in lymphopoiesis
Q35779716Default repression and Notch signaling: Hairless acts as an adaptor to recruit the corepressors Groucho and dCtBP to Suppressor of Hairless
Q34116313Deltex1 redirects lymphoid progenitors to the B cell lineage by antagonizing Notch1.
Q39776571Differential hyperacetylation of histones H3 and H4 upon promoter-specific recruitment of EBNA2 in Epstein-Barr virus chromatin.
Q34372409Dissecting and circumventing the requirement for RAM in CSL-dependent Notch signaling
Q28593674Dual roles for the Notch target gene Hes-1 in the differentiation of 3T3-L1 preadipocytes
Q37596770Dynamic chromatin boundaries delineate a latency control region of Epstein-Barr virus
Q24679432EBNA2 and Activated Notch Induce Expression of BATF
Q37596895EBNA2 is required for protection of latently Epstein-Barr virus-infected B cells against specific apoptotic stimuli.
Q34465612EBNA3A association with RBP-Jkappa down-regulates c-myc and Epstein-Barr virus-transformed lymphoblast growth
Q35889902EBNA3C Directs Recruitment of RBPJ (CBF1) to Chromatin during the Process of Gene Repression in EBV Infected B Cells
Q36710850ETO, but not leukemogenic fusion protein AML1/ETO, augments RBP-Jkappa/SHARP-mediated repression of notch target genes
Q35050406Emerging molecular targets for the treatment of pre-eclampsia
Q37247543Endothelial Jagged-1 is necessary for homeostatic and regenerative hematopoiesis
Q24530175Epstein-Barr virus BamHi-a rightward transcript-encoded RPMS protein interacts with the CBF1-associated corepressor CIR to negatively regulate the activity of EBNA2 and NotchIC
Q34154616Epstein-Barr virus EBNA2 blocks Nur77- mediated apoptosis
Q35024009Epstein-Barr virus nuclear antigen 2 trans-activates the cellular antiapoptotic bfl-1 gene by a CBF1/RBPJ kappa-dependent pathway
Q24540313Epstein-Barr virus nuclear antigen 3C putative repression domain mediates coactivation of the LMP1 promoter with EBNA-2.
Q37156071Epstein-Barr virus nuclear protein 2 interacts with p300, CBP, and PCAF histone acetyltransferases in activation of the LMP1 promoter
Q33965862Essential roles for ankyrin repeat and transactivation domains in induction of T-cell leukemia by notch1.
Q28579505Functional interactions between an atypical NF-kappaB site from the rat CYP2B1 promoter and the transcriptional repressor RBP-Jkappa/CBF1.
Q30832601Fungal CSL transcription factors.
Q64114302HDAC1 negatively regulates selective mitotic chromatin binding of the Notch effector RBPJ in a KDM5A-dependent manner
Q33926323Histone deacetylases, transcriptional control, and cancer
Q33850039Histone deacetylases: silencers for hire.
Q33737810Histone demethylase KDM5A is an integral part of the core Notch-RBP-J repressor complex
Q24336890Human MI-ER1 alpha and beta function as transcriptional repressors by recruitment of histone deacetylase 1 to their conserved ELM2 domain
Q24527215Human herpesvirus 8 LANA interacts with proteins of the mSin3 corepressor complex and negatively regulates Epstein-Barr virus gene expression in dually infected PEL cells
Q24309682Identification of a family of mastermind-like transcriptional coactivators for mammalian notch receptors
Q33938967Identification of a novel activation domain in the Notch-responsive transcription factor CSL
Q24550791IkappaBalpha and p65 regulate the cytoplasmic shuttling of nuclear corepressors: cross-talk between Notch and NFkappaB pathways
Q37424241Ikaros regulates Notch target gene expression in developing thymocytes
Q33843211Induction of Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen by the lytic transactivator RTA: a novel mechanism for establishment of latency
Q33969345Induction of cyclin D1 transcription and CDK2 activity by Notch(ic): implication for cell cycle disruption in transformation by Notch(ic).
Q39155162Inhibition of CK2α down-regulates Notch1 signalling in lung cancer cells.
Q35182362Insensible is a novel nuclear inhibitor of Notch activity in Drosophila
Q35176989Insensitive is a corepressor for Suppressor of Hairless and regulates Notch signalling during neural development
Q38761166Kaposi's Sarcoma-associated herpesvirus lytic switch protein stimulates DNA binding of RBP-Jk/CSL to activate the Notch pathway
Q34838458Keeping a good pathway down: transcriptional repression of Notch pathway target genes by CSL proteins
Q42365079Leptin signaling and cancer chemoresistance: Perspectives
Q35168476Lytic but not latent infection by Kaposi's sarcoma-associated herpesvirus requires host CSL protein, the mediator of Notch signaling
Q24290574MAML1, a human homologue of Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors
Q24540080Mammalian PRP4 kinase copurifies and interacts with components of both the U5 snRNP and the N-CoR deacetylase complexes
Q42211947Mapping the Deltex-binding surface on the notch ankyrin domain using analytical ultracentrifugation
Q24675233Mastermind mediates chromatin-specific transcription and turnover of the Notch enhancer complex
Q37785192Mechanistic insights into Notch receptor signaling from structural and biochemical studies
Q46419557Modulation of Notch Signaling During Somitogenesis
Q33823770Molecular determinants of NOTCH4 transcription in vascular endothelium
Q40459077Murine gammaherpesvirus 68 Rta-dependent activation of the gene 57 promoter.
Q31006410Mutational analysis of the J recombination signal sequence binding protein (RBP-J)/Epstein-Barr virus nuclear antigen 2 (EBNA2) and RBP-J/Notch interaction
Q34130415Mutations in a protein target of the Pim-1 kinase associated with the RP9 form of autosomal dominant retinitis pigmentosa
Q33725493Myeloid translocation gene 16 (MTG16) interacts with Notch transcription complex components to integrate Notch signaling in hematopoietic cell fate specification
Q24292362NAPP2, a peroxisomal membrane protein, is also a transcriptional corepressor
Q24321003NKAP is a transcriptional repressor of notch signaling and is required for T cell development
Q35558109NOTCH-1 and NOTCH-4 are novel gene targets of PEA3 in breast cancer: novel therapeutic implications.
Q39453336Neoplastic transformation by Notch requires nuclear localization
Q24644926Neural restrictive silencer factor recruits mSin3 and histone deacetylase complex to repress neuron-specific target genes
Q46795621Notch Signaling in Development, Tissue Homeostasis, and Disease
Q26752380Notch Signaling in Neuroendocrine Tumors
Q37785199Notch Targets and Their Regulation
Q41882770Notch activation stimulates transient and selective binding of Su(H)/CSL to target enhancers
Q33812251Notch and the immune system.
Q34330869Notch inhibitors for cancer treatment
Q35111778Notch inhibits chondrogenic differentiation of mesenchymal progenitor cells by targeting Twist1.
Q34218051Notch pathway: making sense of suppressor of hairless
Q24291629Notch receptors and hematopoiesis
Q35676281Notch regulation of lymphocyte development and function.
Q34776145Notch signaling and the bone marrow hematopoietic stem cell niche
Q35551147Notch signaling as a therapeutic target in cancer: a new approach to the development of cell fate modifying agents
Q36903753Notch signaling at a glance
Q36429535Notch signaling in T-cell acute lymphoblastic leukemia
Q24293622Notch signaling induces rapid degradation of achaete-scute homolog 1.
Q37169972Notch signaling: targeting cancer stem cells and epithelial-to-mesenchymal transition
Q36684906Notch signalling during peripheral T-cell activation and differentiation
Q34376282Notch signalling in T‐cell lymphoblastic leukaemia/lymphoma and other haematological malignancies
Q29555851Notch signalling: a simple pathway becomes complex
Q36150879Notch: a unique therapeutic target for immunomodulation
Q90315088Novel dynamics of human mucociliary differentiation revealed by single-cell RNA sequencing of nasal epithelial cultures
Q35080412Nrarp is a novel intracellular component of the Notch signaling pathway
Q24550850Nuclear localization of CBF1 is regulated by interactions with the SMRT corepressor complex
Q28287132PAP-1, the mutated gene underlying the RP9 form of dominant retinitis pigmentosa, is a splicing factor
Q38352939Perturbation of Ikaros isoform selection by MLV integration is a cooperative event in Notch(IC)-induced T cell leukemogenesis
Q38420993Phylogenetic analysis of the SAP30 family of transcriptional regulators reveals functional divergence in the domain that binds the nuclear matrix.
Q52586954Proneural enhancement by Notch overcomes Suppressor-of-Hairless repressor function in the developing Drosophila eye.
Q24529191Proteasome-independent disruption of PML oncogenic domains (PODs), but not covalent modification by SUMO-1, is required for human cytomegalovirus immediate-early protein IE1 to inhibit PML-mediated transcriptional repression.
Q58802052RBPJ polymorphisms associated with cerebral infarction diseases in Chinese Han population: A Clinical Trial/Experimental Study (CONSORT Compliant)
Q24613736RING1 inhibits transactivation of RBP-J by Notch through interaction with LIM protein KyoT2
Q37208020Regulation of dendritic cell differentiation in bone marrow during emergency myelopoiesis
Q40471319Regulation of expression of the Epstein-Barr virus BamHI-A rightward transcripts.
Q52603545Regulation of marginal zone B cell development by MINT, a suppressor of Notch/RBP-J signaling pathway
Q24534154Repression by Ikaros and Aiolos is mediated through histone deacetylase complexes
Q35186143Repression by suppressor of hairless and activation by Notch are required to define a single row of single-minded expressing cells in the Drosophila embryo.
Q48209402Role of MAML1 and MEIS1 in Esophageal Squamous Cell Carcinoma Depth of Invasion.
Q64109561Role of MAML1 in targeted therapy against the esophageal cancer stem cells
Q40124399Role of a consensus AP-2 regulatory sequence within the Epstein-Barr virus LMP1 promoter in EBNA2 mediated transactivation
Q24550832SAP30L interacts with members of the Sin3A corepressor complex and targets Sin3A to the nucleolus
Q24534941SHARP is a novel component of the Notch/RBP-Jkappa signalling pathway
Q22253329SKIP, a CBF1-associated protein, interacts with the ankyrin repeat domain of NotchIC To facilitate NotchIC function
Q92635006SWI/SNF chromatin remodeling controls Notch-responsive enhancer accessibility
Q41137199Sca-1+Lin-CD117- mesenchymal stem/stromal cells induce the generation of novel IRF8-controlled regulatory dendritic cells through Notch-RBP-J signaling
Q37941310Selective repression of Notch pathway target gene transcription
Q36648414Signal integration during development: mechanisms of EGFR and Notch pathway function and cross-talk
Q34047262Signal transduction by tumor necrosis factor and gene regulation of the inflammatory cytokine interleukin-6.
Q92574568Skip is essential for Notch signaling to induce Sox2 in cerebral arteriovenous malformations
Q27653832Solution structure of a novel zinc finger motif in the SAP30 polypeptide of the Sin3 corepressor complex and its potential role in nucleic acid recognition
Q37842959Stem cell and lung cancer development: blaming the Wnt, Hh and Notch signalling pathway
Q35188610Structural and functional analysis of the repressor complex in the Notch signaling pathway of Drosophila melanogaster
Q24307538Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes
Q28184514Structural requirements for assembly of the CSL.intracellular Notch1.Mastermind-like 1 transcriptional activation complex
Q27670449Structure of the 30-kDa Sin3-associated Protein (SAP30) in Complex with the Mammalian Sin3A Corepressor and Its Role in Nucleic Acid Binding
Q35804704Suppressors of the egg-laying defective phenotype of sel-12 presenilin mutants implicate the CoREST corepressor complex in LIN-12/Notch signaling in C. elegans
Q59313930TET2 controls chemoresistant slow-cycling cancer cell survival and tumor recurrence
Q26863580Targeting the Notch signaling pathway in cancer therapeutics
Q37299680The AKT1/NF-kappaB/Notch1/PTEN axis has an important role in chemoresistance of gastric cancer cells
Q47069509The C. elegans sex determination protein MOG-3 functions in meiosis and binds to the CSL co-repressor CIR-1.
Q28072734The CSL proteins, versatile transcription factors and context dependent corepressors of the notch signaling pathway
Q38660700The N- and C-terminal regions of RBP-J interact with the ankyrin repeats of Notch1 RAMIC to activate transcription
Q36315299The Notch signaling pathway controls the size of the ocular lens by directly suppressing p57Kip2 expression
Q28235012The PcG protein HPC2 inhibits RBP-J-mediated transcription by interacting with LIM protein KyoT2
Q57094352The Role of Notch Signaling and Leptin-Notch Crosstalk in Pancreatic Cancer
Q61446913The evolution of transcriptional repressors in the Notch signaling pathway: a computational analysis
Q39860135The lytic switch protein of KSHV activates gene expression via functional interaction with RBP-Jkappa (CSL), the target of the Notch signaling pathway.
Q34012680The notch intracellular domain can function as a coactivator for LEF-1
Q34719214The notch pathway: modulation of cell fate decisions in hematopoiesis
Q28201623The origin of the ankyrin repeat region in Notch intracellular domains is critical for regulation of HES promoter activity
Q35196615The role of Kaposi's sarcoma-associated herpesvirus/human herpesvirus-8 regulator of transcription activation (RTA) in control of gene expression
Q35564593The role of Notch in tumorigenesis: oncogene or tumour suppressor?
Q28236852Tip60 histone acetyltransferase acts as a negative regulator of Notch1 signaling by means of acetylation
Q39584884Transcriptional repression by neuron-restrictive silencer factor is mediated via the Sin3-histone deacetylase complex
Q35075783UXT potentiates angiogenesis by attenuating Notch signaling
Q38348963Wide-scale use of Notch signaling factor CSL/RBP-Jkappa in RTA-mediated activation of Kaposi's sarcoma-associated herpesvirus lytic genes
Q77355006XNAP, a conserved ankyrin repeat-containing protein with a role in the Notch pathway during Xenopus primary neurogenesis
Q28592502ZFP423 coordinates Notch and bone morphogenetic protein signaling, selectively up-regulating Hes5 gene expression
Q24548267p300 acts as a transcriptional coactivator for mammalian Notch-1
Q28504559p48 subunit of mouse PTF1 binds to RBP-Jkappa/CBF-1, the intracellular mediator of Notch signalling, and is expressed in the neural tube of early stage embryos

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