Default repression and Notch signaling: Hairless acts as an adaptor to recruit the corepressors Groucho and dCtBP to Suppressor of Hairless

scientific article published on August 2002

Default repression and Notch signaling: Hairless acts as an adaptor to recruit the corepressors Groucho and dCtBP to Suppressor of Hairless is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1101/GAD.987402
P932PMC publication ID186408
P698PubMed publication ID12154126
P5875ResearchGate publication ID11229051

P2093author name stringJames W Posakony
Scott Barolo
Anne G Bang
Tammie Stone
P2860cites workCIR, a corepressor linking the DNA binding factor CBF1 to the histone deacetylase complexQ22008610
A human protein with sequence similarity to Drosophila mastermind coordinates the nuclear form of notch and a CSL protein to build a transcriptional activator complex on target promotersQ24291301
Dominant enhancers of Egfr in Drosophila melanogaster: genetic links between the Notch and Egfr signaling pathwaysQ24533262
Cloning and characterization of mCtBP2, a co-repressor that associates with basic Krüppel-like factor and other mammalian transcriptional regulatorsQ24533307
p300 acts as a transcriptional coactivator for mammalian Notch-1Q24548267
Acetylation of nuclear hormone receptor-interacting protein RIP140 regulates binding of the transcriptional corepressor CtBPQ24550853
Transcriptional repression by Pax5 (BSAP) through interaction with corepressors of the Groucho familyQ24594237
A histone deacetylase corepressor complex regulates the Notch signal transduction pathwayQ24598533
ZEB represses transcription through interaction with the corepressor CtBPQ24653823
HES6 acts as a transcriptional repressor in myoblasts and can induce the myogenic differentiation programQ24685454
Targeted gene expression as a means of altering cell fates and generating dominant phenotypesQ27861039
Notch signaling: cell fate control and signal integration in developmentQ27861061
The interaction of the carboxyl terminus-binding protein with the Smad corepressor TGIF is disrupted by a holoprosencephaly mutation in TGIFQ28139069
The CtBP family: enigmatic and enzymatic transcriptional co-repressorsQ28211777
Signalling downstream of activated mammalian NotchQ28289832
An insect molecular clock dates the origin of the insects and accords with palaeontological and biogeographic landmarksQ29618545
Drosophila CtBP: a Hairy-interacting protein required for embryonic segmentation and hairy-mediated transcriptional repressionQ33888622
Drosophila Notch receptor activity suppresses Hairless function during adult external sensory organ development.Q33966328
Transcriptional repression: the long and the short of it.Q34426886
Three habits of highly effective signaling pathways: principles of transcriptional control by developmental cell signalingQ34649230
Repression by suppressor of hairless and activation by Notch are required to define a single row of single-minded expressing cells in the Drosophila embryo.Q35186143
Conversion of dorsal from an activator to a repressor by the global corepressor GrouchoQ35196355
In vivo interactions of the Drosophila Hairy and Runt transcriptional repressors with target promotersQ35917558
The molecular genetics of Enhancer of split, a gene required for embryonic neural development in DrosophilaQ35996736
Role of the iroquois3 homeobox gene in organizer formationQ36526592
The recombination signal sequence-binding protein RBP-2N functions as a transcriptional repressorQ36652805
Dissecting the mechanisms of suppressor of hairless functionQ38306844
Rapid divergence in the course of Drosophila evolution reveals structural important domains of the Notch antagonist HairlessQ38327062
RBP-J kappa repression activity is mediated by a co-repressor and antagonized by the Epstein-Barr virus transcription factor EBNA2.Q40397055
Nature versus nurture: asymmetric cell divisions in Drosophila bristle developmentQ40816976
Temperature-sensitive periods and autonomy of pleiotropic effects of l(1)Nts1, a conditional notch lethal in DrosophilaQ41366153
Cytogenetic analysis of the chromosomal region immediately adjacent to the rosy locus in Drosophila melanogaster.Q41599884
A conserved region of engrailed, shared among all en-, gsc-, Nk1-, Nk2- and msh-class homeoproteins, mediates active transcriptional repression in vivoQ41902391
The Drosophila gene Hairless encodes a novel basic protein that controls alternative cell fates in adult sensory organ developmentQ42458781
Suppressor of Hairless, the Drosophila homolog of the mouse recombination signal-binding protein gene, controls sensory organ cell fatesQ43575150
Transcriptional repression by suppressor of hairless involves the binding of a hairless-dCtBP complex in Drosophila.Q43621582
Hairless is required for the development of adult sensory organ precursor cells in DrosophilaQ43718472
Masking of the CBF1/RBPJ kappa transcriptional repression domain by Epstein-Barr virus EBNA2.Q44697821
A dual function of the Notch gene in Drosophila sensillum development.Q45930515
Suppressor of hairless directly activates transcription of enhancer of split complex genes in response to Notch receptor activityQ45950823
Hairless promotes stable commitment to the sensory organ precursor cell fate by negatively regulating the activity of the Notch signaling pathwayQ46246453
Antagonistic activities of Suppressor of Hairless and Hairless control alternative cell fates in the Drosophila adult epidermis.Q46371601
A notch-independent activity of suppressor of hairless is required for normal mechanoreceptor physiologyQ46703801
Only a subset of the binary cell fate decisions mediated by Numb/Notch signaling in Drosophila sensory organ lineage requires Suppressor of HairlessQ46781335
The neurogenic suppressor of hairless DNA-binding protein mediates the transcriptional activation of the enhancer of split complex genes triggered by Notch signaling.Q47072129
Inhibition of the DNA-binding activity of Drosophila suppressor of hairless and of its human homolog, KBF2/RBP-J kappa, by direct protein-protein interaction with Drosophila hairlessQ47072311
A model Notch response element detects Suppressor of Hairless-dependent molecular switch.Q52141250
Two different activities of Suppressor of Hairless during wing development in Drosophila.Q52166706
In vivo structure-function analysis of Drosophila Hairless.Q52192271
Suppressor of hairless, the Drosophila homologue of RBP-J kappa, transactivates the neurogenic gene E(spl)m8.Q52207063
Groucho: making its Marx as a transcriptional co-repressor.Q52563560
Molecular evolution in Drosophila and the higher Diptera II. A time scale for fly evolutionQ70517360
P433issue15
P407language of work or nameEnglishQ1860
P921main subjectHairless Dmel_CG5460Q29811841
Suppressor of Hairless Dmel_CG3497Q29813727
P304page(s)1964-1976
P577publication date2002-08-01
P1433published inGenes & DevelopmentQ1524533
P1476titleDefault repression and Notch signaling: Hairless acts as an adaptor to recruit the corepressors Groucho and dCtBP to Suppressor of Hairless
P478volume16

Reverse relations

cites work (P2860)
Q28818306A cell-based computational model of early embryogenesis coupling mechanical behaviour and gene regulation
Q46443793A protocol for unraveling gene regulatory networks
Q30486049Acetylation-dependent interaction of SATB1 and CtBP1 mediates transcriptional repression by SATB1.
Q55265373Activation of the Notch Signaling Pathway In Vivo Elicits Changes in CSL Nuclear Dynamics.
Q36710879Activator-to-repressor conversion of T-box transcription factors by the Ripply family of Groucho/TLE-associated mediators
Q24338176BEND6 is a nuclear antagonist of Notch signaling during self-renewal of neural stem cells
Q37209170Brinker possesses multiple mechanisms for repression because its primary co-repressor, Groucho, may be unavailable in some cell types
Q28594222Common and distinct DNA-binding and regulatory activities of the BEN-solo transcription factor family
Q52365725Complex genetic interactions of novel Suppressor of Hairless alleles deficient in co-repressor binding.
Q39307315Complex interplay of three transcription factors in controlling the tormogen differentiation program of Drosophila mechanoreceptors
Q47871940Conservation of the Notch antagonist Hairless in arthropods: functional analysis of the crustacean Daphnia pulex Hairless gene.
Q38659223Control of Adult Neurogenesis by Short-Range Morphogenic-Signaling Molecules
Q38155311Control of Drosophila embryo patterning by transcriptional co-regulators.
Q33335935Defining a modular signalling network from the fly interactome.
Q35941628Deregulation of the cell cycle by the Epstein-Barr virus
Q108792331Desensitisation of Notch signalling through dynamic adaptation in the nucleus
Q38339670Differential Regulation of Transcription through Distinct Suppressor of Hairless DNA Binding Site Architectures during Notch Signaling in Proneural Clusters
Q34643920Differential effects of Drosophila mastermind on asymmetric cell fate specification and neuroblast formation
Q64057540Division of Labor: Roles of Groucho and CtBP in Notch-Mediated Lateral Inhibition that Controls Intestinal Stem Cell Differentiation in Drosophila
Q42148333Drosophila CtBP regulates proliferation and differentiation of eye precursors and complexes with Eyeless, Dachshund, Dan, and Danr during eye and antennal development
Q56456418DrosophilaPatterning: Delta-Notch Interactions
Q39155079Dynamic binding of RBPJ is determined by Notch signaling status.
Q52653914EGFR signaling attenuates Groucho-dependent repression to antagonize Notch transcriptional output.
Q37100349Erect wing regulates synaptic growth in Drosophila by integration of multiple signaling pathways
Q83228159Evolutionary emergence of Hairless as a novel component of the Notch signaling pathway
Q47073090Fluorescent protein expression driven by her4 regulatory elements reveals the spatiotemporal pattern of Notch signaling in the nervous system of zebrafish embryos
Q33270380Fly-DPI: database of protein interactomes for D. melanogaster in the approach of systems biology
Q52029391Functional analysis of murine CBF1 during Drosophila development.
Q27314638Generation of New Hairless Alleles by Genomic Engineering at the Hairless Locus in Drosophila melanogaster
Q34589848Genetic modifier screens on Hairless gain-of-function phenotypes reveal genes involved in cell differentiation, cell growth and apoptosis in Drosophila melanogaster.
Q36328467Groucho restricts rhomboid expression and couples EGFR activation with R8 selection during Drosophila photoreceptor differentiation
Q53026426HES1 as an independent prognostic marker in esophageal squamous cell carcinoma.
Q34803072Hairless is a cofactor for Runt-dependent transcriptional regulation
Q33708041Hairless-binding deficient Suppressor of Hairless alleles reveal Su(H) protein levels are dependent on complex formation with Hairless
Q39891099Hairless-mediated repression of notch target genes requires the combined activity of Groucho and CtBP corepressors
Q46080158Hipk is an essential protein that promotes Notch signal transduction in the Drosophila eye by inhibition of the global co-repressor Groucho
Q89475630Histone variant H2A.Z deposition and acetylation directs the canonical Notch signaling response
Q42108047How Drosophila melanogaster Forms its Mechanoreceptors
Q34587954Identification of Drosophila genes modulating Janus kinase/signal transducer and activator of transcription signal transduction
Q36994950Ikaros represses the transcriptional response to Notch signaling in T-cell development
Q47713809In vivo functional characterization of the SARS-Coronavirus 3a protein in Drosophila.
Q35176989Insensitive is a corepressor for Suppressor of Hairless and regulates Notch signalling during neural development
Q57761607Integration of Drosophila and Human Genetics to Understand Notch Signaling Related Diseases
Q34518118Integration of Orthogonal Signaling by the Notch and Dpp Pathways in Drosophila
Q34838458Keeping a good pathway down: transcriptional repression of Notch pathway target genes by CSL proteins
Q27329673Ligand-independent traffic of Notch buffers activated Armadillo in Drosophila
Q37201433Lines is required for normal operation of Wingless, Hedgehog and Notch pathways during wing development
Q33318747Loss of TLE1 and TLE4 from the del(9q) commonly deleted region in AML cooperates with AML1-ETO to affect myeloid cell proliferation and survival
Q37785192Mechanistic insights into Notch receptor signaling from structural and biochemical studies
Q33606036Modularity and design principles in the sea urchin embryo gene regulatory network
Q28478094Molecular analysis of the notch repressor-complex in Drosophila: characterization of potential hairless binding sites on suppressor of hairless
Q50625643Mutation of potential MAPK phosphorylation sites in the Notch antagonist Hairless.
Q52060384Mutations in rugose promote cell type-specific apoptosis in the Drosophila eye.
Q89725071Notch Signalling: The Multitask Manager of Inner Ear Development and Regeneration
Q37785199Notch Targets and Their Regulation
Q41882770Notch activation stimulates transient and selective binding of Su(H)/CSL to target enhancers
Q51958587Notch and suppressor of Hairless regulate levels but not patterns of Delta expression in Drosophila.
Q41346788Notch modulates Wnt signalling by associating with Armadillo/beta-catenin and regulating its transcriptional activity
Q51248148Notch receptor encodes two structurally separable functions in Drosophila: a genetic analysis.
Q36903753Notch signaling at a glance
Q91826010Notch signaling coordinates ommatidial rotation in the Drosophila eye via transcriptional regulation of the EGF-Receptor ligand Argos
Q29555851Notch signalling: a simple pathway becomes complex
Q52670911Notch synergizes with axin to regulate the activity of armadillo in Drosophila.
Q33724489Numb proteins specify asymmetric cell fates via an endocytosis- and proteasome-independent pathway.
Q33780723Pervasive regulation of Drosophila Notch target genes by GY-box-, Brd-box-, and K-box-class microRNAs
Q58227153Phenotypically distinct female castes in honey bees are defined by alternative chromatin states during larval development
Q36287819Phylogenetic footprinting analysis in the upstream regulatory regions of the Drosophila enhancer of split genes
Q34010320Proteomic snapshot of breast cancer cell cycle: G1/S transition point.
Q24294890RBP-Jkappa/SHARP recruits CtIP/CtBP corepressors to silence Notch target genes
Q47071192Regulation of expression of Vg and establishment of the dorsoventral compartment boundary in the wing imaginal disc by Suppressor of Hairless
Q37746040Regulation of skeletal myogenesis by Notch
Q42044492Requirement of Split ends for epigenetic regulation of Notch signal-dependent genes during infection-induced hemocyte differentiation
Q35341419Requirements for mediator complex subunits distinguish three classes of notch target genes at the Drosophila wing margin
Q89725067Role of Notch Signaling in Leg Development in Drosophila melanogaster
Q47163350Role of co-repressor genomic landscapes in shaping the Notch response.
Q34477664Sequential Notch signalling at the boundary of fringe expressing and non-expressing cells
Q36085743Setting the Stage for Notch: The Drosophila Su(H)-Hairless Repressor Complex
Q36648414Signal integration during development: mechanisms of EGFR and Notch pathway function and cross-talk
Q36482090Son of Notch, a winged-helix gene involved in boundary formation in the Drosophila wing
Q36464591Spatial specificity of mesodermal even-skipped expression relies on multiple repressor sites
Q35188610Structural and functional analysis of the repressor complex in the Notch signaling pathway of Drosophila melanogaster
Q46922609Structurally related Arabidopsis ANGUSTIFOLIA is functionally distinct from the transcriptional corepressor CtBP.
Q27342255Structure and Function of the Su(H)-Hairless Repressor Complex, the Major Antagonist of Notch Signaling in Drosophila melanogaster
Q43518830Suppressor of Hairless is required for long-term memory formation in Drosophila
Q24315690TBL1 and TBLR1 phosphorylation on regulated gene promoters overcomes dual CtBP and NCoR/SMRT transcriptional repression checkpoints
Q34036170TLX1 and NOTCH coregulate transcription in T cell acute lymphoblastic leukemia cells
Q24323105The BEN domain is a novel sequence-specific DNA-binding domain conserved in neural transcriptional repressors
Q28072734The CSL proteins, versatile transcription factors and context dependent corepressors of the notch signaling pathway
Q38597236The EBNA3 Family: Two Oncoproteins and a Tumour Suppressor that Are Central to the Biology of EBV in B Cells
Q24816494The EH1 motif in metazoan transcription factors
Q35233511The Groucho co-repressor is primarily recruited to local target sites in active chromatin to attenuate transcription
Q57094352The Role of Notch Signaling and Leptin-Notch Crosstalk in Pancreatic Cancer
Q38297049The Transcriptional Coregulator LEUNIG_HOMOLOG Inhibits Light-Dependent Seed Germination in Arabidopsis
Q34350820The bHLH-PAS transcription factor dysfusion regulates tarsal joint formation in response to Notch activity during drosophila leg development
Q29547725The canonical Notch signaling pathway: unfolding the activation mechanism
Q37325443The curious case of the tumour virus: 50 years of Burkitt's lymphoma
Q35776145The drosophila T-box transcription factor midline functions within Insulin/Akt and c-Jun-N terminal kinase stress-reactive signaling pathways to regulate interommatial bristle formation and cell survival.
Q61446913The evolution of transcriptional repressors in the Notch signaling pathway: a computational analysis
Q47072216The first deltex null mutant indicates tissue-specific deltex-dependent Notch signaling in Drosophila
Q50046159The histone deacetylase HDAC1 positively regulates Notch signaling during Drosophila wing development.
Q44612454The role of Suppressor of Hairless in Notch mediated signalling during zebrafish somitogenesis
Q33344243The tiny Hairless protein from Apis mellifera: a potent antagonist of Notch signaling in Drosophila melanogaster
Q40778774Tools and methods for studying Notch signaling in Drosophila melanogaster
Q34249533Transactivation of MCP-1/CCL2 by beta-catenin/TCF-4 in human breast cancer cells
Q39748937Transcriptional Regulatory Properties of Epstein-Barr Virus Nuclear Antigen 3C Are Conserved in Simian Lymphocryptoviruses
Q38432247Transcriptional and histological alterations in gonad of adult zebrafish after exposure to the synthetic progestin norgestrel
Q33684585Transcriptional control of stem cell maintenance in the Drosophila intestine
Q28579873Two nonconsensus sites in the Epstein-Barr virus oncoprotein EBNA3A cooperate to bind the co-repressor carboxyl-terminal-binding protein (CtBP)
Q43170101Ubiquitylation-independent activation of Notch signalling by Delta
Q52039784Visualization of spatiotemporal activation of Notch signaling: live monitoring and significance in neural development.
Q27005607Wnt/Wingless signaling in Drosophila
Q24304410XIAP monoubiquitylates Groucho/TLE to promote canonical Wnt signaling
Q38310420cis-regulatory processing of Notch signaling input to the sea urchin glial cells missing gene during mesoderm specification

Search more.