EBNA3C Directs Recruitment of RBPJ (CBF1) to Chromatin during the Process of Gene Repression in EBV Infected B Cells

scientific article published on 11 January 2016

EBNA3C Directs Recruitment of RBPJ (CBF1) to Chromatin during the Process of Gene Repression in EBV Infected B Cells is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1371/JOURNAL.PPAT.1005383
P932PMC publication ID4708995
P698PubMed publication ID26751214
P5875ResearchGate publication ID290157432

P50authorKostas PaschosQ59384393
Quentin BazotQ59691365
Adam C T GillmanQ87048798
Martin J AlldayQ96115879
P2093author name stringBettina Kempkes
Jens S Kalchschmidt
P2860cites workMastermind is a putative activator for Notch.Q52580782
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CIR, a corepressor linking the DNA binding factor CBF1 to the histone deacetylase complexQ22008610
MAML1, a human homologue of Drosophila mastermind, is a transcriptional co-activator for NOTCH receptorsQ24290574
RBP-Jkappa/SHARP recruits CtIP/CtBP corepressors to silence Notch target genesQ24294890
The X-linked mental retardation gene SMCX/JARID1C defines a family of histone H3 lysine 4 demethylasesQ24298299
The amino-terminal domains of Epstein-Barr virus nuclear proteins 3A, 3B, and 3C interact with RBPJ(kappa)Q24310605
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Two nonconsensus sites in the Epstein-Barr virus oncoprotein EBNA3A cooperate to bind the co-repressor carboxyl-terminal-binding protein (CtBP)Q28579873
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Induction of p16(INK4a) is the major barrier to proliferation when Epstein-Barr virus (EBV) transforms primary B cells into lymphoblastoid cell linesQ31111648
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Epigenetic repression of p16(INK4A) by latent Epstein-Barr virus requires the interaction of EBNA3A and EBNA3C with CtBP.Q33604848
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GC-rich sequence elements recruit PRC2 in mammalian ES cellsQ33775517
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A somatic knockout of CBF1 in a human B-cell line reveals that induction of CD21 and CCR7 by EBNA-2 is strictly CBF1 dependent and that downregulation of immunoglobulin M is partially CBF1 independentQ33884014
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The human J kappa recombination signal sequence binding protein (RBP-J kappa) targets the Epstein-Barr virus EBNA2 protein to its DNA responsive elements.Q34327455
EBNA2 and Notch signalling in Epstein-Barr virus mediated immortalization of B lymphocytesQ34415971
Epstein-Barr virus nuclear antigen 3C regulated genes in lymphoblastoid cell linesQ34472101
The histone H3K4 demethylase SMCX links REST target genes to X-linked mental retardation.Q34624060
RBP2 is an MRG15 complex component and down-regulates intragenic histone H3 lysine 4 methylation.Q34638245
Recruitment of PRC1 function at the initiation of X inactivation independent of PRC2 and silencingQ34767759
Epstein-Barr virus nuclear antigen 3C recruits histone deacetylase activity and associates with the corepressors mSin3A and NCoR in human B-cell linesQ34782258
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EBV nuclear antigen EBNALP dismisses transcription repressors NCoR and RBPJ from enhancers and EBNA2 increases NCoR-deficient RBPJ DNA bindingQ34977875
Epstein-Barr virus nuclear antigen 3A partially coincides with EBNA3C genome-wide and is tethered to DNA through BATF complexesQ34985686
Modulation of enhancer looping and differential gene targeting by Epstein-Barr virus transcription factors directs cellular reprogrammingQ34998243
Inactivation of intergenic enhancers by EBNA3A initiates and maintains polycomb signatures across a chromatin domain encoding CXCL10 and CXCL9Q34998257
Epstein-Barr virus nuclear protein 3C binds to the N-terminal (NTD) and beta trefoil domains (BTD) of RBP/CSL; only the NTD interaction is essential for lymphoblastoid cell growthQ35014692
RBPJ, the major transcriptional effector of Notch signaling, remains associated with chromatin throughout mitosis, suggesting a role in mitotic bookmarkingQ35112753
The mammalian transcriptional repressor RBP (CBF1) targets TFIID and TFIIA to prevent activated transcriptionQ35201509
Epstein-Barr virus exploits intrinsic B-lymphocyte transcription programs to achieve immortal cell growthQ35202714
The Epstein-Barr virus nuclear antigen 2 transactivator is directed to response elements by the J kappa recombination signal binding proteinQ35648541
Epstein-Barr Virus Proteins EBNA3A and EBNA3C Together Induce Expression of the Oncogenic MicroRNA Cluster miR-221/miR-222 and Ablate Expression of Its Target p57KIP2.Q35685797
Hyperconserved CpG domains underlie Polycomb-binding sitesQ35720547
Epstein-Barr virus nuclear protein 3C modulates transcription through interaction with the sequence-specific DNA-binding protein J kappaQ35839108
Viral interactions with the Notch pathwayQ35853119
The polycomb group protein Suz12 is required for embryonic stem cell differentiationQ35856936
EBNA-2 and EBNA-3C extensively and mutually exclusively associate with RBPJkappa in Epstein-Barr virus-transformed B lymphocytesQ35862488
Carboxyl-terminal amino acids 1052 to 1082 of the latency-associated nuclear antigen (LANA) interact with RBP-Jκ and are responsible for LANA-mediated RTA repression.Q35943718
Propagation and recovery of intact, infectious Epstein-Barr virus from prokaryotic to human cellsQ36173276
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The retinoblastoma binding protein RBP2 is an H3K4 demethylaseQ38304373
Epstein-Barr virus EBNA3A and EBNA3C proteins both repress RBP-J kappa-EBNA2-activated transcription by inhibiting the binding of RBP-J kappa to DNA.Q38353695
Epstein-Barr virus (EBV) nuclear antigen 6 induces expression of the EBV latent membrane protein and an activated phenotype in Raji cellsQ38869720
Dynamic binding of RBPJ is determined by Notch signaling status.Q39155079
Downregulation of integrin receptor-signaling genes by Epstein-Barr virus EBNA 3C via promoter-proximal and -distal binding elementsQ39392125
Epstein-Barr virus nuclear antigen 3C interacts with histone deacetylase to repress transcriptionQ39594681
LIM protein KyoT2 negatively regulates transcription by association with the RBP-J DNA-binding proteinQ39631445
Roles of the ankyrin repeats and C-terminal region of the mouse notch1 intracellular regionQ39725752
Long-term stability of large insert genomic DNA episomal shuttle vectors in human cellsQ39727680
Cellular factors associated with latency and spontaneous Epstein-Barr virus reactivation in B-lymphoblastoid cell lines.Q39740136
Identification of patterns in biological sequences at the ALGGEN server: PROMO and MALGEN.Q39804548
Epstein-Barr virus nuclear antigen 3C is a transcriptional regulatorQ39870334
Epstein-Barr virus nuclear antigen 3C is a powerful repressor of transcription when tethered to DNA.Q39874105
Epstein-Barr virus EBNA3C represses Cp, the major promoter for EBNA expression, but has no effect on the promoter of the cell gene CD21.Q39882226
Establishment in continuous culture of a new type of lymphocyte from a “burkitt-like” malignant lymphoma (line d.g.-75)Q40039870
Polycomb response elements mediate the formation of chromosome higher-order structures in the bithorax complex.Q40082937
Physical and functional association of a trimethyl H3K4 demethylase and Ring6a/MBLR, a polycomb-like proteinQ40167322
Variant PRC1 complex-dependent H2A ubiquitylation drives PRC2 recruitment and polycomb domain formation.Q40406465
Generation and precise modification of a herpesvirus saimiri bacterial artificial chromosome demonstrates that the terminal repeats are required for both virus production and episomal persistenceQ40611661
Epstein-Barr virus nuclear antigen 2 exerts its transactivating function through interaction with recombination signal binding protein RBP-J kappa, the homologue of Drosophila Suppressor of Hairless.Q40793575
Involvement of RBP-J in biological functions of mouse Notch1 and its derivatives.Q41078359
Epstein-Barr nuclear antigen-3 and -4 interact with RBP-2N, a major isoform of RBP-J kappa in B lymphocytesQ41145087
The Epstein-Barr virus determined nuclear antigens EBNA-3A, -3B, and -3C repress EBNA-2-mediated transactivation of the viral terminal protein 1 gene promoterQ41415414
Notch activation stimulates transient and selective binding of Su(H)/CSL to target enhancersQ41882770
Two Epstein-Barr virus (EBV) oncoproteins cooperate to repress expression of the proapoptotic tumour-suppressor Bim: clues to the pathogenesis of Burkitt's lymphoma.Q45401541
Epstein-Barr virus EBNA3 proteins bind to the C8/alpha7 subunit of the 20S proteasome and are degraded by 20S proteasomes in vitro, but are very stable in latently infected B cellsQ45482113
Transcriptional repression by the Epstein-Barr virus EBNA3A protein tethered to DNA does not require RBP-Jkappa.Q45757839
Mediation of Epstein-Barr virus EBNA2 transactivation by recombination signal-binding protein J kappaQ45781476
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue1
P304page(s)e1005383
P577publication date2016-01-11
P1433published inPLOS PathogensQ283209
P1476titleEBNA3C Directs Recruitment of RBPJ (CBF1) to Chromatin during the Process of Gene Repression in EBV Infected B Cells
P478volume12

Reverse relations

cites work (P2860)
Q57025486An EBNA3C-deleted Epstein-Barr virus (EBV) mutant causes B-cell lymphomas with delayed onset in a cord blood-humanized mouse model
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