A somatic knockout of CBF1 in a human B-cell line reveals that induction of CD21 and CCR7 by EBNA-2 is strictly CBF1 dependent and that downregulation of immunoglobulin M is partially CBF1 independent

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A somatic knockout of CBF1 in a human B-cell line reveals that induction of CD21 and CCR7 by EBNA-2 is strictly CBF1 dependent and that downregulation of immunoglobulin M is partially CBF1 independent is …
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scholarly articleQ13442814

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P356DOI10.1128/JVI.79.14.8784-8792.2005
P932PMC publication ID1168782
P698PubMed publication ID15994772
P5875ResearchGate publication ID7748988

P50authorKristina GrabusicQ58128851
P2093author name stringSabine Maier
Elisabeth Kremmer
Anja Mantik
Bettina Kempkes
Maja Santak
Wolfgang Hammerschmidt
P2860cites workDNA ligase IV is essential for V(D)J recombination and DNA double-strand break repair in human precursor lymphocytesQ22007974
CIR, a corepressor linking the DNA binding factor CBF1 to the histone deacetylase complexQ22008610
SKIP, a CBF1-associated protein, interacts with the ankyrin repeat domain of NotchIC To facilitate NotchIC functionQ22253329
Human Jk recombination signal binding protein gene (IGKJRB): comparison with its mouse homologueQ24318408
A role for SKIP in EBNA2 activation of CBF1-repressed promotersQ24524363
A histone deacetylase corepressor complex regulates the Notch signal transduction pathwayQ24598533
EBNA2 and Activated Notch Induce Expression of BATFQ24679432
Latent membrane protein 1 of Epstein-Barr virus induces CD83 by the NF-kappaB signaling pathwayQ24682515
Expression of the chemokine receptor BLR2/EBI1 is specifically transactivated by Epstein-Barr virus nuclear antigen 2Q28284326
Two species of human Fc epsilon receptor II (Fc epsilon RII/CD23): tissue-specific and IL-4-specific regulation of gene expressionQ28285961
RBP-L, a transcription factor related to RBP-JkappaQ28508784
A site in the complement receptor 2 (CR2/CD21) silencer is necessary for lineage specific transcriptional regulationQ40811596
Epstein-Barr virus nuclear antigen 2 is a transcriptional suppressor of the immunoglobulin mu gene: implications for the expression of the translocated c-myc gene in Burkitt's lymphoma cells.Q41063703
Epstein-Barr virus nuclear antigen 2 (EBNA2)-oestrogen receptor fusion proteins complement the EBNA2-deficient Epstein-Barr virus strain P3HR1 in transformation of primary B cells but suppress growth of human B cell lymphoma linesQ41234160
Epstein-Barr virus (EBV) nuclear-antigen-2-induced up-regulation of CD21 and CD23 molecules is dependent on a permissive cellular contextQ41579150
Modulation of cellular gene expression in B lymphoma cells followingin vitro infection by Epstein-Barr virus (EBV)Q41718399
Masking of the CBF1/RBPJ kappa transcriptional repression domain by Epstein-Barr virus EBNA2.Q44697821
Rat monoclonal antibodies differentiating between the Epstein-Barr virus nuclear antigens 2A (EBNA2A) and 2B (EBNA2B).Q45733831
Mediation of Epstein-Barr virus EBNA2 transactivation by recombination signal-binding protein J kappaQ45781476
An intronic silencer regulates B lymphocyte cell- and stage-specific expression of the human complement receptor type 2 (CR2, CD21) gene.Q48038461
Optimization of the hygromycin B resistance-conferring gene as a dominant selectable marker in mammalian cellsQ58053916
Conservation of the Notch signalling pathway in mammalian neurogenesisQ28513429
Notch-RBP-J signaling is involved in cell fate determination of marginal zone B cellsQ28594415
Regulation of notch signaling activityQ28610136
Disruption of the mouse RBP-J kappa gene results in early embryonic deathQ28610816
Gene targeting and somatic cell genetics--a rebirth or a coming of age?Q33594280
Activated Notch1 modulates gene expression in B cells similarly to Epstein-Barr viral nuclear antigen 2.Q33797347
Notch1IC partially replaces EBNA2 function in B cells immortalized by Epstein-Barr virusQ33842309
Activated Notch1 can transiently substitute for EBNA2 in the maintenance of proliferation of LMP1-expressing immortalized B cellsQ33850400
Direct and indirect regulation of cytokine and cell cycle proteins by EBNA-2 during Epstein-Barr virus infectionQ33851043
Regulation of B lymphocyte responses to foreign and self-antigens by the CD19/CD21 complexQ33932719
Epstein-Barr virus EBNA2 blocks Nur77- mediated apoptosisQ34154616
Reduction of Background Problems in Nonradioactive Northern and Southern Blot Analyses Enables Higher Sensitivity Than 32P-Based HybridizationsQ34306277
The human J kappa recombination signal sequence binding protein (RBP-J kappa) targets the Epstein-Barr virus EBNA2 protein to its DNA responsive elements.Q34327455
Epstein-Barr virus nuclear antigen 2 specifically induces expression of the B-cell activation antigen CD23.Q34625121
Regulation of B cell development by Notch/RBP-J signalingQ35101899
The Epstein-Barr virus nuclear antigen 2 transactivator is directed to response elements by the J kappa recombination signal binding proteinQ35648541
Viral interactions with the Notch pathwayQ35853119
Gamma ray-induced loss of expression of HLA and glyoxalase I alleles in lymphoblastoid cellsQ36398969
The Epstein-Barr virus immortalizing protein EBNA-2 is targeted to DNA by a cellular enhancer-binding proteinQ36581891
Epstein-Barr virus nuclear protein 2 transactivates a cis-acting CD23 DNA elementQ36797190
Stable transfection of Epstein-Barr virus (EBV) nuclear antigen 2 in lymphoma cells containing the EBV P3HR1 genome induces expression of B-cell activation molecules CD21 and CD23.Q36801839
Epstein-Barr virus latent membrane protein (LMP1) and nuclear proteins 2 and 3C are effectors of phenotypic changes in B lymphocytes: EBNA-2 and LMP1 cooperatively induce CD23Q36806063
Inhibition of Epstein-Barr virus-induced growth proliferation by a nuclear antigen EBNA2-TAT peptideQ37358334
B-cell proliferation and induction of early G1-regulating proteins by Epstein-Barr virus mutants conditional for EBNA2.Q37693393
Epstein-Barr virus nuclear antigen 2-estrogen receptor fusion proteins transactivate viral and cellular genes and interact with RBP-J kappa in a conditional fashion.Q38287860
Expression of transcription factor AML-2 (RUNX3, CBF(alpha)-3) is induced by Epstein-Barr virus EBNA-2 and correlates with the B-cell activation phenotypeQ38289967
Identification and characterization of an Epstein-Barr virus nuclear antigen 2-responsive cis element in the bidirectional promoter region of latent membrane protein and terminal protein 2 genes.Q38302963
EBNA-2 upregulation of Epstein-Barr virus latency promoters and the cellular CD23 promoter utilizes a common targeting intermediate, CBF1.Q38304806
Activated mouse Notch1 transactivates Epstein-Barr virus nuclear antigen 2-regulated viral promotersQ39549769
The proto-oncogene c-myc is a direct target gene of Epstein-Barr virus nuclear antigen 2.Q39551287
Functional replacement of the intracellular region of the Notch1 receptor by Epstein-Barr virus nuclear antigen 2.Q39582561
Epstein-Barr virus EBNA3C represses Cp, the major promoter for EBNA expression, but has no effect on the promoter of the cell gene CD21.Q39882226
Establishment in continuous culture of a new type of lymphocyte from a “burkitt-like” malignant lymphoma (line d.g.-75)Q40039870
Efficient somatic gene targeting in the lymphoid human cell line DG75.Q40488177
AID-dependent somatic hypermutation occurs as a DNA single-strand event in the BL2 cell lineQ40714843
Epstein-Barr virus nuclear antigen 2 exerts its transactivating function through interaction with recombination signal binding protein RBP-J kappa, the homologue of Drosophila Suppressor of Hairless.Q40793575
P433issue14
P407language of work or nameEnglishQ1860
P304page(s)8784-8792
P577publication date2005-07-01
P1433published inJournal of VirologyQ1251128
P1476titleA somatic knockout of CBF1 in a human B-cell line reveals that induction of CD21 and CCR7 by EBNA-2 is strictly CBF1 dependent and that downregulation of immunoglobulin M is partially CBF1 independent
P478volume79

Reverse relations

cites work (P2860)
Q31032788A SILAC-based screen for Methyl-CpG binding proteins identifies RBP-J as a DNA methylation and sequence-specific binding protein
Q34733560Abortive lytic reactivation of KSHV in CBF1/CSL deficient human B cell lines
Q33657311Asymmetric Arginine dimethylation of Epstein-Barr virus nuclear antigen 2 promotes DNA targeting
Q31081505Binding of the heterogeneous ribonucleoprotein K (hnRNP K) to the Epstein-Barr virus nuclear antigen 2 (EBNA2) enhances viral LMP2A expression
Q35101342Cellular target genes of Epstein-Barr virus nuclear antigen 2.
Q45382799Changes in chemokines and chemokine receptor expression on tonsillar B cells upon Epstein-Barr virus infection
Q37237334Differential gene expression patterns of EBV infected EBNA-3A positive and negative human B lymphocytes
Q41926654EBF1 binds to EBNA2 and promotes the assembly of EBNA2 chromatin complexes in B cells.
Q38597233EBNA2 and Its Coactivator EBNA-LP.
Q35784734EBNA2 interferes with the germinal center phenotype by downregulating BCL6 and TCL1 in non-Hodgkin's lymphoma cells
Q35889902EBNA3C Directs Recruitment of RBPJ (CBF1) to Chromatin during the Process of Gene Repression in EBV Infected B Cells
Q58746075Enhancer control of miR-155 expression in Epstein-Barr virus infected B cells
Q35024009Epstein-Barr virus nuclear antigen 2 trans-activates the cellular antiapoptotic bfl-1 gene by a CBF1/RBPJ kappa-dependent pathway
Q34998257Inactivation of intergenic enhancers by EBNA3A initiates and maintains polycomb signatures across a chromatin domain encoding CXCL10 and CXCL9
Q38340693Kaposi's sarcoma-associated herpesvirus viral interferon regulatory factor 4 (vIRF4/K10) is a novel interaction partner of CSL/CBF1, the major downstream effector of Notch signaling.
Q34186964LEDGF/p75-independent HIV-1 replication demonstrates a role for HRP-2 and remains sensitive to inhibition by LEDGINs
Q34924659Loss of the Notch effector RBPJ promotes tumorigenesis
Q35049340Macrophage polarisation: an immunohistochemical approach for identifying M1 and M2 macrophages.
Q36769457Modulation of gene expression via overlapping binding sites exerted by ZNF143, Notch1 and THAP11
Q51897964RBPJkappa-dependent signaling is essential for long-term maintenance of neural stem cells in the adult hippocampus.
Q38793717RUNX super-enhancer control through the Notch pathway by Epstein-Barr virus transcription factors regulates B cell growth.
Q37713998Repression of the proapoptotic cellular BIK/NBK gene by Epstein-Barr virus antagonizes transforming growth factor β1-induced B-cell apoptosis.
Q36042686Synthetic Lethal Screen Demonstrates That a JAK2 Inhibitor Suppresses a BCL6-dependent IL10RA/JAK2/STAT3 Pathway in High Grade B-cell Lymphoma
Q35664999The EBNA-2 N-Terminal Transactivation Domain Folds into a Dimeric Structure Required for Target Gene Activation
Q38348963Wide-scale use of Notch signaling factor CSL/RBP-Jkappa in RTA-mediated activation of Kaposi's sarcoma-associated herpesvirus lytic genes

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