Notch: a unique therapeutic target for immunomodulation

scientific article

Notch: a unique therapeutic target for immunomodulation is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1517/14728222.9.2.395
P698PubMed publication ID15934923

P2093author name stringGrahame J McKenzie
Brian R Champion
Emmanuel Briend
Yvette Stallwood
Mamnunur Khan
P2860cites workCIR, a corepressor linking the DNA binding factor CBF1 to the histone deacetylase complexQ22008610
Recognition and ubiquitination of Notch by Itch, a hect-type E3 ubiquitin ligaseQ24273416
The itchy locus encodes a novel ubiquitin protein ligase that is disrupted in a18H miceQ24308721
Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteinsQ24310048
LNX functions as a RING type E3 ubiquitin ligase that targets the cell fate determinant Numb for ubiquitin-dependent degradationQ24536102
p300 acts as a transcriptional coactivator for mammalian Notch-1Q24548267
SEL-10 is an inhibitor of notch signaling that targets notch for ubiquitin-mediated protein degradationQ24548288
Nuclear localization of CBF1 is regulated by interactions with the SMRT corepressor complexQ24550850
The Notch1 receptor is cleaved constitutively by a furin-like convertaseQ24671866
Mastermind mediates chromatin-specific transcription and turnover of the Notch enhancer complexQ24675233
Notch signaling: cell fate control and signal integration in developmentQ27861061
Epsins: adaptors in endocytosis?Q27939888
RNA interferenceQ28131798
Fringe is a glycosyltransferase that modifies NotchQ28143123
Chemical glycobiologyQ28206826
The Notch intracellular domain is ubiquitinated and negatively regulated by the mammalian Sel-10 homologQ28207494
The human homolog of rat Jagged1 expressed by marrow stroma inhibits differentiation of 32D cells through interaction with Notch1Q28261520
Control of daughter cell fates during asymmetric division: interaction of Numb and NotchQ28286748
Asymmetric localization of a mammalian numb homolog during mouse cortical neurogenesisQ28286759
sel-10, a negative regulator of lin-12 activity in Caenorhabditis elegans, encodes a member of the CDC4 family of proteinsQ28512956
Mind bomb is a ubiquitin ligase that is essential for efficient activation of Notch signaling by DeltaQ28646258
Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survivalQ29547865
Functional diversity of helper T lymphocytesQ29619415
Akt provides the CD28 costimulatory signal for up-regulation of IL-2 and IFN-gamma but not TH2 cytokinesQ31793569
Transferrin-polycation conjugates as carriers for DNA uptake into cellsQ33562690
Distinct IL-2 receptor signaling pattern in CD4+CD25+ regulatory T cellsQ33742099
The notch signalling regulator fringe acts in the Golgi apparatus and requires the glycosyltransferase signature motif DXD.Q33909902
Crystal structure of the nuclear effector of Notch signaling, CSL, bound to DNAQ33980474
Suppressor T cells: Rebirth, function and homeostasisQ34014450
Stimulation of CD25(+)CD4(+) regulatory T cells through GITR breaks immunological self-toleranceQ34111451
CD4(+)CD25(+) immunoregulatory T cells: gene expression analysis reveals a functional role for the glucocorticoid-induced TNF receptorQ34116317
Transcriptional mechanisms underlying lymphocyte tolerance.Q34135663
c-Cbl and Cbl-b regulate T cell responsiveness by promoting ligand-induced TCR down-modulationQ34157660
Mammalian numb proteins promote Notch1 receptor ubiquitination and degradation of the Notch1 intracellular domainQ34189079
Notch1 and T-cell development: insights from conditional knockout miceQ34207634
Toward the rational design of cell fate modifiers: notch signaling as a target for novel biopharmaceuticalsQ34316086
PKB/AKT: functional insights from genetic modelsQ34389540
Numb antagonizes Notch signaling to specify sibling neuron cell fatesQ34392095
Therapeutic aspects of tolerance.Q34441123
Control of T-cell activation by CD4+ CD25+ suppressor T cellsQ34448423
Structural conservation of Notch receptors and ligandsQ34489392
Cell contact-dependent immunosuppression by CD4(+)CD25(+) regulatory T cells is mediated by cell surface-bound transforming growth factor betaQ34517421
CSL-independent Notch signalling: a checkpoint in cell fate decisions during development?Q34801905
Notch signalling in the regulation of peripheral T-cell function.Q35090094
Powder and particle-mediated approaches for delivery of DNA and protein vaccines into the epidermisQ35159097
DNA vaccinationQ35581126
Tolerance and cancer: mechanisms of tumor evasion and strategies for breaking toleranceQ35690984
Notch signaling in T- and B-cell development.Q35692177
T-cell anergyQ35692198
Notch signaling in lymphocyte development and functionQ35768919
Ubiquitin-protein ligases--novel therapeutic targets?Q35794038
Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulationQ36367099
Notch 1-deficient common lymphoid precursors adopt a B cell fate in the thymus.Q36369494
Induction of antigen-specific regulatory T cells following overexpression of a Notch ligand by human B lymphocytesQ39997530
Notch ligation by Delta1 inhibits peripheral immune responses to transplantation antigens by a CD8+ cell-dependent mechanism.Q40271483
In search of the Holy Grail (actively acquired immunologic tolerance).Q40523856
Notch 1 signaling regulates peripheral T cell activationQ40566978
c-Cbl binding and ubiquitin-dependent lysosomal degradation of membrane-associated Notch1.Q40759027
Xenopus neuralized is a ubiquitin ligase that interacts with XDelta1 and regulates Notch signaling.Q40764200
Drosophila nicastrin is essential for the intramembranous cleavage of notchQ41473368
Novel Notch alleles reveal a Deltex-dependent pathway repressing neural fate.Q43806416
Notch1 inhibits differentiation of hematopoietic cells by sustaining GATA-2 expressionQ43806498
A secreted Delta1-Fc fusion protein functions both as an activator and inhibitor of Notch1 signalingQ43972008
Regulation of notch signaling by o-linked fucose.Q44277318
Evidence that C promoter-binding factor 1 binding is required for Notch-1-mediated repression of activator protein-1.Q44674014
Drosophila Epsin mediates a select endocytic pathway that DSL ligands must enter to activate Notch.Q45094726
Mastermind critically regulates Notch-mediated lymphoid cell fate decisions.Q45345202
Overexpression of the Notch ligand, Jagged-1, induces alloantigen-specific human regulatory T cellsQ45863413
An activated form of Notch influences the choice between CD4 and CD8 T cell lineagesQ46109980
Neuralized functions as an E3 ubiquitin ligase during Drosophila developmentQ47071824
Nicastrin is required for gamma-secretase cleavage of the Drosophila Notch receptorQ47072716
Notch1 expression on T cells is not required for CD4+ T helper differentiationQ47431184
Delta1-Notch3 interactions bias the functional differentiation of activated CD4+ T cellsQ47438852
Instruction of distinct CD4 T helper cell fates by different notch ligands on antigen-presenting cellsQ47619638
Immune modulation by silencing IL-12 production in dendritic cells using small interfering RNA.Q47777723
Subversion of the T/B lineage decision in the thymus by lunatic fringe-mediated inhibition of Notch-1.Q51063485
Fat facets and Liquid facets promote Delta endocytosis and Delta signaling in the signaling cells.Q52086944
Specific truncations of Drosophila Notch define dominant activated and dominant negative forms of the receptor.Q52223825
Notch1 is essential for postimplantation development in mice.Q52512097
P433issue2
P407language of work or nameEnglishQ1860
P304page(s)395-410
P577publication date2005-04-01
P1433published inExpert Opinion on Therapeutic TargetsQ5421214
P1476titleNotch: a unique therapeutic target for immunomodulation
P478volume9