Notch signalling in T‐cell lymphoblastic leukaemia/lymphoma and other haematological malignancies

scientific article published on October 21, 2010

Notch signalling in T‐cell lymphoblastic leukaemia/lymphoma and other haematological malignancies is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/PATH.2789
P953full work available at URLhttps://europepmc.org/articles/pmc2996483?pdf=render
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20967796/?tool=EBI
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20967796/pdf/?tool=EBI
https://europepmc.org/articles/PMC2996483
https://europepmc.org/articles/PMC2996483?pdf=render
https://doi.org/10.1002/path.2789
https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fpath.2789
https://onlinelibrary.wiley.com/doi/full/10.1002/path.2789
P932PMC publication ID2996483
P698PubMed publication ID20967796
P5875ResearchGate publication ID47521463

P2093author name stringJon C. Aster
Stephen C. Blacklow
Warren S. Pear
P2860cites workCIR, a corepressor linking the DNA binding factor CBF1 to the histone deacetylase complexQ22008610
NOTCH2 mutations cause Alagille syndrome, a heterogeneous disorder of the notch signaling pathwayQ24293498
RBP-Jkappa/SHARP recruits CtIP/CtBP corepressors to silence Notch target genesQ24294890
Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexesQ24307538
Mutations in NOTCH1 cause aortic valve diseaseQ24307999
Mutations in the human Jagged1 gene are responsible for Alagille syndromeQ24314702
Alagille syndrome is caused by mutations in human Jagged1, which encodes a ligand for Notch1Q24314766
Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnoverQ24315524
TAN-1, the human homolog of the Drosophila Notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasmsQ24320364
p300 and PCAF act cooperatively to mediate transcriptional activation from chromatin templates by notch intracellular domains in vitroQ24537773
p300 acts as a transcriptional coactivator for mammalian Notch-1Q24548267
Nuclear localization of CBF1 is regulated by interactions with the SMRT corepressor complexQ24550850
A histone deacetylase corepressor complex regulates the Notch signal transduction pathwayQ24598533
Direct inhibition of the NOTCH transcription factor complexQ24634015
Identification of a conserved negative regulatory sequence that influences the leukemogenic activity of NOTCH1Q24670708
The Notch1 receptor is cleaved constitutively by a furin-like convertaseQ24671866
Mastermind mediates chromatin-specific transcription and turnover of the Notch enhancer complexQ24675233
Structural basis for autoinhibition of NotchQ27644319
Structure of the Notch1-negative regulatory region: implications for normal activation and pathogenic signaling in T-ALLQ27653136
Effects of S1 Cleavage on the Structure, Surface Export, and Signaling Activity of Human Notch1 and Notch2Q27657133
Therapeutic antibody targeting of individual Notch receptorsQ27660544
Structural and mechanistic insights into cooperative assembly of dimeric Notch transcription complexesQ27665343
Transcription elongation factors repress transcription initiation from cryptic sites.Q27931897
Ikaros DNA-binding proteins direct formation of chromatin remodeling complexes in lymphocytesQ28141631
The Anti-apoptotic Effect of Notch-1 Requires p56 -dependent, Akt/PKB-mediated Signaling in T CellsQ28212977
Radiation-induced deletions in the 5' end region of Notch1 lead to the formation of truncated proteins and are involved in the development of mouse thymic lymphomas.Q53378724
The tumor suppressor gene hCDC4 is frequently mutated in human T-cell acute lymphoblastic leukemia with functional consequences for Notch signaling.Q53545883
NOTCH1 mutations in T-cell acute lymphoblastic leukemia: prognostic significance and implication in multifactorial leukemogenesis.Q54601008
Rag-dependent and Rag-independent mechanisms of Notch1 rearrangement in thymic lymphomas of Atm(-/-) and scid mice.Q54789409
Frequent provirus insertional mutagenesis of Notch1 in thymomas of MMTVD/myc transgenic mice suggests a collaboration of c-myc and Notch1 for oncogenesisQ59285746
Modulation of Notch signaling by antibodies specific for the extracellular negative regulatory region of NOTCH3Q80465114
Constitutively activated Notch signaling is involved in survival and apoptosis resistance of B-CLL cellsQ81974229
Notch signaling in the immune systemQ82881379
Genetic inactivation of Ikaros is a rare event in human T-ALLQ84613405
Identification of a T lineage-committed progenitor in adult blood.Q40183324
Targeting the NF-kappaB signaling pathway in Notch1-induced T-cell leukemia.Q40195204
Activating mutations in NOTCH1 in acute myeloid leukemia and lineage switch leukemias.Q40226175
Leukemia-associated mutations within the NOTCH1 heterodimerization domain fall into at least two distinct mechanistic classesQ40273258
Notch promotes survival of pre-T cells at the beta-selection checkpoint by regulating cellular metabolismQ40390896
Involvement of illegitimate V(D)J recombination or microhomology-mediated nonhomologous end-joining in the formation of intragenic deletions of the Notch1 gene in mouse thymic lymphomas.Q40479977
Jagged1-induced Notch signaling drives proliferation of multiple myeloma cellsQ40598947
Functional Analysis of the TAN-1 Gene, a Human Homolog of Drosophila NotchQ41506198
Notch1 promotes survival of E2A-deficient T cell lymphomas through pre-T cell receptor-dependent and -independent mechanisms.Q42256131
Delta-like 4 is indispensable in thymic environment specific for T cell developmentQ42277361
FBXW7 and NOTCH1 mutations in childhood T cell acute lymphoblastic leukaemia and T cell non-Hodgkin lymphomaQ43721199
Mouse Fbw7/Sel-10/Cdc4 is required for notch degradation during vascular development.Q44691496
Deficient T cell fate specification in mice with an induced inactivation of Notch1.Q45345200
Requirement for Notch1 signals at sequential early stages of intrathymic T cell developmentQ45345203
Notch signaling controls the generation and differentiation of early T lineage progenitorsQ45345206
Suppressor of hairless directly activates transcription of enhancer of split complex genes in response to Notch receptor activityQ45950823
The outcome of molecular-cytogenetic subgroups in pediatric T-cell acute lymphoblastic leukemia: a retrospective study of patients treated according to DCOG or COALL protocols.Q50926294
Notch1 expression in early lymphopoiesis influences B versus T lineage determination.Q51085324
Activation and transposition of endogenous retroviral elements in hypomethylation induced tumors in mice.Q51579160
Prognostic significance of molecular-cytogenetic abnormalities in pediatric T-ALL is not explained by immunophenotypic differences.Q51975366
Regulation of marginal zone B cell development by MINT, a suppressor of Notch/RBP-J signaling pathwayQ52603545
Activating NOTCH1 mutations predict favorable early treatment response and long-term outcome in childhood precursor T-cell lymphoblastic leukemia.Q52933515
Activating Notch1 mutations are an early event in T-cell malignancy of Ikaros point mutant Plastic/+ mice.Q53343606
NOTCH is a key regulator of human T-cell acute leukemia initiating cell activityQ39921283
Aberrant expression of Notch1 interferes with the B-lymphoid phenotype of neoplastic B cells in classical Hodgkin lymphoma.Q39986630
Mutational and energetic studies of Notch 1 transcription complexesQ40031628
Notch signals positively regulate activity of the mTOR pathway in T-cell acute lymphoblastic leukemiaQ40158237
Signalling downstream of activated mammalian NotchQ28289832
Regulation of CD23 expression by Notch2 in B-cell chronic lymphocytic leukemiaQ28300257
Rbm15 modulates Notch-induced transcriptional activation and affects myeloid differentiationQ28591012
Calcium depletion dissociates and activates heterodimeric notch receptorsQ28609673
Notch2 is involved in the overexpression of CD23 in B-cell chronic lymphocytic leukemiaQ28646247
The canonical Notch signaling pathway: unfolding the activation mechanismQ29547725
Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemiaQ29614269
The OTT-MAL fusion oncogene activates RBPJ-mediated transcription and induces acute megakaryoblastic leukemia in a knockin mouse modelQ33383707
NOTCH1/FBXW7 mutation identifies a large subgroup with favorable outcome in adult T-cell acute lymphoblastic leukemia (T-ALL): a Group for Research on Adult Acute Lymphoblastic Leukemia (GRAALL) studyQ33395926
Hes1 potentiates T cell lymphomagenesis by up-regulating a subset of notch target genesQ33494549
Characterization of Notch1 antibodies that inhibit signaling of both normal and mutated Notch1 receptorsQ33531734
Histone demethylase KDM5A is an integral part of the core Notch-RBP-J repressor complexQ33737810
Mutant Ikzf1, KrasG12D, and Notch1 cooperate in T lineage leukemogenesis and modulate responses to targeted agentsQ33739961
The mastermind-like 1 (MAML1) co-activator regulates constitutive NF-kappaB signaling and cell survivalQ33825084
The in vivo pattern of binding of RAG1 and RAG2 to antigen receptor loci.Q33889784
Two distinct Notch1 mutant alleles are involved in the induction of T-cell leukemia in c-myc transgenic miceQ33963617
Combined expression of pTalpha and Notch3 in T cell leukemia identifies the requirement of preTCR for leukemogenesisQ34020330
γ-secretase-dependent cleavage initiates notch signaling from the plasma membraneQ34057805
Notch2 is preferentially expressed in mature B cells and indispensable for marginal zone B lineage developmentQ34197865
Notch activation is an early and critical event during T-Cell leukemogenesis in Ikaros-deficient miceQ34233443
Common sites of retroviral integration in mouse hematopoietic tumors identified by high-throughput, single nucleotide polymorphism-based mapping and bacterial artificial chromosome hybridizationQ34465679
Notch1 mutations are important for leukemic transformation in murine models of precursor-T leukemia/lymphomaQ34481661
Deletion-based mechanisms of Notch1 activation in T-ALL: key roles for RAG recombinase and a conserved internal translational start site in Notch1.Q34541666
NOTCH1 directly regulates c-MYC and activates a feed-forward-loop transcriptional network promoting leukemic cell growthQ34582832
Predominant interaction of both Ikaros and Helios with the NuRD complex in immature thymocytesQ34660281
c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphomaQ34958884
Oncogenic activation of the Notch1 gene by deletion of its promoter in Ikaros-deficient T-ALL.Q34999834
Metalloprotease ADAM10 is required for Notch1 site 2 cleavage.Q35000965
Constitutive activation of NF-kappaB and T-cell leukemia/lymphoma in Notch3 transgenic miceQ35114942
Notch1 contributes to mouse T-cell leukemia by directly inducing the expression of c-mycQ35131413
Quantitative dissection of the Notch:CSL interaction: insights into the Notch-mediated transcriptional switch.Q35749862
Cooperative assembly of higher-order Notch complexes functions as a switch to induce transcriptionQ35844655
Activating Notch1 mutations in mouse models of T-ALL.Q35849320
Regulation of lymphoid development, differentiation, and function by the Notch pathway.Q36072476
Distinct gene expression profiles of acute myeloid/T-lymphoid leukemia with silenced CEBPA and mutations in NOTCH1.Q36141686
Interleukin-7 in T-cell acute lymphoblastic leukemia: an extrinsic factor supporting leukemogenesis?Q36194601
FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to gamma-secretase inhibitorsQ36229551
The SCFFBW7 ubiquitin ligase complex as a tumor suppressor in T cell leukemiaQ36229601
Exclusive development of T cell neoplasms in mice transplanted with bone marrow expressing activated Notch allelesQ36366728
Separation of Notch1 promoted lineage commitment and expansion/transformation in developing T cellsQ36369337
Loss of intestinal crypt progenitor cells owing to inactivation of both Notch1 and Notch2 is accompanied by derepression of CDK inhibitors p27Kip1 and p57Kip2.Q36528951
NOTCH1 extracellular juxtamembrane expansion mutations in T-ALL.Q36787487
Leukemia-associated NOTCH1 alleles are weak tumor initiators but accelerate K-ras-initiated leukemiaQ36800426
K-RasG12D-induced T-cell lymphoblastic lymphoma/leukemias harbor Notch1 mutations and are sensitive to gamma-secretase inhibitorsQ36941105
Oncogenesis of T-ALL and nonmalignant consequences of overexpressing intracellular NOTCH1Q36979929
Ikaros represses the transcriptional response to Notch signaling in T-cell developmentQ36994950
Mutational loss of PTEN induces resistance to NOTCH1 inhibition in T-cell leukemiaQ37009642
Notch signaling in leukemiaQ37014817
Defective cardiovascular development and elevated cyclin E and Notch proteins in mice lacking the Fbw7 F-box proteinQ37073031
CCR7 signalling as an essential regulator of CNS infiltration in T-cell leukaemiaQ37113435
Gamma-secretase inhibitors reverse glucocorticoid resistance in T cell acute lymphoblastic leukemiaQ37215995
Targeting the Notch1 and mTOR pathways in a mouse T-ALL modelQ37234630
Pre-TCR signaling inactivates Notch1 transcription by antagonizing E2A.Q37272317
Chromosomally unstable mouse tumours have genomic alterations similar to diverse human cancersQ37272977
CSL-MAML-dependent Notch1 signaling controls T lineage-specific IL-7R{alpha} gene expression in early human thymopoiesis and leukemiaQ37273302
The impact of NOTCH1, FBW7 and PTEN mutations on prognosis and downstream signaling in pediatric T-cell acute lymphoblastic leukemia: a report from the Children's Oncology GroupQ37303838
Prognostic implications of NOTCH1 and FBXW7 mutations in adults with T-cell acute lymphoblastic leukemia treated on the MRC UKALLXII/ECOG E2993 protocolQ37347511
Notch-induced E2A ubiquitination and degradation are controlled by MAP kinase activitiesQ37368153
Angiogenesis: a team effort coordinated by notch.Q37393190
Ikaros regulates Notch target gene expression in developing thymocytesQ37424241
Notch signaling specifies megakaryocyte development from hematopoietic stem cells.Q37673550
Notch3 and the Notch3-upregulated RNA-binding protein HuD regulate Ikaros alternative splicingQ38304159
Induction of apoptosis by proteasome inhibitors in B-CLL cells is associated with downregulation of CD23 and inactivation of Notch2.Q38333825
Perturbation of Ikaros isoform selection by MLV integration is a cooperative event in Notch(IC)-induced T cell leukemogenesisQ38352939
Gain-of-function mutations and copy number increases of Notch2 in diffuse large B-cell lymphomaQ38354055
BCL6 canalizes Notch-dependent transcription, excluding Mastermind-like1 from selected target genes during left-right patterningQ39684544
Ikaros directly represses the notch target gene Hes1 in a leukemia T cell line: implications for CD4 regulationQ39782908
Selective use of ADAM10 and ADAM17 in activation of Notch1 signalingQ39808768
Transduction of Notch2 in feline leukemia virus-induced thymic lymphomaQ39876976
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectleukemiaQ29496
P304page(s)262-273
P577publication date2010-10-21
P1433published inJournal of PathologyQ400296
P1476titleNotch signalling in T-cell lymphoblastic leukaemia/lymphoma and other haematological malignancies
Notch signalling in T‐cell lymphoblastic leukaemia/lymphoma and other haematological malignancies
P478volume223

Reverse relations

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