| scholarly article | Q13442814 |
| P50 | author | Margaret A Goodell | Q39999833 |
| Vivienne I Rebel | Q52088116 | ||
| Choladda V Curry | Q80852119 | ||
| P2093 | author name string | Wei Li | |
| David Wheeler | |||
| Ting Zhou | |||
| Grant A Challen | |||
| Benjamin Rodriguez | |||
| Liubin Yang | |||
| Allison Mayle | |||
| Edmund Chang | |||
| P2860 | cites work | The R882H DNMT3A mutation associated with AML dominantly inhibits wild-type DNMT3A by blocking its ability to form active tetramers | Q24339485 |
| DNMT3A Mutations in Acute Myeloid Leukemia | Q27559610 | ||
| The molecular profile of adult T-cell acute lymphoblastic leukemia: mutations in RUNX1 and DNMT3A are associated with poor prognosis in T-ALL. | Q27852046 | ||
| The Genome Analysis Toolkit: A MapReduce framework for analyzing next-generation DNA sequencing data | Q27860742 | ||
| The Sequence Alignment/Map format and SAMtools | Q27860966 | ||
| Fast and accurate long-read alignment with Burrows-Wheeler transform | Q29547193 | ||
| Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia | Q29614269 | ||
| Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing | Q29614647 | ||
| A program for annotating and predicting the effects of single nucleotide polymorphisms, SnpEff: SNPs in the genome of Drosophila melanogaster strain w1118; iso-2; iso-3 | Q29614852 | ||
| Isolation and functional properties of murine hematopoietic stem cells that are replicating in vivo | Q29619355 | ||
| Flow cytometry analysis of murine hematopoietic stem cells | Q30539301 | ||
| A stem cell-like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing | Q33268624 | ||
| Clonal evolution of preleukemic hematopoietic stem cells precedes human acute myeloid leukemia. | Q33711497 | ||
| Human aging-associated DNA hypermethylation occurs preferentially at bivalent chromatin domains | Q33762426 | ||
| Epigenomic profiling of young and aged HSCs reveals concerted changes during aging that reinforce self-renewal | Q33804172 | ||
| Epigenetic memory at embryonic enhancers identified in DNA methylation maps from adult mouse tissues | Q33893082 | ||
| Dnmt3a is essential for hematopoietic stem cell differentiation | Q34237926 | ||
| Sensitive detection of somatic point mutations in impure and heterogeneous cancer samples | Q34327021 | ||
| Notch signalling in T‐cell lymphoblastic leukaemia/lymphoma and other haematological malignancies | Q34376282 | ||
| Identification of pre-leukaemic haematopoietic stem cells in acute leukaemia | Q34403931 | ||
| Preleukemic mutations in human acute myeloid leukemia affect epigenetic regulators and persist in remission | Q34405195 | ||
| Array-based genomic resequencing of human leukemia | Q34618836 | ||
| Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia | Q34627568 | ||
| methylKit: a comprehensive R package for the analysis of genome-wide DNA methylation profiles | Q36378100 | ||
| Gel-free multiplexed reduced representation bisulfite sequencing for large-scale DNA methylation profiling | Q36378126 | ||
| Notch 1 activation in the molecular pathogenesis of T-cell acute lymphoblastic leukaemia | Q36448329 | ||
| Bivalent domains enforce transcriptional memory of DNA methylated genes in cancer cells. | Q37000927 | ||
| Age-related epigenetic drift in the pathogenesis of MDS and AML. | Q37683456 | ||
| Functional heterogeneity of genetically defined subclones in acute myeloid leukemia | Q37698123 | ||
| DNA methyltransferases in hematologic malignancies | Q38090880 | ||
| A DNMT3A mutation common in AML exhibits dominant-negative effects in murine ES cells | Q38263823 | ||
| Combinatorial transcriptional control in blood stem/progenitor cells: genome-wide analysis of ten major transcriptional regulators. | Q39649034 | ||
| Defining a chromatin pattern that characterizes DNA-hypermethylated genes in colon cancer cells | Q39960732 | ||
| Large conserved domains of low DNA methylation maintained by Dnmt3a | Q41946470 | ||
| Myeloproliferative neoplasia remodels the endosteal bone marrow niche into a self-reinforcing leukemic niche. | Q42596867 | ||
| Mouse model for NRAS-induced leukemogenesis | Q42815060 | ||
| Landmark analysis of DNMT3A mutations in hematological malignancies | Q44744267 | ||
| Whole-exome sequencing in adult ETP-ALL reveals a high rate of DNMT3A mutations | Q45860675 | ||
| Tumor suppressor functions of Dnmt3a and Dnmt3b in the prevention of malignant mouse lymphopoiesis. | Q45919203 | ||
| Bethesda proposals for classification of lymphoid neoplasms in mice | Q48731693 | ||
| Clonal evolution in relapsed NPM1-mutated acute myeloid leukemia. | Q50963749 | ||
| Bethesda proposals for classification of nonlymphoid hematopoietic neoplasms in mice | Q74314309 | ||
| TET2 and DNMT3A mutations in human T-cell lymphoma | Q83175924 | ||
| P433 | issue | 4 | |
| P407 | language of work or name | English | Q1860 |
| P304 | page(s) | 629-638 | |
| P577 | publication date | 2015-01-01 | |
| P1433 | published in | Blood | Q885070 |
| P1476 | title | Dnmt3a loss predisposes murine hematopoietic stem cells to malignant transformation | |
| P478 | volume | 125 |
| Q52819796 | A common ancestral DNMT3A-mutated preleukemic clone giving rise to AML and MDS in an adolescent girl. |
| Q33420184 | A novel acquired inv(2)(p23.3q24.3) with concurrent submicroscopic deletions at 2p23.3, 2p22.1, 2q24.3 and 1p13.2 in a patient with chronic thrombocytopenia and anemia |
| Q26738706 | Aberrant Promoter Hypomethylation in CLL: Does It Matter for Disease Development? |
| Q50087550 | Abnormal RNA splicing and genomic instability after induction of DNMT3A mutations by CRISPR/Cas9 gene editing. |
| Q36360635 | Acute loss of TET function results in aggressive myeloid cancer in mice |
| Q28384025 | Aging-Induced Stem Cell Mutations as Drivers for Disease and Cancer |
| Q50077837 | Base-Resolution Analysis of DNA Methylation Patterns Downstream of Dnmt3a in Mouse Naïve B Cells. |
| Q101410034 | Bcor deficiency perturbs erythro-megakaryopoiesis and cooperates with Dnmt3a loss in acute erythroid leukemia onset in mice |
| Q50209900 | Clonal Hematopoiesis and Evolution to Hematopoietic Malignancies |
| Q40480218 | Clonal dynamics in a single AML case tracked for 9 years reveals the complexity of leukemia progression. |
| Q41452424 | Clonal hematopoiesis as determined by the HUMARA assay is a marker for acquired mutations in epigenetic regulators in older women |
| Q42776423 | Conditional knockin of Dnmt3a R878H initiates acute myeloid leukemia with mTOR pathway involvement |
| Q52788599 | CpG Island Hypermethylation Mediated by DNMT3A Is a Consequence of AML Progression. |
| Q60303919 | DNA Methylation Clocks in Aging: Categories, Causes, and Consequences |
| Q36113662 | DNA Methylation Dynamics of Germinal Center B Cells Are Mediated by AID |
| Q36395976 | DNA methylation and hydroxymethylation in hematologic differentiation and transformation |
| Q90591655 | DNA methylation disruption reshapes the hematopoietic differentiation landscape |
| Q38834298 | DNA methylation in hematopoietic development and disease |
| Q38760713 | DNA methylation in normal and malignant hematopoiesis |
| Q37597292 | DNA methyltransferases and their roles in tumorigenesis |
| Q42708309 | DNMT3A Loss Drives Enhancer Hypomethylation in FLT3-ITD-Associated Leukemias. |
| Q36009675 | DNMT3A R882 Mutations Predict a Poor Prognosis in AML: A Meta-Analysis From 4474 Patients |
| Q37117574 | DNMT3A and TET2 compete and cooperate to repress lineage-specific transcription factors in hematopoietic stem cells |
| Q39047646 | DNMT3A in Leukemia. |
| Q34463554 | DNMT3A in haematological malignancies |
| Q92826109 | DNMT3A mutations are over-represented in young adults with NPM1 mutated AML and prompt a distinct co-mutational pattern |
| Q36908743 | DNMT3A(R882H) mutant and Tet2 inactivation cooperate in the deregulation of DNA methylation control to induce lymphoid malignancies in mice |
| Q37188783 | DOT1L as a therapeutic target for the treatment of DNMT3A-mutant acute myeloid leukemia |
| Q36118839 | DREAM: A Simple Method for DNA Methylation Profiling by High-throughput Sequencing |
| Q36149906 | Dnmt3a Is a Haploinsufficient Tumor Suppressor in CD8+ Peripheral T Cell Lymphoma |
| Q37688327 | Dnmt3a deletion cooperates with the Flt3/ITD mutation to drive leukemogenesis in a murine model. |
| Q37733030 | Dnmt3a haploinsufficiency cooperates with oncogenic Kras to promote an early-onset T-cell acute lymphoblastic leukemia |
| Q38892316 | Dnmt3a regulates T-cell development and suppresses T-ALL transformation |
| Q34506732 | Dnmt3a regulates myeloproliferation and liver-specific expansion of hematopoietic stem and progenitor cells. |
| Q38975300 | Dnmt3a restrains mast cell inflammatory responses |
| Q28074522 | Emerging concepts of epigenetic dysregulation in hematological malignancies |
| Q30235316 | Epigenetic Guardian: A Review of the DNA Methyltransferase DNMT3A in Acute Myeloid Leukaemia and Clonal Haematopoiesis |
| Q37095702 | Epigenetic Perturbations by Arg882-Mutated DNMT3A Potentiate Aberrant Stem Cell Gene-Expression Program and Acute Leukemia Development |
| Q88963816 | Epigenetic Priming in Cancer Initiation |
| Q36871785 | Epigenetic changes mediated by polycomb repressive complex 2 and E2a are associated with drug resistance in a mouse model of lymphoma. |
| Q34533891 | Epigenetic control of adult stem cell function |
| Q39337306 | Epigenetic dysregulation of hematopoietic stem cells and preleukemic state |
| Q26766149 | Epigenetic modulators, modifiers and mediators in cancer aetiology and progression |
| Q26745718 | Epigenetic perturbations in aging stem cells |
| Q47728104 | Epigenetic restriction of extraembryonic lineages mirrors the somatic transition to cancer |
| Q39441283 | Epigenetics and Cancer Stem Cells: Unleashing, Hijacking, and Restricting Cellular Plasticity. |
| Q88687341 | Epigenetics in myelodysplastic syndromes |
| Q37534907 | Gene-Specific Methylation Analysis in Thymomas of Patients with Myasthenia Gravis. |
| Q37280990 | Generating long-lived CD8(+) T-cell memory: Insights from epigenetic programs. |
| Q38830631 | Genetic and epigenetic heterogeneity in acute myeloid leukemia |
| Q47134051 | Haploinsufficiency for DNA methyltransferase 3A predisposes hematopoietic cells to myeloid malignancies |
| Q26767167 | Hypoxia and Hypoxia-Inducible Factors in Leukemias |
| Q38379074 | Immunohistochemical loss of 5-hydroxymethylcytosine expression in acute myeloid leukaemia: relationship to somatic gene mutations affecting epigenetic pathways |
| Q39106739 | Interaction between epigenetic and metabolism in aging stem cells |
| Q47771125 | Internal deletion of BCOR reveals a tumor suppressor function for BCOR in T lymphocyte malignancies |
| Q52721699 | Loss of Dnmt3a Immortalizes Hematopoietic Stem Cells In Vivo. |
| Q33675655 | Loss of Dnmt3a and Dnmt3b does not affect epidermal homeostasis but promotes squamous transformation through PPAR-γ |
| Q36021698 | Loss of Dnmt3a and endogenous Kras(G12D/+) cooperate to regulate hematopoietic stem and progenitor cell functions in leukemogenesis |
| Q37291484 | Loss of Dnmt3a induces CLL and PTCL with distinct methylomes and transcriptomes in mice |
| Q53110472 | Loss of Dnmt3b accelerates MLL-AF9 leukemia progression. |
| Q57024681 | MBD4 guards against methylation damage and germ line deficiency predisposes to clonal hematopoiesis and early-onset AML |
| Q89489818 | Molecular Pathogenesis and Treatment of Myelodysplastic Syndromes |
| Q38611326 | Mutant DNA methylation regulators endow hematopoietic stem cells with the preleukemic stem cell property, a requisite of leukemia initiation and relapse |
| Q39027793 | Mutations in AML: prognostic and therapeutic implications |
| Q39443070 | Myeloid leukemia with transdifferentiation plasticity developing from T-cell progenitors |
| Q36848353 | Negative regulation of DNMT3A de novo DNA methylation by frequently overexpressed UHRF family proteins as a mechanism for widespread DNA hypomethylation in cancer |
| Q38722225 | Oncogenic ZEB2 activation drives sensitivity toward KDM1A inhibition in T-cell acute lymphoblastic leukemia |
| Q37559783 | Ordering of mutations in acute myeloid leukemia with partial tandem duplication of MLL (MLL-PTD). |
| Q36430688 | PML-RARA requires DNA methyltransferase 3A to initiate acute promyelocytic leukemia |
| Q37338371 | Persistence of DNMT3A R882 mutations during remission does not adversely affect outcomes of patients with acute myeloid leukaemia |
| Q36892794 | Promoter Hypomethylation and Expression Is Conserved in Mouse Chronic Lymphocytic Leukemia Induced by Decreased or Inactivated Dnmt3a |
| Q64921821 | Quiescence Entry, Maintenance, and Exit in Adult Stem Cells. |
| Q46248338 | Rainbow trout exposed to benzo[a]pyrene yields conserved microRNA binding sites in DNA methyltransferases across 500 million years of evolution |
| Q49787651 | Rapid development of myeloproliferative neoplasm in mice with Ptpn11D61Y mutation and haploinsufficient for Dnmt3a |
| Q93038028 | Remethylation of Dnmt3a -/- hematopoietic cells is associated with partial correction of gene dysregulation and reduced myeloid skewing |
| Q26859843 | Revisiting the case for genetically engineered mouse models in human myelodysplastic syndrome research |
| Q97645876 | SERS-Based Assessment of MRD in Acute Promyelocytic Leukemia? |
| Q51696368 | SETD2 and DNMT3A screen in the Sotos-like syndrome French cohort. |
| Q91518791 | Stem cell fate in cancer growth, progression and therapy resistance |
| Q88547706 | Sustained clonal hematopoiesis by HLA-lacking hematopoietic stem cells without driver mutations in aplastic anemia |
| Q91983675 | Telomere dysfunction cooperates with epigenetic alterations to impair murine embryonic stem cell fate commitment |
| Q41191920 | Telomere dysfunction drives aberrant hematopoietic differentiation and myelodysplastic syndrome |
| Q36724810 | The Impact of DNA Methylation in Hematopoietic Malignancies |
| Q90239888 | The Role of HOX Transcription Factors in Cancer Predisposition and Progression |
| Q89985775 | The acute myeloid leukemia variant DNMT3A Arg882His is a DNMT3B-like enzyme |
| Q39089121 | The epigenetic basis of hematopoietic stem cell aging |
| Q91742598 | The extracellular signal-regulated kinase 1/2 modulates the intracellular localization of DNA methyltransferase 3A to regulate erythrocytic differentiation |
| Q38615755 | The microenvironment in myelodysplastic syndromes: niche-mediated disease initiation and progression. |
| Q88355598 | The role of mitochondria in stem cell fate and aging |
| Q40384669 | Transcriptional Control of Stem and Progenitor Potential |
| Q54966913 | Transformation of mouse T cells requires MYC and AKT activity in conjunction with inhibition of intrinsic apoptosis. |
| Q89021654 | [Modification of DNA methylation in leukemia development] |
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