Signal transduction by tumor necrosis factor and gene regulation of the inflammatory cytokine interleukin-6.

scientific article

Signal transduction by tumor necrosis factor and gene regulation of the inflammatory cytokine interleukin-6. is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

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P356DOI10.1016/S0006-2952(00)00412-3
P698PubMed publication ID11007957

P2093author name stringHaegeman G
Vermeulen L
Boone E
Vanden Berghe W
De Bosscher K
De Wilde G
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Mitotic inactivation of a human SWI/SNF chromatin remodeling complexQ24596960
A histone deacetylase corepressor complex regulates the Notch signal transduction pathwayQ24598533
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Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domainQ27860534
The language of covalent histone modificationsQ27860931
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DNA methyltransferase Dnmt1 associates with histone deacetylase activityQ28141500
Transcription factor-specific requirements for coactivators and their acetyltransferase functionsQ28260156
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Triggering of the human interleukin-6 gene by interferon-gamma and tumor necrosis factor-alpha in monocytic cells involves cooperation between interferon regulatory factor-1, NF kappa B, and Sp1 transcription factorsQ38289102
Multiple regulatory elements in the interleukin-6 gene mediate induction by prostaglandins, cyclic AMP, and lipopolysaccharide.Q38306725
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Activation of nuclear factor-kappaB-dependent transcription by tumor necrosis factor-alpha is mediated through phosphorylation of RelA/p65 on serine 529.Q38331909
Nuclear integration of glucocorticoid receptor and nuclear factor-kappaB signaling by CREB-binding protein and steroid receptor coactivator-1.Q38331993
I kappaB alpha-independent downregulation of NF-kappaB activity by glucocorticoid receptor.Q38343666
HIV-1 Tat induces the expression of the interleukin-6 (IL6) gene by binding to the IL6 leader RNA and by interacting with CAAT enhancer-binding protein beta (NF-IL6) transcription factorsQ38345146
Glucocorticoid-mediated repression of NFkappaB activity in endothelial cells does not involve induction of IkappaBalpha synthesisQ38354174
Cooperation between phosphorylation and acetylation processes in transcriptional controlQ39445547
Akt suppresses apoptosis by stimulating the transactivation potential of the RelA/p65 subunit of NF-kappaB.Q39451375
Chromatin disruption and modificationQ39726920
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CREB-binding protein is a nuclear integrator of nuclear factor-kappaB and p53 signalingQ40980349
Activation of p42/p44 mitogen-activated protein kinases (MAPK) and p38 MAPK by tumor necrosis factor (TNF) is mediated through the death domain of the 55-kDa TNF receptorQ40981890
Signal-specific co-activator domain requirements for Pit-1 activationQ41006466
CBP: a signal-regulated transcriptional coactivator controlled by nuclear calcium and CaM kinase IV.Q41010869
Distinct roles of the co-activators p300 and CBP in retinoic-acid-induced F9-cell differentiationQ41038113
p38 and extracellular signal-regulated kinase mitogen-activated protein kinase pathways are required for nuclear factor-kappaB p65 transactivation mediated by tumor necrosis factor.Q41062073
Regulation of NF-kappaB by cyclin-dependent kinases associated with the p300 coactivatorQ41133317
NF-kappa B/Rel family members are physically associated phosphoproteinsQ41435410
Roles of histone acetyltransferases and deacetylases in gene regulationQ28286019
The signal-dependent coactivator CBP is a nuclear target for pp90RSKQ28286828
The anti-inflammatory sesquiterpene lactone helenalin inhibits the transcription factor NF-kappaB by directly targeting p65Q28290401
TPL-2 kinase regulates the proteolysis of the NF-kappaB-inhibitory protein NF-kappaB1 p105Q28296740
Interaction of the COOH-terminal transactivation domain of p65 NF-kappa B with TATA-binding protein, transcription factor IIB, and coactivatorsQ28299369
Chromium(VI) inhibits the transcriptional activity of nuclear factor-kappaB by decreasing the interaction of p65 with cAMP-responsive element-binding protein-binding proteinQ28377525
CBP associates with the p42/p44 MAPK enzymes and is phosphorylated following NGF treatmentQ28572730
Phosphorylation of NF-kappa B p65 by PKA stimulates transcriptional activity by promoting a novel bivalent interaction with the coactivator CBP/p300Q28619230
Cytokines in acute and chronic inflammationQ28645928
p38 MAPK signalling cascades in inflammatory diseaseQ28678986
Methylated DNA and MeCP2 recruit histone deacetylase to repress transcriptionQ29547568
Activators and target genes of Rel/NF-kappaB transcription factorsQ29547882
The transcriptional co-activator p/CIP binds CBP and mediates nuclear-receptor functionQ29547918
Acetylation: a regulatory modification to rival phosphorylation?Q29614886
DNA damage activates p53 through a phosphorylation-acetylation cascadeQ29616294
The anti-inflammatory agents aspirin and salicylate inhibit the activity of I(kappa)B kinase-betaQ29617188
Rad6-dependent ubiquitination of histone H2B in yeastQ29617525
Transcriptional activators direct histone acetyltransferase complexes to nucleosomesQ29620509
Signaling and circuitry of multiple MAPK pathways revealed by a matrix of global gene expression profilesQ29620701
The phosphorylation status of a cyclic AMP-responsive activator is modulated via a chromatin-dependent mechanismQ30453590
Analysis of an activator:coactivator complex reveals an essential role for secondary structure in transcriptional activationQ31998382
Histone acetylases and deacetylases in cell proliferationQ33540069
Multiple signals converging on NF-kappaB.Q33597403
Chromatin-modifying and -remodeling complexesQ33632339
RNA polymerase II as a control panel for multiple coactivator complexesQ33632354
Modifying chromatin and concepts of cancerQ33632362
Histone acetylation and cancerQ33632377
Tumor necrosis factor receptor and Fas signaling mechanisms.Q33652491
A firm hand on NFkappaB: structures of the IkappaBalpha-NFkappaB complex.Q33658270
Gene activation by histone and factor acetyltransferasesQ33680840
Nuclear factor kappaB (NF-kappaB) pathway as a therapeutic target in rheumatoid arthritisQ33685143
The development and therapeutic potential of protein kinase inhibitorsQ33695725
New targets for anti-inflammatory drugsQ33695752
Histone acetylation in signal transduction by growth regulatory signalsQ33707434
MAP kinase-mediated signalling to nucleosomes and immediate-early gene inductionQ33707440
Glucocorticoid-mediated repression of nuclear factor-kappaB-dependent transcription involves direct interference with transactivationQ33708904
Regulated phosphorylation of the RNA polymerase II C-terminal domain (CTD).Q33765328
Organization of chromatin in cancer cells: role of signalling pathwaysQ33765339
Novel approaches and targets for treatment of chronic obstructive pulmonary diseaseQ33771480
Dorsal-mediated repression requires the formation of a multiprotein repression complex at the ventral silencer.Q33781523
How NF-kappaB is activated: the role of the IkappaB kinase (IKK) complexQ33797139
Diverse agents act at multiple levels to inhibit the Rel/NF-kappaB signal transduction pathwayQ33797156
NF-kappaB activation and HIV-1 induced apoptosisQ33824620
NF-kappaB and the innate immune responseQ33840493
CREB-independent regulation by CBP is a novel mechanism of human growth hormone gene expressionQ33859360
The I kappa B/NF-kappa B system: a key determinant of mucosalinflammation and protectionQ33860197
The IKK complex: an integrator of all signals that activate NF-kappaB?Q33877083
Age-associated increased interleukin-6 gene expression, late-life diseases, and frailtyQ33896033
Activation domain-specific and general transcription stimulation by native histone acetyltransferase complexesQ33957284
Reactive oxygen intermediate-dependent NF-kappaB activation by interleukin-1beta requires 5-lipoxygenase or NADPH oxidase activityQ33957447
Transcriptional activation by NF-kappaB requires multiple coactivatorsQ33959552
Mechanisms of anti-inflammatory action and of immunosuppression by glucocorticoids: negative interference of activated glucocorticoid receptor with transcription factorsQ34021421
Nuclear fusion of signaling pathwaysQ34503399
The NF-kappa B activation pathway: a paradigm in information transfer from membrane to nucleusQ34543723
Nuclear import of the Drosophila Rel protein Dorsal is regulated by phosphorylationQ35190695
Conversion of dorsal from an activator to a repressor by the global corepressor GrouchoQ35196355
Histone acetyltransferases regulate HIV-1 enhancer activity in vitroQ35199451
Glucocorticoids repress NF-kappaB-driven genes by disturbing the interaction of p65 with the basal transcription machinery, irrespective of coactivator levels in the cellQ35666145
Cell cycle arrest mediated by the MEK/mitogen-activated protein kinase pathwayQ35952074
Mitogen-activated protein kinases enhance long-range activation by the beta-globin locus control regionQ36217970
Induced expression of trimerized intracellular domains of the human tumor necrosis factor (TNF) p55 receptor elicits TNF effectsQ36266899
Regulation of p21(cip1) expression by growth factors and the extracellular matrix reveals a role for transient ERK activity in G1 phaseQ36301436
Factor-specific modulation of CREB-binding protein acetyltransferase activityQ36448157
The interferon-inducible p202 protein as a modulator of transcription: inhibition of NF-kappa B, c-Fos, and c-Jun activitiesQ36556883
Recombination signal sequence binding protein Jkappa is constitutively bound to the NF-kappaB site of the interleukin-6 promoter and acts as a negative regulatory factorQ36569110
Expression and up-regulation of interleukin-6 in oesophageal carcinoma cells by n-sodium butyrateQ36620446
Interleukin-6 (IL-6)--a molecule with both beneficial and destructive potentialsQ41597822
Eukaryotic transcription: an interlaced network of transcription factors and chromatin-modifying machinesQ41708885
The enhanceosome and transcriptional synergy.Q41715800
Chromatin and transcription--how transcription factors battle with a repressive chromatin environmentQ41716466
Chromatin interaction mechanism of transcriptional control in vivoQ41875311
Role of NF-kappaB in immune and inflammatory responses in the gut.Q41878721
Modulation of cytokine-induced HIV gene expression by competitive binding of transcription factors to the coactivator p300.Q42140547
A weak TATA box is a prerequisite for glucocorticoid-dependent repression of the osteocalcin geneQ42447714
Cell cycle regulation of the transcriptional coactivators p300 and CREB binding proteinQ42460228
The nuclear factor-kappaB engages CBP/p300 and histone acetyltransferase activity for transcriptional activation of the interleukin-6 gene promoter.Q42479390
Sequential DNA damage-independent and -dependent activation of NF-kappaB by UVQ42653589
Histone acetyltransferase activity of CBP is controlled by cycle-dependent kinases and oncoprotein E1A.Q42824374
Activation of SRF-regulated chromosomal templates by Rho-family GTPases requires a signal that also induces H4 hyperacetylationQ42832063
Recruitment of CBP/p300 by the IFN beta enhanceosome is required for synergistic activation of transcriptionQ44445912
Acetylation of HMG I(Y) by CBP turns off IFN beta expression by disrupting the enhanceosomeQ44646118
The p300/CBP family: integrating signals with transcription factors and chromatinQ45155861
Virus infection leads to localized hyperacetylation of histones H3 and H4 at the IFN-beta promoterQ45178460
Allosteric effects of DNA on transcriptional regulatorsQ46483901
Co-activators and co-repressors in the integration of transcriptional responsesQ46623959
JIL-1: a novel chromosomal tandem kinase implicated in transcriptional regulation in DrosophilaQ47072002
Cross-talk between steroids and NF-kappa B: what language?Q47714581
Sesquiterpene lactone containing Mexican Indian medicinal plants and pure sesquiterpene lactones as potent inhibitors of transcription factor NF-kappaB.Q47803095
Long-range transcriptional regulation of cytokine gene expressionQ47933670
Gene silencing. Methylation meets acetylationQ47991752
Conjunction dysfunction: CBP/p300 in human disease.Q48013074
Nuclear factor-kappaB/Rel proteins: a point of convergence of signalling pathways relevant in neuronal function and dysfunctionQ48298914
Inactivation of p42 mitogen-activated protein kinase is required for exit from M-phase after cyclin destructionQ48906664
Two tumour necrosis factor receptors: structure and function.Q49167492
Activation of the nuclear factor kappa B is not sufficient for regulation of tumor necrosis factor-induced interleukin-6 gene expressionQ49168800
Drosophila CBP is required for dorsal-dependent twist gene expression.Q52192359
Disruption of Raf-1/heat shock protein 90 complex and Raf signaling by dexamethasone in mast cells.Q52538241
An exceptionally well-preserved theropod dinosaur from the Yixian Formation of ChinaQ55869278
Peroxisome Proliferator-activated Receptor α Negatively Regulates the Vascular Inflammatory Gene Response by Negative Cross-talk with Transcription Factors NF-κB and AP-1Q57244351
Signal transduction: A central control for cell growthQ58415326
A new target for aspirinQ59060572
Tyrosine phosphorylation of I kappa B-alpha activates NF-kappa B without proteolytic degradation of I kappa B-alphaQ71513462
Tumor necrosis factor-alpha-dependent activation of a RelA homodimer in astrocytes. Increased phosphorylation of RelA and MAD-3 precede activation of RelAQ72536355
Hormone-activated nuclear receptors inhibit the stimulation of the JNK and ERK signalling pathways in endothelial cellsQ73075184
The p38 mitogen-activated protein kinase is required for NF-kappaB-dependent gene expression. The role of TATA-binding protein (TBP)Q73083269
Emerging targets for anti-inflammatory therapyQ73177743
Activation of nuclear transcription factor NF-kappaB by interleukin-1 is accompanied by casein kinase II-mediated phosphorylation of the p65 subunitQ73956120
Chromatin remodeling: a marriage between two families?Q77570570
Nerve growth factor up-regulates the transcriptional activity of CBP through activation of the p42/p44(MAPK) cascadeQ77604380
Nuclear factor kappa B: a pivotal role in the systemic inflammatory response syndrome and new target for therapyQ77757835
Modulation of chromatin structure regulates cytokine gene expression during T cell differentiationQ77769108
Pharmacological modulation of cytokine action and production through signaling pathwaysQ77903807
Innovative treatment programs against cancer: II. Nuclear factor-kappaB (NF-kappaB) as a molecular targetQ77910102
Transcription: Common cofactors and cooperative recruitmentQ78198301
Gene-regulating protein kinases as important anti-inflammatory targetsQ78240850
How chromatin changes its shapeQ78254094
P433issue8
P407language of work or nameEnglishQ1860
P921main subjectinterleukinsQ194908
P304page(s)1185-1195
P577publication date2000-10-01
P1433published inBiochemical PharmacologyQ864229
P1476titleSignal transduction by tumor necrosis factor and gene regulation of the inflammatory cytokine interleukin-6.
P478volume60

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