Association of TRAF1, TRAF2, and TRAF3 with an Epstein-Barr virus LMP1 domain important for B-lymphocyte transformation: role in NF-kappaB activation

scientific article published on December 1996

Association of TRAF1, TRAF2, and TRAF3 with an Epstein-Barr virus LMP1 domain important for B-lymphocyte transformation: role in NF-kappaB activation is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/MCB.16.12.7098
P932PMC publication ID231713
P698PubMed publication ID8943365
P5875ResearchGate publication ID14264637

P50authorElliott D. KieffQ43399614
P2093author name stringO Devergne
G Mosialos
K M Izumi
K M Kaye
E Hatzivassiliou
M F Kleijnen
P2860cites workReducing the complexity of the transforming Epstein-Barr virus genome to 64 kilobase pairs.Q35832104
Stimulation of NF-kappa B-mediated transcription by mutant derivatives of the latent membrane protein of Epstein-Barr virusQ35838888
Lymphotoxin is an autocrine growth factor for Epstein-Barr virus-infected B cell linesQ36361402
Epstein-Barr virus latent membrane protein 1 is essential for B-lymphocyte growth transformationQ36575274
Epstein-Barr virus recombinant molecular genetic analysis of the LMP1 amino-terminal cytoplasmic domain reveals a probable structural role, with no component essential for primary B-lymphocyte growth transformationQ36622140
Phenotypes of Epstein-Barr virus LMP1 deletion mutants indicate transmembrane and amino-terminal cytoplasmic domains necessary for effects in B-lymphoma cellsQ36699262
Epstein-Barr virus latent membrane protein (LMP1) and nuclear proteins 2 and 3C are effectors of phenotypic changes in B lymphocytes: EBNA-2 and LMP1 cooperatively induce CD23Q36806063
Orientation and patching of the latent infection membrane protein encoded by Epstein-Barr virusQ36861507
Epstein-Barr virus latent infection membrane protein alters the human B-lymphocyte phenotype: deletion of the amino terminus abolishes activityQ36881880
Nucleotide sequence of an mRNA transcribed in latent growth-transforming virus infection indicates that it may encode a membrane proteinQ36893502
Epstein-Barr virus-encoded protein found in plasma membranes of transformed cells.Q36904686
A membrane protein encoded by Epstein-Barr virus in latent growth-transforming infectionQ37577729
Comparative analysis identifies conserved tumor necrosis factor receptor-associated factor 3 binding sites in the human and simian Epstein-Barr virus oncogene LMP1.Q39876882
Activation of the B-cell surface receptor CD40 induces A20, a novel zinc finger protein that inhibits apoptosisQ41343773
The Epstein-Barr virus latent membrane protein-1 (LMP1) mediates activation of NF-kappa B and cell surface phenotype via two effector regions in its carboxy-terminal cytoplasmic domain.Q41371042
Lymphotoxin acts as an autocrine growth factor for Epstein-Barr virus-transformed B cells and differentiated Burkitt lymphoma cell lines.Q41450017
Induction of bcl-2 expression by Epstein-Barr virus latent membrane protein 1 protects infected B cells from programmed cell deathQ41678654
Identification of the intracytoplasmic region essential for signal transduction through a B cell activation molecule, CD40.Q41727367
TANK, a co-inducer with TRAF2 of TNF- and CD 40L-mediated NF-kappaB activationQ48064873
A novel RING finger protein interacts with the cytoplasmic domain of CD40Q24306382
A novel member of the TRAF family of putative signal transducing proteins binds to the cytosolic domain of CD40Q24306620
Involvement of CRAF1, a relative of TRAF, in CD40 signalingQ24306746
A novel interleukin-12 p40-related protein induced by latent Epstein-Barr virus infection in B lymphocytesQ24315666
Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genesQ24315805
TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathwaysQ24317441
A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptorQ24318280
Tumor necrosis factor receptor associated factor 2 is a mediator of NF-kappa B activation by latent infection membrane protein 1, the Epstein-Barr virus transforming proteinQ24599252
T cell receptor-dependent cell death of T cell hybridomas mediated by the CD30 cytoplasmic domain in association with tumor necrosis factor receptor-associated factorsQ24678367
Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferaseQ27860571
A new technique for the assay of infectivity of human adenovirus 5 DNAQ27860797
The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteinsQ28117866
The CD40 antigen and its ligandQ28286277
The Epstein-Barr virus transforming protein LMP1 engages signaling proteins for the tumor necrosis factor receptor familyQ28307399
TRAF2-mediated activation of NF-kappa B by TNF receptor 2 and CD40Q28610812
The Epstein-Barr virus LMP1 cytoplasmic carboxy terminus is essential for B-lymphocyte transformation; fibroblast cocultivation complements a critical function within the terminal 155 residues.Q35831016
P433issue12
P407language of work or nameEnglishQ1860
P921main subjectEpstein–Barr virusQ6900
NF-κBQ411114
P304page(s)7098-7108
P577publication date1996-12-01
P1433published inMolecular and Cellular BiologyQ3319478
P1476titleAssociation of TRAF1, TRAF2, and TRAF3 with an Epstein-Barr virus LMP1 domain important for B-lymphocyte transformation: role in NF-kappaB activation
P478volume16

Reverse relations

cites work (P2860)
Q24291050A diverse family of proteins containing tumor necrosis factor receptor-associated factor domains
Q33759787A new domain in the Toll/IL-1R domain-containing adaptor inducing interferon-β factor protein amino terminus is important for tumor necrosis factor-α receptor-associated factor 3 association, protein stabilization and interferon signaling
Q39736828A positive autoregulatory loop of LMP1 expression and STAT activation in epithelial cells latently infected with Epstein-Barr virus.
Q39589857Activation of lymphocyte signaling by the R1 protein of rhesus monkey rhadinovirus
Q24683297Activation of mitogen-activated protein kinase and NF-kappaB pathways by a Kaposi's sarcoma-associated herpesvirus K15 membrane protein
Q40951743Activation of the p38 mitogen-activated protein kinase pathway by Epstein-Barr virus-encoded latent membrane protein 1 coregulates interleukin-6 and interleukin-8 production
Q45752119Adoptive immunotherapy for Epstein-Barr virus-associated lymphoproliferative disorders complicating marrow allografts.
Q39642344An ATF/CRE element mediates both EBNA2-dependent and EBNA2-independent activation of the Epstein-Barr virus LMP1 gene promoter
Q33825713An Epstein-Barr virus that expresses only the first 231 LMP1 amino acids efficiently initiates primary B-lymphocyte growth transformation
Q34656773An Epstein-Barr-related herpesvirus from marmoset lymphomas
Q77873054An aggressive form of polyarticular arthritis in a man with CD154 mutation (X-linked hyper-IgM syndrome)
Q42937211Analysis of the Epstein-Barr virus (EBV) latent membrane protein 1 (LMP-1) gene and promoter in Hodgkin's disease isolates: selection against EBV variants with mutations in the LMP-1 promoter ATF-1/CREB-1 binding site
Q40790023Antisense oligodeoxynucleotides to latent membrane protein 1 induce growth inhibition, apoptosis and Bcl-2 suppression in Epstein-Barr virus (EBV)-transformed B-lymphoblastoid cells, but not in EBV-positive natural killer cell lymphoma cells.
Q35925874Assembly of post-receptor signaling complexes for the tumor necrosis factor receptor superfamily
Q44605546Autocrine lymphotoxin production in Epstein-Barr virus-immortalized B cells: induction via NF-kappaB activation mediated by EBV-derived latent membrane protein 1.
Q24298618BS69 cooperates with TRAF3 in the regulation of Epstein-Barr virus-derived LMP1/CTAR1-induced NF-kappaB activation
Q24317586BS69 negatively regulates the canonical NF-kappaB activation induced by Epstein-Barr virus-derived LMP1
Q36098835Bortezomib induces apoptosis of Epstein-Barr virus (EBV)-transformed B cells and prolongs survival of mice inoculated with EBV-transformed B cells
Q40676095CD30-governor of memory T cells?
Q33964729CD40 induces apoptosis in carcinoma cells through activation of cytotoxic ligands of the tumor necrosis factor superfamily
Q40953967CD40- and HLA-DR-mediated cell death pathways share a lot of similarities but differ in their use of ADP-ribosyltransferase activities
Q34082784CD40-mediated regulation of immune responses by TRAF-dependent and TRAF-independent signaling mechanisms.
Q22008610CIR, a corepressor linking the DNA binding factor CBF1 to the histone deacetylase complex
Q28201693CYLD is a deubiquitinating enzyme that negatively regulates NF-kappaB activation by TNFR family members
Q40775313Caspase-dependent cleavage regulates protein levels of Epstein-Barr virus-derived latent membrane protein 1.
Q35897193Cell transformation by Herpesvirus saimiri
Q38971933Changing patterns in the Epstein-Barr virus (EBV)and Hodgkin lymphoma association in Tunisia
Q45397749Changing patterns in the frequency of Hodgkin lymphoma subtypes and Epstein-Barr virus association in Taiwan
Q44608902Characterization of Epstein-Barr virus (EBV)-positive NK cells isolated from hydroa vacciniforme-like eruptions.
Q39879963Characterization of LMP-1's association with TRAF1, TRAF2, and TRAF3.
Q40686720Characterization of the Cyno-EBV LMP1 homologue and comparison with LMP1s of EBV and other EBV-like viruses
Q38427527Characterization of the latent membrane protein 1 signaling complex of Epstein-Barr virus in the membrane of mammalian cells with bimolecular fluorescence complementation
Q38296227Characterization of the rapamycin-inducible EBV LMP1 activation system
Q34061960Comparative analysis of the transforming mechanisms of Epstein-Barr virus, Kaposi's sarcoma-associated herpesvirus, and Herpesvirus saimiri
Q38919438Comparison of the peptide binding preferences of three closely related TRAF paralogs: TRAF2, TRAF3, and TRAF5
Q93029725Constitutive activation of the canonical NF-κB signaling pathway in EBV-associated gastric carcinoma
Q33813615Control of cell cycle entry and apoptosis in B lymphocytes infected by Epstein-Barr virus.
Q34234140Cytokine signaling and Epstein-Barr virus-mediated cell transformation
Q35146582Death receptors and melanoma resistance to apoptosis
Q44330153Deletions within the epstein-barr virus latent membrane protein-1 oncogene in adult ordinary, HIV-associated and paediatric Hodgkin's disease
Q37781398Differential B-lymphocyte regulation by CD40 and its viral mimic, latent membrane protein 1.
Q41682745Differential requirements for tumor necrosis factor receptor-associated factor family proteins in CD40-mediated induction of NF-kappaB and Jun N-terminal kinase activation.
Q36369236Differential signaling and tumor necrosis factor receptor-associated factor (TRAF) degradation mediated by CD40 and the Epstein-Barr virus oncoprotein latent membrane protein 1 (LMP1).
Q39634112Dominant expression of survival signals of endoplasmic reticulum stress response in Hodgkin lymphoma
Q28255713Dominant negative mutants of TRAF3 reveal an important role for the coiled coil domains in cell death signaling by the lymphotoxin-beta receptor
Q36508964EBV LMP2A affects LMP1-mediated NF-kappaB signaling and survival of lymphoma cells by regulating TRAF2 expression
Q93035970EBV down-regulates COX-2 expression via TRAF2 and ERK signal pathway in EBV-associated gastric cancer
Q57186814EBV genes and B cell proliferation
Q30837949EBV latent membrane protein 1 activates Akt, NFkappaB, and Stat3 in B cell lymphomas
Q36222552EBV-Encoded Latent Membrane Protein 1 Cooperates with BAFF/BLyS and APRIL to Induce T Cell-Independent Ig Heavy Chain Class Switching
Q29618716Early lethality, functional NF-kappaB activation, and increased sensitivity to TNF-induced cell death in TRAF2-deficient mice
Q28207648Effects of the NIK aly mutation on NF-kappaB activation by the Epstein-Barr virus latent infection membrane protein, lymphotoxin beta receptor, and CD40
Q44519499Electroporation-mediated and EBV LMP1-regulated gene therapy in a syngenic mouse tumor model
Q26859114Emerging therapeutic strategies for Epstein-Barr virus+ post-transplant lymphoproliferative disorder
Q35609384Enhanced Toll-like receptor (TLR) responses of TNFR-associated factor 3 (TRAF3)-deficient B lymphocytes
Q58803477Epstein-Barr Virus-Associated Malignancies: Roles of Viral Oncoproteins in Carcinogenesis
Q39604074Epstein-Barr virus LMP-1 natural sequence variants differ in their potential to activate cellular signaling pathways.
Q35875444Epstein-Barr virus LMP1 induction of the epidermal growth factor receptor is mediated through a TRAF signaling pathway distinct from NF-kappaB activation
Q36559750Epstein-Barr virus LMP1 modulates lipid raft microdomains and the vimentin cytoskeleton for signal transduction and transformation
Q27345929Epstein-Barr virus LMP2A reduces hyperactivation induced by LMP1 to restore normal B cell phenotype in transgenic mice
Q35165290Epstein-Barr virus down-regulates tumor suppressor DOK1 expression.
Q30941129Epstein-Barr virus encoded latent membrane protein 1 (LMP1) and TNF receptor associated factors (TRAF): colocalisation of LMP1 and TRAF1 in primary EBV infection and in EBV associated Hodgkin lymphoma
Q28082701Epstein-Barr virus latent genes
Q35121711Epstein-Barr virus latent infection membrane protein 1 TRAF-binding site induces NIK/IKK alpha-dependent noncanonical NF-kappaB activation
Q34789652Epstein-Barr virus latent membrane protein 1 activation of NF-kappaB through IRAK1 and TRAF6.
Q34721581Epstein-Barr virus latent membrane protein 1 induces cellular MicroRNA miR-146a, a modulator of lymphocyte signaling pathways
Q36845616Epstein-Barr virus latent membrane protein 1 represses DNA repair through the PI3K/Akt/FOXO3a pathway in human epithelial cells
Q34224026Epstein-Barr virus latent membrane protein 1: structure and functions
Q33887684Epstein-Barr virus latent membrane protein-1 triggers AP-1 activity via the c-Jun N-terminal kinase cascade
Q35291650Epstein-Barr virus latent-infection membrane proteins are palmitoylated and raft-associated: protein 1 binds to the cytoskeleton through TNF receptor cytoplasmic factors
Q41594644Epstein-Barr virus oncogenesis
Q34313818Epstein-Barr virus-associated Hodgkin's lymphoma.
Q34270437Epstein-Barr virus-encoded LMP1 interacts with FGD4 to activate Cdc42 and thereby promote migration of nasopharyngeal carcinoma cells
Q24516975Epstein-Barr virus-encoded latent membrane protein 1 activates the JNK pathway through its extreme C terminus via a mechanism involving TRADD and TRAF2
Q40509666Epstein-Barr virus-encoded latent membrane protein 1 promotes stress-induced apoptosis upstream of caspase-2-dependent mitochondrial perturbation
Q33888498Epstein-Barr virus-mediated B-cell proliferation is dependent upon latent membrane protein 1, which simulates an activated CD40 receptor
Q36285724Epstein-Barr virus-transforming protein latent infection membrane protein 1 activates transcription factor NF-kappaB through a pathway that includes the NF-kappaB-inducing kinase and the IkappaB kinases IKKalpha and IKKbeta
Q41725733Epstein-Barr virus: LMP1 masquerades as an active receptor
Q33797179Epstein-barr virus transformation: involvement of latent membrane protein 1-mediated activation of NF-kappaB.
Q56917395Evidence of LMP1-TRAF3 interactions in glycosphingolipid-rich complexes of lymphoblastoid and nasopharyngeal carcinoma cells
Q34089478Evolutionary aspects of oncogenic herpesviruses
Q39544175Exosomal sorting of the viral oncoprotein LMP1 is restrained by TRAF2 association at signalling endosomes
Q40868229Expression of the matrix metalloproteinase 9 in Hodgkin's disease is independent of EBV status
Q38462802Expression of the tumor necrosis factor receptor-associated factors (TRAFs) 1 and 2 is a characteristic feature of Hodgkin and Reed-Sternberg cells
Q40518385Expression of tumor necrosis factor receptor-associated factor 1 in nasopharyngeal carcinoma: possible upregulation by Epstein-Barr virus latent membrane protein 1.
Q40957203Functional analysis of different LMP1 proteins isolated from Epstein-Barr virus-positive carriers
Q48114248Functional analysis of the C. elegans cyld-1 gene reveals extensive similarity with its human homolog
Q34682093Generation and characterization of a novel recombinant antibody against LMP1-TES1 of Epstein-Barr virus isolated by phage display
Q36108705HMG CoA reductase inhibitors (statins) to treat Epstein-Barr virus-driven lymphoma
Q33809963Hairy leukoplakia: an unusual combination of transforming and permissive Epstein-Barr virus infections
Q39699142Hantavirus pulmonary syndrome-associated hantaviruses contain conserved and functional ITAM signaling elements
Q35784954Herpesvirus saimiri STP-A oncoprotein utilizes Src family protein tyrosine kinase and tumor necrosis factor receptor-associated factors to elicit cellular signal transduction
Q39579218Herpesvirus saimiri transforms human T-cell clones to stable growth without inducing resistance to apoptosis.
Q37587096High molecular weight complex analysis of Epstein-Barr virus Latent Membrane Protein 1 (LMP-1): structural insights into LMP-1's homo-oligomerization and lipid raft association
Q45722276High-resolution methylation analysis and in vivo protein-DNA binding at the promoter of the viral oncogene LMP2A in B cell lines carrying latent Epstein-Barr virus genomes
Q33297034Hodgkin-lymphoma-derived cells show high sensitivity to dactinomycin and paclitaxel.
Q34295801Human herpesvirus-8 and Kaposi's sarcoma: relationship with the multistep concept of tumorigenesis.
Q24337884Human ubiquitin specific protease 31 is a deubiquitinating enzyme implicated in activation of nuclear factor-kappaB
Q34479733IL-1 receptor-associated kinase 1 is critical for latent membrane protein 1-induced p65/RelA serine 536 phosphorylation and NF-kappaB activation
Q36984994IRF7 activation by Epstein-Barr virus latent membrane protein 1 requires localization at activation sites and TRAF6, but not TRAF2 or TRAF3
Q28280342Identification and functional characterization of DR6, a novel death domain-containing TNF receptor
Q39595507Identification of a spliced gene from Kaposi's sarcoma-associated herpesvirus encoding a protein with similarities to latent membrane proteins 1 and 2A of Epstein-Barr virus
Q44022376Identification of protein kinase CK2 as a potent kinase of Epstein-Barr virus latent membrane protein 1.
Q31159325Identification of protein kinase inhibitors with a selective negative effect on the viability of Epstein-Barr virus infected B cell lines
Q24633907Identification of transmembrane protein 134 as a novel LMP1-binding protein by using bimolecular fluorescence complementation and an enhanced retroviral mutagen
Q39594099Immortalization of CD4(+) and CD8(+) T lymphocytes by human T-cell leukemia virus type 1 Tax mutants expressed in a functional molecular clone
Q38168950Immunoglobulin class switch recombination deficiency type 1 or CD40 ligand deficiency: from bedside to bench and back again
Q45660602In Hodgkin's disease Reed-Sternberg cells and normal B-lymphocytes are infected by related Epstein-Barr virus strains.
Q36242117Induction of cyclooxygenase-2 by Epstein-Barr virus latent membrane protein 1 is involved in vascular endothelial growth factor production in nasopharyngeal carcinoma cells
Q42808155Induction of inducible nitric oxide synthase by Epstein-Barr virus B95-8-derived LMP1 in Balb/3T3 cells promotes stress-induced cell death and impairs LMP1-mediated transformation
Q39410061Inhibition of latent membrane protein 1 impairs the growth and tumorigenesis of latency II Epstein-Barr virus-transformed T cells.
Q45734171Inhibition of transforming growth factor beta signaling and Smad-dependent activation of transcription by the Latent Membrane Protein 1 of Epstein-Barr virus
Q40629419Interaction of Epstein-Barr virus latent membrane protein 1 with SCFHOS/beta-TrCP E3 ubiquitin ligase regulates extent of NF-kappaB activation.
Q33786551Interaction of tumor necrosis factor receptor-associated factor signaling proteins with the latent membrane protein 1 PXQXT motif is essential for induction of epidermal growth factor receptor expression
Q33834888Interferon regulatory factor 7 mediates activation of Tap-2 by Epstein-Barr virus latent membrane protein 1.
Q33870488Intracellular signaling molecules activated by Epstein-Barr virus for induction of interferon regulatory factor 7.
Q45436282LMP1 protein from the Epstein-Barr virus is a structural CD40 decoy in B lymphocytes for binding to TRAF3.
Q33890869LMP1 signal transduction differs substantially from TNF receptor 1 signaling in the molecular functions of TRADD and TRAF2
Q81398990LMP1 signaling and activation of NF-kappaB in LMP1 transgenic mice
Q34717145LMP1 strain variants: biological and molecular properties.
Q35139273LMP1 transmembrane domain 1 and 2 (TM1-2) FWLY mediates intermolecular interactions with TM3-6 to activate NF-kappaB
Q39777437LMP1, a viral relative of the TNF receptor family, signals principally from intracellular compartments
Q34430225LMP1-induced downregulation of CD99 molecules in Hodgkin and Reed-Sternberg cells
Q79105060Latent Membrane Protein 1, Tumor Necrosis Factor Receptor–Associated Factor (TRAF) 1, TRAF-2, TRAF-3, and Nuclear Factor Kappa B Expression in Posttransplantation Lymphoproliferative Disorders
Q35122447Latent infection membrane protein transmembrane FWLY is critical for intermolecular interaction, raft localization, and signaling
Q40912121Latent membrane protein 1 associated signaling pathways are important in tumor cells of Epstein-Barr virus negative Hodgkin's disease
Q40114217Latent membrane protein 1 encoded by Epstein-Barr virus induces telomerase activity via p16INK4A/Rb/E2F1 and JNK signaling pathways
Q34532370Latent membrane protein 1 inhibits Epstein-Barr virus lytic cycle induction and progress via different mechanisms.
Q24682515Latent membrane protein 1 of Epstein-Barr virus induces CD83 by the NF-kappaB signaling pathway
Q39593467Latent membrane protein 1 of Epstein-Barr virus inhibits as well as stimulates gene expression
Q33891012Latent membrane protein 1 of Epstein-Barr virus interacts with JAK3 and activates STAT proteins
Q34250209Latent membrane protein 1 of Epstein-Barr virus mimics a constitutively active receptor molecule.
Q40628193Latent membrane protein 1 of Epstein-Barr virus stimulates processing of NF-kappa B2 p100 to p52.
Q43601461Latent membrane protein 1-induced EGFR signalling is negatively regulated by TGF alpha prior to neoplasia.
Q33866046Linkage between STAT regulation and Epstein-Barr virus gene expression in tumors
Q28535439Lupeol is one of active components in the extract of Chrysanthemum indicum Linne that inhibits LMP1-induced NF-κB activation
Q24564927Lymphotoxin-beta receptor signaling complex: role of tumor necrosis factor receptor-associated factor 3 recruitment in cell death and activation of nuclear factor kappaB
Q22254016MIP-T3, a novel protein linking tumor necrosis factor receptor-associated factor 3 to the microtubule network
Q36637910Manipulation of the nuclear factor-kappaB pathway and the innate immune response by viruses
Q37535521Marek's disease is a natural model for lymphomas overexpressing Hodgkin's disease antigen (CD30)
Q33815241Matrix metalloproteinase 9 expression is induced by Epstein-Barr virus latent membrane protein 1 C-terminal activation regions 1 and 2.
Q43508237Mechanism of action of a novel latent membrane protein-1 dominant negative
Q92238951Modulation of Angiogenic Processes by the Human Gammaherpesviruses, Epstein-Barr Virus and Kaposi's Sarcoma-Associated Herpesvirus
Q35110891Molecular biology of Epstein-Barr virus and Kaposi's sarcoma-associated herpesvirus
Q33835041Molecular mechanisms of IgE regulation
Q40599250Molecular mechanisms of the effect of herpesvirus saimiri protein StpC on the signaling pathway leading to NF-kappaB activation
Q34225554Molecular virology of Epstein-Barr virus
Q36961021Multiple roles of TRAF3 signaling in lymphocyte function.
Q40551263Multiple signal transducers and activators of transcription are induced by EBV LMP-1.
Q36416479NF-kappaB activation in melanoma
Q34225148NF-kappaB and cell-cycle regulation: the cyclin connection
Q40335673NF-kappaB is essential for the progression of KSHV- and EBV-infected lymphomas in vivo
Q28078299NF-κB Pathways in the Pathogenesis of Multiple Sclerosis and the Therapeutic Implications
Q34352790NF-κB and IRF7 pathway activation by Epstein-Barr virus Latent Membrane Protein 1
Q40321857NFkappaB signaling is induced by the oncoprotein Tio through direct interaction with TRAF6.
Q77357711Nasopharyngeal carcinoma
Q24806909Natural antisense RNA inhibits the expression of BCMA, a tumour necrosis factor receptor homologue
Q40549193Nuclear factor kappa B (NFkappaB) dependent modulation of Epstein-Barr virus latent membrane protein 1 (LMP1) in epidermal growth factor receptor (EGFR) promoter activity
Q36961875Nuclear factor kappa B-dependent activation of the antiapoptotic bfl-1 gene by the Epstein-Barr virus latent membrane protein 1 and activated CD40 receptor.
Q45753136Paediatric Hodgkin's disease in Spain: association with Epstein-Barr virus strains carrying latent membrane protein-1 oncogene deletions and high frequency of dual infections
Q34292013Pathogenetic and histogenetic features of HIV-associated Hodgkin's disease.
Q34584067Persistent gamma-herpesvirus infections: what can we learn from an experimental mouse model?
Q40380273Porcine arterivirus activates the NF-kappaB pathway through IkappaB degradation
Q40985093Post-transplant lymphoproliferative disease (PTLD): lymphokine production and PTLD.
Q36944141Potential selection of LMP1 variants in nasopharyngeal carcinoma
Q21134119Proof-of-concept, randomized, controlled clinical trial of Bacillus-Calmette-Guerin for treatment of long-term type 1 diabetes
Q28114910Protein kinase A associates with HA95 and affects transcriptional coactivation by Epstein-Barr virus nuclear proteins
Q34659176Recent advances in the diagnosis and therapy of Richter's syndrome
Q28137640Receptor activator of NF-kappaB recruits multiple TRAF family adaptors and activates c-Jun N-terminal kinase
Q40742977Regulation of TRAF2 signaling by self-induced degradation.
Q24293065Regulation of transactivation function of the aryl hydrocarbon receptor by the Epstein-Barr virus-encoded EBNA-3 protein
Q36403897Requirement for TRAF3 in signaling by LMP1 but not CD40 in B lymphocytes
Q43808671Reversal of EBV immortalization precedes apoptosis in IL-6-induced human B cell terminal differentiation
Q34373335Richter syndrome: biology, incidence, and therapeutic strategies
Q36845685Role of AID in tumorigenesis
Q37546963Role of Ca2+/calmodulin-dependent kinase II-IRAK1 interaction in LMP1-induced NF-κB activation
Q33784729Role of the TRAF binding site and NF-kappaB activation in Epstein-Barr virus latent membrane protein 1-induced cell gene expression
Q45374927Roles of TRAF2 and TRAF3 in Epstein-Barr virus latent membrane protein 1-induced alternative NF-kappaB activation
Q39814540Roles of the TRAF2/3 binding site in differential B cell signaling by CD40 and its viral oncogenic mimic, LMP1
Q26853280Roles of tumor necrosis factor receptor associated factor 3 (TRAF3) and TRAF5 in immune cell functions
Q39968995STAP-2 negatively regulates both canonical and noncanonical NF-kappaB activation induced by Epstein-Barr virus-derived latent membrane protein 1.
Q37693272STAT1 and pathogens, not a friendly relationship
Q45413248Sequence variations of Epstein-Barr virus LMP1 gene in nasal NK/T-cell lymphoma
Q57355843Signal transduction by the Epstein-Barr virus oncogene latent membrane protein 1 (LMP1)
Q33822504Signaling activities of gammaherpesvirus membrane proteins
Q33772240Simian homologues of human herpesvirus 8
Q34992568Specificities of CD40 signaling: involvement of TRAF2 in CD40-induced NF-kappaB activation and intercellular adhesion molecule-1 up-regulation
Q24292094Sphingosine kinase interacts with TRAF2 and dissects tumor necrosis factor-alpha signaling
Q34374436Src kinase and Syk activation initiate PI3K signaling by a chimeric latent membrane protein 1 in Epstein-Barr virus (EBV)+ B cell lymphomas
Q43472687Stimulation of Epstein-Barr virus-infected human B cell growth by physiological concentrations of 4-hydroxynonenal
Q35078625Subversion of B lymphocyte signaling by infectious agents.
Q41052237Synergistic regulation of the human interleukin-12 p40 promoter by NFkappaB and Ets transcription factors in Epstein-Barr virus-transformed B cells and macrophages.
Q40323227TAK1 is a component of the Epstein-Barr virus LMP1 complex and is essential for activation of JNK but not of NF-kappaB.
Q33864629TNF receptor (TNFR)-associated factor (TRAF) 3 serves as an inhibitor of TRAF2/5-mediated activation of the noncanonical NF-kappaB pathway by TRAF-binding TNFRs
Q30578474TNF receptor associated factors in cytokine signaling.
Q41718695TRAF binding is required for a distinct subset of in vivo B cell functions of the oncoprotein LMP1.
Q24338458TRAF family proteins link PKR with NF-kappa B activation
Q36972287TRAF molecules in cell signaling and in human diseases
Q24678181TRAF-4 expression in epithelial progenitor cells. Analysis in normal adult, fetal, and tumor tissues
Q35634395TRAF1 Coordinates Polyubiquitin Signaling to Enhance Epstein-Barr Virus LMP1-Mediated Growth and Survival Pathway Activation
Q38359234TRAF1 is a critical regulator of JNK signaling by the TRAF-binding domain of the Epstein-Barr virus-encoded latent infection membrane protein 1 but not CD40.
Q28138885TRAF1 is a substrate of caspases activated during tumor necrosis factor receptor-alpha-induced apoptosis
Q34649278TRAF1: lord without a RING.
Q38801811TRAF3 as a powerful and multitalented regulator of lymphocyte functions.
Q28361340TRAF6 is a critical mediator of signal transduction by the viral oncogene latent membrane protein 1
Q22253885TTRAP, a novel protein that associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor-associated factors (TRAFs), and that inhibits nuclear factor-kappa B activation
Q39578471The 30-base-pair deletion in Chinese variants of the Epstein-Barr virus LMP1 gene is not the major effector of functional differences between variant LMP1 genes in human lymphocytes.
Q33763373The EGFR as a target for viral oncoproteins.
Q34267599The Epstein-Barr virus (EBV)-induced tumor suppressor microRNA MiR-34a is growth promoting in EBV-infected B cells
Q35076801The Epstein-Barr virus BRRF1 protein, Na, induces lytic infection in a TRAF2- and p53-dependent manner
Q35997566The Epstein-Barr virus LMP1 amino acid sequence that engages tumor necrosis factor receptor associated factors is critical for primary B lymphocyte growth transformation
Q33882153The Epstein-Barr virus and its association with human cancers
Q34275895The Epstein-Barr virus and post-transplant lymphoproliferative disease: interplay of immunosuppression, EBV, and the immune system in disease pathogenesis
Q34327176The Epstein-Barr virus latent membrane protein 1 putative Janus kinase 3 (JAK3) binding domain does not mediate JAK3 association or activation in B-lymphoma or lymphoblastoid cell lines
Q24646694The Epstein-Barr virus oncogene product latent membrane protein 1 engages the tumor necrosis factor receptor-associated death domain protein to mediate B lymphocyte growth transformation and activate NF-kappaB
Q34099074The Epstein-Barr virus oncogene product, latent membrane protein 1, induces the downregulation of E-cadherin gene expression via activation of DNA methyltransferases
Q24554457The Epstein-Barr virus oncoprotein latent membrane protein 1 engages the tumor necrosis factor receptor-associated proteins TRADD and receptor-interacting protein (RIP) but does not induce apoptosis or require RIP for NF-kappaB activation
Q40485060The Epstein-Barr virus oncoprotein latent membrane protein 1 induces expression of the chemokine IP-10: importance of mRNA half-life regulation
Q39321358The Epstein-Barr virus-encoded LMP-1 oncoprotein negatively affects Tyk2 phosphorylation and interferon signaling in human B cells
Q39985447The ID proteins contribute to the growth of rodent fibroblasts during LMP1-mediated transformation
Q38597238The Latent Membrane Protein 1 (LMP1).
Q40893186The amino-terminus and membrane-spanning domains of LMP-1 inhibit cell proliferation
Q77740355The antiviral prophylaxis of post-transplant lymphoproliferative disorder
Q33711382The biology of Epstein-Barr virus: lessons learned from the virus and the host
Q40782239The cytoplasmic amino-terminus of the Latent Membrane Protein-1 of Epstein-Barr Virus: relationship between transmembrane orientation and effector functions of the carboxy-terminus and transmembrane domain
Q34577080The effects of the Epstein-Barr virus latent membrane protein 2A on B cell function
Q34089485The expression and function of Epstein-Barr virus encoded latent genes
Q34384112The germinal center kinase TNIK is required for canonical NF-κB and JNK signaling in B-cells by the EBV oncoprotein LMP1 and the CD40 receptor
Q35850668The in vivo function of a noncanonical TRAF2-binding domain in the C-terminus of CD40 in driving B-cell growth and differentiation
Q50064513The interactome of EBV LMP1 evaluated by proximity-based BioID approach
Q39589143The late lytic LMP-1 protein of Epstein-Barr virus can negatively regulate LMP-1 signaling
Q33845947The latency-associated nuclear antigen encoded by Kaposi's sarcoma-associated herpesvirus activates two major essential Epstein-Barr virus latent promoters
Q40061524The latent membrane protein 1 (LMP1) encoded by Epstein-Barr virus induces expression of the putative oncogene Bcl-3 through activation of the nuclear factor-kappaB.
Q34253049The latent membrane protein 1 (LMP1) oncogene of Epstein-Barr virus can simultaneously induce and inhibit apoptosis in B cells
Q40044863The latent membrane protein 1 oncogene modifies B-cell physiology by regulating autophagy
Q35140197The molecular basis for the generation of Hodgkin and Reed-Sternberg cells in Hodgkin's lymphoma
Q35906085The multifaceted roles of TRAFs in the regulation of B-cell function.
Q24674848The oncogenic protein kinase Tpl-2/Cot contributes to Epstein-Barr virus-encoded latent infection membrane protein 1-induced NF-kappaB signaling downstream of TRAF2
Q39596927The residues between the two transformation effector sites of Epstein-Barr virus latent membrane protein 1 are not critical for B-lymphocyte growth transformation
Q33929840The role of chemokines in Hodgkin's disease
Q35145613The signaling adaptors and pathways activated by TNF superfamily
Q35008886The significance of LMP1 expression in nasopharyngeal carcinoma
Q27619945The structural basis for the recognition of diverse receptor sequences by TRAF2
Q21146664The tumor marker Fascin is induced by the Epstein-Barr virus-encoded oncoprotein LMP1 via NF-κB in lymphocytes and contributes to their invasive migration
Q24685892The viral etiology of AIDS-associated malignancies
Q35192167Thermodynamic characterization of the interaction between TRAF2 and tumor necrosis factor receptor peptides by isothermal titration calorimetry
Q39787510Transcriptional downregulation of p27KIP1 through regulation of E2F function during LMP1-mediated transformation.
Q40884755Transformation of Madin-Darby canine kidney (MDCK) epithelial cells by Epstein-Barr virus latent membrane protein 1 (LMP1) induces expression of Ets1 and invasive growth
Q28199382Tumor necrosis factor receptor-associated factors (TRAFs)
Q37021555Tumor-derived variants of Epstein-Barr virus latent membrane protein 1 induce sustained Erk activation and c-Fos
Q28565703Two carboxyl-terminal activation regions of Epstein-Barr virus latent membrane protein 1 activate NF-kappaB through distinct signaling pathways in fibroblast cell lines
Q24676338Two differently regulated nuclear factor kappaB activation pathways triggered by the cytoplasmic tail of CD40
Q39997624Tyrosine Residues Direct the Ubiquitination and Degradation of the NY-1 Hantavirus G1 Cytoplasmic Tail
Q40714517Unimpaired activation of c-Jun NH2-terminal kinase (JNK) 1 upon CD40 stimulation in B cells of patients with X-linked agammaglobulinemia
Q36098869Unique signaling properties of CTAR1 in LMP1-mediated transformation
Q38303038VP4 differentially regulates TRAF2 signaling, disengaging JNK activation while directing NF-kappa B to effect rotavirus-specific cellular responses
Q40564088Vitamin E inhibits cyclosporin A and H2O2 promoted Epstein-Barr virus (EBV) transformation of human B cells as assayed by EBV oncogene LMP1 expression