TRAF3 as a powerful and multitalented regulator of lymphocyte functions.

scientific article published on 6 May 2016

TRAF3 as a powerful and multitalented regulator of lymphocyte functions. is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1189/JLB.2MR0216-063R
P932PMC publication ID6608063
P698PubMed publication ID27154354

P50authorGail A BishopQ56650269
P2093author name stringGail A Bishop
P2860cites workThe EBV transforming protein, latent membrane protein 1, mimics and cooperates with CD40 signaling in B lymphocytesQ74595824
T cell activation by TLRs: a role for TLRs in the adaptive immune responseQ81039397
Recruitment of CD40 and tumor necrosis factor receptor-associated factors 2 and 3 to membrane microdomains during CD40 signalingQ22253441
CD40 AND CD154 IN CELL-MEDIATED IMMUNITYQ22255634
Involvement of CRAF1, a relative of TRAF, in CD40 signalingQ24306746
The autoimmunity-associated gene PTPN22 potentiates toll-like receptor-driven, type 1 interferon-dependent immunityQ24310219
Signaling by proinflammatory cytokines: oligomerization of TRAF2 and TRAF6 is sufficient for JNK and IKK activation and target gene induction via an amino-terminal effector domainQ24604330
TRAF5, a novel tumor necrosis factor receptor-associated factor family protein, mediates CD40 signalingQ24634187
Roles of tumor necrosis factor receptor associated factor 3 (TRAF3) and TRAF5 in immune cell functionsQ26853280
BAFF/BLyS receptor 3 binds the B cell survival factor BAFF ligand through a discrete surface loop and promotes processing of NF-kappaB2Q27639845
The TNF-receptor-associated factor family: scaffold molecules for cytokine receptors, kinases and their regulatorsQ28198125
Caspase-mediated cleavage of TRAF3 in FasL-stimulated Jurkat-T cellsQ28205963
TNFR-associated factor-3 is associated with BAFF-R and negatively regulates BAFF-R-mediated NF-kappa B activation and IL-10 productionQ28216865
Binding sites of cytoplasmic effectors TRAF1, 2, and 3 on CD30 and other members of the TNF receptor superfamilyQ28239398
Tumor necrosis factor receptor associated factor 4 (TRAF4) expression pattern during mouse developmentQ28265102
TRAF5, an activator of NF-kappaB and putative signal transducer for the lymphotoxin-beta receptorQ28282051
TRAF6 is a critical mediator of signal transduction by the viral oncogene latent membrane protein 1Q28361340
LMP1 signaling can replace CD40 signaling in B cells in vivo and has unique features of inducing class-switch recombination to IgG1Q57198201
Expression of the Cytoplasmic Tail of LMP1 in Mice Induces Hyperactivation of B Lymphocytes and Disordered Lymphoid ArchitectureQ57791640
TRAF2 is essential for JNK but not NF-kappaB activation and regulates lymphocyte proliferation and survivalQ73925277
Identification of TRAF6, a novel tumor necrosis factor receptor-associated factor protein that mediates signaling from an amino-terminal domain of the CD40 cytoplasmic regionQ28511583
Tumor necrosis factor receptor-associated factor 2 (TRAF2)-deficient B lymphocytes reveal novel roles for TRAF2 in CD40 signalingQ28511980
TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signalingQ28513445
Targeted disruption of Traf5 gene causes defects in CD40- and CD27-mediated lymphocyte activationQ28584897
Tumor necrosis factor receptor-associated factors (TRAFs)--a family of adapter proteins that regulates life and deathQ28609905
CD40 regulates the processing of NF-kappaB2 p100 to p52Q28610678
TRAF2-mediated activation of NF-kappa B by TNF receptor 2 and CD40Q28610812
IL-15 regulates homeostasis and terminal maturation of NKT cellsQ28741430
Early lethality, functional NF-kappaB activation, and increased sensitivity to TNF-induced cell death in TRAF2-deficient miceQ29618716
Role of the TRAF binding site and NF-kappaB activation in Epstein-Barr virus latent membrane protein 1-induced cell gene expressionQ33784729
Interaction of tumor necrosis factor receptor-associated factor signaling proteins with the latent membrane protein 1 PXQXT motif is essential for induction of epidermal growth factor receptor expressionQ33786551
TNF receptor (TNFR)-associated factor (TRAF) 3 serves as an inhibitor of TRAF2/5-mediated activation of the noncanonical NF-kappaB pathway by TRAF-binding TNFRsQ33864629
TRAF3 regulates homeostasis of CD8+ central memory T cells.Q33882681
Epstein-Barr virus-mediated B-cell proliferation is dependent upon latent membrane protein 1, which simulates an activated CD40 receptorQ33888498
The TRAF3 adaptor protein drives proliferation of anaplastic large cell lymphoma cells by regulating multiple signaling pathwaysQ33953115
The adaptor TRAF3 restrains the lineage determination of thymic regulatory T cells by modulating signaling via the receptor for IL-2.Q34071164
B lymphocyte activation by contact-mediated interactions with T lymphocytes.Q34282293
Modulation of experimental autoimmune encephalomyelitis through TRAF3-mediated suppression of interleukin 17 receptor signalingQ34340648
A BAFF-R mutation associated with non-Hodgkin lymphoma alters TRAF recruitment and reveals new insights into BAFF-R signaling.Q34340672
Differential TRAF3 utilization by a variant human CD40 receptor with enhanced signalingQ34580224
TNF receptor-associated factor 3 is required for T cell-mediated immunity and TCR/CD28 signalingQ34603380
Myeloid cell TRAF3 regulates immune responses and inhibits inflammation and tumor development in mice.Q34749424
Reprogramming of murine macrophages through TLR2 confers viral resistance via TRAF3-mediated, enhanced interferon productionQ34819672
The CD40-CD154 interaction in B cell-T cell liaisonsQ35145640
CD40-mediated maintenance of immune homeostasis in the adipose tissue microenvironment.Q35360534
Antigen-specific B-lymphocyte activation.Q35570847
Enhanced Toll-like receptor (TLR) responses of TNFR-associated factor 3 (TRAF3)-deficient B lymphocytesQ35609384
Epstein-Barr virus latent membrane protein (LMP1) is not sufficient to maintain proliferation of B cells but both it and activated CD40 can prolong their survival.Q35917481
Tumor necrosis factor receptor-associated factor 3 is a critical regulator of B cell homeostasis in secondary lymphoid organsQ36156167
Specific deletion of TRAF3 in B lymphocytes leads to B-lymphoma development in mice.Q36208548
TRAF3: a novel tumor suppressor gene in macrophages.Q36357661
Differential signaling and tumor necrosis factor receptor-associated factor (TRAF) degradation mediated by CD40 and the Epstein-Barr virus oncoprotein latent membrane protein 1 (LMP1).Q36369236
Requirement for TRAF3 in signaling by LMP1 but not CD40 in B lymphocytesQ36403897
The adaptor protein TRAF3 inhibits interleukin-6 receptor signaling in B cells to limit plasma cell development.Q36485370
Nuclear TRAF3 is a negative regulator of CREB in B cellsQ36551524
Association of TRAF1, TRAF2, and TRAF3 with an Epstein-Barr virus LMP1 domain important for B-lymphocyte transformation: role in NF-kappaB activationQ36564433
A novel polymorphism of the human CD40 receptor with enhanced functionQ36843735
Control points in NKT-cell developmentQ36858868
TNF receptor associated factor 3 plays a key role in development and function of invariant natural killer T cellsQ36907898
Noncanonical NF-kappaB activation requires coordinated assembly of a regulatory complex of the adaptors cIAP1, cIAP2, TRAF2 and TRAF3 and the kinase NIK.Q37178911
TRAF3 regulates the effector function of regulatory T cells and humoral immune responsesQ37483143
Functional roles for T cell CD40 in infection and autoimmune disease: the role of CD40 in lymphocyte homeostasis.Q37524800
Differential B-lymphocyte regulation by CD40 and its viral mimic, latent membrane protein 1.Q37781398
Expanding TRAF function: TRAF3 as a tri-faced immune regulatorQ37887494
The seventh ring: exploring TRAF7 functions.Q37959350
T cell receptor signalling networks: branched, diversified and boundedQ38092568
Latent membrane protein 1 and the B lymphocyte-a complex relationship.Q38221181
TRAF2 and TRAF3 signal adapters act cooperatively to control the maturation and survival signals delivered to B cells by the BAFF receptor.Q38293065
Upregulation of TRAF-3 by shear stress blocks CD40-mediated endothelial activationQ38294592
TRAF3, ubiquitination, and B-lymphocyte regulation.Q38530616
Spatiotemporal pattern of TRAF3 expression after rat spinal cord injuryQ38997693
Activation-induced tumor necrosis factor receptor-associated factor 3 (Traf3) alternative splicing controls the noncanonical nuclear factor κB pathway and chemokine expression in human T cellsQ39011442
A Complex Relationship between TRAF3 and Non-Canonical NF-κB2 Activation in B LymphocytesQ39037203
TRAF5 negatively regulates TLR signaling in B lymphocytesQ39060065
Consequences of the direct interaction of helper T cells with B cells presenting antigenQ39483731
Activated human neonatal CD8+ T cells are subject to immunomodulation by direct TLR2 or TLR5 stimulation.Q40015976
A novel mechanism for TNFR-associated factor 6-dependent CD40 signalingQ40078976
Cooperation between TNF receptor-associated factors 1 and 2 in CD40 signaling.Q40290683
Differential regulation of CD40-mediated TNF receptor-associated factor degradation in B lymphocytes.Q40376295
Regulation of the NF-kappaB-inducing kinase by tumor necrosis factor receptor-associated factor 3-induced degradationQ40566781
Role of TNF receptor-associated factor 3 in the CD40 signaling by production of reactive oxygen species through association with p40phox, a cytosolic subunit of nicotinamide adenine dinucleotide phosphate oxidaseQ40605243
Cutting edge: molecular mechanisms of synergy between CD40 and the B cell antigen receptor: role for TNF receptor-associated factor 2 in receptor interaction.Q40716536
Regulation of TRAF2 signaling by self-induced degradation.Q40742977
TLR2 stimulation regulates the balance between regulatory T cell and Th17 function: a novel mechanism of reduced regulatory T cell function in multiple sclerosis.Q40933796
Cutting edge: contrasting roles of TNF receptor-associated factor 2 (TRAF2) and TRAF3 in CD40-activated B lymphocyte differentiationQ40951300
A site-directed chromosomal translocation induced in embryonic stem cells by Cre-loxP recombination.Q41352964
Nonredundant and complementary functions of TRAF2 and TRAF3 in a ubiquitination cascade that activates NIK-dependent alternative NF-kappaB signalingQ43142702
Deletion of cIAP1 and cIAP2 in murine B lymphocytes constitutively activates cell survival pathways and inactivates the germinal center responseQ44233229
Regulation of B-cell survival by BAFF-dependent PKCdelta-mediated nuclear signalling.Q45054574
LMP1 protein from the Epstein-Barr virus is a structural CD40 decoy in B lymphocytes for binding to TRAF3.Q45436282
Mimicry of CD40 signals by Epstein-Barr virus LMP1 in B lymphocyte responsesQ45746898
NEDD4 ubiquitinates TRAF3 to promote CD40-mediated AKT activationQ46195385
An intact zinc ring finger is required for tumor necrosis factor receptor-associated factor-mediated nuclear factor-kappaB activation but is dispensable for c-Jun N-terminal kinase signalingQ46630234
TRAF3 forms heterotrimers with TRAF2 and modulates its ability to mediate NF-{kappa}B activation.Q50792035
TLR2 stimulation drives human naive and effector regulatory T cells into a Th17-like phenotype with reduced suppressive function.Q50999206
TLR2 engagement on CD8 T cells enables generation of functional memory cells in response to a suboptimal TCR signal.Q51833450
Targeted disruption of TRAF3 leads to postnatal lethality and defective T-dependent immune responses.Q52522634
Complete structural characterisation of the mammalian and Drosophila TRAF genes: implications for TRAF evolution and the role of RING finger splice variants.Q52587074
P433issue5
P304page(s)919-926
P577publication date2016-05-06
P1433published inJournal of Leukocyte BiologyQ1524048
P1476titleTRAF3 as a powerful and multitalented regulator of lymphocyte functions
P478volume100

Reverse relations

cites work (P2860)
Q90054533Difference of genomic copy numbers alterations between hairy cell leukemia-variant and classical hairy cell leukemia: a pilot retrospective study in Chinese
Q64990463Regulation of Interleukin-6 Receptor Signaling by TNF Receptor-Associated Factor 2 and 5 During Differentiation of Inflammatory CD4+ T Cells.
Q93053015TGFβ-induced degradation of TRAF3 in mesenchymal progenitor cells causes age-related osteoporosis
Q52661592TRAF molecules in inflammation and inflammatory diseases.
Q57810578TRAF2 Deficiency in B Cells Impairs CD40-Induced Isotype Switching That Can Be Rescued by Restoring NF-κB1 Activation
Q57492396TRAF3 as a Multifaceted Regulator of B Lymphocyte Survival and Activation
Q90002815TRAF3 regulates the oncogenic proteins Pim2 and c-Myc to restrain survival in normal and malignant B cells

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