Activation-induced tumor necrosis factor receptor-associated factor 3 (Traf3) alternative splicing controls the noncanonical nuclear factor κB pathway and chemokine expression in human T cells

scientific article published on 26 March 2014

Activation-induced tumor necrosis factor receptor-associated factor 3 (Traf3) alternative splicing controls the noncanonical nuclear factor κB pathway and chemokine expression in human T cells is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1074/JBC.M113.526269
P932PMC publication ID4036369
P698PubMed publication ID24671418

P2093author name stringAstrid-Solveig Schultz
Florian Heyd
Marco Preussner
Ilka Wilhelmi
Monika Michel
P2860cites workTissue-specific alternative splicing remodels protein-protein interaction networksQ48455031
TRAF3 forms heterotrimers with TRAF2 and modulates its ability to mediate NF-{kappa}B activation.Q50792035
Getting under the skin of alternative splicing: identification of epithelial-specific splicing factors.Q51747407
The evolutionary landscape of alternative splicing in vertebrate speciesQ56894874
Mature antigen-experienced T helper cells synthesize and secrete the B cell chemoattractant CXCL13 in the inflammatory environment of the rheumatoid jointQ79765411
Phosphorylation-Dependent Regulation of PSF by GSK3 Controls CD45 Alternative SplicingQ24302148
Specificity of TRAF3 in its negative regulation of the noncanonical NF-kappa B pathwayQ24324346
Activation of IKKalpha target genes depends on recognition of specific kappaB binding sites by RelB:p52 dimersQ24562579
T cell activationQ24658051
Mechanisms of alternative pre-messenger RNA splicingQ28131822
A chemokine-driven positive feedback loop organizes lymphoid folliclesQ28142202
OTUD7B controls non-canonical NF-κB activation through deubiquitination of TRAF3Q28513798
ASF/SF2-regulated CaMKIIdelta alternative splicing temporally reprograms excitation-contraction coupling in cardiac muscleQ28592239
The two NF-kappaB activation pathways and their role in innate and adaptive immunityQ29614355
TRAF-3 mRNA splice-deletion variants encode isoforms that induce NF-kappaB activationQ33876001
The noncanonical NF-κB pathwayQ34031207
An alternative splicing switch regulates embryonic stem cell pluripotency and reprogrammingQ34216981
TNF receptor-associated factor 3 is required for T cell-mediated immunity and TCR/CD28 signalingQ34603380
A cell-based screen for splicing regulators identifies hnRNP LL as a distinct signal-induced repressor of CD45 variable exon 4.Q34811491
Noncanonical NF-kappaB regulates inducible costimulator (ICOS) ligand expression and T follicular helper cell developmentQ35149531
PSF controls expression of histone variants and cellular viability in thymocytesQ35534322
Evolutionary dynamics of gene and isoform regulation in Mammalian tissues.Q36598797
Control of alternative splicing in immune responses: many regulators, many predictions, much still to learnQ36751866
Noncanonical NF-kappaB activation requires coordinated assembly of a regulatory complex of the adaptors cIAP1, cIAP2, TRAF2 and TRAF3 and the kinase NIK.Q37178911
Expanding TRAF function: TRAF3 as a tri-faced immune regulatorQ37887494
Non-canonical NF-κB signaling activation and regulation: principles and perspectivesQ37948121
Complex changes in alternative pre-mRNA splicing play a central role in the epithelial-to-mesenchymal transition (EMT).Q38006770
Alternative splicing networks regulated by signaling in human T cells.Q39372815
A model system for activation-induced alternative splicing of CD45 pre-mRNA in T cells implicates protein kinase C and Ras.Q39450030
CXCL13/CXCR5 signaling enhances BCR-triggered B-cell activation by shaping cell dynamicsQ39527436
An ESRP-regulated splicing programme is abrogated during the epithelial-mesenchymal transitionQ39667327
HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancerQ39763266
Regulation of the NF-kappaB-inducing kinase by tumor necrosis factor receptor-associated factor 3-induced degradationQ40566781
Tissue-specific splicing of disordered segments that embed binding motifs rewires protein interaction networksQ41884066
Essential role of nuclear factor (NF)-kappaB-inducing kinase and inhibitor of kappaB (IkappaB) kinase alpha in NF-kappaB activation through lymphotoxin beta receptor, but not through tumor necrosis factor receptor IQ42015911
Opposing roles for TRAF1 in the alternative versus classical NF-κB pathway in T cellsQ42227779
Nonredundant and complementary functions of TRAF2 and TRAF3 in a ubiquitination cascade that activates NIK-dependent alternative NF-kappaB signalingQ43142702
Germinal center dark and light zone organization is mediated by CXCR4 and CXCR5.Q44999948
Regulation of naive T cell function by the NF-kappaB2 pathwayQ46071109
Unique gene expression program of human germinal center T helper cellsQ47303246
P4510describes a project that usesImageQuantQ112270642
P433issue19
P407language of work or nameEnglishQ1860
P921main subjectalternative mRNA splicing, via spliceosomeQ21114084
P1104number of pages10
P304page(s)13651-13660
P577publication date2014-03-26
P1433published inJournal of Biological ChemistryQ867727
P1476titleActivation-induced tumor necrosis factor receptor-associated factor 3 (Traf3) alternative splicing controls the noncanonical nuclear factor κB pathway and chemokine expression in human T cells
P478volume289

Reverse relations

cites work (P2860)
Q93027444A Perspective Review on the Role of Nanomedicine in the Modulation of TNF-TNFR2 Axis in Breast Cancer Immunotherapy
Q39056768Activation-Dependent TRAF3 Exon 8 Alternative Splicing Is Controlled by CELF2 and hnRNP C Binding to an Upstream Intronic Element
Q92501366Differential Interleukin-2 Transcription Kinetics Render Mouse but Not Human T Cells Vulnerable to Splicing Inhibition Early after Activation
Q92901441Metabonomic-Transcriptome Integration Analysis on Osteoarthritis and Rheumatoid Arthritis
Q52337490Negative Regulation of Interferon-β Production by Alternative Splicing of Tumor Necrosis Factor Receptor-Associated Factor 3 in Ducks.
Q40105947Novel nonsense gain-of-function NFKB2 mutations associated with a combined immunodeficiency phenotype
Q58580426Role of TRAFs in Signaling Pathways Controlling T Follicular Helper Cell Differentiation and T Cell-Dependent Antibody Responses
Q27023925Roles of TRAF3 in T cells: many surprises
Q42365219Sec16 alternative splicing dynamically controls COPII transport efficiency
Q38801811TRAF3 as a powerful and multitalented regulator of lymphocyte functions.
Q35759267Targeting signaling factors for degradation, an emerging mechanism for TRAF functions

Search more.