TRAF2 Deficiency in B Cells Impairs CD40-Induced Isotype Switching That Can Be Rescued by Restoring NF-κB1 Activation

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TRAF2 Deficiency in B Cells Impairs CD40-Induced Isotype Switching That Can Be Rescued by Restoring NF-κB1 Activation is …
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scholarly articleQ13442814

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P356DOI10.4049/JIMMUNOL.1800337
P932PMC publication ID6246814
P698PubMed publication ID30341187

P50authorYonatan DollinQ86554816
Jing H WangQ86554818
Rachel WoolaverQ91302219
Zhangguo ChenQ92426171
P2093author name stringPing Xie
Xiaoguang Wang
P2860cites workEssential function for the kinase TAK1 in innate and adaptive immune responsesQ50335551
Targeted disruption of TRAF3 leads to postnatal lethality and defective T-dependent immune responses.Q52522634
CD40 Ligand Gene Defects Responsible for X-Linked Hyper-IgM SyndromeQ55670500
CD40 ligand-transduced co-stimulation of T cells in the development of helper functionQ58882277
The binding site for TRAF2 and TRAF3 but not for TRAF6 is essential for CD40-mediated immunoglobulin class switchingQ78298237
TRAF2 differentially regulates the canonical and noncanonical pathways of NF-kappaB activation in mature B cellsQ80991122
Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2)Q24290325
BCR-signalling synergizes with TLR-signalling for induction of AID and immunoglobulin class-switching through the non-canonical NF-κB pathwayQ24632504
HoxC4 binds to the promoter of the cytidine deaminase AID gene to induce AID expression, class-switch DNA recombination and somatic hypermutationQ24645030
Regulation of Aicda expression and AID activityQ26853622
IgH chain class switch recombination: mechanism and regulationQ27001131
Tumor necrosis factor receptor-associated factors (TRAFs)Q28199382
CD40:CD40L interactions in X-linked and non-X-linked hyper-IgM syndromesQ28216904
IgH class switching and translocations use a robust non-classical end-joining pathwayQ28241679
Class-switch recombination: interplay of transcription, DNA deamination and DNA repairQ28269740
Tumor necrosis factor receptor-associated factor 2 (TRAF2)-deficient B lymphocytes reveal novel roles for TRAF2 in CD40 signalingQ28511980
Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzymeQ29547201
Early lethality, functional NF-kappaB activation, and increased sensitivity to TNF-induced cell death in TRAF2-deficient miceQ29618716
Alternative end-joining catalyzes class switch recombination in the absence of both Ku70 and DNA ligase 4.Q33656097
Generation and repair of AID-initiated DNA lesions in B lymphocytesQ33690522
Roles of the kinase TAK1 in TRAF6-dependent signaling by CD40 and its oncogenic viral mimic, LMP1Q34364910
All TRAFs are not created equal: common and distinct molecular mechanisms of TRAF-mediated signal transductionQ34543653
AID-initiated DNA lesions are differentially processed in distinct B cell populationsQ34550504
TNF receptor-associated factor 3 is required for T cell-mediated immunity and TCR/CD28 signalingQ34603380
Mechanism and regulation of class switch recombinationQ34764888
Roles of the kinase TAK1 in CD40-mediated effects on vascular oxidative stress and neointima formation after vascular injuryQ35210912
Targeting TRAF3 Downstream Signaling Pathways in B cell NeoplasmsQ35575662
Enhanced Toll-like receptor (TLR) responses of TNFR-associated factor 3 (TRAF3)-deficient B lymphocytesQ35609384
Constraints contributed by chromatin looping limit recombination targeting during Ig class switch recombinationQ35633829
CD40/CD154 interactions at the interface of tolerance and immunityQ35698455
Transforming growth factor beta-activated kinase 1 (TAK1)-dependent checkpoint in the survival of dendritic cells promotes immune homeostasis and function.Q35750832
Tumor necrosis factor receptor-associated factor 3 is a critical regulator of B cell homeostasis in secondary lymphoid organsQ36156167
Viral induction of AID is independent of the interferon and the Toll-like receptor signaling pathways but requires NF-kappaB.Q36229720
Three-dimensional architecture of the IgH locus facilitates class switch recombinationQ36235676
Imbalanced PTEN and PI3K Signaling Impairs Class Switch Recombination.Q36304948
CD40-CD40 ligand interactions are critical in T-B cooperation but not for other anti-viral CD4+ T cell functionsQ36366592
Nuclear factor (NF)-kappa B2 (p100/p52) is required for normal splenic microarchitecture and B cell-mediated immune responsesQ36400158
Immunoglobulin class-switch DNA recombination: induction, targeting and beyondQ36534234
Molecular mechanisms of antibody somatic hypermutation.Q36747477
Nuclear factor κB mediates suppression of canonical transient receptor potential 6 expression by reactive oxygen species and protein kinase C in kidney cellsQ36812431
TRAF2 and TRAF3 independently mediate Ig class switching driven by CD40.Q37291416
B cells that simultaneously express surface IgM and IgE in Nippostrongylus brasiliensis-infected SJA/9 mice do not provide evidence for isotype switching without gene deletionQ37675351
Expanding TRAF function: TRAF3 as a tri-faced immune regulatorQ37887494
AID targeting in antibody diversityQ37901614
The role of activation-induced deaminase in antibody diversification and genomic instabilityQ38041514
Classical and alternative end-joining pathways for repair of lymphocyte-specific and general DNA double-strand breaksQ38051860
TRAF2 and TRAF3 signal adapters act cooperatively to control the maturation and survival signals delivered to B cells by the BAFF receptor.Q38293065
B cell-specific and stimulation-responsive enhancers derepress Aicda by overcoming the effects of silencersQ38348243
Cancer immunotherapy: activating innate and adaptive immunity through CD40 agonists.Q38786054
TRAF3 as a powerful and multitalented regulator of lymphocyte functions.Q38801811
Pharmacological and genomic profiling identifies NF-κB-targeted treatment strategies for mantle cell lymphomaQ39040982
Induction of an IgE response in mice by Nippostrongylus brasiliensis: characterization of lymphoid cells with intracytoplasmic or surface IgE.Q39348498
Regulation of the NF-kappaB-inducing kinase by tumor necrosis factor receptor-associated factor 3-induced degradationQ40566781
Targeted disruption of the p50 subunit of NF-kappa B leads to multifocal defects in immune responsesQ42488424
TRAF2 deficiency results in hyperactivity of certain TNFR1 signals and impairment of CD40-mediated responses.Q44217852
Regulation of class-switch recombination and plasma cell differentiation by phosphatidylinositol 3-kinase signalingQ44677754
Prospects for modulating the CD40/CD40L pathway in the therapy of the hyper-IgM syndrome.Q45874408
NEDD4 ubiquitinates TRAF3 to promote CD40-mediated AKT activationQ46195385
P433issue11
P407language of work or nameEnglishQ1860
P304page(s)3421-3430
P577publication date2018-10-19
P1433published inJournal of ImmunologyQ3521441
P1476titleTRAF2 Deficiency in B Cells Impairs CD40-Induced Isotype Switching That Can Be Rescued by Restoring NF-κB1 Activation
P478volume201

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Q99594459Targeting NF-κB pathway for the therapy of diseases: mechanism and clinical studycites workP2860

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