The adaptor protein TRAF3 inhibits interleukin-6 receptor signaling in B cells to limit plasma cell development.

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The adaptor protein TRAF3 inhibits interleukin-6 receptor signaling in B cells to limit plasma cell development. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1126/SCISIGNAL.AAA5157
P932PMC publication ID4720969
P698PubMed publication ID26329582

P50authorLinda A ShermanQ42403205
Christian J. MaineQ55089465
Gail A BishopQ56650269
P2093author name stringZuoan Yi
Laura L Stunz
Wai W Lin
P2860cites workSubcellular localization of intracellular protein tyrosine phosphatases in T cellsQ24273420
The T cell protein tyrosine phosphatase is a negative regulator of janus family kinases 1 and 3Q24292506
Identification of a nuclear Stat1 protein tyrosine phosphataseQ24302061
The autoimmunity-associated gene PTPN22 potentiates toll-like receptor-driven, type 1 interferon-dependent immunityQ24310219
Plasmacytoid dendritic cells induce plasma cell differentiation through type I interferon and interleukin 6Q24317429
Large-scale structural analysis of the classical human protein tyrosine phosphatomeQ24321557
Principles of interleukin (IL)-6-type cytokine signalling and its regulationQ24530173
Regulation of type I interferon responsesQ26853177
Therapeutic strategies for the clinical blockade of IL-6/gp130 signalingQ27002391
Identification of copy number abnormalities and inactivating mutations in two negative regulators of nuclear factor-kappaB signaling pathways in Waldenstrom's macroglobulinemiaQ28240713
High-resolution genomic analysis in Waldenström's macroglobulinemia identifies disease-specific and common abnormalities with marginal zone lymphomasQ28241121
IL-6-induced homodimerization of gp130 and associated activation of a tyrosine kinaseQ28270103
Interleukin-6 family of cytokines and gp130Q28295098
PEST domain-enriched tyrosine phosphatase (PEP) regulation of effector/memory T cellsQ28590230
The JAK2 inhibitor AZD1480 potently blocks Stat3 signaling and oncogenesis in solid tumorsQ33613105
IL-21 regulates germinal center B cell differentiation and proliferation through a B cell-intrinsic mechanismQ33656121
Tyrosine phosphatase PTPN22: multifunctional regulator of immune signaling, development, and disease.Q34039427
The adaptor TRAF3 restrains the lineage determination of thymic regulatory T cells by modulating signaling via the receptor for IL-2.Q34071164
Analysis of the coding genome of diffuse large B-cell lymphomaQ34205133
IgG1 plasmacytosis in interleukin 6 transgenic miceQ34308376
Modulation of experimental autoimmune encephalomyelitis through TRAF3-mediated suppression of interleukin 17 receptor signalingQ34340648
Impact of interleukin-6 in hematological malignanciesQ34387624
TNF receptor-associated factor 3 is required for T cell-mediated immunity and TCR/CD28 signalingQ34603380
The tumor microenvironment is the main source of IL-6 for plasma cell tumor development in miceQ34861202
The effect of the autoimmunity-associated gene, PTPN22, on a BXSB-derived model of lupusQ34918378
The PTPN22 allele encoding an R620W variant interferes with the removal of developing autoreactive B cells in humansQ35187072
An oncogenic role for alternative NF-κB signaling in DLBCL revealed upon deregulated BCL6 expressionQ35588767
Regulation of JAK-STAT signalling in the immune systemQ35605437
Analysis of interleukin-21-induced Prdm1 gene regulation reveals functional cooperation of STAT3 and IRF4 transcription factorsQ35736556
Regulation of plasma-cell developmentQ36058417
Overexpression of the autoimmunity-associated phosphatase PTPN22 promotes survival of antigen-stimulated CLL cells by selectively activating AKT.Q36058554
Late interleukin-6 escalates T follicular helper cell responses and controls a chronic viral infectionQ36073682
Promiscuous mutations activate the noncanonical NF-kappaB pathway in multiple myeloma.Q36155317
Tumor necrosis factor receptor-associated factor 3 is a critical regulator of B cell homeostasis in secondary lymphoid organsQ36156167
Specific deletion of TRAF3 in B lymphocytes leads to B-lymphoma development in mice.Q36208548
High affinity germinal center B cells are actively selected into the plasma cell compartment.Q36228042
Requirement for TRAF3 in signaling by LMP1 but not CD40 in B lymphocytesQ36403897
STAT3-mediated up-regulation of BLIMP1 Is coordinated with BCL6 down-regulation to control human plasma cell differentiation.Q36677337
Protein tyrosine phosphatase function: the substrate perspectiveQ36713273
A disease-associated PTPN22 variant promotes systemic autoimmunity in murine modelsQ36802757
The induction of antibody production by IL-6 is indirectly mediated by IL-21 produced by CD4+ T cellsQ37061850
Plasma cell development: from B-cell subsets to long-term survival niches.Q37068273
Frequent engagement of the classical and alternative NF-kappaB pathways by diverse genetic abnormalities in multiple myelomaQ37314736
PTPN22 controls the germinal center by influencing the numbers and activity of T follicular helper cellsQ37600124
The establishment of the plasma cell survival niche in the bone marrowQ38070792
Roles for TNF-receptor associated factor 3 (TRAF3) in lymphocyte functionsQ38179139
TRAF2 and TRAF3 signal adapters act cooperatively to control the maturation and survival signals delivered to B cells by the BAFF receptor.Q38293065
A Complex Relationship between TRAF3 and Non-Canonical NF-κB2 Activation in B LymphocytesQ39037203
Cytokine-induced proliferation and immunoglobulin production of human B lymphocytes triggered through their CD40 antigenQ41694124
Interleukin-6 is a growth factor for nonmalignant human plasmablasts.Q52021179
Impaired immune and acute-phase responses in interleukin-6-deficient mice.Q52514391
Cellular interaction in germinal centers. Roles of CD40 ligand and B7-2 in established germinal centers.Q54167674
Differential expression of CD126 and CD130 mediates different STAT-3 phosphorylation in CD4+CD25- and CD25high regulatory T cells.Q54613582
Autocrine generation and requirement of BSF-2/IL-6 for human multiple myelomasQ59077136
Interleukin-6 is a prognostic factor in multiple myelomaQ70176421
STAT-3 activation by differential cytokines is critical for human in vivo-generated plasma cell survival and Ig secretionQ86487354
P433issue392
P304page(s)ra88
P577publication date2015-09-01
P1433published inScience SignalingQ7433604
P1476titleThe adaptor protein TRAF3 inhibits interleukin-6 receptor signaling in B cells to limit plasma cell development
P478volume8

Reverse relations

cites work (P2860)
Q37465240Antibody responses to de novo identified citrullinated fibrinogen peptides in rheumatoid arthritis and visualization of the corresponding B cells
Q41751738Enhanced T cell responses to IL-6 in type 1 diabetes are associated with early clinical disease and increased IL-6 receptor expression
Q57191736Genetic Alterations of TRAF Proteins in Human Cancers
Q64106861Genetic variants differentially associated with rheumatoid arthritis and systemic lupus erythematosus reveal the disease-specific biology
Q39233347Protein Tyrosine Phosphatases in Systemic Sclerosis: Potential Pathogenic Players and Therapeutic Targets.
Q64990463Regulation of Interleukin-6 Receptor Signaling by TNF Receptor-Associated Factor 2 and 5 During Differentiation of Inflammatory CD4+ T Cells.
Q58580426Role of TRAFs in Signaling Pathways Controlling T Follicular Helper Cell Differentiation and T Cell-Dependent Antibody Responses
Q57492396TRAF3 as a Multifaceted Regulator of B Lymphocyte Survival and Activation
Q38801811TRAF3 as a powerful and multitalented regulator of lymphocyte functions.
Q41855689TRAF3 enhances TCR signaling by regulating the inhibitors Csk and PTPN22.
Q90002815TRAF3 regulates the oncogenic proteins Pim2 and c-Myc to restrain survival in normal and malignant B cells
Q47652771TRAF3 regulation of inhibitory signaling pathways in B and T lymphocytes by kinase and phosphatase localization.
Q90207982The Contribution of PTPN22 to Rheumatic Disease
Q91105567The cytokine network involved in the host immune response to periodontitis
Q89777732The oncogenic membrane protein LMP1 sequesters TRAF3 in B-cell lymphoma cells to produce functional TRAF3 deficiency

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