KSHV induces aerobic glycolysis and angiogenesis through HIF-1-dependent upregulation of pyruvate kinase 2 in Kaposi's sarcoma

scientific article

KSHV induces aerobic glycolysis and angiogenesis through HIF-1-dependent upregulation of pyruvate kinase 2 in Kaposi's sarcoma is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1007/S10456-015-9475-4
P932PMC publication ID4659376
P698PubMed publication ID26092770

P50authorGregg L. SemenzaQ1545025
P2093author name stringTao Ma
Harsh Patel
Akrit Sodhi
Silvia Montaner
Savalan Babapoor-Farrokhran
Renty Franklin
P2860cites workKaposi's sarcoma and its associated herpesvirusQ36487309
Treatment of AIDS-related Kaposi's sarcoma with interleukin-12: rationale and preliminary evidence of clinical activityQ37058091
The Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor: Lessons on dysregulated angiogenesis from a viral oncogeneQ37070142
Metabolic pathway alterations that support cell proliferation.Q37977398
Rocking cell metabolism: revised functions of the key glycolytic regulator PKM2 in cancerQ38012878
Recent advances in Kaposi sarcoma herpesvirus-associated multicentric Castleman disease.Q38021339
Pyruvate kinase M2: multiple faces for conferring benefits on cancer cells.Q38052531
The multifaceted regulation and functions of PKM2 in tumor progressionQ38234285
Kaposi's sarcoma-associated herpesvirus viral IFN regulatory factor 3 stabilizes hypoxia-inducible factor-1 alpha to induce vascular endothelial growth factor expressionQ40002571
A potential alpha-helix motif in the amino terminus of LANA encoded by Kaposi's sarcoma-associated herpesvirus is critical for nuclear accumulation of HIF-1alpha in normoxiaQ40106826
HIF-1 inhibits mitochondrial biogenesis and cellular respiration in VHL-deficient renal cell carcinoma by repression of C-MYC activityQ40136909
The TSC2/mTOR pathway drives endothelial cell transformation induced by the Kaposi's sarcoma-associated herpesvirus G protein-coupled receptorQ40244438
Hypoxia-inducible factor-1alpha and hypoxia-inducible factor-2alpha are expressed in kaposi sarcoma and modulated by insulin-like growth factor-I.Q40245270
The Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor as a therapeutic target for the treatment of Kaposi's sarcoma.Q40333151
Use of the red fluorescent protein as a marker of Kaposi's sarcoma-associated herpesvirus lytic gene expressionQ40537413
The Kaposi's sarcoma-associated herpes virus G protein-coupled receptor up-regulates vascular endothelial growth factor expression and secretion through mitogen-activated protein kinase and p38 pathways acting on hypoxia-inducible factor 1alphaQ42796220
Real‐Time Quantitative PCR Analysis of Mitochondrial DNA ContentQ54392675
Endothelial infection with KSHV genes in vivo reveals that vGPCR initiates Kaposi's sarcomagenesis and can promote the tumorigenic potential of viral latent genesQ78860218
Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1Q24304533
Understanding the Warburg effect: the metabolic requirements of cell proliferationQ24604760
HIF-1: upstream and downstream of cancer metabolismQ24647482
Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesisQ27671695
Targeting HIF-1 for cancer therapyQ27860504
Pyruvate kinase type M2 and its role in tumor growth and spreadingQ28252131
Molecular virology of Kaposi's sarcoma-associated herpesvirusQ28363323
The biology of cancer: metabolic reprogramming fuels cell growth and proliferationQ29547301
The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growthQ29547680
Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeuticsQ29615944
EC5S ubiquitin complex is recruited by KSHV latent antigen LANA for degradation of the VHL and p53 tumor suppressorsQ33261811
Amplification of the angiogenic signal through the activation of the TSC/mTOR/HIF axis by the KSHV vGPCR in Kaposi's sarcomaQ33895137
Induction of the Warburg effect by Kaposi's sarcoma herpesvirus is required for the maintenance of latently infected endothelial cellsQ33934809
Viral G protein-coupled receptor up-regulates Angiopoietin-like 4 promoting angiogenesis and vascular permeability in Kaposi's sarcomaQ34069841
Kaposi's sarcoma herpesvirus microRNAs induce metabolic transformation of infected cellsQ34257830
Regulation of mTORC1 and its impact on gene expression at a glanceQ34342717
Evidence for an alternative glycolytic pathway in rapidly proliferating cellsQ34535762
Latent Kaposi's sarcoma-associated herpesvirus infection of endothelial cells activates hypoxia-induced factorsQ35139228
Kaposi's Sarcoma-Associated Herpesvirus Latency-Associated Nuclear Antigen Induction by Hypoxia and Hypoxia-Inducible FactorsQ35665756
Quantitative Assessment of Angiogenic Responses by the Directed in Vivo Angiogenesis AssayQ35749086
Rapamycin with antiretroviral therapy in AIDS-associated Kaposi sarcoma: an AIDS Malignancy Consortium studyQ35827892
Treatment of Kaposi sarcoma-associated herpesvirus-associated cancersQ35895560
Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapyQ36220497
Emerging roles of PKM2 in cell metabolism and cancer progressionQ36303571
P433issue4
P304page(s)477-488
P577publication date2015-06-20
P1433published inAngiogenesisQ15753544
P1476titleKSHV induces aerobic glycolysis and angiogenesis through HIF-1-dependent upregulation of pyruvate kinase 2 in Kaposi's sarcoma
P478volume18

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