KSHV reactivation and novel implications of protein isomerization on lytic switch control

scientific article

KSHV reactivation and novel implications of protein isomerization on lytic switch control is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.3390/V7010072
P932PMC publication ID4306829
P698PubMed publication ID25588053
P5875ResearchGate publication ID270965872

P2093author name stringJonathan Guito
David Lukac
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Histone deacetylase classes I and II regulate Kaposi's sarcoma-associated herpesvirus reactivationQ30570559
Cellular corepressor TLE2 inhibits replication-and-transcription- activator-mediated transactivation and lytic reactivation of Kaposi's sarcoma-associated herpesvirus.Q30919397
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A comprehensive analysis of recruitment and transactivation potential of K-Rta and K-bZIP during reactivation of Kaposi's sarcoma-associated herpesvirusQ33415884
KSHV manipulates Notch signaling by DLL4 and JAG1 to alter cell cycle genes in lymphatic endotheliaQ33509506
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KSHV-induced notch components render endothelial and mural cell characteristics and cell survivalQ33627013
High-level variability in the ORF-K1 membrane protein gene at the left end of the Kaposi's sarcoma-associated herpesvirus genome defines four major virus subtypes and multiple variants or clades in different human populationsQ33647633
Kinetics of Kaposi's sarcoma-associated herpesvirus gene expressionQ33653424
The Ess1 prolyl isomerase: traffic cop of the RNA polymerase II transcription cycleQ33726010
Kaposi's sarcoma-associated herpesvirus reactivation is regulated by interaction of latency-associated nuclear antigen with recombination signal sequence-binding protein Jkappa, the major downstream effector of the Notch signaling pathwayQ33737793
Kaposi's sarcoma-associated herpesvirus open reading frame 50 represses p53-induced transcriptional activity and apoptosisQ33842738
DNA binding by Kaposi's sarcoma-associated herpesvirus lytic switch protein is necessary for transcriptional activation of two viral delayed early promotersQ33844093
CREB-binding protein and histone deacetylase regulate the transcriptional activity of Kaposi's sarcoma-associated herpesvirus open reading frame 50Q33854980
Inhibition of the phosphatidylinositol 3-kinase-Akt pathway enhances gamma-2 herpesvirus lytic replication and facilitates reactivation from latencyQ33923893
Peptidyl-prolyl isomerase Pin1 is a cellular factor required for hepatitis C virus propagationQ33934864
Loss of Pin1 function in the mouse causes phenotypes resembling cyclin D1-null phenotypesQ34009230
A viral nuclear noncoding RNA binds re-localized poly(A) binding protein and is required for late KSHV gene expressionQ34055296
Elevated PIN1 expression by C/EBPalpha-p30 blocks C/EBPalpha-induced granulocytic differentiation through c-Jun in AMLQ34072688
beta-Adrenoreceptors reactivate Kaposi's sarcoma-associated herpesvirus lytic replication via PKA-dependent control of viral RTAQ34092690
Convergence of Kaposi's Sarcoma-Associated Herpesvirus Reactivation with Epstein-Barr Virus Latency and Cellular Growth Mediated by the Notch Signaling Pathway in Coinfected CellsQ34178226
Pinning down cell signaling, cancer and Alzheimer's diseaseQ34313141
Gamma-herpesviruses and cellular signaling in AIDS-associated malignanciesQ36886330
Catalysis of protein folding by parvulinQ36889249
A mobile functional region of Kaposi's sarcoma-associated herpesvirus ORF50 protein independently regulates DNA binding and protein abundanceQ36898798
Early activation of the Kaposi's sarcoma-associated herpesvirus RTA, RAP, and MTA promoters by the tetradecanoyl phorbol acetate-induced AP1 pathway.Q37093134
Peptidylproline cis-trans-isomerase Pin1 interacts with human T-cell leukemia virus type 1 tax and modulates its activation of NF-kappaBQ37127860
Genome-wide identification of binding sites for Kaposi's sarcoma-associated herpesvirus lytic switch protein, RTA.Q37144643
NF-kappaB serves as a cellular sensor of Kaposi's sarcoma-associated herpesvirus latency and negatively regulates K-Rta by antagonizing the RBP-Jkappa coactivator.Q37157187
Pin1 promotes histone H1 dephosphorylation and stabilizes its binding to chromatinQ37233602
Polyadenylylated nuclear RNA encoded by Kaposi sarcoma-associated herpesvirusQ37273424
Immune evasion in Kaposi's sarcoma-associated herpes virus associated oncogenesisQ37307209
MicroRNAs of Kaposi's sarcoma-associated herpes virusQ37327019
Peptidyl-prolyl cis/trans isomerase Pin1 is critical for the regulation of PKB/Akt stability and activation phosphorylationQ37356550
The latency-associated nuclear antigen, a multifunctional protein central to Kaposi's sarcoma-associated herpesvirus latencyQ37380228
Modulation of the immune system by Kaposi's sarcoma-associated herpesvirus.Q37397204
Role of ORF74-encoded viral G protein-coupled receptor in human herpesvirus 8 lytic replicationQ37452466
The prolyl isomerase pin1 regulates mRNA levels of genes with short half-lives by targeting specific RNA binding proteinsQ37458768
Posttranscriptional gene regulation in Kaposi's sarcoma-associated herpesvirusQ37475295
Epigenetic regulation of Kaposi's sarcoma-associated herpesvirus replicationQ37476243
Modeling breast cancer in vivo and ex vivo reveals an essential role of Pin1 in tumorigenesisQ37485770
KSHV Rta Promoter Specification and Viral ReactivationQ37986049
Tegument Proteins of Kaposi's Sarcoma-Associated Herpesvirus and Related Gamma-HerpesvirusesQ37995595
Kaposi sarcoma associated herpesvirus pathogenesis (KSHV)--an updateQ38114627
Cyclophilins as modulators of viral replicationQ38121470
X box binding protein XBP-1s transactivates the Kaposi's sarcoma-associated herpesvirus (KSHV) ORF50 promoter, linking plasma cell differentiation to KSHV reactivation from latencyQ38297437
Kaposi's sarcoma-associated herpesvirus glycoproteins B and K8.1 regulate virion egress and synthesis of vascular endothelial growth factor and viral interleukin-6 in BCBL-1 cellsQ38348410
Kaposi's sarcoma-associated herpesvirus K-bZIP is a coregulator of K-Rta: physical association and promoter-dependent transcriptional repression.Q38359222
Kaposi's Sarcoma-associated herpesvirus lytic switch protein stimulates DNA binding of RBP-Jk/CSL to activate the Notch pathwayQ38761166
Kaposi's sarcoma-associated herpesvirus Rta tetramers make high-affinity interactions with repetitive DNA elements in the Mta promoter to stimulate DNA binding of RBP-Jk/CSL.Q38959859
Phosphorylation of human immunodeficiency virus type 1 capsid protein at serine 16, required for peptidyl-prolyl isomerase-dependent uncoating, is mediated by virion-incorporated extracellular signal-regulated kinase 2.Q39025822
The cellular peptidyl-prolyl cis/trans isomerase Pin1 regulates reactivation of Kaposi's sarcoma-associated herpesvirus from latencyQ39068717
Pin1 interacts with the Epstein-Barr virus DNA polymerase catalytic subunit and regulates viral DNA replication.Q39230419
Pin1 modulates RNA polymerase II activity during the transcription cycleQ39258906
Negative elongation factor-mediated suppression of RNA polymerase II elongation of Kaposi's sarcoma-associated herpesvirus lytic gene expressionQ39323907
Kaposi's sarcoma-associated herpesvirus open reading frame 57 encodes a posttranscriptional regulator with multiple distinct activitiesQ39590466
Transcriptional activation by the product of open reading frame 50 of Kaposi's sarcoma-associated herpesvirus is required for lytic viral reactivation in B cellsQ39596534
Immunoreceptor tyrosine-based activation motif-dependent signaling by Kaposi's sarcoma-associated herpesvirus K1 protein: effects on lytic viral replicationQ39603164
Uncoating of human immunodeficiency virus type 1 requires prolyl isomerase Pin1.Q39696042
Characterization of interactions between RTA and the promoter of polyadenylated nuclear RNA in Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8.Q34338900
Pin1 regulates centrosome duplication, and its overexpression induces centrosome amplification, chromosome instability, and oncogenesisQ34353633
Clinicopathologic characteristics of gastric carcinoma in elderly patients: a comparison with young patientsQ34382472
Molecular mimicry of human cytokine and cytokine response pathway genes by KSHV.Q34408877
Molecular chaperones in protein quality controlQ34424856
Kaposi's sarcoma: etiology and pathogenesis, inducing factors, causal associations, and treatments: facts and controversiesQ34653644
Update on Kaposi's sarcoma and other HHV8 associated diseases. Part 1: epidemiology, environmental predispositions, clinical manifestations, and therapyQ34683604
Abortive lytic reactivation of KSHV in CBF1/CSL deficient human B cell linesQ34733560
Update on Kaposi's sarcoma and other HHV8 associated diseases. Part 2: pathogenesis, Castleman's disease, and pleural effusion lymphomaQ34764819
The HIV protease inhibitor nelfinavir inhibits Kaposi's sarcoma-associated herpesvirus replication in vitroQ35005190
Mechanisms of Kaposi's Sarcoma-Associated Herpesvirus Latency and ReactivationQ35010647
Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) contains hypoxia response elements: relevance to lytic induction by hypoxiaQ35019982
Molecular genetics of Kaposi's sarcoma-associated herpesvirus (human herpesvirus-8) epidemiology and pathogenesisQ35026060
Prevalent overexpression of prolyl isomerase Pin1 in human cancersQ35097986
Structure and function of latency-associated nuclear antigenQ35124429
Never say never. The NIMA-related protein kinases in mitotic controlQ35125628
Kaposi sarcoma-associated herpesvirus (KSHV): molecular biology and oncogenesisQ35127940
Lytic but not latent infection by Kaposi's sarcoma-associated herpesvirus requires host CSL protein, the mediator of Notch signalingQ35168476
The role of Kaposi's sarcoma-associated herpesvirus/human herpesvirus-8 regulator of transcription activation (RTA) in control of gene expressionQ35196615
Post-Translational Modifications of Kaposi's Sarcoma-Associated Herpesvirus Regulatory Proteins - SUMO and KSHVQ35755464
Ser-634 and Ser-636 of Kaposi's Sarcoma-Associated Herpesvirus RTA are Involved in Transactivation and are Potential Cdk9 Phosphorylation SitesQ35770298
KSHV-Encoded MicroRNAs: Lessons for Viral Cancer Pathogenesis and Emerging ConceptsQ35810446
Oncogenic gamma-herpesviruses: comparison of viral proteins involved in tumorigenesisQ35841060
Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8 ORF50/Rta lytic switch protein functions as a tetramerQ35857736
Cell-homologous genes in the Kaposi's sarcoma-associated rhadinovirus human herpesvirus 8: determinants of its pathogenicity?Q35885806
Kaposi's sarcoma herpesvirus-encoded latency-associated nuclear antigen stabilizes intracellular activated Notch by targeting the Sel10 proteinQ36019173
Evolution and function of CAG/polyglutamine repeats in protein-protein interaction networks.Q36044701
Suppressive regulation of KSHV RTA with O-GlcNAcylationQ36092308
Promoter- and cell-specific transcriptional transactivation by the Kaposi's sarcoma-associated herpesvirus ORF57/Mta proteinQ36315189
The unfolded protein response: a novel component of the hypoxic stress response in tumors.Q36326570
The interaction between KSHV RTA and cellular RBP-Jkappa and their subsequent DNA binding are not sufficient for activation of RBP-JkappaQ36427142
Chromatin remodeling of the Kaposi's sarcoma-associated herpesvirus ORF50 promoter correlates with reactivation from latencyQ36538689
Kaposi's sarcoma-associated herpesvirus latent gene vFLIP inhibits viral lytic replication through NF-kappaB-mediated suppression of the AP-1 pathway: a novel mechanism of virus control of latencyQ36540187
Kaposi's sarcoma-associated herpesvirus ori-Lyt-dependent DNA replication: cis-acting requirements for replication and ori-Lyt-associated RNA transcriptionQ36684599
PIN1 gene overexpression and beta-catenin gene mutation/expression in hepatocellular carcinoma and their significance.Q53335167
TPA-induced cell transformation provokes a complex formation between Pin1 and 90 kDa ribosomal protein S6 kinase 2.Q54512822
Prolyl isomerases do not catalyze isomerization of non-prolyl peptide bondsQ74490362
Pinning down transcription: regulation of RNA polymerase II activity during the cell cycleQ75320782
Reactivation of Kaposi's sarcoma-associated herpesvirus infection from latency by expression of the ORF 50 transactivator, a homolog of the EBV R proteinQ77760836
Endothelial infection with KSHV genes in vivo reveals that vGPCR initiates Kaposi's sarcomagenesis and can promote the tumorigenic potential of viral latent genesQ78860218
The KSHV immediate-early transcription factor RTA encodes ubiquitin E3 ligase activity that targets IRF7 for proteosome-mediated degradationQ81304838
Regulation of KSHV lytic switch protein expression by a virus-encoded microRNA: an evolutionary adaptation that fine-tunes lytic reactivationQ39763904
Enhancement of vascular endothelial growth factor-mediated angiogenesis in tamoxifen-resistant breast cancer cells: role of Pin1 overexpressionQ39813847
The prolyl isomerase Pin1 regulates the NF-kappaB signaling pathway and interleukin-8 expression in glioblastomaQ39814307
Kaposi sarcoma-associated herpes virus (KSHV) G protein-coupled receptor (vGPCR) activates the ORF50 lytic switch promoter: a potential positive feedback loop for sustained ORF50 gene expressionQ39819343
X-box binding protein 1 contributes to induction of the Kaposi's sarcoma-associated herpesvirus lytic cycle under hypoxic conditionsQ39858771
The lytic switch protein of KSHV activates gene expression via functional interaction with RBP-Jkappa (CSL), the target of the Notch signaling pathway.Q39860135
Kaposi's sarcoma-associated herpesvirus RTA promotes degradation of the Hey1 repressor protein through the ubiquitin proteasome pathwayQ39860632
Essential role of Pin1 in the regulation of TRF1 stability and telomere maintenanceQ39908170
Autoregulation of DNA binding and protein stability of Kaposi's sarcoma-associated herpesvirus ORF50 proteinQ39992227
Induction of vascular endothelial growth factor by peptidyl-prolyl isomerase Pin1 in breast cancer cellsQ40009835
Kaposi's sarcoma-associated herpesvirus transactivator RTA promotes degradation of the repressors to regulate viral lytic replicationQ40021229
Hypoxia and the unfolded protein response.Q40053046
Notch inhibition in Kaposi's sarcoma tumor cells leads to mitotic catastrophe through nuclear factor-kappaB signaling.Q40112910
Direct interactions of Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8 ORF50/Rta protein with the cellular protein octamer-1 and DNA are critical for specifying transactivation of a delayed-early promoter and stimulating viral reactivatiQ40126113
The transcriptional repressor K-RBP modulates RTA-mediated transactivation and lytic replication of Kaposi's sarcoma-associated herpesvirusQ40149571
Poly(ADP-Ribose) Polymerase 1 and Ste20-Like Kinase hKFC Act as Transcriptional Repressors for Gamma-2 Herpesvirus Lytic ReplicationQ40172406
Pin1 modulates the structure and function of human RNA polymerase II.Q40266169
Intracellular activated Notch1 is critical for proliferation of Kaposi's sarcoma-associated herpesvirus-associated B-lymphoma cell lines in vitroQ40267803
Intracellular-activated Notch1 can reactivate Kaposi's sarcoma-associated herpesvirus from latencyQ40279784
The Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor as a therapeutic target for the treatment of Kaposi's sarcoma.Q40333151
Stable suppression of tumorigenicity by Pin1-targeted RNA interference in prostate cancerQ40358876
Kaposi's Sarcoma-associated herpesvirus open reading frame 50 stimulates the transcriptional activity of STAT3.Q40763723
Hypoxia induces lytic replication of Kaposi sarcoma-associated herpesvirusQ40807418
Comparison of the Rta/Orf50 transactivator proteins of gamma-2-herpesviruses.Q40815022
Protein folding. Prolyl isomerases join the foldQ40935542
In vivo-restricted and reversible malignancy induced by human herpesvirus-8 KSHV: a cell and animal model of virally induced Kaposi's sarcoma.Q41839438
The zinc finger DNA-binding domain of K-RBP plays an important role in regulating Kaposi's sarcoma-associated herpesvirus RTA-mediated gene expressionQ41906267
Pinning down viral proteins: a new prototype for virus-host cell interactionQ42005266
Pin1 overexpression in colorectal cancer and its correlation with aberrant beta-catenin expressionQ42020447
Kaposi's sarcoma-associated herpesvirus latent protein LANA interacts with HIF-1 alpha to upregulate RTA expression during hypoxia: Latency control under low oxygen conditionsQ42049779
A Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8 ORF50 deletion mutant is defective for reactivation of latent virus and DNA replicationQ42150768
Inhibition of 12-O-tetradecanoylphorbol-13-acetate induction of c-fos mRNA by the protein kinase A inhibitor N-[2-(p-bromocinnamylamino)ethyl]-5-isoquinoline sulfonamideQ42809475
Critical role of WW domain phosphorylation in regulating phosphoserine binding activity and Pin1 functionQ43809033
Prevalence and determinants of anti-lytic and anti-latent antibodies to human herpesvirus-8 among Italian individuals at risk of sexually and parenterally transmitted infectionsQ43895475
The prolyl isomerase Pin1 is a regulator of p53 in genotoxic response.Q44192183
The prolyl isomerase Pin1 is a novel prognostic marker in human prostate cancer.Q44618217
The prolyl isomerase Pin1 interacts with and downregulates the activity of AMPK leading to induction of tumorigenicity of hepatocarcinoma cellsQ44785984
Hepatitis B virus x protein and pin1 in liver cancer: "les liaisons dangereuses".Q45405874
Actin-binding cellular proteins inside human immunodeficiency virus type 1.Q45745422
Modulation of host gene expression by the constitutively active G protein-coupled receptor of Kaposi's sarcoma-associated herpesvirus.Q46029178
The prolyl isomerase Pin1 interacts with a ribosomal protein S6 kinase to enhance insulin-induced AP-1 activity and cellular transformation.Q46147838
Moritz Kaposi: idiopathic pigmented sarcoma of the skinQ46168427
Gamma secretase inhibitor blocks Notch activation and induces apoptosis in Kaposi's sarcoma tumor cellsQ46531701
LANA-1, Bcl-2, Mcl-1 and HIF-1alpha protein expression in HIV-associated Kaposi sarcoma.Q47684034
P275copyright licenseCreative Commons AttributionQ6905323
P6216copyright statuscopyrightedQ50423863
P433issue1
P407language of work or nameEnglishQ1860
P921main subjecttranscription factorQ407384
regulation of gene expressionQ411391
viral proteinQ952587
virusQ808
DNA-binding proteinQ2252764
virus latencyQ4115619
enzymeQ8047
trans-activatorsQ67206335
host microbial interactionQ68260314
viral gene expression regulationQ70682269
immediate-early proteinsQ77944262
P304page(s)72-109
P577publication date2015-01-12
P1433published inVirusesQ7935305
P1476titleKSHV reactivation and novel implications of protein isomerization on lytic switch control
P478volume7

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