KSHV-Encoded MicroRNAs: Lessons for Viral Cancer Pathogenesis and Emerging Concepts

scientific article published on 19 February 2012

KSHV-Encoded MicroRNAs: Lessons for Viral Cancer Pathogenesis and Emerging Concepts is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1155/2012/603961
P932PMC publication ID3296157
P698PubMed publication ID22505930
P5875ResearchGate publication ID224050130

P50authorVictoria FindlayQ38523395
P2093author name stringChris Parsons
Zhiqiang Qin
Andrew Jakymiw
P2860cites workInvolvement of interleukin-10 (IL-10) and viral IL-6 in the spontaneous growth of Kaposi's sarcoma herpesvirus-associated infected primary effusion lymphoma cellsQ44761629
LANA-1, Bcl-2, Mcl-1 and HIF-1alpha protein expression in HIV-associated Kaposi sarcoma.Q47684034
Diverse herpesvirus microRNAs target the stress-induced immune ligand MICB to escape recognition by natural killer cellsQ47978435
KSHV sequences in biopsies and cultured spindle cells of epidemic, iatrogenic and Mediterranean forms of Kaposi's sarcomaQ58907143
Characterization of in vitro culture of HIV-negative Kaposi's sarcoma-derived cells. In vitro responses to alfa interferonQ73567575
Viral and cellular cytokines in AIDS-related malignant lymphomatous effusionsQ74171859
The manipulation of miRNA-gene regulatory networks by KSHV induces endothelial cell motilityQ84470156
MicroRNA biogenesis and cancerQ85172584
Identification of cellular genes targeted by KSHV-encoded microRNAsQ21131610
Integrin alphaVbeta3 Binds to the RGD motif of glycoprotein B of Kaposi's sarcoma-associated herpesvirus and functions as an RGD-dependent entry receptorQ24301712
The Microprocessor complex mediates the genesis of microRNAsQ24312976
Kaposi's sarcoma-associated herpesvirus expresses an array of viral microRNAs in latently infected cellsQ24555724
The microRNA miR-34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44Q24617130
Stress-dependent cardiac remodeling occurs in the absence of microRNA-21 in miceQ24623247
Local restoration of dystrophin expression with the morpholino oligomer AVI-4658 in Duchenne muscular dystrophy: a single-blind, placebo-controlled, dose-escalation, proof-of-concept studyQ24643018
Antagonism of microRNA-122 in mice by systemically administered LNA-antimiR leads to up-regulation of a large set of predicted target mRNAs in the liverQ24649633
Hypoxia-inducible mir-210 regulates normoxic gene expression involved in tumor initiation.Q24651016
A viral microRNA functions as an orthologue of cellular miR-155Q24652947
Silencing of microRNA-155 in mice during acute inflammatory response leads to derepression of c/ebp Beta and down-regulation of G-CSFQ24653834
Kaposi's sarcoma-associated herpesvirus encodes an ortholog of miR-155Q24681400
Silencing Viral MicroRNA as a Novel Antiviral Therapy?Q27488437
The functions of animal microRNAsQ27860621
Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targetsQ27860792
Silencing of microRNAs in vivo with 'antagomirs'Q27860891
Processing of primary microRNAs by the Microprocessor complexQ27860986
MicroRNAs: genomics, biogenesis, mechanism, and functionQ27861070
Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcomaQ28242984
Molecular basis for the recognition of primary microRNAs by the Drosha-DGCR8 complexQ28243956
Development of a lung cancer therapeutic based on the tumor suppressor microRNA-34Q28285980
Kaposi's sarcoma-associated herpesvirus-like DNA sequences in AIDS-related body-cavity-based lymphomasQ28299069
Upregulation of xCT by KSHV-encoded microRNAs facilitates KSHV dissemination and persistence in an environment of oxidative stressQ28472699
miR-K12-7-5p encoded by Kaposi's sarcoma-associated herpesvirus stabilizes the latent state by targeting viral ORF50/RTAQ28476790
Intracellular Kaposi's sarcoma-associated herpesvirus load determines early loss of immune synapse componentsQ28757509
Therapeutic silencing of microRNA-122 in primates with chronic hepatitis C virus infectionQ29615959
Identification of microRNAs of the herpesvirus familyQ29618671
Kaposi's sarcoma-associated herpesvirus-like DNA sequences in multicentric Castleman's diseaseQ29619158
Augmentation of tumor angiogenesis by a Myc-activated microRNA clusterQ29620726
Silencing of microRNA families by seed-targeting tiny LNAsQ36522844
CpG island hypermethylation of tumor suppressor microRNAs in human cancerQ36854202
A microRNA DNA methylation signature for human cancer metastasisQ36861111
Contribution of viral and cellular cytokines to Kaposi's sarcoma-associated herpesvirus pathogenesisQ36882284
The guardian's little helper: microRNAs in the p53 tumor suppressor networkQ37023130
The M type K15 protein of Kaposi's sarcoma-associated herpesvirus regulates microRNA expression via its SH2-binding motif to induce cell migration and invasionQ37033356
Cellular microRNA expression correlates with susceptibility of monocytes/macrophages to HIV-1 infectionQ37066263
Tumor suppressor microRNAs are underrepresented in primary effusion lymphoma and Kaposi sarcomaQ37237479
Viral and cellular messenger RNA targets of viral microRNAsQ37374202
Immunological functions of hyaluronan and its receptors in the lymphaticsQ37548667
Tandem array-based expression screens identify host mRNA targets of virus-encoded microRNAsQ38357974
Characterization of entry and infection of monocytic THP-1 cells by Kaposi's sarcoma associated herpesvirus (KSHV): role of heparan sulfate, DC-SIGN, integrins and signalingQ39673166
MicroRNA-101 negatively regulates Ezh2 and its expression is modulated by androgen receptor and HIF-1alpha/HIF-1betaQ39703169
Systematic analysis of viral and cellular microRNA targets in cells latently infected with human gamma-herpesviruses by RISC immunoprecipitation assayQ39711736
KSHV-encoded miRNAs target MAF to induce endothelial cell reprogrammingQ39751014
Regulation of KSHV lytic switch protein expression by a virus-encoded microRNA: an evolutionary adaptation that fine-tunes lytic reactivationQ39763904
Kaposi's sarcoma-associated herpesvirus gene expression in endothelial (spindle) tumor cellsQ39877852
Suppression of dendritic cell differentiation through cytokines released by Primary Effusion Lymphoma cellsQ39953809
Kaposi's sarcoma-associated herpesvirus viral IFN regulatory factor 3 stabilizes hypoxia-inducible factor-1 alpha to induce vascular endothelial growth factor expressionQ40002571
Human herpesvirus 8 infects and replicates in primary cultures of activated B lymphocytes through DC-SIGN.Q40002946
A potential alpha-helix motif in the amino terminus of LANA encoded by Kaposi's sarcoma-associated herpesvirus is critical for nuclear accumulation of HIF-1alpha in normoxiaQ40106826
Expression and function of microRNAs encoded by Kaposi's sarcoma-associated herpesvirusQ40155119
The human let-7a-3 locus contains an epigenetically regulated microRNA gene with oncogenic function.Q40169748
Conservation of virally encoded microRNAs in Kaposi sarcoma--associated herpesvirus in primary effusion lymphoma cell lines and in patients with Kaposi sarcoma or multicentric Castleman diseaseQ40177470
DC-SIGN is a receptor for human herpesvirus 8 on dendritic cells and macrophagesQ40327365
Inefficient establishment of KSHV latency suggests an additional role for continued lytic replication in Kaposi sarcoma pathogenesis.Q40364647
Integrin alpha3beta1 (CD 49c/29) is a cellular receptor for Kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8) entry into the target cellsQ40749885
Kaposi's sarcoma-associated herpesvirus latent protein LANA interacts with HIF-1 alpha to upregulate RTA expression during hypoxia: Latency control under low oxygen conditionsQ42049779
Prediction of human targets for viral-encoded microRNAs by thermodynamics and empirical constraintsQ42121608
The magic and mystery of miR-21Q42396388
Mono/oligoclonal pattern of Kaposi Sarcoma-associated herpesvirus (KSHV/HHV-8) episomes in primary effusion lymphoma cellsQ43890736
High levels of human herpesvirus 8 viral load, human interleukin-6, interleukin-10, and C reactive protein correlate with exacerbation of multicentric castleman disease in HIV-infected patients.Q44424254
Cooperative roles for emmprin and LYVE-1 in the regulation of chemoresistance for primary effusion lymphomaQ30418735
Antagomir-17-5p abolishes the growth of therapy-resistant neuroblastoma through p21 and BIMQ33336561
Pre-micro RNA signatures delineate stages of endothelial cell transformation in Kaposi sarcoma.Q33432690
In-depth analysis of Kaposi's sarcoma-associated herpesvirus microRNA expression provides insights into the mammalian microRNA-processing machineryQ33558454
Pivotal advance: Kaposi's sarcoma-associated herpesvirus (KSHV)-encoded microRNA specifically induce IL-6 and IL-10 secretion by macrophages and monocytesQ33571183
Regulation of NF-kappaB inhibitor IkappaBalpha and viral replication by a KSHV microRNAQ33625562
Kaposi's sarcoma-associated herpesvirus-encoded viral FLICE inhibitory protein (vFLIP) K13 suppresses CXCR4 expression by upregulating miR-146aQ33753956
Therapeutic silencing of miR-10b inhibits metastasis in a mouse mammary tumor modelQ33780722
A human herpesvirus microRNA inhibits p21 expression and attenuates p21-mediated cell cycle arrestQ33826818
Cloning and identification of a microRNA cluster within the latency-associated region of Kaposi's sarcoma-associated herpesvirusQ33883910
Morpholino antisense oligomers: the case for an RNase H-independent structural typeQ33901587
Comprehensive analysis of human microRNA target networksQ33935461
Computational prediction of intronic microRNA targets using host gene expression reveals novel regulatory mechanismsQ33939100
Morpholinos and their peptide conjugates: therapeutic promise and challenge for Duchenne muscular dystrophyQ34021322
Epigenetic regulation of Kaposi's sarcoma-associated herpesvirus latency by virus-encoded microRNAs that target Rta and the cellular Rbl2-DNMT pathwayQ34092628
Kaposi sarcoma (KS)-associated herpesvirus microRNA sequence analysis and KS risk in a European AIDS-KS case control study.Q34101588
miR-132 regulates antiviral innate immunity through suppression of the p300 transcriptional co-activator.Q34112056
MicroRNAs encoded by Kaposi's sarcoma-associated herpesvirus regulate viral life cycle.Q34166899
Regulation of tumor necrosis factor-like weak inducer of apoptosis receptor protein (TWEAKR) expression by Kaposi's sarcoma-associated herpesvirus microRNA prevents TWEAK-induced apoptosis and inflammatory cytokine expressionQ34291063
Transcriptional regulation of mammalian miRNA genesQ34482425
Kaposi's sarcoma-associated herpesvirus fusion-entry receptor: cystine transporter xCT.Q34507156
A combined computational and microarray-based approach identifies novel microRNAs encoded by human gamma-herpesvirusesQ34547697
A novel assay for viral microRNA function identifies a single nucleotide polymorphism that affects Drosha processingQ34648273
Target protectors reveal dampening and balancing of Nodal agonist and antagonist by miR-430.Q34673364
Kaposi's sarcoma-associated herpesvirus ORF57 promotes escape of viral and human interleukin-6 from microRNA-mediated suppressionQ34742851
Inhibition of anti-HIV microRNA expression: a mechanism for opioid-mediated enhancement of HIV infection of monocytesQ34756351
miR-145 participates with TP53 in a death-promoting regulatory loop and targets estrogen receptor-alpha in human breast cancer cellsQ35001206
Retinoic acid-inducible gene I-inducible miR-23b inhibits infections by minor group rhinoviruses through down-regulation of the very low density lipoprotein receptorQ35111113
A Kaposi's sarcoma-associated herpesvirus-encoded ortholog of microRNA miR-155 induces human splenic B-cell expansion in NOD/LtSz-scid IL2Rγnull miceQ35382266
Silencing of microRNA-21 in vivo ameliorates autoimmune splenomegaly in lupus miceQ35673271
A human herpesvirus miRNA attenuates interferon signaling and contributes to maintenance of viral latency by targeting IKKε.Q35885525
Evidence for multiclonality in multicentric Kaposi's sarcomaQ36173459
The pleiotropic effects of Kaposi's sarcoma herpesvirusQ36346099
Kaposi's sarcoma and its associated herpesvirusQ36487309
P275copyright licenseCreative Commons Attribution 3.0 UnportedQ14947546
P6216copyright statuscopyrightedQ50423863
P921main subjectmicroRNAQ310899
P304page(s)603961
P577publication date2012-02-19
P1433published inInternational Journal of Cell BiologyQ26842205
P1476titleKSHV-Encoded MicroRNAs: Lessons for Viral Cancer Pathogenesis and Emerging Concepts
P478volume2012

Reverse relations

cites work (P2860)
Q30152630A viral microRNA downregulates metastasis suppressor CD82 and induces cell invasion and angiogenesis by activating the c-Met signaling
Q37671291Andrographolide suppresses RANKL-induced osteoclastogenesis in vitro and prevents inflammatory bone loss in vivo.
Q35237492Chromatinization of the KSHV Genome During the KSHV Life Cycle
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Q38108700The chromatin landscape of Kaposi's sarcoma-associated herpesvirus
Q37593352Viral microRNAs Target a Gene Network, Inhibit STAT Activation, and Suppress Interferon Responses

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