Hepatitis B virus X protein enhances transcriptional activity of hypoxia-inducible factor-1alpha through activation of mitogen-activated protein kinase pathway

scientific article

Hepatitis B virus X protein enhances transcriptional activity of hypoxia-inducible factor-1alpha through activation of mitogen-activated protein kinase pathway is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1074/JBC.M305101200
P698PubMed publication ID12855680

P50authorJe Kyung SeongQ90612417
P2093author name stringHyunsung Park
Mi-Ock Lee
Young-Gun Yoo
Eun Sook Park
Dae Kyong Kim
Dae-Yeul Yu
Hyeseong Cho
Seung Hyun Oh
Naery Lee
P2860cites workGene transfer of antisense hypoxia inducible factor-1 alpha enhances the therapeutic efficacy of cancer immunotherapyQ43587138
The hepatitis B virus X protein (HBx) induces a migratory phenotype in a CD44-dependent manner: possible role of HBx in invasion and metastasis.Q43601225
NF-kappaB activation by hepatitis B virus X (HBx) protein shifts the cellular fate toward survival.Q44053478
Hepatitis B virus X protein induced expression of interleukin 18 (IL-18): a potential mechanism for liver injury caused by hepatitis B virus (HBV) infectionQ45731369
Human hepatitis B virus X protein is a possible mediator of hypoxia-induced angiogenesis in hepatocarcinogenesisQ45744352
The molecular basis of the hypoxia response pathway: tumour hypoxia as a therapy targetQ45889563
Insulin-like growth factor II (IGF-II) secreted from HepG2 human hepatocellular carcinoma cells shows angiogenic activityQ47886447
Transcriptional regulation of the rat vascular endothelial growth factor gene by hypoxiaQ48072985
p42/p44 mitogen-activated protein kinases phosphorylate hypoxia-inducible factor 1alpha (HIF-1alpha) and enhance the transcriptional activity of HIF-1.Q52173333
Oncogenes and tumor angiogenesis: the HPV-16 E6 oncoprotein activates the vascular endothelial growth factor (VEGF) gene promoter in a p53 independent mannerQ62566479
Increased proliferation activities of vascular endothelial cells and tumour cells in residual hepatocellular carcinoma following transcatheter arterial embolizationQ73511024
Regulation of the hypoxia-inducible transcription factor 1alpha by the ubiquitin-proteasome pathwayQ74485172
FIH-1: a novel protein that interacts with HIF-1α and VHL to mediate repression of HIF-1 transcriptional activityQ24291819
FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factorQ24300161
Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1Q24316075
Molecular mechanisms of transcription activation by HLF and HIF1alpha in response to hypoxia: their stabilization and redox signal-induced interaction with CBP/p300.Q24534053
Mechanism of regulation of the hypoxia-inducible factor-1 alpha by the von Hippel-Lindau tumor suppressor proteinQ24599442
Activation of HIF1alpha ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complexQ24655274
Regulation of hypoxia-inducible factor 1α is mediated by an O 2 -dependent degradation domain via the ubiquitin-proteasome pathwayQ24672316
A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1alpha regulates the VEGF expression and is potentially involved in lung and vascular developmentQ24681396
VHL mutations and their correlation with tumour cell proliferation, microvessel density, and patient prognosis in clear cell renal cell carcinomaQ27824781
Structural and functional characterization of interaction between hepatitis B virus X protein and the proteasome complexQ28140767
Binding and regulation of HIF-1alpha by a subunit of the proteasome complex, PSMA7Q28199261
Angiogenesis in cancer, vascular, rheumatoid and other diseaseQ29547165
Hypoxia inducible factor-alpha binding and ubiquitylation by the von Hippel-Lindau tumor suppressor proteinQ29615931
Hypoxia modulated gene expression: angiogenesis, metastasis and therapeutic exploitationQ34013802
Hepatitis B virus X protein induced expression of the Nur77 gene.Q34100896
X protein of hepatitis B virus modulates cytokine and growth factor related signal transduction pathways during the course of viral infections and hepatocarcinogenesisQ34234112
Hypoxia-inducible factor 1: oxygen homeostasis and disease pathophysiologyQ34343405
Transcription. Oxygen sensing gets a second windQ34520727
Vascular endothelial growth factor: its prognostic, predictive, and therapeutic implicationsQ34569994
Hepatitis B virus X protein inhibits p53 sequence-specific DNA binding, transcriptional activity, and association with transcription factor ERCC3Q35101216
Fas/Fas ligand interaction in human colorectal hepatic metastases: A mechanism of hepatocyte destruction to facilitate local tumor invasionQ35786307
Nonhypoxic pathway mediates the induction of hypoxia-inducible factor 1alpha in vascular smooth muscle cellsQ38311709
Incidence of hepatocellular carcinoma in transgenic mice expressing the hepatitis B virus X-proteinQ38527672
Enhanced expression of vascular endothelial growth factor (VEGF) plays a critical role in the tumor progression potential induced by simian virus 40 large T antigenQ40735845
Effect of the hepatitis B virus HBx protein on integrin-mediated adhesion to and migration on extracellular matrixQ40810028
Chemotherapeutic drug, adriamycin, restores the function of p53 protein in hepatitis B virus X (HBx) protein-expressing liver cellsQ40844117
ERK activation upon hypoxia: involvement in HIF-1 activationQ40898952
Hepatitis B virus-induced hepatocellular carcinoma: possible roles for HBx.Q41129969
Signal transduction in hypoxic cells: inducible nuclear translocation and recruitment of the CBP/p300 coactivator by the hypoxia-inducible factor-1alphaQ41843388
Insulin induces transcription of target genes through the hypoxia-inducible factor HIF-1alpha /ARNTQ41954036
Sp1 recognition sites in the proximal promoter of the human vascular endothelial growth factor gene are essential for platelet-derived growth factor-induced gene expressionQ42443053
P433issue40
P407language of work or nameEnglishQ1860
P921main subjecthepatitis BQ6853
Hepatitis B virusQ6844
hypoxiaQ105688
P304page(s)39076-39084
P577publication date2003-07-10
P1433published inJournal of Biological ChemistryQ867727
P1476titleHepatitis B virus X protein enhances transcriptional activity of hypoxia-inducible factor-1alpha through activation of mitogen-activated protein kinase pathway
P478volume278

Reverse relations

cites work (P2860)
Q402006146-Mercaptopurine, an activator of Nur77, enhances transcriptional activity of HIF-1alpha resulting in new vessel formation
Q37049417A mechanism for induction of a hypoxic response by vaccinia virus
Q37068909A novel mutant 10Ala/Arg together with mutant 144Ser/Arg of hepatitis B virus X protein involved in hepatitis B virus-related hepatocarcinogenesis in HepG2 cell lines
Q24304579Akt augments the oncogenic potential of the HBx protein of hepatitis B virus by phosphorylation
Q39547638Aryl hydrocarbon receptor nuclear translocator is associated with tumor growth and progression of hepatocellular carcinoma
Q36084511Bioinformatics Analysis Reveals Distinct Molecular Characteristics of Hepatitis B-Related Hepatocellular Carcinomas from Very Early to Advanced Barcelona Clinic Liver Cancer Stages
Q90625299Deficiency of HIF-1α enhances influenza A virus replication by promoting autophagy in alveolar type II epithelial cells
Q26766311Dendritic Cells under Hypoxia: How Oxygen Shortage Affects the Linkage between Innate and Adaptive Immunity
Q92444036Determination of liver fibrosis stages in Egyptian chronic hepatitis B patients by a noninvasive tool
Q39646942Development of an oncolytic herpes simplex virus using a tumor-specific HIF-responsive promoter
Q38961911Dissecting the pleiotropic actions of HBx mutants against hypoxia in hepatocellular carcinoma.
Q39751672Down-regulation of HIF-1alpha by oncolytic reovirus infection independently of VHL and p53.
Q85661812Effects of hepatitis B virus X protein on chronic hepatitis B pathophysiology
Q36415128Epigenetic control of metastasis-associated protein 1 gene expression by hepatitis B virus X protein during hepatocarcinogenesis.
Q34856882Functional implications of mitochondrial reactive oxygen species generated by oncogenic viruses
Q37594352HBx mutants differentially affect the activation of hypoxia-inducible factor-1α in hepatocellular carcinoma.
Q35137138HIF transcription factors, inflammation, and immunity
Q34359262Hepatitis B Virus X Protein Upregulates mTOR Signaling through IKKβ to Increase Cell Proliferation and VEGF Production in Hepatocellular Carcinoma
Q38690987Hepatitis B Virus X and Regulation of Viral Gene Expression
Q45325992Hepatitis B Virus-Associated Hepatocellular Carcinoma
Q39556322Hepatitis B and C virus infections as possible risk factor for pancreatic adenocarcinoma
Q40574198Hepatitis B virus (HBV) X protein-mediated regulation of hepatocyte metabolic pathways affects viral replication
Q34666783Hepatitis B virus X protein and the estrogen receptor variant lacking exon 5 inhibit estrogen receptor signaling in hepatoma cells
Q37596738Hepatitis B virus X protein in liver tumor microenvironment
Q34324015Hepatitis B virus X protein induces expression of Fas ligand gene through enhancing transcriptional activity of early growth response factor
Q35828537Hepatitis B virus X protein induces expression of alpha-fetoprotein and activates PI3K/mTOR signaling pathway in liver cells.
Q45397229Hepatitis B virus X protein induces the expression of MTA1 and HDAC1, which enhances hypoxia signaling in hepatocellular carcinoma cells
Q37621008Hepatitis B virus X protein molecular functions and its role in virus life cycle and pathogenesis
Q40399517Hepatitis B virus X protein represses E-cadherin expression via activation of DNA methyltransferase 1.
Q21245106Hepatitis B virus X protein upregulates HSP90alpha expression via activation of c-Myc in human hepatocarcinoma cell line, HepG2
Q35222133Hepatitis B virus promotes angiopoietin-2 expression in liver tissue: role of HBV x protein
Q36349941Hepatitis B virus stimulates G6PD expression through HBx-mediated Nrf2 activation
Q36519025Hepatitis B virus-related hepatocellular carcinoma: paradigms for viral-related human carcinogenesis
Q27481487Hepatitis C Virus Stabilizes Hypoxia-Inducible Factor 1 and Stimulates the Synthesis of Vascular Endothelial Growth Factor
Q27490543Hepatitis C Virus-Linked Mitochondrial Dysfunction Promotes Hypoxia-Inducible Factor 1 -Mediated Glycolytic Adaptation
Q55211469Hepatitis transactivator protein X promotes extracellular matrix modification through HIF/LOX pathway in liver cancer.
Q39414795Human cytomegalovirus encoded chemokine receptor US28 activates the HIF-1α/PKM2 axis in glioblastoma cells.
Q37711147Human viral oncogenesis: a cancer hallmarks analysis
Q37009862Hypoxia inducible factor (HIF) function in innate immunity and infection
Q33796549Hypoxia inducible factor-1 alpha activation of the JCV promoter: role in the pathogenesis of progressive multifocal leukoencephalopathy
Q34726144Hypoxia-Inducible Factor (HIF) as a Pharmacological Target for Prevention and Treatment of Infectious Diseases
Q27001095Hypoxia-inducible factor 1 and its role in viral carcinogenesis
Q39819002Hypoxia-inducible factor-1alpha suppresses the expression of macrophage scavenger receptor 1.
Q26752304Hypoxia-inducible factors as molecular targets for liver diseases
Q98665122Hypoxic gene expression in chronic hepatitis B virus infected patients is not observed in state-of-the-art in vitro and mouse infection models
Q39905546Id-1 activates Akt-mediated Wnt signaling and p27(Kip1) phosphorylation through PTEN inhibition
Q39136677Identification of daidzein as a ligand of retinoic acid receptor that suppresses expression of matrix metalloproteinase-9 in HaCaT cells
Q43508020Impact of the hepatitis B virus genotype and genotype mixtures on the course of liver disease in Vietnam
Q54597465Interaction of the human cytomegalovirus particle with the host cell induces hypoxia-inducible factor 1 alpha
Q37586121Interdependence of hypoxic and innate immune responses
Q47606249Interplay Between Microenvironmental Abnormalities and Infectious Agents in Tumorigenesis
Q40495935Involvement of extracellular signal-regulated kinase/mitogen-activated protein kinase pathway in multidrug resistance induced by HBx in hepatoma cell line
Q59808085Krüppel-like factor 8 regulates VEGFA expression and angiogenesis in hepatocellular carcinoma
Q39902213Liver X receptor mediates hepatitis B virus X protein-induced lipogenesis in hepatitis B virus-associated hepatocellular carcinoma
Q44039622MAPK/ERK and Wnt/β-Catenin pathways are synergistically involved in proliferation of Sca-1 positive hepatic progenitor cells
Q24306316Metastasis-associated protein 1 enhances stability of hypoxia-inducible factor-1alpha protein by recruiting histone deacetylase 1.
Q36226733Mitochondria as functional targets of proteins coded by human tumor viruses
Q36432730Modulation of Apoptotic Signaling by the Hepatitis B Virus X Protein
Q83235743Modulation of p53 by mitogen-activated protein kinase pathways and protein kinase C delta during avian reovirus S1133-induced apoptosis
Q37105814Non-chromatographic Method for the Hepatitis B Virus X Protein Using Elastin-Like Polypeptide Fusion Protein
Q40512348Novel function of orphan nuclear receptor Nur77 in stabilizing hypoxia-inducible factor-1alpha
Q38768252Nuclear translocation of HIF-1α induced by influenza A (H1N1) infection is critical to the production of proinflammatory cytokines
Q38121335Oxygen tension level and human viral infections.
Q28284012Pathogenic mechanisms in HBV- and HCV-associated hepatocellular carcinoma
Q40394559Possible mechanism for hepatitis B virus X gene to induce apoptosis of hepatocytes
Q27014079Potential mechanisms of hepatitis B virus induced liver injury
Q40003436Progressive changes in hepatoma cells stably transfected with hepatitis B virus X gene
Q34769837Regulation of gene expression in HBV- and HCV-related hepatocellular carcinoma: integrated GWRS and GWGS analyses
Q40198005Risk of Onset of Hematological Malignancies in Patients Infected with the Hepatitis B Virus: Results from a Large-Scale Retrospective Cohort Study in China
Q39396910Scutellaria barbata inhibits angiogenesis through downregulation of HIF-1 α in lung tumor.
Q92565591Stabilization of E2-EPF UCP protein is implicated in hepatitis B virus-associated hepatocellular carcinoma progression
Q61811187Systemically Administered Reovirus-Induced Downregulation of Hypoxia Inducible Factor-1α in Subcutaneous Tumors
Q40495822The carboxy-terminus of the hepatitis B virus X protein is necessary and sufficient for the activation of hypoxia-inducible factor-1alpha
Q38246712The direct and indirect roles of HBV in liver cancer: prospective markers for HCC screening and potential therapeutic targets.
Q41684662The hepatitis B virus (HBV) HBx protein activates AKT to simultaneously regulate HBV replication and hepatocyte survival
Q37900925The molecular and pathophysiological implications of hepatitis B X antigen in chronic hepatitis B virus infection
Q33523861The role of NF-kappaB in Hepatitis b virus X protein-mediated upregulation of VEGF and MMPs
Q35081469The roles of hepatitis B virus-encoded X protein in virus replication and the pathogenesis of chronic liver disease
Q38131006The signaling pathway of hypoxia inducible factor and its role in renal diseases
Q24324150Transcriptional activation of hypoxia-inducible factor-1alpha by HDAC4 and HDAC5 involves differential recruitment of p300 and FIH-1
Q33552832Transformation of human liver L-O2 cells mediated by stable HBx transfection
Q40020501Up-regulation of Murid herpesvirus 4 ORF50 by hypoxia: possible implication for virus reactivation from latency.
Q55618701VEGF Upregulation in Viral Infections and Its Possible Therapeutic Implications.
Q37871527Viruses as key regulators of angiogenesis

Search more.