Hepatitis B virus X protein represses E-cadherin expression via activation of DNA methyltransferase 1.

scientific article published on October 2005

Hepatitis B virus X protein represses E-cadherin expression via activation of DNA methyltransferase 1. is …
instance of (P31):
scholarly articleQ13442814

External links are
P6179Dimensions Publication ID1034663146
P356DOI10.1038/SJ.ONC.1208827
P698PubMed publication ID16007161
P5875ResearchGate publication ID7737710

P50authorHyun Jin KwunQ54023425
P2093author name stringDo Sik Min
Kyung Hee Choi
Kyung Lib Jang
Jung-Ok Lee
Jin Kyu Jung
P2860cites workHepatitis B virus X gene variability in French-born patients with chronic hepatitis and hepatocellular carcinomaQ45740490
Hepatitis B virus X protein inhibits transforming growth factor-beta -induced apoptosis through the activation of phosphatidylinositol 3-kinase pathwayQ45742150
High prevalence of 1762(T) 1764(A) mutations in the basic core promoter of hepatitis B virus isolated from black Africans with hepatocellular carcinoma compared with asymptomatic carriers.Q45751000
Hepatitis B virus genomic sequence in the circulation of hepatocellular carcinoma patients: comparative analysis of 40 full-length isolatesQ45751517
Hot-spot mutations in hepatitis B virus X gene in hepatocellular carcinomaQ45768755
HBx gene of hepatitis B virus induces liver cancer in transgenic miceQ45852802
Functional interplay between p53 and E2F through co-activator p300Q47886777
Transcriptional regulation of the human DNA Methyltransferase (dnmt1) geneQ73559076
Altered expression of E-cadherin in hepatocellular carcinoma: correlations with genetic alterations, beta-catenin expression, and clinical featuresQ74669751
E-cadherin/catenin complex in benign and malignant melanocytic lesionsQ77343999
Methylation-specific PCR: a novel PCR assay for methylation status of CpG islandsQ24631957
The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expressionQ28595042
Natural variants of hepatitis B virus X protein have differential effects on the expression of cyclin-dependent kinase inhibitor p21 geneQ33833014
CpG methylation is maintained in human cancer cells lacking DNMT1.Q33901029
Silencing of the E-cadherin invasion-suppressor gene by CpG methylation in human carcinomasQ34053843
The Epstein-Barr virus oncogene product, latent membrane protein 1, induces the downregulation of E-cadherin gene expression via activation of DNA methyltransferasesQ34099074
Cell adhesion system and human cancer morphogenesisQ34211371
X protein of hepatitis B virus modulates cytokine and growth factor related signal transduction pathways during the course of viral infections and hepatocarcinogenesisQ34234112
Hepatitis B virus X protein inhibits p53 sequence-specific DNA binding, transcriptional activity, and association with transcription factor ERCC3Q35101216
Molecular viral oncology of hepatocellular carcinomaQ35196596
Cadherins as Modulators of Cellular PhenotypeQ35564806
Inactivation of the E-Cadherin-Mediated Cell Adhesion System in Human CancersQ35753235
Hepatitis B virus HBx protein induces transcription factor AP-1 by activation of extracellular signal-regulated and c-Jun N-terminal mitogen-activated protein kinasesQ35865743
Cadherin-mediated cell-cell adhesion and tissue segregation in relation to malignancyQ35878884
Hepatocellular carcinoma: role of hepatitis B and hepatitis C viruses proteins in hepatocarcinogenesisQ35882733
Induction of polarized cell-cell association and retardation of growth by activation of the E-cadherin-catenin adhesion system in a dispersed carcinoma lineQ36234689
The Rous sarcoma virus long terminal repeat is a strong promoter when introduced into a variety of eukaryotic cells by DNA-mediated transfectionQ36320006
Covalent bond formation between a DNA-cytosine methyltransferase and DNA containing 5-azacytosineQ37576837
Novel and therapeutic effect of caffeic acid and caffeic acid phenyl ester on hepatocarcinoma cells: complete regression of hepatoma growth and metastasis by dual mechanismQ38516002
The hepatitis B virus X protein promotes tumor cell invasion by inducing membrane-type matrix metalloproteinase-1 and cyclooxygenase-2 expressionQ39740159
Loss of E-cadherin-dependent cell-cell adhesion due to mutation of the beta-catenin gene in a human cancer cell line, HSC-39Q40015710
Evaluation of nuclear factor-kappaB, urokinase-type plasminogen activator, and HBx and their clinicopathological significance in hepatocellular carcinomaQ40541663
Alterations in cadherin and catenin expression during the biological progression of melanocytic tumoursQ40794777
The hepatitis B virus HBx protein induces adherens junction disruption in a src-dependent manner.Q40796694
Effect of the hepatitis B virus HBx protein on integrin-mediated adhesion to and migration on extracellular matrixQ40810028
Hepatitis B virus X protein inhibits nucleotide excision repairQ40967417
The hepatitis B virus X gene potentiates c-myc-induced liver oncogenesis in transgenic miceQ42651224
E-cadherin-mediated cell-cell adhesion prevents invasiveness of human carcinoma cellsQ43107815
The hepatitis B virus X protein (HBx) induces a migratory phenotype in a CD44-dependent manner: possible role of HBx in invasion and metastasis.Q43601225
Hepatitis B virus X protein enhances transcriptional activity of hypoxia-inducible factor-1alpha through activation of mitogen-activated protein kinase pathwayQ44509761
P433issue44
P407language of work or nameEnglishQ1860
P921main subjectHepatitis B virusQ6844
hepatitis BQ6853
P304page(s)6617-6625
P577publication date2005-10-01
P1433published inOncogeneQ1568657
P1476titleHepatitis B virus X protein represses E-cadherin expression via activation of DNA methyltransferase 1.
P478volume24

Reverse relations

cites work (P2860)
Q84839083All-trans retinoic acid activates E-cadherin expression via promoter hypomethylation in the human colon carcinoma HCT116 cells
Q43952154Association of p16INK4A hypermethylation with hepatitis B virus X protein expression in the early stage of HBV-associated hepatocarcinogenesis
Q59358229Cancer Progression Goes Viral: The Role of Oncoviruses in Aggressiveness of Malignancies
Q37688204Carboxyl-terminal truncated HBx contributes to invasion and metastasis via deregulating metastasis suppressors in hepatocellular carcinoma
Q40199783Chimeric DNA methyltransferases target DNA methylation to specific DNA sequences and repress expression of target genes.
Q36557635Chronic hepatitis B in hepatocarcinogenesis
Q38463886Comparative study of the different activities of hepatitis B virus whole-X protein and HBx in hepatocarcinogenesis by proteomics and bioinformatics analysis
Q64110985Control of viral infections by epigenetic-targeted therapy
Q24296626DDX3, a DEAD box RNA helicase, is deregulated in hepatitis virus-associated hepatocellular carcinoma and is involved in cell growth control
Q50042001DNA Tumor Virus Regulation of Host DNA Methylation and Its Implications for Immune Evasion and Oncogenesis
Q39116979DNA methyltransferase inhibitor assay system based on the HBx-induced DNA methylation of E-cadherin
Q39688414Down-regulated microRNA-152 induces aberrant DNA methylation in hepatitis B virus-related hepatocellular carcinoma by targeting DNA methyltransferase 1.
Q44661351E-cadherin can be expressed by a small population of rat undifferentiated spermatogonia in vivo and in vitro
Q35665775Epigenetic Changes Mediated by MicroRNA miR29 Activate Cyclooxygenase 2 and Lambda-1 Interferon Production during Viral Infection
Q38692795Epigenetic Pathways of Oncogenic Viruses: Therapeutic Promises
Q90312408Epigenetic Regulation of Innate Immunity by microRNAs
Q36415128Epigenetic control of metastasis-associated protein 1 gene expression by hepatitis B virus X protein during hepatocarcinogenesis.
Q36411144Epigenetic instability and chromosomal instability in hepatocellular carcinoma
Q43492270Epigenetic instability is rare in fibrolamellar carcinomas but common in viral-associated hepatocellular carcinomas
Q37834897Epigenetic modulation of host: new insights into immune evasion by viruses
Q34092628Epigenetic regulation of Kaposi's sarcoma-associated herpesvirus latency by virus-encoded microRNAs that target Rta and the cellular Rbl2-DNMT pathway
Q33829192Epigenetic repression of E-cadherin by human papillomavirus 16 E7 protein
Q35243806Epigenetic repression of E-cadherin expression by hepatitis B virus x antigen in liver cancer.
Q37781197Epigenetic reprogramming of host genes in viral and microbial pathogenesis
Q30157007Epigenetic silence of ankyrin-repeat-containing, SH3-domain-containing, and proline-rich-region- containing protein 1 (ASPP1) and ASPP2 genes promotes tumor growth in hepatitis B virus-positive hepatocellular carcinoma
Q35793851Epigenetic silencing of BCL6B inactivates p53 signaling and causes human hepatocellular carcinoma cell resist to 5-FU.
Q35933706Epigenome-Microbiome crosstalk: A potential new paradigm influencing neonatal susceptibility to disease
Q40365783Farnesoid X receptor ablation sensitizes mice to hepatitis b virus X protein-induced hepatocarcinogenesis.
Q91706089Genetic And Epigenetic Regulation Of E-Cadherin Signaling In Human Hepatocellular Carcinoma
Q36401985Global DNA methylation levels in white blood cells as a biomarker for hepatocellular carcinoma risk: a nested case-control study
Q41130200HBx genotype D represses GSTP1 expression and increases the oxidative level and apoptosis in HepG2 cells
Q38840132HBx triggers either cellular senescence or cell proliferation depending on cellular phenotype
Q46669089HBx-mediated miR-21 upregulation represses tumor-suppressor function of PDCD4 in hepatocellular carcinoma
Q90284131Hepatitis B Virus X Protein Stimulates Virus Replication Via DNA Methylation of the C-1619 in Covalently Closed Circular DNA
Q38690987Hepatitis B Virus X and Regulation of Viral Gene Expression
Q37776350Hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC): Molecular mechanisms and novel paradigms
Q37885837Hepatitis B virus X gene and hepatocarcinogenesis.
Q37621008Hepatitis B virus X protein molecular functions and its role in virus life cycle and pathogenesis
Q39034561Hepatitis B virus X protein promotes P3 transcript expression of the insulin-like growth factor 2 gene via inducing hypomethylation of P3 promoter in hepatocellular carcinoma
Q39283583Hepatitis B virus X protein promotes hepatoma cell invasion and metastasis by stabilizing Snail protein
Q39682076Hepatitis B virus X protein promotes hypermethylation of p16(INK4A) promoter through upregulation of DNA methyltransferases in hepatocarcinogenesis
Q34380488Hepatitis B virus X protein suppresses caveolin-1 expression in hepatocellular carcinoma by regulating DNA methylation
Q21245106Hepatitis B virus X protein upregulates HSP90alpha expression via activation of c-Myc in human hepatocarcinoma cell line, HepG2
Q38110262Hepatitis B virus X protein-induced aberrant epigenetic modifications contributing to human hepatocellular carcinoma pathogenesis
Q35643951Hepatitis B virus infection in hepatocellular carcinoma tissues upregulates expression of DNA methyltransferases
Q34157250Hepatitis B virus x protein in the pathogenesis of hepatitis B virus‐induced hepatocellular carcinoma
Q27024874Hepatitis B virus, HBx mutants and their role in hepatocellular carcinoma
Q36519025Hepatitis B virus-related hepatocellular carcinoma: paradigms for viral-related human carcinogenesis
Q37888329Hepatocellular carcinoma: the point of view of the hepatitis B virus
Q27485909Host epigenetic modifications by oncogenic viruses
Q38156891How virus persistence can initiate the tumorigenesis process
Q46344926Human tumour viruses and the deregulation of cell polarity in cancer
Q37484492Immunoregulatory functions of KLRG1 cadherin interactions are dependent on forward and reverse signaling
Q39561459Inhibition of p53 represses E-cadherin expression by increasing DNA methyltransferase-1 and promoter methylation in serous borderline ovarian tumor cells
Q35133354Kaposi's sarcoma-associated herpesvirus (KSHV) vIL-6 promotes cell proliferation and migration by upregulating DNMT1 via STAT3 activation
Q37889223Liver development and cancer formation in zebrafish.
Q84971318Methylation of the Glutathione-S-Transferase M3 Gene Promoter is Associated with Oxidative Stress in Acute-on-Chronic Hepatitis B Liver Failure
Q81763354Methylation of tumor associated genes in tissue and plasma samples from liver disease patients
Q39717541Modulation of E-cadherin expression by K-Ras; involvement of DNA methyltransferase-3b
Q39419969Modulation of Wnt signaling pathway by hepatitis B virus
Q27686923Molecular Mechanisms Underlying Occult Hepatitis B Virus Infection
Q33855801Molecular Pathogenesis of Hepatitis-B-virus-associated Hepatocellular Carcinoma
Q37295260Molecular alterations in hepatocellular carcinoma associated with hepatitis B and hepatitis C infections
Q26823512Molecular mechanism of hepatitis B virus-induced hepatocarcinogenesis
Q40593364New horizon for radical cure of chronic hepatitis B virus infection
Q36519041New therapies for hepatocellular carcinoma.
Q37636626Nuclear IKKα mediates microRNA-7/-103/107/21 inductions to downregulate maspin expression in response to HBx overexpression
Q36729107Protumor activities of the immune response: insights in the mechanisms of immunological shift, oncotraining, and oncopromotion.
Q35080754Recruitment of the de novo DNA methyltransferase Dnmt3a by Kaposi's sarcoma-associated herpesvirus LANA
Q30439948Remodeling of endothelial adherens junctions by Kaposi's sarcoma-associated herpesvirus
Q37445233Role of DNA methyltransferase 1 on the altered eNOS expression in human umbilical endothelium from intrauterine growth restricted fetuses
Q41055982Sera DNA Methylation of CDH1, DNMT3b and ESR1 Promoters as Biomarker for the Early Diagnosis of Hepatitis B Virus-Related Hepatocellular Carcinoma.
Q34632966Targeting the PI3K/Akt/mTOR pathway in hepatocellular carcinoma.
Q26771469The Epigenetic Control of Hepatitis B Virus Modulates the Outcome of Infection
Q38246712The direct and indirect roles of HBV in liver cancer: prospective markers for HCC screening and potential therapeutic targets.
Q36691070The natural history of cervical HPV infection: unresolved issues
Q39270483The regulation of proteins associated with the cytoskeleton by hepatitis B virus X protein during hepatocarcinogenesis
Q28288613The role of the hepatitis viruses in cholangiocarcinoma
Q35081469The roles of hepatitis B virus-encoded X protein in virus replication and the pathogenesis of chronic liver disease
Q38794412The unique role of the hepatitis virus B X protein on HEK 293 cell morphology and cellular change
Q37151661Towards incorporating epigenetic mechanisms into carcinogen identification and evaluation
Q33552832Transformation of human liver L-O2 cells mediated by stable HBx transfection
Q37388344Transforming growth factor-beta gene expression signature in mouse hepatocytes predicts clinical outcome in human cancer
Q53589780Up-regulation of cyclin D1 by HBx is mediated by NF-kappaB2/BCL3 complex through kappaB site of cyclin D1 promoter
Q36557254Up-regulation of human cervical cancer proto-oncogene contributes to hepatitis B virus-induced malignant transformation of hepatocyte by down-regulating E-cadherin
Q59349302Upsetting the Balance: When Viruses Manipulate Cell Polarity Control
Q51891134Uropathogenic E. coli infection provokes epigenetic downregulation of CDKN2A (p16INK4A) in uroepithelial cells
Q38643087Wild type HBx and truncated HBx: Pleiotropic regulators driving sequential genetic and epigenetic steps of hepatocarcinogenesis and progression of HBV-associated neoplasms
Q83879251[Methylation and other new concepts for the origin of hepatocellular carcinoma]

Search more.