SUMOylation of the Hyperpolarization-Activated Cyclic Nucleotide-Gated Channel 2 Increases Surface Expression and the Maximal Conductance of the Hyperpolarization-Activated Current

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SUMOylation of the Hyperpolarization-Activated Cyclic Nucleotide-Gated Channel 2 Increases Surface Expression and the Maximal Conductance of the Hyperpolarization-Activated Current is …
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scholarly articleQ13442814

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P356DOI10.3389/FNMOL.2016.00168
P932PMC publication ID5226956
P698PubMed publication ID28127275

P2093author name stringDeborah J Baro
Lori A Forster
Meghyn A Welch
Anna R Parker
Janhavi A Dubhashi
Sarah M Tasneem
P2860cites workSUMO-specific protease 1 is essential for stabilization of HIF1alpha during hypoxiaQ24299542
SUMOylation regulates Kv2.1 and modulates pancreatic beta-cell excitabilityQ24311712
Identification of the structural and functional human homolog of the yeast ubiquitin conjugating enzyme UBC9Q24546896
Dual modification of BMAL1 by SUMO2/3 and ubiquitin promotes circadian activation of the CLOCK/BMAL1 complexQ24646355
SUMOylation: Novel Neuroprotective Approach for Alzheimer's Disease?Q26783370
Function and regulation of SUMO proteasesQ26991707
Cortical HCN channels: function, trafficking and plasticityQ27027165
Hyper-SUMOylation of the Kv7 potassium channel diminishes the M-current leading to seizures and sudden deathQ27306560
Structural basis for modulation and agonist specificity of HCN pacemaker channelsQ27642009
Sumoylation: a regulatory protein modification in health and diseaseQ27865267
Different roles for the cyclic nucleotide binding domain and amino terminus in assembly and expression of hyperpolarization-activated, cyclic nucleotide-gated channelsQ28201116
Role of subunit heteromerization and N-linked glycosylation in the formation of functional hyperpolarization-activated cyclic nucleotide-gated channelsQ28202686
Identification of the cyclic-nucleotide-binding domain as a conserved determinant of ion-channel cell-surface localizationQ28257065
Ubch9 conjugates SUMO but not ubiquitinQ28257546
Covalent modification of PML by the sentrin family of ubiquitin-like proteinsQ28260723
Characterization of a second member of the sentrin family of ubiquitin-like proteinsQ28268631
Modification in reverse: the SUMO proteasesQ28302162
Regulation of hyperpolarization-activated HCN channel gating and cAMP modulation due to interactions of COOH terminus and core transmembrane regionsQ28346769
Activity-dependent heteromerization of the hyperpolarization-activated, cyclic-nucleotide gated (HCN) channels: role of N-linked glycosylationQ28564899
Hyperpolarization-activated, cyclic nucleotide-gated HCN2 cation channel forms a protein assembly with multiple neuronal scaffold proteins in distinct modes of protein-protein interactionQ28569156
Trafficking and surface expression of hyperpolarization-activated cyclic nucleotide-gated channels in hippocampal neuronsQ28572166
SUMOylation regulates kainate-receptor-mediated synaptic transmissionQ28576922
Regulation of HCN channel surface expression by a novel C-terminal protein-protein interactionQ28586966
SUMO-1 conjugation in vivo requires both a consensus modification motif and nuclear targetingQ29619527
Regulation of cell surface expression of functional pacemaker channels by a motif in the B-helix of the cyclic nucleotide-binding domainQ30157645
Resonance, oscillation and the intrinsic frequency preferences of neuronsQ33899474
Neuronal SUMOylation: mechanisms, physiology, and roles in neuronal dysfunctionQ34295237
Kainate receptor activation induces glycine receptor endocytosis through PKC deSUMOylationQ34348693
Neurophysiology of HCN channels: from cellular functions to multiple regulationsQ34382121
SUMOylation is required for glycine-induced increases in AMPA receptor surface expression (ChemLTP) in hippocampal neurons.Q34550934
HCN channelopathy in external globus pallidus neurons in models of Parkinson's disease.Q34680409
SUMO modification of cell surface Kv2.1 potassium channels regulates the activity of rat hippocampal neuronsQ34865655
Hyperpolarization-activated cation currents: from molecules to physiological functionQ35019781
Trafficking and gating of hyperpolarization-activated cyclic nucleotide-gated channels are regulated by interaction with tetratricopeptide repeat-containing Rab8b-interacting protein (TRIP8b) and cyclic AMP at distinct sitesQ35063427
Novel HCN2 mutation contributes to febrile seizures by shifting the channel's kinetics in a temperature-dependent mannerQ35063727
Rapid loss of dendritic HCN channel expression in hippocampal pyramidal neurons following status epilepticusQ35530042
Agonist-induced PKC phosphorylation regulates GluK2 SUMOylation and kainate receptor endocytosisQ35621378
SUMO modification regulates inactivation of the voltage-gated potassium channel Kv1.5.Q35629481
System-wide identification of wild-type SUMO-2 conjugation sitesQ35814214
SUMO: regulating the regulator.Q36522036
CRMP2 protein SUMOylation modulates NaV1.7 channel traffickingQ37112626
HCN channels: structure, cellular regulation and physiological functionQ37309228
Alternatively spliced isoforms of TRIP8b differentially control h channel trafficking and function.Q37315111
SUMOylation and De-SUMOylation: wrestling with life's processesQ37325310
Starting and stopping SUMOylation. What regulates the regulator?Q38118140
SUMO and Parkinson's diseaseQ38131751
Dysfunctional HCN ion channels in neurological diseasesQ38389906
Seizure-induced plasticity of h channels in entorhinal cortical layer III pyramidal neuronsQ38531931
Hyperpolarization-Activated Cyclic Nucleotide-Gated (HCN) Channels in EpilepsyQ38756898
SUMO-regulated mitochondrial function in Parkinson's diseaseQ38757045
Absence epilepsy and sinus dysrhythmia in mice lacking the pacemaker channel HCN2Q39696685
Functional modulation of parkin through physical interaction with SUMO-1.Q40235074
RIM1α SUMOylation is required for fast synaptic vesicle exocytosis.Q41885145
SUMOylation and phosphorylation of GluK2 regulate kainate receptor trafficking and synaptic plasticity.Q42323396
Isoform dependent regulation of human HCN channels by cholesterolQ43237928
The small ubiquitin-like modifier-1 (SUMO-1) consensus sequence mediates Ubc9 binding and is essential for SUMO-1 modificationQ43548130
Activity-dependent regulation of the sumoylation machinery in rat hippocampal neurons.Q43908333
Recessive loss-of-function mutation in the pacemaker HCN2 channel causing increased neuronal excitability in a patient with idiopathic generalized epilepsy.Q46015905
A conserved tripeptide in CNG and HCN channels regulates ligand gating by controlling C-terminal oligomerizationQ48161798
Does sumoylation control K2P1/TWIK1 background K+ channels?Q48785878
Recycling endosomes supply cardiac pacemaker channels for regulated surface expression.Q50643593
Global Map of SUMO Function Revealed by Protein-Protein Interaction and Genetic NetworksQ57953593
A new 30-kDa ubiquitin-related SUMO-1 hydrolase from bovine brainQ73107006
A conserved domain in the NH2 terminus important for assembly and functional expression of pacemaker channelsQ74650124
Regulation of hyperpolarization-activated HCN channels by cAMP through a gating switch in binding domain symmetryQ79349337
Increased expression of HCN2 channel protein in L4 dorsal root ganglion neurons following axotomy of L5- and inflammation of L4-spinal nerves in ratsQ86999671
P4510describes a project that usesImageJQ1659584
P407language of work or nameEnglishQ1860
P921main subjectprotein sumoylationQ3503705
P304page(s)168
P577publication date2016-01-01
P1433published inFrontiers in Molecular NeuroscienceQ27721913
P1476titleSUMOylation of the Hyperpolarization-Activated Cyclic Nucleotide-Gated Channel 2 Increases Surface Expression and the Maximal Conductance of the Hyperpolarization-Activated Current
P478volume9

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cites work (P2860)
Q95644850Alterations in SUMOylation of the hyperpolarization-activated cyclic nucleotide gated ion channel 2 during persistent inflammation
Q90028941Modulator-Gated, SUMOylation-Mediated, Activity-Dependent Regulation of Ionic Current Densities Contributes to Short-Term Activity Homeostasis
Q64917488SUMOylating Two Distinct Sites on the A-type Potassium Channel, Kv4.2, Increases Surface Expression and Decreases Current Amplitude.

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