The SUMO pathway is essential for nuclear integrity and chromosome segregation in mice

scientific article published on 01 December 2005

The SUMO pathway is essential for nuclear integrity and chromosome segregation in mice is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.DEVCEL.2005.10.007
P698PubMed publication ID16326389

P50authorMichel Cohen-TannoudjiQ48278302
Jérôme ArtusQ57789431
Mantu BhaumikQ125195678
Pier Paolo PandolfiQ7191735
P2093author name stringFrançois Lehembre
Anne Dejean
Charles Babinet
Karim Nacerddine
P2860cites workSUMO: a history of modificationQ28243325
P433issue6
P1104number of pages11
P304page(s)769-779
P577publication date2005-12-01
P1433published inDevelopmental CellQ1524277
P1476titleThe SUMO pathway is essential for nuclear integrity and chromosome segregation in mice
P478volume9

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cites work (P2860)
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Q36320597Global Reprogramming of Host SUMOylation during Influenza Virus Infection.
Q36238048Global SUMO Proteome Responses Guide Gene Regulation, mRNA Biogenesis, and Plant Stress Responses
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Q92344236How Does SUMO Participate in Spindle Organization?
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Q90690751Identification of sumoylated targets in proliferating mouse spermatogonia and human testicular seminomas
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Q35529185In vivo analysis of protein sumoylation induced by a viral protein: Detection of HCMV pp71-induced Daxx sumoylation
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Q88919604Inhibition of the Ubc9 E2 SUMO-conjugating enzyme-CRMP2 interaction decreases NaV1.7 currents and reverses experimental neuropathic pain
Q35748435Insights into cytoprotection from ground squirrel hibernation, a natural model of tolerance to profound brain oligaemia
Q60045379Insights into the transcriptional and post-transcriptional regulation of the rice SUMOylation machinery and into the role of two rice SUMO proteases
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Q42211570Interferon controls SUMO availability via the Lin28 and let-7 axis to impede virus replication
Q42450172Intracellular retention and insulin-stimulated mobilization of GLUT4 glucose transporters
Q37333353Investigating the mechanisms underlying neuronal death in ischemia using in vitro oxygen-glucose deprivation: potential involvement of protein SUMOylation
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Q39004536KDM4C (GASC1) lysine demethylase is associated with mitotic chromatin and regulates chromosome segregation during mitosis
Q61795920Lack of androgen receptor SUMOylation results in male infertility due to epididymal dysfunction
Q39711579Listeria monocytogenes impairs SUMOylation for efficient infection
Q36467112Localization and identification of sumoylated proteins in human sperm: excessive sumoylation is a marker of defective spermatozoa
Q36548438Loss of the Ubiquitin-conjugating Enzyme UBE2W Results in Susceptibility to Early Postnatal Lethality and Defects in Skin, Immune, and Male Reproductive Systems
Q51159598Manipulating PML SUMOylation via Silencing UBC9 and RNF4 Regulates Cardiac Fibrosis
Q26799547Mapping the SUMOylated landscape
Q27865251Mechanisms, regulation and consequences of protein SUMOylation
Q52374566Mitotic and Meiotic Functions for the SUMOylation Pathway in the Caenorhabditis elegans Germline.
Q38115818Molecular targets underlying SUMO‐mediated neuroprotection in brain ischemia
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Q35642137Myocardin sumoylation transactivates cardiogenic genes in pluripotent 10T1/2 fibroblasts
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Q38510909Novel proteomics strategy brings insight into the prevalence of SUMO-2 target sites
Q35378365Oncogenesis driven by the Ras/Raf pathway requires the SUMO E2 ligase Ubc9.
Q37770818Orphan nuclear bodies
Q51890847Overexpression of SUMO perturbs the growth and development of Caenorhabditis elegans
Q37721763Oxidative stress-induced assembly of PML nuclear bodies controls sumoylation of partner proteins
Q28248545PIAS proteins: pleiotropic interactors associated with SUMO
Q34317000PIASy-dependent SUMOylation regulates DNA topoisomerase IIalpha activity.
Q38008909PML body meets telomere: the beginning of an ALTernate ending?
Q91843058PML is recruited to heterochromatin during S phase and represses DAXX-mediated histone H3.3 chromatin assembly
Q22065791PML nuclear bodies
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Q28482092Phosphorylation of Ubc9 by Cdk1 enhances SUMOylation activity
Q42721929Pias1 is essential for erythroid and vascular development in the mouse embryo.
Q33830595Pias3 is necessary for dorso-ventral patterning and visual response of retinal cones but is not required for rod photoreceptor differentiation
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Q47823549Probing the roles of SUMOylation in cancer cell biology by using a selective SAE inhibitor.
Q47903181Protein Modifications with Ubiquitin as Response to Cerebral Ischemia-Reperfusion Injury
Q33884482Protein Profile in Corpus Luteum during Pregnancy in Korean Native Cows
Q37553976Protein SUMOylation in neuropathological conditions.
Q37952957Protein SUMOylation in spine structure and function
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Q35842627Protein SUMOylation modulates calcium influx and glutamate release from presynaptic terminals
Q38125942Protein sumoylation in brain development, neuronal morphology and spinogenesis.
Q39201092Proteome-wide identification of SUMO2 modification sites
Q39125376Proteomic profile of maternal-aged blastocoel fluid suggests a novel role for ubiquitin system in blastocyst quality.
Q37379609Proteomics analysis of nucleolar SUMO-1 target proteins upon proteasome inhibition.
Q38855621Proteotoxic stress reprograms the chromatin landscape of SUMO modification.
Q24298480RSUME, a small RWD-containing protein, enhances SUMO conjugation and stabilizes HIF-1alpha during hypoxia
Q36437164Regulation of germ cell function by SUMOylation
Q30409858Regulation of stress-inducible phosphoprotein 1 nuclear retention by protein inhibitor of activated STAT PIAS1.
Q38072052Regulation of the tumor suppressor PML by sequential post-translational modifications
Q33966800Rhes, a physiologic regulator of sumoylation, enhances cross-sumoylation between the basic sumoylation enzymes E1 and Ubc9.
Q90664369Rigidity enhances a magic-number effect in polymer phase separation
Q37825489Role of Promyelocytic Leukemia Protein in Host Antiviral Defense
Q36499051Role of SUMO/Ubc9 in DNA damage repair and tumorigenesis
Q37863916Roles of Small Ubiquitin-Related Modifiers in Male Reproductive Function
Q35380380Roles of ubiquitination and SUMOylation on prostate cancer: mechanisms and clinical implications
Q33273549SAGE and antibody array analysis of melanoma-infiltrated lymph nodes: identification of Ubc9 as an important molecule in advanced-stage melanomas
Q58597568SENP1 has an important role in lung development and influences the differentiation of alveolar type 2 cells
Q41709472SENP3 grants tight junction integrity and cytoskeleton architecture in mouse Sertoli cells
Q37820200SUMO Losing Balance: SUMO Proteases Disrupt SUMO Homeostasis to Facilitate Cancer Development and Progression
Q30274768SUMO and Chromatin Remodeling
Q40950182SUMO conjugation to spliceosomal proteins is required for efficient pre-mRNA splicing
Q37207512SUMO modification of DNA topoisomerase II: trying to get a CENse of it all
Q35950115SUMO modification regulates MafB-driven macrophage differentiation by enabling Myb-dependent transcriptional repression
Q52374177SUMO polymeric chains are involved in nuclear foci formation and chromatin organization in Trypanosoma brucei procyclic forms
Q35245641SUMO proteomics to decipher the SUMO-modified proteome regulated by various diseases
Q36393042SUMO regulates p21Cip1 intracellular distribution and with p21Cip1 facilitates multiprotein complex formation in the nucleolus upon DNA damage
Q38132691SUMO rules: regulatory concepts and their implication in neurologic functions.
Q52352276SUMO targets the APC/C to regulate transition from metaphase to anaphase.
Q36997854SUMO wrestling with Ras.
Q34400369SUMO--a post-translational modification with therapeutic potential?
Q24647369SUMO-2/3 modification and binding regulate the association of CENP-E with kinetochores and progression through mitosis
Q58803049SUMO-Mediated Regulation of Nuclear Functions and Signaling Processes
Q48085230SUMO-conjugating and SUMO-deconjugating enzymes from Arabidopsis
Q38294254SUMO-conjugating enzyme (Sce) and FK506-binding protein (FKBP) encoding rice (Oryza sativa L.) genes: genome-wide analysis, expression studies and evidence for their involvement in abiotic stress response
Q30352713SUMO-specific protease 1 (SENP1) reverses the hormone-augmented SUMOylation of androgen receptor and modulates gene responses in prostate cancer cells.
Q24299542SUMO-specific protease 1 is essential for stabilization of HIF1alpha during hypoxia
Q38854332SUMO-specific protease 6 promotes gastric cancer cell growth via deSUMOylation of FoxM1.
Q36439087SUMO-targeted ubiquitin ligases in genome stability.
Q42529820SUMO1 negatively regulates reactive oxygen species production from NADPH oxidases
Q39248635SUMO1-activating enzyme subunit 1 is essential for the survival of hematopoietic stem/progenitor cells in zebrafish
Q34338850SUMO2 is essential while SUMO3 is dispensable for mouse embryonic development
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Q52718563SUMOYLATION REGULATES GERMINAL VESICLE BREAK-DOWN AND THE AKT/PKB PATHWAY DURING MOUSE OOCYTE MATURATION.
Q45073706SUMOylation Promotes Nuclear Import and Stabilization of Polo-like Kinase 1 to Support Its Mitotic Function
Q35568644SUMOylation and PARylation cooperate to recruit and stabilize SLX4 at DNA damage sites.
Q97884803SUMOylation and calcium signalling: potential roles in the brain and beyond
Q52973342SUMOylation by a stress-specific small ubiquitin-like modifier E2 conjugase is essential for survival of Chlamydomonas reinhardtii under stress conditions
Q46311411SUMOylation controls stem cell proliferation and regional cell death through Hedgehog signaling in planarians.
Q90317112SUMOylation coordinates BERosome assembly in active DNA demethylation during cell differentiation
Q47392649SUMOylation in brain ischemia: Patterns, targets, and translational implications.
Q35031726SUMOylation is developmentally regulated and required for cell pairing during conjugation in Tetrahymena thermophila
Q52597096SUMOylation is required for fungal development and pathogenicity in the rice blast fungus Magnaporthe oryzae
Q34043389SUMOylation modulates the function of Aurora-B kinase
Q41941328SUMOylation regulates the chromatin occupancy and anti-proliferative gene programs of glucocorticoid receptor
Q26776081SUMOylation-Mediated Regulation of Cell Cycle Progression and Cancer
Q37392596Small ubiquitin-like modifiers in cellular malignancy and metastasis
Q43286701Small ubiquitin-related modifier paralogs are indispensable but functionally redundant during early development of zebrafish
Q41335010Smc5/6 Mediated Sumoylation of the Sgs1-Top3-Rmi1 Complex Promotes Removal of Recombination Intermediates.
Q50676884Spatiotemporal distribution of SUMOylation components during mouse brain development
Q51791049Stage-specific Importin13 activity influences meiosis of germ cells in the mouse
Q24313610Structure of Importin13-Ubc9 complex: nuclear import and release of a key regulator of sumoylation
Q29620390Structure, dynamics and functions of promyelocytic leukaemia nuclear bodies
Q42066873Sumo E2 enzyme UBC9 is required for efficient protein quality control in cardiomyocytes
Q51137597Sumo Modification of Ion Channels
Q36846094Sumo-1 function is dispensable in normal mouse development
Q37097348Sumoylation and regulation of cardiac gene expression
Q37136043Sumoylation and the function of CCAAT enhancer binding protein alpha (C/EBP alpha).
Q27933175Sumoylation and the structural maintenance of chromosomes (Smc) 5/6 complex slow senescence through recombination intermediate resolution
Q42478411Sumoylation by Ubc9 Regulates the Stem Cell Compartment and Structure and Function of the Intestinal Epithelium in Mice
Q41840965Sumoylation controls host anti-bacterial response to the gut invasive pathogen Shigella flexneri
Q42923529Sumoylation controls retinal progenitor proliferation by repressing cell cycle exit in Xenopus laevis
Q40875210Sumoylation coordinates the repression of inflammatory and anti-viral gene-expression programs during innate sensing
Q36313889Sumoylation dynamics during keratinocyte differentiation
Q38757476Sumoylation in Craniofacial Disorders
Q50455844Sumoylation in Development and Differentiation
Q27865271Sumoylation in gene regulation, human disease, and therapeutic action
Q38046126Sumoylation in neurodegenerative diseases
Q38343560Sumoylation of Arabidopsis heat shock factor A2 (HsfA2) modifies its activity during acquired thermotholerance
Q30626632Sumoylation of CCAAT/enhancer-binding protein α is implicated in hematopoietic stem/progenitor cell development through regulating runx1 in zebrafish
Q40324916Sumoylation of Krüppel-like factor 4 inhibits pluripotency induction but promotes adipocyte differentiation.
Q24302311Sumoylation of eIF4E activates mRNA translation
Q36118507Sumoylation of the budding yeast kinetochore protein Ndc10 is required for Ndc10 spindle localization and regulation of anaphase spindle elongation
Q46742348Synthetic derivatives of the SUMO consensus sequence provide a basis for improved substrate recognition.
Q38901752System-wide Analysis of SUMOylation Dynamics in Response to Replication Stress Reveals Novel Small Ubiquitin-like Modified Target Proteins and Acceptor Lysines Relevant for Genome Stability.
Q35814214System-wide identification of wild-type SUMO-2 conjugation sites
Q53280723TRIM proteins and cancer
Q104561842Targeting SUMO Signaling to Wrestle Cancer
Q39017134Targeting nuclear thymidylate biosynthesis
Q37728628Targets and consequences of protein SUMOylation in neurons.
Q47263437Temporal and SUMO-specific SUMOylation contribute to the dynamics of Polo-like kinase 1 (PLK1) and spindle integrity during mouse oocyte meiosis
Q38948604The Anaplasma phagocytophilum effector AmpA hijacks host cell SUMOylation
Q51593619The Arabidopsis SUMO E3 ligase AtMMS21 dissociates the E2Fa/DPa complex in cell cycle regulation
Q26765181The RNA helicase A in malignant transformation
Q39194387The Role of PIAS SUMO E3-Ligases in Cancer
Q47095192The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.
Q92570284The SUMO Pathway in Hematomalignancies and Their Response to Therapies
Q35878489The SUMO pathway functions in mouse oocyte maturation
Q57022065The SUMO protease SENP1 and the chromatin remodeler CHD3 interact and jointly affect chromatin accessibility and gene expression
Q41669688The SUMO protease SENP6 is a direct regulator of PML nuclear bodies
Q27863924The SUMO-specific protease SENP5 is required for cell division
Q90283991The best of both worlds-bringing together cell biology and infection at the Institut Pasteur
Q33716143The chromatin modification by SUMO-2/3 but not SUMO-1 prevents the epigenetic activation of key immune-related genes during Kaposi's sarcoma associated herpesvirus reactivation
Q35476824The chromatin scaffold protein SAFB1 localizes SUMO-1 to the promoters of ribosomal protein genes to facilitate transcription initiation and splicing.
Q36761196The epigenetic regulation of mammalian telomeres
Q46931366The function of EHD2 in endocytosis and defense signaling is affected by SUMO.
Q28600908The language-related transcription factor FOXP2 is post-translationally modified with small ubiquitin-like modifiers
Q28586313The murine ortholog of notchless, a direct regulator of the notch pathway in Drosophila melanogaster, is essential for survival of inner cell mass cells
Q35706611The prognostic value of SUMO1/Sentrin specific peptidase 1 (SENP1) in prostate cancer is limited to ERG-fusion positive tumors lacking PTEN deletion
Q36619437The role of SUMO in chromosome segregation
Q91811364The significance of SUMOylation of angiogenic factors in cancer progression
Q33529370Three-dimensional organization of promyelocytic leukemia nuclear bodies.
Q31153788Tomosyn interacts with the SUMO E3 ligase PIASγ.
Q50219777Tools to Study SUMO Conjugation in Caenorhabditis elegans
Q36850393Trafficking of the transcription factor Nrf2 to promyelocytic leukemia-nuclear bodies: implications for degradation of NRF2 in the nucleus
Q47599750Two SUMO Proteases SUMO PROTEASE RELATED TO FERTILITY1 and 2 Are Required for Fertility in Arabidopsis
Q39798030UBC9-Mediated Sumoylation Favorably Impacts Cardiac Function in Compromised Hearts
Q37273040UBE2I (UBC9), a SUMO-conjugating enzyme, localizes to nuclear speckles and stimulates transcription in mouse oocytes
Q33567980Ubc9 Is Required for Positive Selection and Late-Stage Maturation of Thymocytes
Q33753966Ubc9 promotes breast cell invasion and metastasis in a sumoylation-independent manner
Q35191018Ubc9 regulates mitosis and cell survival during zebrafish development
Q28387076Ubiquitin and SUMO systems in the regulation of mitotic checkpoints
Q38663141Ubiquitin and ubiquitin-like proteins in cardiac disease and protection
Q34347040Ubiquitin and ubiquitin-like proteins in the nucleolus: multitasking tools for a ribosome factory.
Q36307179Ubiquitin proteolytic system: focus on SUMO.
Q41022416Ubiquitin-Conjugating Enzyme 9 Phosphorylation as a Novel Mechanism for Potentiation of the Inflammatory Response
Q42076334Ubiquitin-specific Protease 11 (USP11) Deubiquitinates Hybrid Small Ubiquitin-like Modifier (SUMO)-Ubiquitin Chains to Counteract RING Finger Protein 4 (RNF4).
Q36575234Uncoupling phototoxicity-elicited neural dysmorphology and death by insidious function and selective impairment of Ran-binding protein 2 (Ranbp2).
Q35615172Uncovering Ubiquitin and Ubiquitin-like Signaling Networks
Q34041994Uncovering global SUMOylation signaling networks in a site-specific manner
Q60510247XSUMO-1 is required for normal mesoderm induction and axis elongation during earlyXenopus development
Q28543055hnRNP K coordinates transcriptional silencing by SETDB1 in embryonic stem cells

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