| scholarly article | Q13442814 |
| P50 | author | Toru Akiyama | Q43233344 |
| Sakae Tanaka | Q39065998 | ||
| P2860 | cites work | Journal of Clinical Investigation | Q3186904 |
| RACK1 and CIS mediate the degradation of BimEL in cancer cells | Q24322936 | ||
| Bim: a novel member of the Bcl-2 family that promotes apoptosis | Q24532974 | ||
| BOD (Bcl-2-related ovarian death gene) is an ovarian BH3 domain-containing proapoptotic Bcl-2 protein capable of dimerization with diverse antiapoptotic Bcl-2 members | Q28118771 | ||
| Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity | Q28138855 | ||
| BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes | Q28203083 | ||
| FoxO3a transcriptional regulation of Bim controls apoptosis in paclitaxel-treated breast cancer cell lines | Q28207468 | ||
| Cell death: critical control points | Q28240722 | ||
| Mesothelin promotes anchorage-independent growth and prevents anoikis via extracellular signal-regulated kinase signaling pathway in human breast cancer cells | Q28267065 | ||
| betaTrCP- and Rsk1/2-mediated degradation of BimEL inhibits apoptosis | Q28306984 | ||
| Causal relationship between the loss of RUNX3 expression and gastric cancer | Q28509530 | ||
| BIM regulates apoptosis during mammary ductal morphogenesis, and its absence reveals alternative cell death mechanisms | Q28510331 | ||
| Dicer is essential for mouse development | Q28511142 | ||
| Concomitant loss of proapoptotic BH3-only Bcl-2 antagonists Bik and Bim arrests spermatogenesis | Q28511476 | ||
| Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand | Q28513283 | ||
| Nerve growth factor blocks thapsigargin-induced apoptosis at the level of the mitochondrion via regulation of Bim | Q28578213 | ||
| An early developmental role for miRNAs in the maintenance of extraembryonic stem cells in the mouse embryo | Q28594818 | ||
| The biochemistry of apoptosis | Q29547741 | ||
| ER stress triggers apoptosis by activating BH3-only protein Bim | Q29617730 | ||
| Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities | Q29617768 | ||
| Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis | Q30080034 | ||
| Akt1 in osteoblasts and osteoclasts controls bone remodeling | Q33303666 | ||
| Mutations in Fas associated with human lymphoproliferative syndrome and autoimmunity | Q33488225 | ||
| Cdc42 regulates bone modeling and remodeling in mice by modulating RANKL/M-CSF signaling and osteoclast polarization | Q33882828 | ||
| BH3-only proteins in apoptosis and beyond: an overview | Q34085370 | ||
| Negative feedback loop in the Bim-caspase-3 axis regulating apoptosis and activity of osteoclasts. | Q40115153 | ||
| Regulation of osteoclast apoptosis by ubiquitylation of proapoptotic BH3-only Bcl-2 family member Bim. | Q40323778 | ||
| Key roles of BIM-driven apoptosis in epithelial tumors and rational chemotherapy. | Q40446996 | ||
| Apoptosis of non-small-cell lung cancer cell lines after paclitaxel treatment involves the BH3-only proapoptotic protein Bim. | Q40458245 | ||
| Extracellular signal-regulated kinases 1/2 are serum-stimulated "Bim(EL) kinases" that bind to the BH3-only protein Bim(EL) causing its phosphorylation and turnover | Q40606380 | ||
| Role of Bim in the survival pathway induced by Raf in epithelial cells | Q40607194 | ||
| Phosphorylation of Bim-EL by Erk1/2 on serine 69 promotes its degradation via the proteasome pathway and regulates its proapoptotic function. | Q40626751 | ||
| Anti-apoptotic molecule Bcl-2 regulates the differentiation, activation, and survival of both osteoblasts and osteoclasts | Q42063420 | ||
| Regulation of bim in glucocorticoid-mediated osteoblast apoptosis. | Q42918078 | ||
| c-Cbl is not required for ERK1/2-dependent degradation of BimEL. | Q43098314 | ||
| Apoptosis regulators Bim and Fas function concurrently to control autoimmunity and CD8+ T cell contraction | Q43493690 | ||
| Integrins and EGFR coordinately regulate the pro-apoptotic protein Bim to prevent anoikis | Q44502162 | ||
| Bim expression is reduced in human cutaneous melanomas | Q44625470 | ||
| Akt1/Akt2 and mammalian target of rapamycin/Bim play critical roles in osteoclast differentiation and survival, respectively, whereas Akt is dispensable for cell survival in isolated osteoclast precursors | Q45151645 | ||
| Mutant B-RAF mediates resistance to anoikis via Bad and Bim. | Q46774780 | ||
| Downregulation of Bim by brain-derived neurotrophic factor activation of TrkB protects neuroblastoma cells from paclitaxel but not etoposide or cisplatin-induced cell death | Q48495085 | ||
| Nomenclature of dynein light chain-linked BH3-only protein Bim isoforms | Q48713168 | ||
| Combined deficiency of proapoptotic regulators Bim and Fas results in the early onset of systemic autoimmunity | Q80703822 | ||
| Expression of Bcl-2 family proteins and association with clinicopathological characteristics of oral squamous cell carcinoma | Q84752495 | ||
| Prognostic impact of bim, puma, and noxa expression in human colon carcinomas. | Q34167987 | ||
| Osteoblast apoptosis and bone turnover | Q34274481 | ||
| The RUNX3 tumor suppressor upregulates Bim in gastric epithelial cells undergoing transforming growth factor beta-induced apoptosis | Q34718167 | ||
| How death shapes life during development | Q34931816 | ||
| Deficiency of Bim in dendritic cells contributes to overactivation of lymphocytes and autoimmunity. | Q35828628 | ||
| The role of BH3-only proteins in the immune system | Q36047162 | ||
| Taxanes and COX-2 inhibitors: from molecular pathways to clinical practice | Q36409363 | ||
| Down-regulation of 14-3-3zeta suppresses anchorage-independent growth of lung cancer cells through anoikis activation | Q36423378 | ||
| Anoikis, initiated by Mcl-1 degradation and Bim induction, is deregulated during oncogenesis | Q36482941 | ||
| Apoptosis regulators Fas and Bim cooperate in shutdown of chronic immune responses and prevention of autoimmunity | Q36501636 | ||
| Multisite phosphorylation regulates Bim stability and apoptotic activity | Q36756298 | ||
| Posttranslational regulation of Bim by caspase-3. | Q36856307 | ||
| Signaling axis in osteoclast biology and therapeutic targeting in the RANKL/RANK/OPG system | Q36891815 | ||
| TGF beta-mediated BIM expression and apoptosis are regulated through SMAD3-dependent expression of the MAPK phosphatase MKP2 | Q36946967 | ||
| Elimination of antigen-presenting cells and autoreactive T cells by Fas contributes to prevention of autoimmunity | Q36955782 | ||
| Lucifer's labyrinth--ten years of path finding in cell death | Q37033143 | ||
| Essential and overlapping functions for mammalian Argonautes in microRNA silencing | Q37111125 | ||
| Anoikis resistance and tumor metastasis | Q37199998 | ||
| MAP4K3 modulates cell death via the post-transcriptional regulation of BH3-only proteins | Q37254165 | ||
| Novel therapeutic strategy for osteosarcoma targeting osteoclast differentiation, bone-resorbing activity, and apoptosis pathway. | Q37323023 | ||
| c-Cbl and Cbl-b act redundantly to protect osteoclasts from apoptosis and to displace HDAC6 from beta-tubulin, stabilizing microtubules and podosomes | Q37346002 | ||
| Transforming growth factor-beta1 (TGF-beta1) induces human osteoclast apoptosis by up-regulating Bim. | Q37358112 | ||
| Immortalization of osteoclast precursors by targeting Bcl -XL and Simian virus 40 large T antigen to the osteoclast lineage in transgenic mice | Q37387048 | ||
| CD95, BIM and T cell homeostasis | Q37526364 | ||
| BH3-only proteins and their roles in programmed cell death | Q37566201 | ||
| Mitochondria in neurodegenerative disorders: regulation of the redox state and death signaling leading to neuronal death and survival | Q37599639 | ||
| Bim-targeted cancer therapy: a link between drug action and underlying molecular changes. | Q37637694 | ||
| PINCH-1 regulates the ERK-Bim pathway and contributes to apoptosis resistance in cancer cells | Q38295612 | ||
| Active N-Ras and B-Raf inhibit anoikis by downregulating Bim expression in melanocytic cells. | Q39955638 | ||
| Redox regulation of anoikis: reactive oxygen species as essential mediators of cell survival. | Q40015294 | ||
| Activation of the JNK pathway promotes phosphorylation and degradation of BimEL--a novel mechanism of chemoresistance in T-cell acute lymphoblastic leukemia | Q40028509 | ||
| Transcriptional regulation of Bim by FoxO3A mediates hepatocyte lipoapoptosis | Q40108223 | ||
| P433 | issue | 4 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | tissue homeostasis | Q14873636 |
| P304 | page(s) | 277-287 | |
| P577 | publication date | 2011-06-03 | |
| P13046 | publication type of scholarly work | review article | Q7318358 |
| P1433 | published in | Archivum Immunologiae et Therapiae Experimentalis | Q15760838 |
| P1476 | title | Bim: guardian of tissue homeostasis and critical regulator of the immune system, tumorigenesis and bone biology | |
| Bim: Guardian of Tissue Homeostasis and Critical Regulator of the Immune System, Tumorigenesis and Bone Biology | |||
| P478 | volume | 59 |
| Q51768533 | Activated Nrf2 impairs liver regeneration in mice by activation of genes involved in cell-cycle control and apoptosis |
| Q38961040 | Downregulation of proapoptotic Bim augments IL-2-independent T-cell transformation by human T-cell leukemia virus type-1 Tax. |
| Q41830027 | Methylsulfonylmethane Induces p53 Independent Apoptosis in HCT-116 Colon Cancer Cells |
| Q91106443 | Prostaglandin E1 attenuates high glucose-induced apoptosis in proximal renal tubular cells by inhibiting the JNK/Bim pathway |
| Q60046979 | Protective Effect of Salidroside Against Diabetic Kidney Disease Through Inhibiting BIM-Mediated Apoptosis of Proximal Renal Tubular Cells in Rats |
| Q38059246 | Role of Bcl-2 in tumour cell survival and implications for pharmacotherapy. |
| Q38097425 | Role of T cell death in maintaining immune tolerance during persistent viral hepatitis |
| Q36497263 | TGF-β upregulates miR-181a expression to promote breast cancer metastasis |
| Q35688708 | Targeting Cdc20 as a novel cancer therapeutic strategy |
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