Mutant B-RAF mediates resistance to anoikis via Bad and Bim.

scientific article

Mutant B-RAF mediates resistance to anoikis via Bad and Bim. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/SJ.ONC.1211003
P698PubMed publication ID18246127
P5875ResearchGate publication ID5606306

P2093author name stringA E Aplin
K Boisvert-Adamo
P2860cites workThe Hallmarks of CancerQ221226
Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell deathQ24311298
Bim: a novel member of the Bcl-2 family that promotes apoptosisQ24532974
Disruption of epithelial cell-matrix interactions induces apoptosisQ24673611
Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machineryQ27860586
Mutations of the BRAF gene in human cancerQ27860760
A new mathematical model for relative quantification in real-time RT-PCRQ27860781
BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosisQ28189945
Gene structure alternative splicing, and chromosomal localization of pro-apoptotic Bcl-2 relative BimQ28201672
Mutant B-RAF signaling and cyclin D1 regulate Cks1/S-phase kinase-associated protein 2-mediated degradation of p27Kip1 in human melanoma cellsQ28259285
Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)Q28297419
Androgen-dependent apoptosis in male germ cells is regulated through the proto-oncoprotein CblQ28564996
BCL-2 family members and the mitochondria in apoptosisQ29614427
The Bcl2 family: regulators of the cellular life-or-death switchQ29614982
Raf and the road to cell survival: a tale of bad spells, ring bearers and detoursQ33193874
The Bad guy cooperates with good cop p53: Bad is transcriptionally up-regulated by p53 and forms a Bad/p53 complex at the mitochondria to induce apoptosisQ35131647
Positional Control of Cell Fate Through Joint Integrin/Receptor Protein Kinase SignalingQ35564801
B-RAF and PI-3 kinase signaling protect melanoma cells from anoikisQ40302263
Regulation of osteoclast apoptosis by ubiquitylation of proapoptotic BH3-only Bcl-2 family member Bim.Q40323778
Proteasome inhibitors trigger NOXA-mediated apoptosis in melanoma and myeloma cellsQ40396792
V599EB-RAF is an oncogene in melanocytesQ40520428
Bim is an apoptosis sensor that responds to loss of survival signals delivered by epidermal growth factor but not those provided by integrinsQ40528952
Augmenting chemosensitivity of malignant melanoma tumors via proteasome inhibition: implication for bortezomib (VELCADE, PS-341) as a therapeutic agent for malignant melanomaQ40534845
Role of Bim in the survival pathway induced by Raf in epithelial cellsQ40607194
Phosphorylation of Bim-EL by Erk1/2 on serine 69 promotes its degradation via the proteasome pathway and regulates its proapoptotic function.Q40626751
Activation of the ERK1/2 signaling pathway promotes phosphorylation and proteasome-dependent degradation of the BH3-only protein, Bim.Q40662652
Activation of ERK1/2 by deltaRaf-1:ER* represses Bim expression independently of the JNK or PI3K pathwaysQ40666435
Pharmacological manipulation of Bcl-2 family members to control cell deathQ42115619
Adhesion-dependent activation of the ERK1/2 cascade is by-passed in melanoma cellsQ42443534
Bcl-2 does not require Raf kinase activity for its death-protective functionQ42986516
Role of PI3-kinase-dependent Bad phosphorylation and altered transcription in cytokine-mediated neutrophil survivalQ44142851
Integrins and EGFR coordinately regulate the pro-apoptotic protein Bim to prevent anoikisQ44502162
Bortezomib in combination with dexamethasone for relapsed multiple myelomaQ45310359
Phase I/II trial assessing bortezomib and melphalan combination therapy for the treatment of patients with relapsed or refractory multiple myelomaQ46898065
Adhesion control of cyclin D1 and p27Kip1 levels is deregulated in melanoma cells through BRAF-MEK-ERK signalingQ58450931
EGFR-dependent downregulation of Bim in epithelial cells requires MAPK and PKC-delta activitiesQ83045380
P433issue23
P407language of work or nameEnglishQ1860
P304page(s)3301-3312
P577publication date2008-02-04
P1433published inOncogeneQ1568657
P1476titleMutant B-RAF mediates resistance to anoikis via Bad and Bim.
P478volume27

Reverse relations

cites work (P2860)
Q54939484A low microRNA-630 expression confers resistance to tyrosine kinase inhibitors in EGFR-mutated lung adenocarcinomas via miR-630/YAP1/ERK feedback loop.
Q28479007A novel role for BDNF-TrkB in the regulation of chemotherapy resistance in head and neck squamous cell carcinoma
Q36425600ABT-737 synergizes with Bortezomib to kill melanoma cells
Q37727061Acquired and intrinsic BRAF inhibitor resistance in BRAF V600E mutant melanoma
Q39955638Active N-Ras and B-Raf inhibit anoikis by downregulating Bim expression in melanocytic cells.
Q34069302Akt3-mediated resistance to apoptosis in B-RAF-targeted melanoma cells
Q39588369Anti-proliferative and pro-apoptotic actions of a novel human and mouse ovarian tumor-associated gene OTAG-12: downregulation, alternative splicing and drug sensitization
Q37605160Apoptosis and autophagy: BIM as a mediator of tumour cell death in response to oncogene-targeted therapeutics
Q41983817BAD contributes to RAF-mediated proliferation and cooperates with B-RAF-V600E in cancer signaling
Q39645072BH3-only protein Bim predicts advanced stage of cutaneous melanoma
Q36418729BH3-only protein silencing contributes to acquired resistance to PLX4720 in human melanoma
Q35090029BRAF inhibitor resistance mediated by the AKT pathway in an oncogenic BRAF mouse melanoma model
Q37883974Bim: guardian of tissue homeostasis and critical regulator of the immune system, tumorigenesis and bone biology
Q35550888Biomarkers as key contributors in treating malignant melanoma metastases
Q38237431Cancer cell survival during detachment from the ECM: multiple barriers to tumour progression
Q33830911Clinical profiling of BCL-2 family members in the setting of BRAF inhibition offers a rationale for targeting de novo resistance using BH3 mimetics
Q41836780Colorectal cancer cells with the BRAF(V600E) mutation are addicted to the ERK1/2 pathway for growth factor-independent survival and repression of BIM.
Q51112339Comparing BRAF mutation status in matched primary and metastatic cutaneous melanomas: implications on optimized targeted therapy.
Q34334499Critical role of STAT3 in melanoma metastasis through anoikis resistance
Q39712781Differential sensitivity of melanoma cell lines with BRAFV600E mutation to the specific Raf inhibitor PLX4032.
Q57476780Discovery of a small-molecule inhibitor of specific serine residue BAD phosphorylation
Q36439920Downregulation of Noxa by RAF/MEK inhibition counteracts cell death response in mutant B-RAF melanoma cells
Q35723900ERK2 phosphorylation of serine 77 regulates Bmf pro-apoptotic activity
Q38145387Emerging BRAF inhibitors for melanoma.
Q33767083FOXD3 is a mutant B-RAF-regulated inhibitor of G(1)-S progression in melanoma cells
Q43127268Future perspectives in melanoma research. Meeting report from the "Melanoma Bridge. Napoli, December 2nd-4th 2012".
Q53302291Hyperactivation of MEK–ERK1/2 signaling and resistance to apoptosis induced by the oncogenic B-RAF inhibitor, PLX4720, in mutant N-RAS melanoma cells
Q37547526Inhibition of Bim enhances replication of varicella-zoster virus and delays plaque formation in virus-infected cells
Q36931453Inhibition of Wee1, AKT, and CDK4 underlies the efficacy of the HSP90 inhibitor XL888 in an in vivo model of NRAS-mutant melanoma
Q37705251Inhibition of autophagy enhances the effects of the AKT inhibitor MK-2206 when combined with paclitaxel and carboplatin in BRAF wild-type melanoma.
Q90216637KRAS and BRAF mutations induce anoikis resistance and characteristic 3D phenotypes in Caco‑2 cells
Q38040353MAP kinase signaling and inhibition in melanoma
Q43119901Mcl-1 is required for melanoma cell resistance to anoikis
Q38146707Melanoma mutagenesis and aberrant cell signaling
Q39010041Melanoma never says die.
Q93007229Modulating Tumor Cell Functions by Tunable Nanopatterned Ligand Presentation
Q34052520Molecular pathways: targeting NRAS in melanoma and acute myelogenous leukemia
Q38739256Mutant BRAF Upregulates MCL-1 to Confer Apoptosis Resistance that Is Reversed by MCL-1 Antagonism and Cobimetinib in Colorectal Cancer.
Q37689575NRAS mutant melanoma: biological behavior and future strategies for therapeutic management
Q37028555Oncogenic BRAF(V600E) inhibits BIM expression to promote melanoma cell survival
Q34761941PTEN loss confers BRAF inhibitor resistance to melanoma cells through the suppression of BIM expression
Q35320304Phosphoproteomic analysis of basal and therapy-induced adaptive signaling networks in BRAF and NRAS mutant melanoma
Q93366452Prognostic Value of NRAS Gene for Survival of Colorectal Cancer Patients: A Systematic Review and Meta-Analysis
Q30791975Receptor tyrosine kinase Met promotes cell survival via kinase-independent maintenance of integrin α3β1
Q55492453Reversal of Resistance in Targeted Therapy of Metastatic Melanoma: Lessons Learned from Vemurafenib (BRAFV600E-Specific Inhibitor).
Q30486572Rnd3 regulation of the actin cytoskeleton promotes melanoma migration and invasive outgrowth in three dimensions
Q36954187Skp2 regulates G2/M progression in a p53-dependent manner
Q35859282Targeting mutant BRAF in melanoma: current status and future development of combination therapy strategies
Q51746852Targeting the intrinsic apoptosis pathway as a strategy for melanoma therapy.
Q34165045The HSP90 inhibitor XL888 overcomes BRAF inhibitor resistance mediated through diverse mechanisms
Q35691278The Novel ATP-Competitive MEK/Aurora Kinase Inhibitor BI-847325 Overcomes Acquired BRAF Inhibitor Resistance through Suppression of Mcl-1 and MEK Expression
Q38696187The RhoJ-BAD signaling network: An Achilles' heel for BRAF mutant melanomas
Q35878248The current state of targeted therapy in melanoma: this time it's personal
Q37826353The extracellular matrix in digestive cancer
Q39803993The oncogenic BRAF kinase inhibitor PLX4032/RG7204 does not affect the viability or function of human lymphocytes across a wide range of concentrations
Q37290943Tumour cell survival signalling by the ERK1/2 pathway
Q36173303Unlocking Pandora's box: personalising cancer cell death in non-small cell lung cancer
Q35640196Using quantitative proteomic analysis to understand genotype specific intrinsic drug resistance in melanoma
Q38466630Wnt/β-catenin signaling and AXIN1 regulate apoptosis triggered by inhibition of the mutant kinase BRAFV600E in human melanoma.
Q37492231hvTRA, a novel TRAIL receptor agonist, induces apoptosis and sustained growth retardation in melanoma