scholarly article | Q13442814 |
P2093 | author name string | A E Aplin | |
K Boisvert-Adamo | |||
P2860 | cites work | The Hallmarks of Cancer | Q221226 |
Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death | Q24311298 | ||
Bim: a novel member of the Bcl-2 family that promotes apoptosis | Q24532974 | ||
Disruption of epithelial cell-matrix interactions induces apoptosis | Q24673611 | ||
Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery | Q27860586 | ||
Mutations of the BRAF gene in human cancer | Q27860760 | ||
A new mathematical model for relative quantification in real-time RT-PCR | Q27860781 | ||
BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis | Q28189945 | ||
Gene structure alternative splicing, and chromosomal localization of pro-apoptotic Bcl-2 relative Bim | Q28201672 | ||
Mutant B-RAF signaling and cyclin D1 regulate Cks1/S-phase kinase-associated protein 2-mediated degradation of p27Kip1 in human melanoma cells | Q28259285 | ||
Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L) | Q28297419 | ||
Androgen-dependent apoptosis in male germ cells is regulated through the proto-oncoprotein Cbl | Q28564996 | ||
BCL-2 family members and the mitochondria in apoptosis | Q29614427 | ||
The Bcl2 family: regulators of the cellular life-or-death switch | Q29614982 | ||
Raf and the road to cell survival: a tale of bad spells, ring bearers and detours | Q33193874 | ||
The Bad guy cooperates with good cop p53: Bad is transcriptionally up-regulated by p53 and forms a Bad/p53 complex at the mitochondria to induce apoptosis | Q35131647 | ||
Positional Control of Cell Fate Through Joint Integrin/Receptor Protein Kinase Signaling | Q35564801 | ||
B-RAF and PI-3 kinase signaling protect melanoma cells from anoikis | Q40302263 | ||
Regulation of osteoclast apoptosis by ubiquitylation of proapoptotic BH3-only Bcl-2 family member Bim. | Q40323778 | ||
Proteasome inhibitors trigger NOXA-mediated apoptosis in melanoma and myeloma cells | Q40396792 | ||
V599EB-RAF is an oncogene in melanocytes | Q40520428 | ||
Bim is an apoptosis sensor that responds to loss of survival signals delivered by epidermal growth factor but not those provided by integrins | Q40528952 | ||
Augmenting chemosensitivity of malignant melanoma tumors via proteasome inhibition: implication for bortezomib (VELCADE, PS-341) as a therapeutic agent for malignant melanoma | Q40534845 | ||
Role of Bim in the survival pathway induced by Raf in epithelial cells | Q40607194 | ||
Phosphorylation of Bim-EL by Erk1/2 on serine 69 promotes its degradation via the proteasome pathway and regulates its proapoptotic function. | Q40626751 | ||
Activation of the ERK1/2 signaling pathway promotes phosphorylation and proteasome-dependent degradation of the BH3-only protein, Bim. | Q40662652 | ||
Activation of ERK1/2 by deltaRaf-1:ER* represses Bim expression independently of the JNK or PI3K pathways | Q40666435 | ||
Pharmacological manipulation of Bcl-2 family members to control cell death | Q42115619 | ||
Adhesion-dependent activation of the ERK1/2 cascade is by-passed in melanoma cells | Q42443534 | ||
Bcl-2 does not require Raf kinase activity for its death-protective function | Q42986516 | ||
Role of PI3-kinase-dependent Bad phosphorylation and altered transcription in cytokine-mediated neutrophil survival | Q44142851 | ||
Integrins and EGFR coordinately regulate the pro-apoptotic protein Bim to prevent anoikis | Q44502162 | ||
Bortezomib in combination with dexamethasone for relapsed multiple myeloma | Q45310359 | ||
Phase I/II trial assessing bortezomib and melphalan combination therapy for the treatment of patients with relapsed or refractory multiple myeloma | Q46898065 | ||
Adhesion control of cyclin D1 and p27Kip1 levels is deregulated in melanoma cells through BRAF-MEK-ERK signaling | Q58450931 | ||
EGFR-dependent downregulation of Bim in epithelial cells requires MAPK and PKC-delta activities | Q83045380 | ||
P433 | issue | 23 | |
P407 | language of work or name | English | Q1860 |
P304 | page(s) | 3301-3312 | |
P577 | publication date | 2008-02-04 | |
P1433 | published in | Oncogene | Q1568657 |
P1476 | title | Mutant B-RAF mediates resistance to anoikis via Bad and Bim. | |
P478 | volume | 27 |
Q54939484 | A low microRNA-630 expression confers resistance to tyrosine kinase inhibitors in EGFR-mutated lung adenocarcinomas via miR-630/YAP1/ERK feedback loop. |
Q28479007 | A novel role for BDNF-TrkB in the regulation of chemotherapy resistance in head and neck squamous cell carcinoma |
Q36425600 | ABT-737 synergizes with Bortezomib to kill melanoma cells |
Q37727061 | Acquired and intrinsic BRAF inhibitor resistance in BRAF V600E mutant melanoma |
Q39955638 | Active N-Ras and B-Raf inhibit anoikis by downregulating Bim expression in melanocytic cells. |
Q34069302 | Akt3-mediated resistance to apoptosis in B-RAF-targeted melanoma cells |
Q39588369 | Anti-proliferative and pro-apoptotic actions of a novel human and mouse ovarian tumor-associated gene OTAG-12: downregulation, alternative splicing and drug sensitization |
Q37605160 | Apoptosis and autophagy: BIM as a mediator of tumour cell death in response to oncogene-targeted therapeutics |
Q41983817 | BAD contributes to RAF-mediated proliferation and cooperates with B-RAF-V600E in cancer signaling |
Q39645072 | BH3-only protein Bim predicts advanced stage of cutaneous melanoma |
Q36418729 | BH3-only protein silencing contributes to acquired resistance to PLX4720 in human melanoma |
Q35090029 | BRAF inhibitor resistance mediated by the AKT pathway in an oncogenic BRAF mouse melanoma model |
Q37883974 | Bim: guardian of tissue homeostasis and critical regulator of the immune system, tumorigenesis and bone biology |
Q35550888 | Biomarkers as key contributors in treating malignant melanoma metastases |
Q38237431 | Cancer cell survival during detachment from the ECM: multiple barriers to tumour progression |
Q33830911 | Clinical profiling of BCL-2 family members in the setting of BRAF inhibition offers a rationale for targeting de novo resistance using BH3 mimetics |
Q41836780 | Colorectal cancer cells with the BRAF(V600E) mutation are addicted to the ERK1/2 pathway for growth factor-independent survival and repression of BIM. |
Q51112339 | Comparing BRAF mutation status in matched primary and metastatic cutaneous melanomas: implications on optimized targeted therapy. |
Q34334499 | Critical role of STAT3 in melanoma metastasis through anoikis resistance |
Q39712781 | Differential sensitivity of melanoma cell lines with BRAFV600E mutation to the specific Raf inhibitor PLX4032. |
Q57476780 | Discovery of a small-molecule inhibitor of specific serine residue BAD phosphorylation |
Q36439920 | Downregulation of Noxa by RAF/MEK inhibition counteracts cell death response in mutant B-RAF melanoma cells |
Q35723900 | ERK2 phosphorylation of serine 77 regulates Bmf pro-apoptotic activity |
Q38145387 | Emerging BRAF inhibitors for melanoma. |
Q33767083 | FOXD3 is a mutant B-RAF-regulated inhibitor of G(1)-S progression in melanoma cells |
Q43127268 | Future perspectives in melanoma research. Meeting report from the "Melanoma Bridge. Napoli, December 2nd-4th 2012". |
Q53302291 | Hyperactivation of MEK–ERK1/2 signaling and resistance to apoptosis induced by the oncogenic B-RAF inhibitor, PLX4720, in mutant N-RAS melanoma cells |
Q37547526 | Inhibition of Bim enhances replication of varicella-zoster virus and delays plaque formation in virus-infected cells |
Q36931453 | Inhibition of Wee1, AKT, and CDK4 underlies the efficacy of the HSP90 inhibitor XL888 in an in vivo model of NRAS-mutant melanoma |
Q37705251 | Inhibition of autophagy enhances the effects of the AKT inhibitor MK-2206 when combined with paclitaxel and carboplatin in BRAF wild-type melanoma. |
Q90216637 | KRAS and BRAF mutations induce anoikis resistance and characteristic 3D phenotypes in Caco‑2 cells |
Q38040353 | MAP kinase signaling and inhibition in melanoma |
Q43119901 | Mcl-1 is required for melanoma cell resistance to anoikis |
Q38146707 | Melanoma mutagenesis and aberrant cell signaling |
Q39010041 | Melanoma never says die. |
Q93007229 | Modulating Tumor Cell Functions by Tunable Nanopatterned Ligand Presentation |
Q34052520 | Molecular pathways: targeting NRAS in melanoma and acute myelogenous leukemia |
Q38739256 | Mutant BRAF Upregulates MCL-1 to Confer Apoptosis Resistance that Is Reversed by MCL-1 Antagonism and Cobimetinib in Colorectal Cancer. |
Q37689575 | NRAS mutant melanoma: biological behavior and future strategies for therapeutic management |
Q37028555 | Oncogenic BRAF(V600E) inhibits BIM expression to promote melanoma cell survival |
Q34761941 | PTEN loss confers BRAF inhibitor resistance to melanoma cells through the suppression of BIM expression |
Q35320304 | Phosphoproteomic analysis of basal and therapy-induced adaptive signaling networks in BRAF and NRAS mutant melanoma |
Q93366452 | Prognostic Value of NRAS Gene for Survival of Colorectal Cancer Patients: A Systematic Review and Meta-Analysis |
Q30791975 | Receptor tyrosine kinase Met promotes cell survival via kinase-independent maintenance of integrin α3β1 |
Q55492453 | Reversal of Resistance in Targeted Therapy of Metastatic Melanoma: Lessons Learned from Vemurafenib (BRAFV600E-Specific Inhibitor). |
Q30486572 | Rnd3 regulation of the actin cytoskeleton promotes melanoma migration and invasive outgrowth in three dimensions |
Q36954187 | Skp2 regulates G2/M progression in a p53-dependent manner |
Q35859282 | Targeting mutant BRAF in melanoma: current status and future development of combination therapy strategies |
Q51746852 | Targeting the intrinsic apoptosis pathway as a strategy for melanoma therapy. |
Q34165045 | The HSP90 inhibitor XL888 overcomes BRAF inhibitor resistance mediated through diverse mechanisms |
Q35691278 | The Novel ATP-Competitive MEK/Aurora Kinase Inhibitor BI-847325 Overcomes Acquired BRAF Inhibitor Resistance through Suppression of Mcl-1 and MEK Expression |
Q38696187 | The RhoJ-BAD signaling network: An Achilles' heel for BRAF mutant melanomas |
Q35878248 | The current state of targeted therapy in melanoma: this time it's personal |
Q37826353 | The extracellular matrix in digestive cancer |
Q39803993 | The oncogenic BRAF kinase inhibitor PLX4032/RG7204 does not affect the viability or function of human lymphocytes across a wide range of concentrations |
Q37290943 | Tumour cell survival signalling by the ERK1/2 pathway |
Q36173303 | Unlocking Pandora's box: personalising cancer cell death in non-small cell lung cancer |
Q35640196 | Using quantitative proteomic analysis to understand genotype specific intrinsic drug resistance in melanoma |
Q38466630 | Wnt/β-catenin signaling and AXIN1 regulate apoptosis triggered by inhibition of the mutant kinase BRAFV600E in human melanoma. |
Q37492231 | hvTRA, a novel TRAIL receptor agonist, induces apoptosis and sustained growth retardation in melanoma |