The Bad guy cooperates with good cop p53: Bad is transcriptionally up-regulated by p53 and forms a Bad/p53 complex at the mitochondria to induce apoptosis

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The Bad guy cooperates with good cop p53: Bad is transcriptionally up-regulated by p53 and forms a Bad/p53 complex at the mitochondria to induce apoptosis is …
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scholarly articleQ13442814

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P356DOI10.1128/MCB.01025-06
P932PMC publication ID1636833
P698PubMed publication ID17000778

P50authorKlaus HeeseQ40702073
P2093author name stringPeng Jiang
Wenjing Du
Mian Wu
P2860cites workp53 transcriptional activity is essential for p53-dependent apoptosis following DNA damageQ35123816
Bad-deficient mice develop diffuse large B cell lymphomaQ35234507
Transcription, apoptosis and p53: catch-22.Q36056198
Mitochondria-to-nucleus stress signaling in mammalian cells: nature of nuclear gene targets, transcription regulation, and induced resistance to apoptosisQ40404993
Up-regulation of Bcl-2 homology 3 (BH3)-only proteins by E2F1 mediates apoptosisQ42833059
Oxidative stress induces p53-mediated apoptosis in glia: p53 transcription-independent way to die.Q44702140
A transcriptional activation function of p53 is dispensable for and inhibitory of its apoptotic functionQ45876577
p53 in the cytoplasm: a question of overkill?Q51023123
Phosphorylation and inactivation of BAD by mitochondria-anchored protein kinase AQ77406620
PUMA, a novel proapoptotic gene, is induced by p53Q24291463
p53 has a direct apoptogenic role at the mitochondriaQ24298888
Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosisQ24307994
Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell deathQ24311298
MAP-1 is a mitochondrial effector of Bax.Q24337383
The mitochondrial ARTS protein promotes apoptosis through targeting XIAPQ24610254
WAF1, a potential mediator of p53 tumor suppressionQ27861121
14-3-3 proteins and survival kinases cooperate to inactivate BAD by BH3 domain phosphorylationQ28144100
Direct interaction between survivin and Smac/DIABLO is essential for the anti-apoptotic activity of survivin during taxol-induced apoptosisQ28186614
BID regulation by p53 contributes to chemosensitivityQ28211208
BAD/BCL-[X(L)] heterodimerization leads to bypass of G0/G1 arrestQ28211754
Tumor suppressor p53 is a direct transcriptional activator of the human bax geneQ28306186
p53DINP1, a p53-inducible gene, regulates p53-dependent apoptosisQ28609684
Live or let die: the cell's response to p53Q29547663
Functionally distinct polymorphic sequences in the human genome that are targets for p53 transactivation.Q33772124
Mitochondria as the central control point of apoptosisQ33994978
Mitochondrial p53 activates Bak and causes disruption of a Bak-Mcl1 complex.Q34312488
P433issue23
P407language of work or nameEnglishQ1860
P921main subjectapoptotic processQ14599311
P304page(s)9071-9082
P577publication date2006-09-25
P1433published inMolecular and Cellular BiologyQ3319478
P1476titleThe Bad guy cooperates with good cop p53: Bad is transcriptionally up-regulated by p53 and forms a Bad/p53 complex at the mitochondria to induce apoptosis
P478volume26

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