Emerging BRAF inhibitors for melanoma.

scientific article published on 27 September 2013

Emerging BRAF inhibitors for melanoma. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1517/14728214.2013.842975
P8608Fatcat IDrelease_fam73eh2bzferbqjch2b6qmduu
P698PubMed publication ID24073999

P50authorSoldano FerroneQ90626068
Francesco SabbatinoQ42325106
P2093author name stringXinhui Wang
Cristina R Ferrone
Yangyang Wang
P2860cites workDabrafenib; Preclinical Characterization, Increased Efficacy when Combined with Trametinib, while BRAF/MEK Tool Combination Reduced Skin LesionsQ21004109
Kinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAFQ24298749
Survival in BRAF V600-mutant advanced melanoma treated with vemurafenibQ24594790
Durable complete responses in heavily pretreated patients with metastatic melanoma using T-cell transfer immunotherapyQ24596055
Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanomaQ24597152
PLX4032, a selective BRAF(V600E) kinase inhibitor, activates the ERK pathway and enhances cell migration and proliferation of BRAF melanoma cellsQ24606438
Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulationQ24629474
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Combined BRAF and MEK inhibition in melanoma with BRAF V600 mutationsQ24632064
Safety, Activity, and Immune Correlates of Anti–PD-1 Antibody in CancerQ24633070
GRP94: An HSP90-like protein specialized for protein folding and quality control in the endoplasmic reticulumQ26860153
Personalized cancer medicine: molecular diagnostics, predictive biomarkers, and drug resistanceQ26866517
RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growthQ27659493
BRAF gene amplification can promote acquired resistance to MEK inhibitors in cancer cells harboring the BRAF V600E mutationQ27851610
Dissecting therapeutic resistance to RAF inhibition in melanoma by tumor genomic profilingQ27851628
NRAS mutation status is an independent prognostic factor in metastatic melanomaQ27851695
Dabrafenib in patients with melanoma, untreated brain metastases, and other solid tumours: a phase 1 dose-escalation trial.Q27851801
Safety, pharmacokinetic, pharmacodynamic, and efficacy data for the oral MEK inhibitor trametinib: a phase 1 dose-escalation trialQ27851852
Activity of the oral MEK inhibitor trametinib in patients with advanced melanoma: a phase 1 dose-escalation trialQ27851856
Inhibition of Mutated, Activated BRAF in Metastatic MelanomaQ27860458
Cancer statistics, 2012Q27860574
Safety and Tumor Responses with Lambrolizumab (Anti–PD-1) in MelanomaQ27860650
Mutations of the BRAF gene in human cancerQ27860760
Safety and Activity of Anti–PD-L1 Antibody in Patients with Advanced CancerQ27860857
Improved Survival with Ipilimumab in Patients with Metastatic MelanomaQ27861062
Ipilimumab plus dacarbazine for previously untreated metastatic melanomaQ28131634
Fotemustine compared with dacarbazine in patients with disseminated malignant melanoma: a phase III studyQ28250432
Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAFQ28251989
Role of the mitogen-activated protein kinase signaling pathway in the regulation of human melanocytic antigen expressionQ28269191
Modelling vemurafenib resistance in melanoma reveals a strategy to forestall drug resistanceQ28282963
B-Raf acts via the ROCKII/LIMK/cofilin pathway to maintain actin stress fibers in fibroblastsQ28508452
Dabrafenib in BRAF-mutated metastatic melanoma: a multicentre, open-label, phase 3 randomised controlled trialQ29614756
Acquired resistance to BRAF inhibitors mediated by a RAF kinase switch in melanoma can be overcome by cotargeting MEK and IGF-1R/PI3KQ29614757
COT drives resistance to RAF inhibition through MAP kinase pathway reactivationQ29615032
MAP kinase signalling pathways in cancerQ29615542
Tumor regression in patients with metastatic synovial cell sarcoma and melanoma using genetically engineered lymphocytes reactive with NY-ESO-1Q29616128
RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAFQ29616828
Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretionQ29617359
BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesisQ29617585
High-dose recombinant interleukin 2 therapy for patients with metastatic melanoma: analysis of 270 patients treated between 1985 and 1993Q29619885
RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E)Q29620033
B-RAF regulation of Rnd3 participates in actin cytoskeletal and focal adhesion organizationQ30443185
Positive phase II study in the treatment of advanced malignant melanoma with fotemustineQ33374887
Results of a phase III, randomized, placebo-controlled study of sorafenib in combination with carboplatin and paclitaxel as second-line treatment in patients with unresectable stage III or stage IV melanomaQ33384029
Induction of beta3-integrin gene expression by sustained activation of the Ras-regulated Raf-MEK-extracellular signal-regulated kinase signaling pathwayQ33968056
Congenital melanocytic nevi: clinical and histopathologic features, risk of melanoma, and clinical managementQ33984859
BRAF Inhibition Increases Tumor Infiltration by T cells and Enhances the Antitumor Activity of Adoptive Immunotherapy in MiceQ33996674
Akt3-mediated resistance to apoptosis in B-RAF-targeted melanoma cellsQ34069302
The HSP90 inhibitor XL888 overcomes BRAF inhibitor resistance mediated through diverse mechanismsQ34165045
gp100 peptide vaccine and interleukin-2 in patients with advanced melanomaQ34188859
CD8+ Enriched “Young” Tumor Infiltrating Lymphocytes Can Mediate Regression of Metastatic MelanomaQ34299986
Interferon alfa-2b adjuvant therapy of high-risk resected cutaneous melanoma: the Eastern Cooperative Oncology Group Trial EST 1684.Q34371245
Apoptosis of human melanoma cells induced by inhibition of B-RAFV600E involves preferential splicing of bimSQ34545490
Phase III trial comparing concurrent biochemotherapy with cisplatin, vinblastine, dacarbazine, interleukin-2, and interferon alfa-2b with cisplatin, vinblastine, and dacarbazine alone in patients with metastatic malignant melanoma (E3695): a trial cQ34600089
Extended schedule, escalated dose temozolomide versus dacarbazine in stage IV melanoma: final results of a randomised phase III study (EORTC 18032).Q34629364
Selumetinib plus dacarbazine versus placebo plus dacarbazine as first-line treatment for BRAF-mutant metastatic melanoma: a phase 2 double-blind randomised studyQ34652628
A study of tumor progression: the precursor lesions of superficial spreading and nodular melanomaQ34710725
PTEN loss confers BRAF inhibitor resistance to melanoma cells through the suppression of BIM expressionQ34761941
Combinatorial treatments that overcome PDGFRβ-driven resistance of melanoma cells to V600EB-RAF inhibitionQ35146471
Concurrent loss of the PTEN and RB1 tumor suppressors attenuates RAF dependence in melanomas harboring (V600E)BRAFQ35700459
Targeting mutant BRAF in melanoma: current status and future development of combination therapy strategiesQ35859282
Management of cutaneous melanomaQ35877006
Raf: a strategic target for therapeutic development against cancerQ36260492
Oncogenic BRAF(V600E) inhibits BIM expression to promote melanoma cell survivalQ37028555
RAS mutations in cutaneous squamous-cell carcinomas in patients treated with BRAF inhibitorsQ37048053
Increased cyclin D1 expression can mediate BRAF inhibitor resistance in BRAF V600E-mutated melanomasQ37118264
Mitogen-activated protein kinase inhibition induces translocation of Bmf to promote apoptosis in melanoma.Q37149695
TORC1 Suppression Predicts Responsiveness to RAF and MEK Inhibition in BRAF- Mutant MelanomaQ37401151
Interferon alpha adjuvant therapy in patients with high-risk melanoma: a systematic review and meta-analysis.Q37697383
Molecular pathways: coexpression of immune checkpoint molecules: signaling pathways and implications for cancer immunotherapyQ37734285
CSPG4 in cancer: multiple rolesQ37747536
Melanoma as a model tumour for immuno-oncologyQ38037486
BRAF inhibition is associated with enhanced melanoma antigen expression and a more favorable tumor microenvironment in patients with metastatic melanoma.Q39212469
Oncogenic BRAF(V600E) promotes stromal cell-mediated immunosuppression via induction of interleukin-1 in melanomaQ39304634
Combinations of BRAF, MEK, and PI3K/mTOR Inhibitors Overcome Acquired Resistance to the BRAF Inhibitor GSK2118436 Dabrafenib, Mediated byNRASorMEKMutationsQ39385617
The CSPG4-specific monoclonal antibody enhances and prolongs the effects of the BRAF inhibitor in melanoma cellsQ39515657
Oncogenic BRAF induces melanoma cell invasion by downregulating the cGMP-specific phosphodiesterase PDE5A.Q39610715
PLX4032, a potent inhibitor of the B-Raf V600E oncogene, selectively inhibits V600E-positive melanomasQ39640222
RG7204 (PLX4032), a selective BRAFV600E inhibitor, displays potent antitumor activity in preclinical melanoma modelsQ39692674
Selective BRAFV600E inhibition enhances T-cell recognition of melanoma without affecting lymphocyte functionQ39692699
Differential sensitivity of melanoma cell lines with BRAFV600E mutation to the specific Raf inhibitor PLX4032.Q39712781
Braf(V600E) cooperates with Pten loss to induce metastatic melanomaQ39873596
Elevated CRAF as a potential mechanism of acquired resistance to BRAF inhibition in melanomaQ39971699
The BRAF-MAPK signaling pathway is essential for cancer-immune evasion in human melanoma cellsQ40262620
B-RAF is a therapeutic target in melanomaQ40543086
Activation of the ERK1/2 signaling pathway promotes phosphorylation and proteasome-dependent degradation of the BH3-only protein, Bim.Q40662652
Paradoxical activation of Raf by a novel Raf inhibitorQ40939473
BRAF inhibition improves tumor recognition by the immune system: Potential implications for combinatorial therapies against melanoma involving adoptive T-cell transferQ42417533
Factors associated with response to high-dose interleukin-2 in patients with metastatic melanomaQ43693202
Dabrafenib in patients with Val600Glu or Val600Lys BRAF-mutant melanoma metastatic to the brain (BREAK-MB): a multicentre, open-label, phase 2 trialQ44442912
Mutant B-RAF mediates resistance to anoikis via Bad and Bim.Q46774780
BRAF alterations are associated with complex mutational profiles in malignant melanomaQ47349130
Selective BRAF inhibitors induce marked T-cell infiltration into human metastatic melanomaQ47573472
Meeting report from the 2011 International Melanoma Congress, Tampa, FloridaQ53141067
Multidisciplinary approach to patient with malignant melanomaQ54462557
Prognostic and clinicopathologic associations of oncogenic BRAF in metastatic melanoma.Q54610975
MelanomaQ56428909
P433issue4
P407language of work or nameEnglishQ1860
P304page(s)431-443
P577publication date2013-09-27
P1433published inExpert Opinion on Emerging DrugsQ5421207
P1476titleEmerging BRAF inhibitors for melanoma
P478volume18

Reverse relations

cites work (P2860)
Q35811459Induction of Resistance to BRAF Inhibitor Is Associated with the Inability of Spry2 to Inhibit BRAF-V600E Activity in BRAF Mutant Cells
Q54964481KIT, NRAS, BRAF and FMNL2 mutations in oral mucosal melanoma and a systematic review of the literature.
Q35773340Targeted Therapies Compared to Dacarbazine for Treatment of BRAF(V600E) Metastatic Melanoma: A Cost-Effectiveness Analysis

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