TORC1 Suppression Predicts Responsiveness to RAF and MEK Inhibition in BRAF- Mutant Melanoma

scientific article published on July 31, 2013

TORC1 Suppression Predicts Responsiveness to RAF and MEK Inhibition in BRAF- Mutant Melanoma is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1126/SCITRANSLMED.3005753
P953full work available at URLhttps://doi.org/10.1126/scitranslmed.3005753
https://europepmc.org/articles/PMC3867020
https://europepmc.org/articles/pmc3867020?pdf=render
https://europepmc.org/articles/PMC3867020?pdf=render
https://www.science.org/doi/pdf/10.1126/scitranslmed.3005753
P932PMC publication ID3867020
P698PubMed publication ID23903755

P50authorDaniel HaberQ5217393
Keith FlahertyQ6384357
Jennifer WargoQ32650026
Mari Mino-KenudsonQ40930518
Rosalynn M. NazarianQ51791961
Aaron N HataQ80043157
Shyamala MaheswaranQ89582233
Adriano PirisQ125315301
P2093author name stringJohn Walsh
Ronald D. Brown
Jeffrey Settleman
Daniel Winokur
Keith T. Flaherty
Daniel A. Haber
Jennifer A. Wargo
Anthony C. Faber
Ryan B. Corcoran
Stephen Michael Rothenberg
Jeffrey A. Engelman
Jason T. Godfrey
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Fine-needle biopsy of metastatic melanoma: clinical use and new applicationsQ37682482
mTOR signaling and drug development in cancerQ37710367
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Apoptosis induction in human melanoma cells by inhibition of MEK is caspase-independent and mediated by the Bcl-2 family members PUMA, Bim, and Mcl-1.Q40102679
Activation of the ERK1/2 signaling pathway promotes phosphorylation and proteasome-dependent degradation of the BH3-only protein, Bim.Q40662652
Basal and treatment-induced activation of AKT mediates resistance to cell death by AZD6244 (ARRY-142886) in Braf-mutant human cutaneous melanoma cellsQ42478581
AZD8055 is a potent, selective, and orally bioavailable ATP-competitive mammalian target of rapamycin kinase inhibitor with in vitro and in vivo antitumor activityQ43211411
P433issue196
P407language of work or nameEnglishQ1860
P304page(s)196ra98
P577publication date2013-07-01
2013-07-31
P1433published inScience Translational MedicineQ1573955
P1476titleTORC1 suppression predicts responsiveness to RAF and MEK inhibition in BRAF-mutant melanoma
TORC1 Suppression Predicts Responsiveness to RAF and MEK Inhibition in BRAF- Mutant Melanoma
P478volume5

Reverse relations

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