Systemic treatment in EGFR-ALK NSCLC patients: second line therapy and beyond

scientific article published on 10 March 2014

Systemic treatment in EGFR-ALK NSCLC patients: second line therapy and beyond is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1586/14737140.2014.896210
P698PubMed publication ID24611674
P5875ResearchGate publication ID260680838

P50authorRafael RosellQ30003989
P2093author name stringSantiago Viteri
Daniela Morales-Espinosa
Niki Karachaliou
P2860cites workThe biology and treatment of EML4-ALK non-small cell lung cancerQ24632625
LKB1/AMPK/mTOR signaling pathway in non-small-cell lung cancerQ27026346
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Anaplastic lymphoma kinase inhibition in non-small-cell lung cancerQ27851588
Genotypic and histological evolution of lung cancers acquiring resistance to EGFR inhibitorsQ27851633
Mechanisms of resistance to crizotinib in patients with ALK gene rearranged non-small cell lung cancer.Q27851702
Optimal detection of ALK rearranged lung adenocarcinomasQ44979559
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Pretreatment EGFR T790M mutation and BRCA1 mRNA expression in erlotinib-treated advanced non-small-cell lung cancer patients with EGFR mutations.Q54620289
Mechanisms of acquired crizotinib resistance in ALK-rearranged lung CancersQ27851710
Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC): a multicentre, open-label, randomised phase 3 trialQ27851712
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Discovery of a mutant-selective covalent inhibitor of EGFR that overcomes T790M-mediated resistance in NSCLC.Q27852553
Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinomaQ27860881
Gefitinib-sensitizing EGFR mutations in lung cancer activate anti-apoptotic pathwaysQ28274882
Benchmarking of mutation diagnostics in clinical lung cancer specimensQ28740430
BIM mediates EGFR tyrosine kinase inhibitor-induced apoptosis in lung cancers with oncogenic EGFR mutationsQ28756824
Detection of mutations in EGFR in circulating lung-cancer cellsQ29615033
Targeted inhibition of the molecular chaperone Hsp90 overcomes ALK inhibitor resistance in non-small cell lung cancerQ33860904
Pretreatment epidermal growth factor receptor (EGFR) T790M mutation predicts shorter EGFR tyrosine kinase inhibitor response duration in patients with non-small-cell lung cancer.Q34116750
Impact of EGFR inhibitor in non-small cell lung cancer on progression-free and overall survival: a meta-analysisQ34339890
Rebiopsy of lung cancer patients with acquired resistance to EGFR inhibitors and enhanced detection of the T790M mutation using a locked nucleic acid-based assayQ34762839
Targeting the FOXO1/KLF6 axis regulates EGFR signaling and treatment response.Q36068326
Targeted resequencing reveals ALK fusions in non-small cell lung carcinomas detected by FISH, immunohistochemistry, and real-time RT-PCR: a comparison of four methodsQ36635602
TORC1 suppression predicts responsiveness to RAF and MEK inhibition in BRAF-mutant melanomaQ37401151
Tyrosine kinase gene rearrangements in epithelial malignanciesQ37515966
Activity and safety of crizotinib in patients with ALK-positive non-small-cell lung cancer: updated results from a phase 1 studyQ37606591
Anaplastic lymphoma kinase in human cancerQ37866541
Irreversible protein kinase inhibitorsQ37886215
Second-generation irreversible epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs): a better mousetrap? A review of the clinical evidenceQ37976901
Novel small molecule EGFR inhibitors as candidate drugs in non-small cell lung cancer.Q38110796
Genetics and biomarkers in personalisation of lung cancer treatmentQ38131166
Afatinib prolongs survival compared with gefitinib in an epidermal growth factor receptor-driven lung cancer modelQ39188098
The activation of MAPK in melanoma cells resistant to BRAF inhibition promotes PD-L1 expression that is reversible by MEK and PI3K inhibitionQ39254036
HGF induces novel EGFR functions involved in resistance formation to tyrosine kinase inhibitorsQ39263953
Akt kinase-interacting protein1, a novel therapeutic target for lung cancer with EGFR-activating and gatekeeper mutationsQ39263992
Activation of IL-6R/JAK1/STAT3 signaling induces de novo resistance to irreversible EGFR inhibitors in non-small cell lung cancer with T790M resistance mutationQ39297840
Combined effect of ALK and MEK inhibitors in EML4-ALK-positive non-small-cell lung cancer cellsQ39413086
FAS and NF-κB signalling modulate dependence of lung cancers on mutant EGFR.Q39571776
Role of ERK-BIM and STAT3-survivin signaling pathways in ALK inhibitor-induced apoptosis in EML4-ALK-positive lung cancerQ39574492
Enhanced anticancer effect of the combination of BIBW2992 and thymidylate synthase-targeted agents in non-small cell lung cancer with the T790M mutation of epidermal growth factor receptorQ39695840
Combined vascular endothelial growth factor receptor and epidermal growth factor receptor (EGFR) blockade inhibits tumor growth in xenograft models of EGFR inhibitor resistanceQ39850353
Targeted therapies: Afatinib--new therapy option for EGFR-mutant lung cancerQ41837868
Activation of HER family signaling as a mechanism of acquired resistance to ALK inhibitors in EML4-ALK-positive non-small cell lung cancerQ42716713
P433issue7
P921main subjectnon-small-cell lung carcinomaQ3658562
P304page(s)807-815
P577publication date2014-03-10
P1433published inExpert Review of Anticancer TherapyQ2999044
P1476titleSystemic treatment in EGFR-ALK NSCLC patients: second line therapy and beyond
P478volume14

Reverse relations

cites work (P2860)
Q39278116Anaplastic lymphoma kinase inhibitors in phase I and phase II clinical trials for non-small cell lung cancer
Q61455304Epidermal Growth Factor Receptor (EGFR) Mutations and Anaplastic Lymphoma Kinase/Oncogene or C-Ros Oncogene 1 (ALK/ROS1) Fusions Inflict Non-Small Cell Lung Cancer (NSCLC) Female Patients Older Than 60 Years of Age
Q58573308MicroRNA-133a downregulated EGFR expression in human non-small cell lung cancer cells via AKT/ERK signaling
Q39095285Pharmacological management of relapsed/refractory NSCLC with chemical drugs
Q92236871Profile of alectinib for the treatment of ALK-positive non-small cell lung cancer (NSCLC): patient selection and perspectives
Q39139907Targeted treatment of mutated EGFR-expressing non-small-cell lung cancer: focus on erlotinib with companion diagnostics
Q37046602The molecular and clinical verification of therapeutic resistance via the p38 MAPK-Hsp27 axis in lung cancer

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