Targeting the FOXO1/KLF6 axis regulates EGFR signaling and treatment response.

scientific article

Targeting the FOXO1/KLF6 axis regulates EGFR signaling and treatment response. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1172/JCI62058
P932PMC publication ID3386822
P698PubMed publication ID22653055
P5875ResearchGate publication ID225087920

P50authorGoutham NarlaQ72345872
Huma RanaQ84265636
P2093author name stringEric Yuan
Katerina Politi
Michael Ohlmeyer
Matthew Galsky
Analisa Difeo
David Burstein
Heather Melville
David Zhang
Sudeh Izadmehr
Neil S Dhawan
Jaya Sangodkar
Sahar Mazhar
Suzanna Katz
Caroline Farrington
Varan J Singh
Pearlann Arnovitz
Rachel Okrent
Tara Albano
P2860cites workKRAS mutations and primary resistance of lung adenocarcinomas to gefitinib or erlotinibQ21563446
A module of negative feedback regulators defines growth factor signalingQ45345602
Mutation-specific antibodies for the detection of EGFR mutations in non-small-cell lung cancerQ46051178
Differentially expressed genes in nonsmall cell lung cancer: expression profiling of cancer-related genes in squamous cell lung cancerQ47906539
Roles of KLF6 and KLF6-SV1 in ovarian cancer progression and intraperitoneal dissemination.Q54596671
Search for Large Extra Dimensions in Dielectron and Diphoton ProductionQ56942433
Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factorQ22009126
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complexQ24295120
Phosphorylation of serine 256 suppresses transactivation by FKHR (FOXO1) by multiple mechanisms. Direct and indirect effects on nuclear/cytoplasmic shuttling and DNA bindingQ24306703
Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domainQ24794765
EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapyQ27824812
EGFR mutation and resistance of non-small-cell lung cancer to gefitinibQ27824829
MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signalingQ27851406
Genotypic and histological evolution of lung cancers acquiring resistance to EGFR inhibitorsQ27851633
Cancer statistics, 2010Q27860525
PTEN loss contributes to erlotinib resistance in EGFR-mutant lung cancer by activation of Akt and EGFRQ28240702
FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasisQ28285131
Combination Treatment with MEK and AKT Inhibitors Is More Effective than Each Drug Alone in Human Non-Small Cell Lung Cancer In Vitro and In VivoQ28476362
Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systemsQ28586004
Erlotinib in previously treated non-small-cell lung cancerQ29547546
Gene-expression profiles predict survival of patients with lung adenocarcinomaQ29614443
Classification of human lung carcinomas by mRNA expression profiling reveals distinct adenocarcinoma subclassesQ29616071
EGF-ERBB signalling: towards the systems levelQ29619032
Krüppel-like factor 6 is frequently down-regulated and induces apoptosis in non-small cell lung cancer cells.Q30762846
Integrative genomic approaches identify IKBKE as a breast cancer oncogeneQ33287979
Phosphatidylinositol 3-kinase signaling in proliferating cells maintains an anti-apoptotic transcriptional program mediated by inhibition of FOXO and non-canonical activation of NFkappaB transcription factorsQ33316851
Targeted reduction of KLF6-SV1 restores chemotherapy sensitivity in resistant lung adenocarcinoma.Q33699499
Lung adenocarcinomas induced in mice by mutant EGF receptors found in human lung cancers respond to a tyrosine kinase inhibitor or to down-regulation of the receptorsQ34666826
PTEN deficiency accelerates tumour progression in a mouse model of thyroid cancerQ36278234
FOXO transcription factors: key regulators of cell fateQ36628599
Ras promotes growth by alternative splicing-mediated inactivation of the KLF6 tumor suppressor in hepatocellular carcinoma.Q37010442
The role of KLF6 and its splice variants in cancer therapyQ37355353
Proteasomal degradation of the FoxO1 transcriptional regulator in cells transformed by the P3k and Akt oncoproteinsQ37535142
MK-2206, an allosteric Akt inhibitor, enhances antitumor efficacy by standard chemotherapeutic agents or molecular targeted drugs in vitro and in vivoQ38431323
FAS and NF-κB signalling modulate dependence of lung cancers on mutant EGFR.Q39571776
Inferring dynamic gene networks under varying conditions for transcriptomic network comparison.Q39733251
Expression and localization of FOXO1 in non-small cell lung cancer.Q39840324
AZD6244 (ARRY-142886), a potent inhibitor of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase 1/2 kinases: mechanism of action in vivo, pharmacokinetic/pharmacodynamic relationship, and potential for combination in preclQ40093939
Functional inactivation of the KLF6 tumor suppressor gene by loss of heterozygosity and increased alternative splicing in glioblastomaQ40130158
Biological characterization of ARRY-142886 (AZD6244), a potent, highly selective mitogen-activated protein kinase kinase 1/2 inhibitorQ40164535
Somatic activation of the K-ras oncogene causes early onset lung cancer in miceQ40809826
Phosphorylation and nuclear exclusion of the forkhead transcription factor FKHR after epidermal growth factor treatment in human breast cancer cells.Q40849405
A chemical genetic screen identifies inhibitors of regulated nuclear export of a Forkhead transcription factor in PTEN-deficient tumor cellsQ44714283
PTEN and PIK3CA expression is associated with prolonged survival after gefitinib treatment in EGFR-mutated lung cancer patients.Q44846498
P4510describes a project that usesImageJQ1659584
P433issue7
P407language of work or nameEnglishQ1860
P304page(s)2637-2651
P577publication date2012-06-01
P1433published inJournal of Clinical InvestigationQ3186904
P1476titleTargeting the FOXO1/KLF6 axis regulates EGFR signaling and treatment response
P478volume122

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