Reduced phosphorylation of ribosomal protein S6 is associated with sensitivity to MEK inhibition in gastric cancer cells

scientific article published on 03 October 2016

Reduced phosphorylation of ribosomal protein S6 is associated with sensitivity to MEK inhibition in gastric cancer cells is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1111/CAS.13094
P932PMC publication ID5198963
P698PubMed publication ID27699948

P50authorHidekatsu IhaQ55271494
Naoki HijiyaQ89308701
Kazunari MurakamiQ98167151
Kuniaki ShiraoQ115365988
Masatsugu MoriyamaQ115626768
Keiko MatsuuraQ115626771
Yoshiyuki TsukamotoQ115626775
Tomohisa UchidaQ115626776
P2093author name stringKazuyoshi Yanagihara
Masataka Seike
Tsutomu Daa
Masaaki Kodama
Tadayoshi Okimoto
Shoichi Fumoto
Chisato Nakada
Yuka Hirashita
P2860cites workImproved survival with vemurafenib in melanoma with BRAF V600E mutationQ24631953
Dual Inhibition of MEK and PI3K Pathway in KRAS and BRAF Mutated Colorectal CancersQ26781362
Targeting receptor tyrosine kinases in gastric cancerQ27013050
Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trialQ27851578
Comprehensive Predictive Biomarker Analysis for MEK Inhibitor GSK1120212Q27851693
Intrinsic resistance to MEK inhibition in KRAS mutant lung and colon cancer through transcriptional induction of ERBB3.Q27852991
RAF suppression synergizes with MEK inhibition in KRAS mutant cancer cellsQ27853064
Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012Q27861047
Defining the role of mTOR in cancerQ28235431
Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancerQ28240089
Comprehensive molecular characterization of gastric adenocarcinomaQ28244985
Gefitinib or chemotherapy for non-small-cell lung cancer with mutated EGFRQ29547545
Five-year follow-up of patients receiving imatinib for chronic myeloid leukemiaQ29614280
Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancerQ29618155
mTOR signaling at a glanceQ29619857
Identification of a novel human ankyrin-repeated protein homologous to CARP.Q30687802
Amplification of HER-2 in gastric carcinoma: association with Topoisomerase IIalpha gene amplification, intestinal type, poor prognosis and sensitivity to trastuzumab.Q34554455
S-1 plus cisplatin versus S-1 alone for first-line treatment of advanced gastric cancer (SPIRITS trial): a phase III trialQ34588472
Randomized phase III study comparing the efficacy and safety of irinotecan plus S-1 with S-1 alone as first-line treatment for advanced gastric cancer (study GC0301/TOP-002)Q34669648
A comprehensive survey of genomic alterations in gastric cancer reveals systematic patterns of molecular exclusivity and co-occurrence among distinct therapeutic targetsQ35878807
A unifying model for mTORC1-mediated regulation of mRNA translation.Q35945036
HER2 in gastric cancer: a new prognostic factor and a novel therapeutic targetQ37149210
TORC1 Suppression Predicts Responsiveness to RAF and MEK Inhibition in BRAF- Mutant MelanomaQ37401151
Translational control in cancer.Q37717999
MEK inhibitor for gastric cancer with MEK1 gene mutations.Q38953493
KRAS/BRAF mutation status and ERK1/2 activation as biomarkers for MEK1/2 inhibitor therapy in colorectal cancerQ39860040
Identification of a conserved motif required for mTOR signalingQ40736711
Antiproliferative effects of isoflavones on human cancer cell lines established from the gastrointestinal tract.Q41511697
Establishment and characterization of a human gastric scirrhous carcinoma cell line in serum-free chemically defined mediumQ41554018
Establishment of two cell lines from human gastric scirrhous carcinoma that possess the potential to metastasize spontaneously in nude miceQ42800324
Establishment and characterization of human signet ring cell gastric carcinoma cell lines with amplification of the c-myc oncogeneQ42808616
Fluorouracil versus combination of irinotecan plus cisplatin versus S-1 in metastatic gastric cancer: a randomised phase 3 studyQ43264239
BRAF and KRAS mutations in stomach cancerQ44611189
Mutually exclusive FGFR2, HER2, and KRAS gene amplifications in gastric cancer revealed by multicolour FISH.Q44952322
ADAM17-dependent c-MET-STAT3 signaling mediates resistance to MEK inhibitors in KRAS mutant colorectal cancer.Q45954184
Growth-promoting effect of gastrin on human gastric carcinoma cell line TMK-1Q70122834
Trastuzumab in the treatment of breast cancerQ81374982
P433issue12
P921main subjectphosphorylationQ242736
P304page(s)1919-1928
P577publication date2016-10-03
P1433published inCancer ScienceQ326125
P1476titleReduced phosphorylation of ribosomal protein S6 is associated with sensitivity to MEK inhibition in gastric cancer cells
P478volume107

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cites work (P2860)
Q92254021Concomitant targeting of BCL2 with venetoclax and MAPK signaling with cobimetinib in acute myeloid leukemia models
Q31165479Gastric Cancer Associated Genes Identified by an Integrative Analysis of Gene Expression Data.
Q132042932Ribosomal Protein S6: A Potential Therapeutic Target against Cancer?
Q64998809The nucleolus, an ally, and an enemy of cancer cells.