mTORC1/autophagy-regulated MerTK in mutant BRAFV600 melanoma with acquired resistance to BRAF inhibition

scientific article published on 25 May 2017

mTORC1/autophagy-regulated MerTK in mutant BRAFV600 melanoma with acquired resistance to BRAF inhibition is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.18632/ONCOTARGET.18213
P932PMC publication ID5642473
P698PubMed publication ID29050198

P50authorBrian HemmingsQ4964012
Reinhard DummerQ32650033
P2093author name stringYuhua Wang
Alfred Zippelius
Peter Cron
Mario Mandalà
Andreas Wicki
Mitchell P Levesque
Stephan Dirnhofer
Daniela Massi
Fengyuan Tang
Taha Merghoub
Curzio Rüegg
Daniela Taverna
Francesca Orso
Giulio C Spagnoli
Huifang Tang
Christel Genoud
Tim Roloff
Reto Ritschard
Gongda Xue
Manuele G Muraro
Petra Hirschmann
Vincent Prêtre
Debby Hynx
Sandrine Bichet
Reto Kohler
Alexandra G Meyer
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Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulationQ24629474
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Cleavage of Mer tyrosine kinase (MerTK) from the cell surface contributes to the regulation of retinal phagocytosisQ35103962
Delayed apoptotic cell clearance and lupus-like autoimmunity in mice lacking the c-mer membrane tyrosine kinaseQ36371130
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MerTK inhibition in tumor leukocytes decreases tumor growth and metastasisQ37052927
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TORC1 Suppression Predicts Responsiveness to RAF and MEK Inhibition in BRAF- Mutant MelanomaQ37401151
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Overcoming resistance to rapalogs in gliomas by combinatory therapiesQ38080364
Signal integration by mTORC1 coordinates nutrient input with biosynthetic output.Q38111226
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Acquired Resistance to Clinical Cancer Therapy: A Twist in Physiological SignalingQ38824661
Targeting ER stress-induced autophagy overcomes BRAF inhibitor resistance in melanoma.Q39020884
Down-regulation of autophagy-related protein 5 (ATG5) contributes to the pathogenesis of early-stage cutaneous melanomaQ39096897
Akt/PKB-mediated phosphorylation of Twist1 promotes tumor metastasis via mediating cross-talk between PI3K/Akt and TGF-β signaling axes.Q39348238
Mer receptor tyrosine kinase promotes invasion and survival in glioblastoma multiformeQ39370401
Cobimetinib combined with vemurafenib in advanced BRAF(V600)-mutant melanoma (coBRIM): updated efficacy results from a randomised, double-blind, phase 3 trialQ39537308
Defective regulation of autophagy upon leucine deprivation reveals a targetable liability of human melanoma cells in vitro and in vivo.Q39541632
A proliferative melanoma cell phenotype is responsive to RAF/MEK inhibition independent of BRAF mutation statusQ39802879
Dabrafenib and trametinib versus dabrafenib and placebo for Val600 BRAF-mutant melanoma: a multicentre, double-blind, phase 3 randomised controlled trialQ40875359
Autophagy-deficient mice develop multiple liver tumorsQ42099409
The TAM family: phosphatidylserine sensing receptor tyrosine kinases gone awry in cancerQ54298179
A switch in the expression of embryonic EMT-inducers drives the development of malignant melanoma.Q54406377
P433issue41
P407language of work or nameEnglishQ1860
P921main subjectautophagyQ288322
P304page(s)69204-69218
P577publication date2017-05-25
P1433published inOncotargetQ1573155
P1476titlemTORC1/autophagy-regulated MerTK in mutant BRAFV600 melanoma with acquired resistance to BRAF inhibition
P478volume8

Reverse relations

cites work (P2860)
Q64974212Plasma lncRNA expression profile as a prognostic tool in BRAF-mutant metastatic melanoma patients treated with BRAF inhibitor.
Q53694245The Role of Autophagy in the Resistance to BRAF Inhibition in BRAF-Mutated Melanoma
Q57821061The efficacy of re-challenge with BRAF inhibitors after previous progression to BRAF inhibitors in melanoma: A retrospective multicenter study

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