Circumventing Cancer Drug Resistance in the Era of Personalized Medicine

scientific article published on February 28, 2012

Circumventing Cancer Drug Resistance in the Era of Personalized Medicine is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1158/2159-8290.CD-12-0012
P953full work available online athttps://aacrjournals.org/cancerdiscovery/article-pdf/2/3/214/1712704/214.pdf
https://cancerdiscovery.aacrjournals.org/content/candisc/2/3/214.full.pdf
P698PubMed publication ID22585993

P50authorPasi A JänneQ74766165
Levi A GarrawayQ89916155
P2860cites workIdentification of CDK10 as an important determinant of resistance to endocrine therapy for breast cancerQ24309649
Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulationQ24629474
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MET amplification occurs with or without T790M mutations in EGFR mutant lung tumors with acquired resistance to gefitinib or erlotinibQ24646295
AP24534, a pan-BCR-ABL inhibitor for chronic myeloid leukemia, potently inhibits the T315I mutant and overcomes mutation-based resistanceQ24648017
The T790M mutation in EGFR kinase causes drug resistance by increasing the affinity for ATPQ24649549
BIBW2992, an irreversible EGFR/HER2 inhibitor highly effective in preclinical lung cancer modelsQ24649935
Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domainQ24794765
KIT kinase mutants show unique mechanisms of drug resistance to imatinib and sunitinib in gastrointestinal stromal tumor patientsQ27653496
Novel mutant-selective EGFR kinase inhibitors against EGFR T790MQ27658766
Discovery of a small-molecule type II inhibitor of wild-type and gatekeeper mutants of BCR-ABL, PDGFR , Kit, and Src kinases: novel type II inhibitor of gatekeeper mutantsQ27660281
MEK1 mutations confer resistance to MEK and B-RAF inhibitionQ27777362
Molecular correlates of imatinib resistance in gastrointestinal stromal tumors.Q27777367
EGFR mutation and resistance of non-small-cell lung cancer to gefitinibQ27824829
Allelic dilution obscures detection of a biologically significant resistance mutation in EGFR-amplified lung cancerQ27851396
MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signalingQ27851406
A functional genetic approach identifies the PI3K pathway as a major determinant of trastuzumab resistance in breast cancerQ27851414
Primary and secondary kinase genotypes correlate with the biological and clinical activity of sunitinib in imatinib-resistant gastrointestinal stromal tumorQ27851455
Anaplastic lymphoma kinase inhibition in non-small-cell lung cancerQ27851588
EML4-ALK mutations in lung cancer that confer resistance to ALK inhibitors.Q27851590
The Neuroblastoma-Associated F1174L ALK Mutation Causes Resistance to an ALK Kinase Inhibitor in ALK-Translocated CancersQ27851591
BRAF gene amplification can promote acquired resistance to MEK inhibitors in cancer cells harboring the BRAF V600E mutationQ27851610
Dissecting therapeutic resistance to RAF inhibition in melanoma by tumor genomic profilingQ27851628
Genotypic and histological evolution of lung cancers acquiring resistance to EGFR inhibitorsQ27851633
Differential inhibitor sensitivity of anaplastic lymphoma kinase variants found in neuroblastoma.Q27851684
Inhibition of Mutated, Activated BRAF in Metastatic MelanomaQ27860458
Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinomaQ27860881
Multidrug resistance in cancer: role of ATP-dependent transportersQ28208049
Lineage dependency and lineage-survival oncogenes in human cancerQ28253671
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Microenvironmental influence on pre-clinical activity of polo-like kinase inhibition in multiple myeloma: implications for clinical translationQ28478937
Topoisomerase levels determine chemotherapy responsein vitroandin vivoQ29395563
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mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates AktQ29547767
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Multiple BCR-ABL kinase domain mutations confer polyclonal resistance to the tyrosine kinase inhibitor imatinib (STI571) in chronic phase and blast crisis chronic myeloid leukemiaQ29615030
COT drives resistance to RAF inhibition through MAP kinase pathway reactivationQ29615032
Mefloquine resistance in Plasmodium falciparum and increased pfmdr1 gene copy numberQ29615128
EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancerQ29616360
Principles of cancer therapy: oncogene and non-oncogene addictionQ29616779
Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumorsQ29618610
Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplificationQ29618788
RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E)Q29620033
Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosomeQ33336718
Amplification of EGFR T790M causes resistance to an irreversible EGFR inhibitorQ33810574
TGF-beta IL-6 axis mediates selective and adaptive mechanisms of resistance to molecular targeted therapy in lung cancerQ34100276
Preexistence and clonal selection of MET amplification in EGFR mutant NSCLC.Q34307548
AKT inhibition relieves feedback suppression of receptor tyrosine kinase expression and activityQ34511038
Nilotinib versus imatinib for newly diagnosed chronic myeloid leukemiaQ34620246
Mechanisms of acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors in non-small cell lung cancerQ34778936
Therapeutic strategies to overcome crizotinib resistance in non-small cell lung cancers harboring the fusion oncogene EML4-ALK.Q34938204
Oncogenic PIK3CA-driven mammary tumors frequently recur via PI3K pathway-dependent and PI3K pathway-independent mechanismsQ35204583
MECHANISMS OF RESISTANCE TO ANTICANCER AGENTS.Q35443005
The molecular basis of multidrug resistance in cancer: the early years of P-glycoprotein researchQ36365560
Acquired resistance to EGFR tyrosine kinase inhibitors in cancer cells is mediated by loss of IGF-binding proteinsQ36726112
Applying the discovery of the Philadelphia chromosomeQ36900109
Basal subtype and MAPK/ERK kinase (MEK)-phosphoinositide 3-kinase feedback signaling determine susceptibility of breast cancer cells to MEK inhibitionQ37331610
Targeted selection of recombinant clones through gene dosage effectsQ37510502
Epithelial to mesenchymal transition in an epidermal growth factor receptor-mutant lung cancer cell line with acquired resistance to erlotinibQ39539475
Bone marrow stroma-secreted cytokines protect JAK2(V617F)-mutated cells from the effects of a JAK2 inhibitorQ39554914
Amplification of the driving oncogene, KRAS or BRAF, underpins acquired resistance to MEK1/2 inhibitors in colorectal cancer cells.Q39568646
FAS and NF-κB signalling modulate dependence of lung cancers on mutant EGFR.Q39571776
Mechanisms of sunitinib resistance in gastrointestinal stromal tumors harboring KITAY502-3ins mutation: an in vitro mutagenesis screen for drug resistanceQ39782803
Crosstalk to stromal fibroblasts induces resistance of lung cancer to epidermal growth factor receptor tyrosine kinase inhibitorsQ39785355
Combined vascular endothelial growth factor receptor and epidermal growth factor receptor (EGFR) blockade inhibits tumor growth in xenograft models of EGFR inhibitor resistanceQ39850353
Hepatocyte growth factor induces gefitinib resistance of lung adenocarcinoma with epidermal growth factor receptor-activating mutations.Q39916367
PF00299804, an irreversible pan-ERBB inhibitor, is effective in lung cancer models with EGFR and ERBB2 mutations that are resistant to gefitinibQ40033522
Emergence of epidermal growth factor receptor T790M mutation during chronic exposure to gefitinib in a non small cell lung cancer cell lineQ40093771
Evidence for multidrug-resistant cells in human tumor cell populationsQ40137710
Dynamics of chronic myeloid leukaemia.Q40403398
Erlotinib resistance in mouse models of epidermal growth factor receptor-induced lung adenocarcinomaQ42017054
Comparison of imatinib mesylate, dasatinib (BMS-354825), and nilotinib (AMN107) in an N-ethyl-N-nitrosourea (ENU)-based mutagenesis screen: high efficacy of drug combinationsQ42742043
Dasatinib versus imatinib in newly diagnosed chronic-phase chronic myeloid leukemiaQ43043759
Benefit of cyclosporine modulation of drug resistance in patients with poor-risk acute myeloid leukemia: a Southwest Oncology Group studyQ43806484
BCR-ABL point mutants isolated from patients with imatinib mesylate-resistant chronic myeloid leukemia remain sensitive to inhibitors of the BCR-ABL chaperone heat shock protein 90.Q44155448
A phase I/II study of the MDR modulator Valspodar (PSC 833) combined with daunorubicin and cytarabine in patients with relapsed and primary refractory acute myeloid leukemiaQ44280538
Gemtuzumab, fludarabine, cytarabine, and cyclosporine in patients with newly diagnosed acute myelogenous leukemia or high-risk myelodysplastic syndromesQ44356043
Mechanisms of autoinhibition and STI-571/imatinib resistance revealed by mutagenesis of BCR-ABL.Q44373949
Phase II study of dexverapamil plus anthracycline in patients with metastatic breast cancer who have progressed on the same anthracycline regimenQ47975546
Phase I and pharmacodynamic study of the topoisomerase I-inhibitor topotecan in patients with refractory acute leukemiaQ52213829
Daunorubicin-resistant Chinese hamster ovary cells expressing multidrug resistance and a cell-surface P-glycoproteinQ52829691
MDR1 inhibition: less resistance or less relevance?Q53948727
Cross-resistance to alkylating agents in multiple myelomaQ71788593
Quinidine as a resistance modulator of epirubicin in advanced breast cancer: mature results of a placebo-controlled randomized trialQ72182720
Cell Surface P-Glycoprotein Associated with Multidrug Resistance in Mammalian Cell LinesQ72561176
Verapamil increases the survival of patients with anthracycline-resistant metastatic breast carcinomaQ73356015
Acquired resistance to the antitumor effect of epidermal growth factor receptor-blocking antibodies in vivo: a role for altered tumor angiogenesisQ74114483
Bcr-Abl kinase domain mutations, drug resistance, and the road to a cure for chronic myeloid leukemiaQ80317123
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectpersonalized medicineQ2072214
P304page(s)214-226
P577publication date2012-02-28
P1433published inCancer DiscoveryQ15724440
P1476titleCircumventing cancer drug resistance in the era of personalized medicine
Circumventing Cancer Drug Resistance in the Era of Personalized Medicine
P478volume2

Reverse relations

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