Combination of ibrutinib with ABT-199: synergistic effects on proliferation inhibition and apoptosis in mantle cell lymphoma cells through perturbation of BTK, AKT and BCL2 pathways.

scientific article published on 4 October 2014

Combination of ibrutinib with ABT-199: synergistic effects on proliferation inhibition and apoptosis in mantle cell lymphoma cells through perturbation of BTK, AKT and BCL2 pathways. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1111/BJH.13149
P698PubMed publication ID25284608

P50authorMitchell SmithQ47320517
P2093author name stringEric D Hsi
Jeffrey Lin
Lisa Durkin
Juraj Bodo
Xiaoxian Zhao
Danyu Sun
P2860cites workChronic active B-cell-receptor signalling in diffuse large B-cell lymphomaQ24613755
Targeting BTK with ibrutinib in relapsed or refractory mantle-cell lymphomaQ30371806
Circumventing Cancer Drug Resistance in the Era of Personalized MedicineQ34274940
Induction of bcl-2 expression by phosphorylated CREB proteins during B-cell activation and rescue from apoptosisQ36562739
Acquired mutations in BCL2 family proteins conferring resistance to the BH3 mimetic ABT-199 in lymphoma.Q38999783
Combinatorial drug screening identifies synergistic co-targeting of Bruton's tyrosine kinase and the proteasome in mantle cell lymphomaQ42553000
B cell receptor-induced cAMP-response element-binding protein activation in B lymphocytes requires novel protein kinase CdeltaQ44892444
Mcl-1 down-regulation potentiates ABT-737 lethality by cooperatively inducing Bak activation and Bax translocationQ44926251
Toward New Treatments for Mantle-Cell Lymphoma?Q46607983
P433issue5
P407language of work or nameEnglishQ1860
P921main subjectmantle cell lymphomaQ268713
ibrutinibQ5984881
P304page(s)765-768
P577publication date2014-10-04
P1433published inBritish Journal of HaematologyQ4970200
P1476titleCombination of ibrutinib with ABT-199: synergistic effects on proliferation inhibition and apoptosis in mantle cell lymphoma cells through perturbation of BTK, AKT and BCL2 pathways.
P478volume168

Reverse relations

cites work (P2860)
Q38659428B-cell receptor pathway modulators in NHL.
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Q42553373CCMCL1: a new model of aggressive mantle cell lymphoma
Q39325783Current Status of Bruton's Tyrosine Kinase Inhibitor Development and Use in B-Cell Malignancies
Q37702281Development of venetoclax for therapy of lymphoid malignancies.
Q38919666Distinct and Overlapping Functions of TEC Kinase and BTK in B Cell Receptor Signaling
Q93223071Dynamic molecular monitoring reveals that SWI-SNF mutations mediate resistance to ibrutinib plus venetoclax in mantle cell lymphoma
Q47424531Experience with ibrutinib for first-line use in patients with chronic lymphocytic leukemia
Q37404843FBXO10 deficiency and BTK activation upregulate BCL2 expression in mantle cell lymphoma.
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Q39694093p53-independent ibrutinib responses in an Eμ-TCL1 mouse model demonstrates efficacy in high-risk CLL.

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