Induction of bcl-2 expression by phosphorylated CREB proteins during B-cell activation and rescue from apoptosis

scientific article published on October 1996

Induction of bcl-2 expression by phosphorylated CREB proteins during B-cell activation and rescue from apoptosis is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1128/MCB.16.10.5546
P932PMC publication ID231554
P698PubMed publication ID8816467
P5875ResearchGate publication ID14387779

P2093author name stringE Mochon
L M Boxer
B E Wilson
P2860cites workThree distinct IL-2 signaling pathways mediated by bcl-2, c-myc, and lck cooperate in hematopoietic cell proliferationQ24316156
B-cell apoptosis induced by antigen receptor crosslinking is blocked by a T-cell signal through CD40Q60065798
Lymphocyte stimulation by protein A ofStaphylococcus aureusQ66889128
Second-messenger pathways involved in the regulation of survival in germinal-centre B cells and in Burkitt lymphoma linesQ67599951
Cross-linking of surface Ig receptors on murine B lymphocytes stimulates the expression of nuclear tetradecanoyl phorbol acetate-response element-binding proteinsQ67985056
Regulation of bcl-2 proto-oncogene expression during normal human lymphocyte proliferationQ68821821
Involvement of a specific guanine nucleotide binding protein in receptor immunoglobulin stimulated inositol phospholipid hydrolysisQ69241485
G protein coupling of antigen receptor-stimulated polyphosphoinositide hydrolysis in B cellsQ69824734
Translocation of protein kinase C during membrane immunoglobulin-mediated transmembrane signaling in B lymphocytesQ70128453
Protein kinase C mediates activation of nuclear cAMP response element-binding protein (CREB) in B lymphocytes stimulated through surface IgQ72467778
Characterization of cis-regulating elements and trans-activating factors of the rat cardiac troponin T geneQ72863735
Function of major histocompatibility complex class II promoters requires cooperative binding between factors RFX and NF-YQ24562002
Activation of Src-like protein-tyrosine kinase Lyn and its association with phosphatidylinositol 3-kinase upon B-cell antigen receptor-mediated signalingQ24563239
Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform ExtractionQ25938986
Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133Q29617856
Interleukin-10 prevents spontaneous death of germinal center B cells by induction of the bcl-2 proteinQ33493389
Protein tyrosine phosphorylation is induced in murine B lymphocytes in response to stimulation with anti-immunoglobulin.Q33920584
Signal transduction and gene regulation: the nuclear response to cAMP.Q34329571
Stimulation of protein tyrosine phosphorylation by the B-lymphocyte antigen receptorQ34561889
Expression of Bcl-2 and Bcl-2-Ig fusion transcripts in normal and neoplastic cellsQ35582433
Increased spacing between Sp1 and TATAA renders human immunodeficiency virus type 1 replication defective: implication for Tat function.Q36654807
A negative regulatory element in the bcl-2 5'-untranslated region inhibits expression from an upstream promoterQ36686916
Identification of a cyclic-AMP-responsive element within the rat somatostatin geneQ37398428
Surface immunoglobulin crosslinking activates a tyrosine kinase pathway in B cells that is independent of protein kinase C.Q37401313
Programmed cell death in the immune system.Q37512286
Anti-immunoglobulin stimulation of B lymphocytes activates src-related protein-tyrosine kinasesQ37582902
Transmembrane signals and intracellular "second messengers" in the regulation of quiescent B-lymphocyte activationQ38173936
Regulation of cAMP-responsive enhancer binding proteins during cell cycle progression in T lymphocytes stimulated by IL-2.Q38300316
Three distinct regions within the constitutive activation domain of cAMP regulatory element-binding protein (CREB) are required for transcription activationQ38302361
Cyclosporin-A sensitive induction of NF-AT in murine B cellsQ38307826
Inducible nuclear expression of NF-kappa B in primary B cells stimulated through the surface Ig receptorQ38336317
Pi 1 binding sites are negative regulators of bcl-2 expression in pre-B cellsQ40016702
DEAE-dextran enhances electroporation of mammalian cellsQ40536296
Cyclic adenosine 3',5'-monophosphate response element binding protein (CREB) and related transcription-activating deoxyribonucleic acid-binding proteinsQ40820023
Transcriptional regulation by CREB and its relativesQ40847156
Programmed cell death by bcl-2-dependent and independent mechanisms in B lymphoma cellsQ40872600
Alternative promoters and exons, somatic mutation and deregulation of the Bcl-2-Ig fusion gene in lymphomaQ41090576
Early gene signalling-dependent and -independent induction of apoptosis in Ramos human B cells can be inhibited by over-expression of Bcl-2.Q41284480
Human interleukin-3 receptor modulates bcl-2 mRNA and protein levels through protein kinase C in TF-1 cellsQ41328391
Involvement of a guanine-nucleotide-binding component in membrane IgM-stimulated phosphoinositide breakdownQ41332919
Tumor necrosis factor-alpha up-regulates Bcl-2 expression and decreases calcium-dependent apoptosis in human B cell linesQ41356592
B cell antigen receptor-mediated apoptosis. Importance of accessory molecules CD19 and CD22, and of surface IgM cross-linking.Q41357423
Organization of the transcription factor binding sites in the kappa Ig intron enhancer. Effects of position, orientation, and spacingQ41428932
A monomeric derivative of the cellular transcription factor CREB functions as a constitutive activator.Q41431643
Identification of a p53-dependent negative response element in the bcl-2 geneQ41461046
The phosphoprotein phosphatase calcineurin controls calcium-dependent apoptosis in B cell linesQ41489248
Consensus AP-1 and CRE motifs upstream from the human cytotoxic serine protease B (CSP-B/CGL-1) gene synergize to activate transcription.Q41517641
Distinct activation domains within cAMP response element-binding protein (CREB) mediate basal and cAMP-stimulated transcription.Q41533668
Induction of CREB activity via the surface Ig receptor of B cells.Q41541674
Rescue from anti‐IgM‐induced programmed cell death by the B cell surface proteins CD20 and CD40Q41593581
Germinal center cells express bcl-2 protein after activation by signals which prevent their entry into apoptosisQ41671465
The role of tyrosine phosphorylation in signal transduction through surface Ig in human B cells. Inhibition of tyrosine phosphorylation prevents intracellular calcium releaseQ41699635
Surface immunoglobulins are involved in the interaction of protein A with human B cells and in the triggering of B cell proliferation induced by protein A-containing Staphylococcus aureusQ42669584
Phosphorylation-induced binding and transcriptional efficacy of nuclear factor CREB.Q43778599
Molecular analysis of mbcl-2: structure and expression of the murine gene homologous to the human gene involved in follicular lymphomaQ44720768
Somatotroph hypoplasia and dwarfism in transgenic mice expressing a non-phosphorylatable CREB mutantQ44768920
Activation of Epstein-Barr virus latent genes protects human B cells from death by apoptosisQ45859903
Structure of wild-type and mutant mouse β2-microglobulin genesQ48404514
Elimination of self-reactive B lymphocytes proceeds in two stages: arrested development and cell death.Q52227004
Defective thymocyte proliferation and IL-2 production in transgenic mice expressing a dominant-negative form of CREBQ59064185
P433issue10
P407language of work or nameEnglishQ1860
P921main subjectphosphorylationQ242736
apoptotic processQ14599311
P304page(s)5546-5556
P577publication date1996-10-01
P1433published inMolecular and Cellular BiologyQ3319478
P1476titleInduction of bcl-2 expression by phosphorylated CREB proteins during B-cell activation and rescue from apoptosis
P478volume16

Reverse relations

cites work (P2860)
Q5453846517Beta-estradiol signaling and regulation of proliferation and apoptosis of rat Sertoli cells.
Q3396290317beta-estradiol inhibits apoptosis in MCF-7 cells, inducing bcl-2 expression via two estrogen-responsive elements present in the coding sequence.
Q36123720A Coral-Derived Compound Improves Functional Recovery after Spinal Cord Injury through Its Antiapoptotic and Anti-Inflammatory Effects.
Q35194537A cell-permeable phosphine-borane complex delays retinal ganglion cell death after axonal injury through activation of the pro-survival extracellular signal-regulated kinases 1/2 pathway
Q35013700A decrease in phosphorylation of cAMP-response element-binding protein (CREBP) promotes retinal degeneration
Q37569994A noncanonical Flt3ITD/NF-κB signaling pathway represses DAPK1 in acute myeloid leukemia
Q36681959A novel SATB1 binding site in the BCL2 promoter region possesses transcriptional regulatory function
Q38621454A prostacyclin analog prevents radiocontrast nephropathy via phosphorylation of cyclic AMP response element binding protein
Q39048563A role for activator of G-protein signaling 3 (AGS3) in multiple myeloma
Q38332936A transcriptional regulatory element in the coding sequence of the human Bcl-2 gene.
Q40897795A-Myb up-regulates Bcl-2 through a Cdx binding site in t(14;18) lymphoma cells.
Q74139783AMPA receptor-mediated, calcium-dependent CREB phosphorylation in a subpopulation of auditory neurons surviving activity deprivation
Q36201760Acidosis promotes Bcl-2 family-mediated evasion of apoptosis: involvement of acid-sensing G protein-coupled receptor Gpr65 signaling to Mek/Erk
Q40429203Activation of CREB by tauroursodeoxycholic acid protects cholangiocytes from apoptosis induced by mTOR inhibition
Q77519062Activation of protein kinase C is required for protection of cells against apoptosis induced by singlet oxygen
Q39727977Activation of the Bcl-2 promoter by nerve growth factor is mediated by the p42/p44 MAPK cascade
Q64094403Activation of the ERK/Creb/Bcl‑2 pathway protects periodontal ligament stem cells against hydrogen peroxide‑induced oxidative stress
Q45249977Activity-dependent neuroprotection and cAMP response element-binding protein (CREB): kinase coupling, stimulus intensity, and temporal regulation of CREB phosphorylation at serine 133.
Q61776692Acute lymphoblastic leukemia associated with RCSD1–ABL1 novel fusion gene has a distinct gene expression profile from BCR–ABL1 fusion
Q30461475Adenosine kinase inhibition in the cochlea delays the onset of age-related hearing loss
Q22009996Aiolos transcription factor controls cell death in T cells by regulating Bcl-2 expression and its cellular localization
Q39718902Amplification at 11q23 targets protein kinase SIK2 in diffuse large B-cell lymphoma
Q78946402An extranuclear locus of cAMP-dependent protein kinase action is necessary and sufficient for promotion of spiral ganglion neuronal survival by cAMP
Q34047984Antioxidants modulate mitochondrial PKA and increase CREB binding to D-loop DNA of the mitochondrial genome in neurons
Q28505126Apoptosis, axonal growth defects, and degeneration of peripheral neurons in mice lacking CREB
Q89767049Azoramide protects iPSC-derived dopaminergic neurons with PLA2G6 D331Y mutation through restoring ER function and CREB signaling
Q44892444B cell receptor-induced cAMP-response element-binding protein activation in B lymphocytes requires novel protein kinase Cdelta
Q58741742BC094916 suppressed SP 2/0 xenograft tumor by down-regulating Creb1 and Bcl2 transcription
Q36458739BP1 transcriptionally activates bcl-2 and inhibits TNFalpha-induced cell death in MCF7 breast cancer cells
Q36496619Bcl-2 overexpression in PhIP-induced colon tumors: cloning of the rat Bcl-2 promoter and characterization of a pathway involving beta-catenin, c-Myc and E2F1
Q38336118Bcl-2 transcription from the proximal P2 promoter is activated in neuronal cells by the Brn-3a POU family transcription factor
Q51504173CHIP buffers heterogeneous Bcl-2 expression levels to prevent augmentation of anticancer drug-resistant cell population.
Q75332680CRE-mediated gene transcription in the peri-infarct area after focal cerebral ischemia in mice
Q40749841CRE-mediated transcriptional activation is involved in cAMP protection of T-cell receptor-induced apoptosis but not in cAMP potentiation of glucocorticoid-mediated programmed cell death.
Q24680427CREB DNA binding activity is inhibited by glycogen synthase kinase-3 beta and facilitated by lithium
Q33857179CREB couples neurotrophin signals to survival messages
Q33908482CREB is a key regulator of striatal vulnerability in chemical and genetic models of Huntington's disease
Q33968736CREB is one component of the binding complex of the Ces-2/E2A-HLF binding element and is an integral part of the interleukin-3 survival signal
Q37983795CREB signalling in neural stem/progenitor cells: recent developments and the implications for brain tumour biology
Q40288418CREB transcription factor modulates Bcl2 transcription in response to C5a in HL-60-derived neutrophils
Q38352033CREB, a possible upstream regulator of Bcl-2 in trichosanthin-induced HeLa cell apoptosis
Q54471897CREB-mediated Bcl-2 expression contributes to RCAN1 protection from hydrogen peroxide-induced neuronal death.
Q38332115CREB-mediated Bcl-2 protein expression after ischemic preconditioning.
Q40827277CREB/ATF proteins enhance the basal and CD154- and IL-4-induced transcriptional activity of the human Igamma1 proximal promoter
Q34060539CRTC1/MAML2 gain-of-function interactions with MYC create a gene signature predictive of cancers with CREB-MYC involvement.
Q42611589CaMKII and CaMKIV mediate distinct prosurvival signaling pathways in response to depolarization in neurons.
Q35143875Calcium signals inhibition sensitizes ovarian carcinoma cells to anti-Bcl-xL strategies through Mcl-1 down-regulation
Q46601584Calmodulin-dependent protein kinase IV regulates hematopoietic stem cell maintenance
Q34325190Cannabinoid receptor type 2 agonist attenuates apoptosis by activation of phosphorylated CREB-Bcl-2 pathway after subarachnoid hemorrhage in rats.
Q36425487Cell death regulation by B-cell lymphoma protein
Q44297273Chronic lithium treatment antagonizes glutamate-induced decrease of phosphorylated CREB in neurons via reducing protein phosphatase 1 and increasing MEK activities
Q37409271Codon 104 variation of p53 gene provides adaptive apoptotic responses to extreme environments in mammals of the Tibet plateau
Q55070853Combination of ibrutinib with ABT-199: synergistic effects on proliferation inhibition and apoptosis in mantle cell lymphoma cells through perturbation of BTK, AKT and BCL2 pathways.
Q34567563Combination of therapeutic hypothermia and other neuroprotective strategies after an ischemic cerebral insult
Q33921020Computational identification of transcriptional regulators in human endotoxemia
Q34390190Control of Bcl-2 expression by reactive oxygen species
Q39332546Control of cell death and mitochondrial fission by ERK1/2 MAP kinase signalling.
Q46711244Coordinate regulation of forskolin-induced cellular proliferation in macrophages by protein kinase A/cAMP-response element-binding protein (CREB) and Epac1-Rap1 signaling: effects of silencing CREB gene expression on Akt activation
Q40685816Cross-linking of surface IgM in the Burkitt's lymphoma cell line ST486 provides protection against arsenite- and stress-induced apoptosis that is mediated by ERK and phosphoinositide 3-kinase signaling pathways
Q28538024Curcumin significantly enhances dual PI3K/Akt and mTOR inhibitor NVP-BEZ235-induced apoptosis in human renal carcinoma Caki cells through down-regulation of p53-dependent Bcl-2 expression and inhibition of Mcl-1 protein stability
Q39351756Cyclic AMP response element modulator-1 (CREM-1) involves in neuronal apoptosis after traumatic brain injury
Q34804633Cyclic AMP-response element regulated cell cycle arrests in cancer cells
Q40798208Cytokine-induced cell death in immortalized Schwann cells: roles of nitric oxide and cyclic AMP.
Q40658019Cytokine-mediated down-regulation of the transcription factor cAMP-response element-binding protein in pancreatic beta-cells
Q37656349DNA damage-binding complex recruits HDAC1 to repress Bcl-2 transcription in human ovarian cancer cells
Q36966230Deconvoluting the structural and drug-recognition complexity of the G-quadruplex-forming region upstream of the bcl-2 P1 promoter
Q27333843Diminished CRE-Induced Plasticity is Linked to Memory Deficits in Familial Alzheimer's Disease Mice
Q36482583Directing DNA methylation to inhibit gene expression
Q34124865Disruption of CREB function in brain leads to neurodegeneration
Q35815013Disruption of type 5 adenylyl cyclase gene preserves cardiac function against pressure overload.
Q42514696Dominant negative mutant forms of the cAMP response element binding protein induce apoptosis and decrease the anti-apoptotic action of growth factors in human islets.
Q46873036Dual inhibition of protein phosphatase-1/2A and calpain rescues nerve growth factor-differentiated PC12 cells from oxygen-glucose deprivation-induced cell death.
Q93229380ERα activity depends on interaction and target site corecruitment with phosphorylated CREB1
Q35045097Effect of theophylline and specific phosphodiesterase IV inhibition on proliferation and apoptosis of progenitor cells in bronchial asthma.
Q34293684Effects of estrogen treatment on expression of brain-derived neurotrophic factor and cAMP response element-binding protein expression and phosphorylation in rat amygdaloid and hippocampal structures
Q37691313Elevated production of docosahexaenoic acid in females: potential molecular mechanisms
Q33631733Epac is required for GLP-1R-mediated inhibition of oxidative stress and apoptosis in cardiomyocytes
Q41925318Essential role of CREB family proteins during Xenopus embryogenesis
Q34530662Estradiol rescues neurons from global ischemia-induced cell death: multiple cellular pathways of neuroprotection
Q37414220Estrogen treatment following severe burn injury reduces brain inflammation and apoptotic signaling
Q51828362Evaluation of the immune humoral response of Brazilian patients with Rubinstein-Taybi syndrome
Q37460388Evidence for involvement of ERK, PI3K, and RSK in induction of Bcl-2 by valproate
Q39738865FKBP38 protects Bcl-2 from caspase-dependent degradation.
Q79751169Failure of stress-induced downregulation of Bcl-2 contributes to apoptosis resistance in senescent human diploid fibroblasts
Q35568467Flow-induced protein kinase A-CREB pathway acts via BMP signaling to promote HSC emergence
Q90061412Follistatin is a novel therapeutic target and biomarker in FLT3/ITD acute myeloid leukemia
Q37037146Functional long-range interactions of the IgH 3' enhancers with the bcl-2 promoter region in t(14;18) lymphoma cells
Q33363144GRK5 Deficiency Leads to Selective Basal Forebrain Cholinergic Neuronal Vulnerability
Q34438832GRK5 deficiency accelerates {beta}-amyloid accumulation in Tg2576 mice via impaired cholinergic activity.
Q42686862Germline BCL-2 sequence variants and inherited predisposition to prostate cancer.
Q28067465Glucagon-Like Peptide-1 and Its Class B G Protein-Coupled Receptors: A Long March to Therapeutic Successes
Q28572231Glucose-dependent insulinotropic polypeptide-mediated up-regulation of beta-cell antiapoptotic Bcl-2 gene expression is coordinated by cyclic AMP (cAMP) response element binding protein (CREB) and cAMP-responsive CREB coactivator 2
Q43517559Helicobacter pylori lipopolysaccharide induces apoptosis of cultured guinea pig gastric mucosal cells
Q33860585Histone deacetylase inhibitors down-regulate bcl-2 expression and induce apoptosis in t(14;18) lymphomas
Q37135881Hypercholesterolemia-induced Abeta accumulation in rabbit brain is associated with alteration in IGF-1 signaling
Q34078171IFNgamma restores breast cancer sensitivity to fulvestrant by regulating STAT1, IFN regulatory factor 1, NF-kappaB, BCL2 family members, and signaling to caspase-dependent apoptosis
Q36529009Identification of a novel Bcl-2 promoter region that counteracts in a p53-dependent manner the inhibitory P2 region.
Q38362114Impaired proliferation and survival of activated B cells in transgenic mice that express a dominant-negative cAMP-response element-binding protein transcription factor in B cells
Q35668165In Vitro and In Vivo Antitumor Effects of n-Butanol Extracts of Pterocephalus hookeri on Hep3B Cancer Cell
Q36072797In vitro analysis of ovarian cancer response to cisplatin, carboplatin, and paclitaxel identifies common pathways that are also associated with overall patient survival.
Q42442947Inducible cAMP early repressor, an endogenous antagonist of cAMP responsive element-binding protein, evokes neuronal apoptosis in vitro.
Q37416799Induction of Akt activity by chemotherapy confers acquired resistance
Q38361881Induction of apoptosis in K562 cells by dominant negative c-myb
Q89668208Inhaled Gases for Neuroprotection of Neonates: A Review
Q34512913Inhibition of Raf-1 alters multiple downstream pathways to induce pancreatic beta-cell apoptosis.
Q28272200Inhibition of the cyclic AMP signaling cascade and nuclear factor binding to CRE and kappaB elements by cannabinol, a minimally CNS-active cannabinoid
Q52539573Inhibition of tumor growth and metastasis of human melanoma by intracellular anti-ATF-1 single chain Fv fragment.
Q42466887Insulin-like growth factor I-mediated activation of the transcription factor cAMP response element-binding protein in PC12 cells. Involvement of p38 mitogen-activated protein kinase-mediated pathway.
Q40928862Insulin-like growth factor-I induces bcl-2 promoter through the transcription factor cAMP-response element-binding protein.
Q44326399Interleukin-1beta converting enzyme subfamily inhibitors prevent induction of CD86 molecules by butyrate through a CREB-dependent mechanism in HL60 cells
Q52656382Intracellular cAMP Sensor EPAC: Physiology, Pathophysiology, and Therapeutics Development.
Q43715535Involvement of the brain-derived neurotrophic factor/TrkB pathway in neuroprotecive effect of cyclosporin A in forebrain ischemia
Q43688069Involvement of transcriptional repressor ATF3 in acceleration of caspase protease activation during DNA damaging agent-induced apoptosis
Q33826749Is CREB a key to neuronal survival?
Q36279695Liraglutide is neurotrophic and neuroprotective in neuronal cultures and mitigates mild traumatic brain injury in mice
Q41862498Lithium-induced neuroprotection is associated with epigenetic modification of specific BDNF gene promoter and altered expression of apoptotic-regulatory proteins
Q39113182Low expression of cyclic AMP response element modulator-1 can increase the migration and invasion of esophageal squamous cell carcinoma
Q34264134Maintaining mitochondrial membrane impermeability. an opportunity for new therapy in glaucoma?
Q59134376Mechanisms and Consequences of Anesthetic-Induced Neuroapoptosis in the Developing Brain
Q42790236Mechanisms of toxic effect of streptozotocin on β-cells in the islets of langerhans
Q34221689MicroRNA-34c enhances murine male germ cell apoptosis through targeting ATF1.
Q37015652Mitochondrial nuclear receptors and transcription factors: who's minding the cell?
Q34272789Molecular balance between the regulatory and catalytic subunits of phosphoinositide 3-kinase regulates cell signaling and survival.
Q40729431NF-kappaB activates Bcl-2 expression in t(14;18) lymphoma cells
Q40811024Negative regulation of bcl-2 expression by p53 in hematopoietic cells
Q77343222Neuronal death and survival in two models of hypoxic-ischemic brain damage
Q38521999Neuroprotective effects of prostaglandin E2 or cAMP against microglial and neuronal free radical mediated toxicity associated with inflammation
Q38341264Neurotrophin-3 and a CREB-mediated signaling pathway regulate Bcl-2 expression in oligodendrocyte progenitor cells
Q40202931Nitric oxide mediates natural polyphenol-induced Bcl-2 down-regulation and activation of cell death in metastatic B16 melanoma.
Q36551524Nuclear TRAF3 is a negative regulator of CREB in B cells
Q38897119Nuclear Transcription Factors in the Mitochondria: A New Paradigm in Fine-Tuning Mitochondrial Metabolism
Q81267242Oct transcription factors mediate t(14;18) lymphoma cell survival by directly regulating bcl-2 expression
Q91979985Oncogenic Effect of the Novel Fusion Gene VAPA-Rab31 in Lung Adenocarcinoma
Q39005322Overexpression of CREB protein protects from tunicamycin-induced apoptosis in various rat cell types.
Q40668530Oxidative stress-mediated down-regulation of bcl-2 promoter in hippocampal neurons.
Q43701623PTEN induces chemosensitivity in PTEN-mutated prostate cancer cells by suppression of Bcl-2 expression
Q34184485Par-4 transcriptionally regulates Bcl-2 through a WT1-binding site on the bcl-2 promoter
Q39201922Parathyroid hormone-related protein protects renal tubuloepithelial cells from apoptosis by activating transcription factor Runx2.
Q97887377Phosphodiesterase Inhibitors for Alzheimer's Disease: A Systematic Review of Clinical Trials and Epidemiology with a Mechanistic Rationale
Q39909679Phosphoinositide 3-kinase/Akt signalling is responsible for the differential susceptibility of myoblasts and myotubes to menadione-induced oxidative stress
Q37708202Possible mechanisms of trichosanthin-induced apoptosis of tumor cells
Q27316498Profiling of luteal transcriptome during prostaglandin F2-alpha treatment in buffalo cows: analysis of signaling pathways associated with luteolysis
Q50676792Prosurvival and proapoptotic intracellular signaling in rat spiral ganglion neurons in vivo after the loss of hair cells.
Q44605245Proteasomal degradation of Runx2 shortens parathyroid hormone-induced anti-apoptotic signaling in osteoblasts. A putative explanation for why intermittent administration is needed for bone anabolism
Q38913901Pterostilbene mediates neuroprotection against oxidative toxicity via oestrogen receptor α signalling pathways
Q48674795Rapid deafferentation-induced upregulation of bcl-2 mRNA in the chick cochlear nucleus
Q73934235Regulation of Bcl-2 expression by C/EBP in t(14;18) lymphoma cells
Q33639047Regulation of Cancer Cell Responsiveness to Ionizing Radiation Treatment by Cyclic AMP Response Element Binding Nuclear Transcription Factor
Q36731304Regulation of ERα-mediated transcription of Bcl-2 by PI3K-AKT crosstalk: Implications for breast cancer cell survival
Q40299475Regulation of bcl-2 expression by Ubc9.
Q35063194Regulation of cardiac myocyte cell death
Q33659665Regulation of the Primate Corpus Luteum: Cellular and Molecular Perspectives
Q73274217Regulation of tumor growth and metastasis of human melanoma by the CREB transcription factor family
Q48476741Relationship between the activation of cyclic AMP responsive element binding protein and ischemic tolerance in the penumbra region of rat cerebral cortex
Q40527113Relevance of CREB phosphorylation in the anti-apoptotic function of human T-lymphotropic virus type 1 tax protein in serum-deprived murine fibroblasts
Q40694264Resistance to chemotherapy via Stat3-dependent overexpression of Bcl-2 in metastatic breast cancer cells
Q51763589Restoration of CREB function is linked to completion and stabilization of adaptive cardiac hypertrophy in response to exercise.
Q33742019Retracted: Downregulation of uPAR and Cathepsin B Induces Apoptosis via Regulation of Bcl-2 and Bax and Inhibition of the PI3K/Akt Pathway in Gliomas
Q50050926Rifampicin Prevents SH-SY5Y Cells from Rotenone-Induced Apoptosis via the PI3K/Akt/GSK-3β/CREB Signaling Pathway.
Q36407914Rit-mediated stress resistance involves a p38-mitogen- and stress-activated protein kinase 1 (MSK1)-dependent cAMP response element-binding protein (CREB) activation cascade
Q35131571Role of the cyclic AMP response element in the bcl-2 promoter in the regulation of endogenous Bcl-2 expression and apoptosis in murine B cells
Q37865381Roles of the Ras/Raf/MEK/ERK pathway in leukemia therapy.
Q40788155SRF regulates Bcl-2 expression and promotes cell survival during murine embryonic development
Q33680286STAT5 requires the N-domain for suppression of miR15/16, induction of bcl-2, and survival signaling in myeloproliferative disease
Q34433639Secretomes of apoptotic mononuclear cells ameliorate neurological damage in rats with focal ischemia.
Q35166852Signal transduction mediated by the Ras/Raf/MEK/ERK pathway from cytokine receptors to transcription factors: potential targeting for therapeutic intervention.
Q34582666Signatures of murine B-cell development implicate Yy1 as a regulator of the germinal center-specific program
Q36846424Small molecule kaempferol modulates PDX-1 protein expression and subsequently promotes pancreatic β-cell survival and function via CREB.
Q36359456Stable over-expression of the 2-oxoglutarate carrier enhances neuronal cell resistance to oxidative stress via Bcl-2-dependent mitochondrial GSH transport
Q39685812Status epilepticus stimulates NDEL1 expression via the CREB/CRE pathway in the adult mouse brain
Q39735889Stimulation of prostaglandin EP2 receptors on RGC-5 cells in culture blunts the negative effect of serum withdrawal
Q36654996Structure-activity relationship studies of naphthol AS-E and its derivatives as anticancer agents by inhibiting CREB-mediated gene transcription
Q52546912Survival signaling mediated by c-Jun NH(2)-terminal kinase in transformed B lymphoblasts.
Q36760430Syk inhibits the activity of protein kinase A by phosphorylating tyrosine 330 of the catalytic subunit
Q34835627T cell apoptosis and reactive oxygen species
Q24674168TORC2 regulates germinal center repression of the TCL1 oncoprotein to promote B cell development and inhibit transformation
Q37766899Targeting CREB signalling in neurogenesis
Q40154931Targeting the RAF/MEK/ERK, PI3K/AKT and p53 pathways in hematopoietic drug resistance.
Q34173253Targeting the translational apparatus to improve leukemia therapy: roles of the PI3K/PTEN/Akt/mTOR pathway
Q38104439That which does not kill me makes me stronger; combining ERK1/2 pathway inhibitors and BH3 mimetics to kill tumour cells and prevent acquired resistance.
Q35040949The BCL2 gene is regulated by a special AT-rich sequence binding protein 1-mediated long range chromosomal interaction between the promoter and the distal element located within the 3'-UTR
Q40216814The BCL2 major breakpoint region (mbr) regulates gene expression
Q36809538The Myb-p300-CREB axis modulates intestine homeostasis, radiosensitivity and tumorigenesis
Q34677187The N-terminal domain unique to the long form of the Brn-3a transcription factor is essential to protect neuronal cells from apoptosis and for the activation of Bbcl-2 gene expression
Q41098050The WT1 protein is a negative regulator of the normal bcl-2 allele in t(14;18) lymphomas
Q43694144The cyclic AMP response element in the Bcl-2 promoter confers inducibility by hypoxia in neuronal cells
Q36050987The emerging role of the PI3-K-Akt pathway in prostate cancer progression
Q37455886The i-motif in the bcl-2 P1 promoter forms an unexpectedly stable structure with a unique 8:5:7 loop folding pattern
Q38299684The mood stabilizer valproic acid activates mitogen-activated protein kinases and promotes neurite growth
Q29620489The multifaceted roles of glycogen synthase kinase 3beta in cellular signaling
Q37725561The mutational landscape of ocular marginal zone lymphoma identifies frequent alterations in TNFAIP3 followed by mutations in TBL1XR1 and CREBBP.
Q39488712The natural diterpene ent-16β-17α-dihydroxykaurane down-regulates Bcl-2 by disruption of the Ap-2α/Rb transcription activating complex and induces E2F1 up-regulation in MCF-7 cells
Q39030462The oncoprotein HBXIP enhances angiogenesis and growth of breast cancer through modulating FGF8 and VEGF.
Q37087125The potential roles for embryotrophic ligands in preimplantation embryo development
Q39677796The retinoblastoma protein binds the promoter of the survival gene bcl-2 and regulates its transcription in epithelial cells through transcription factor AP-2.
Q35117293The role of activating transcription factor-2 in skeletal growth control
Q33980966The role of p27(Kip1) in dasatinib-enhanced paclitaxel cytotoxicity in human ovarian cancer cells
Q37837732Therapeutic resistance resulting from mutations in Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR signaling pathways.
Q40769199Transcriptional regulation of bcl-2 by nuclear factor kappa B and its significance in prostate cancer
Q43237515Transcriptional regulation of tumor suppressor p53 by cAMP-responsive element-binding protein/AMP-activated protein kinase complex in response to glucose deprivation
Q34303151Transcriptional reprogramming during T helper cell differentiation
Q37190206Transforming growth factor-beta1 causes pulmonary microvascular endothelial cell apoptosis via ALK5.
Q36315718Transient CREB-mediated transcription is key in direct neuronal reprogramming
Q37352120Transthyretin provides trophic support via megalin by promoting neurite outgrowth and neuroprotection in cerebral ischemia
Q38668758Triplex forming oligonucleotide targeted to 3'UTR downregulates the expression of the bcl-2 proto-oncogene in HeLa cells
Q44027700Trophic agents that prevent neuronal apoptosis activate calpain and down-regulate CaMKIV.
Q44527543Upregulation of CREM-1 relates to retinal ganglion cells apoptosis after light-induced damage in vivo.
Q37242900VIP down-regulates the inflammatory potential and promotes survival of dying (neural crest-derived) corneal endothelial cells ex vivo: necrosis to apoptosis switch and up-regulation of Bcl-2 and N-cadherin
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