Negative regulation of bcl-2 expression by p53 in hematopoietic cells

scientific article published on January 2001

Negative regulation of bcl-2 expression by p53 in hematopoietic cells is …
instance of (P31):
scholarly articleQ13442814

External links are
P6179Dimensions Publication ID1033615667
P356DOI10.1038/SJ.ONC.1204067
P698PubMed publication ID11313951
P5875ResearchGate publication ID12020764

P2093author name stringBoxer LM
Heckman CA
Arcinas M
Mehew JW
Wu Y
P2860cites workWild-type p53 binds to the TATA-binding protein and represses transcriptionQ24300991
Identification of a novel p53 functional domain that is necessary for efficient growth suppressionQ24311276
CREB proteins function as positive regulators of the translocated bcl-2 allele in t(14;18) lymphomasQ24321494
Two domains of p53 interact with the TATA-binding protein, and the adenovirus 13S E1A protein disrupts the association, relieving p53-mediated transcriptional repressionQ24336035
The requirement for the p53 proline-rich functional domain for mediation of apoptosis is correlated with specific PIG3 gene transactivation and with transcriptional repressionQ24533291
Transcriptional repression by YY1 is mediated by interaction with a mammalian homolog of the yeast global regulator RPD3Q24648290
p53, the cellular gatekeeper for growth and divisionQ27860990
Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosisQ28144256
Histone deacetylase activity is required for full transcriptional repression by mSin3AQ28238079
Histone deacetylases associated with the mSin3 corepressor mediate mad transcriptional repressionQ28238089
p21 is a universal inhibitor of cyclin kinasesQ28257305
Rb interacts with histone deacetylase to repress transcriptionQ28263985
Tumor suppressor p53 is a direct transcriptional activator of the human bax geneQ28306186
p53 suppresses the activation of the Bcl-2 promoter by the Brn-3a POU family transcription factorQ28609751
p53: puzzle and paradigmQ29618407
Characterization of structural p53 mutants which show selective defects in apoptosis but not cell cycle arrestQ33774492
Transcriptional regulation of the MDR1 gene by histone acetyltransferase and deacetylase is mediated by NF-Y.Q33775085
Transcriptional repression by the SMRT-mSin3 corepressor: multiple interactions, multiple mechanisms, and a potential role for TFIIB.Q33779119
Inhibition of p53 transactivation required for transformation by adenovirus early 1B proteinQ34343950
The p53 proto-oncogene can act as a suppressor of transformationQ34440370
Cloning and structural analysis of cDNAs for bcl-2 and a hybrid bcl-2/immunoglobulin transcript resulting from the t(14;18) translocationQ34559025
Transcriptional repression by wild-type p53 utilizes histone deacetylases, mediated by interaction with mSin3a.Q35207550
Analysis of the structure, transcripts, and protein products of bcl-2, the gene involved in human follicular lymphomaQ35617276
Relief of p53-mediated transcriptional repression by the adenovirus E1B 19-kDa protein or the cellular Bcl-2 proteinQ35755347
Induction of bcl-2 expression by phosphorylated CREB proteins during B-cell activation and rescue from apoptosisQ36562739
A negative regulatory element in the bcl-2 5'-untranslated region inhibits expression from an upstream promoterQ36686916
Identification of a minimal transforming domain of p53: negative dominance through abrogation of sequence-specific DNA bindingQ36706865
Negative regulation of Rb expression by the p53 gene productQ37049477
Overlap of the p53-responsive element and cAMP-responsive element in the enhancer of human T-cell leukemia virus type IQ37058260
Wild-type p53 can down-modulate the activity of various promotersQ37617210
Bcl-2 transcription from the proximal P2 promoter is activated in neuronal cells by the Brn-3a POU family transcription factorQ38336118
p53 expression in lymphatic malignanciesQ39398079
Pi 1 binding sites are negative regulators of bcl-2 expression in pre-B cellsQ40016702
A-Myb up-regulates Bcl-2 through a Cdx binding site in t(14;18) lymphoma cells.Q40897795
p53 in growth control and neoplasiaQ41009705
The polyproline region of p53 is required to activate apoptosis but not growth arrest.Q41093439
Overexpression of the MDM2 oncogene in leukemia and lymphomaQ41489317
Specific repression of TATA-mediated but not initiator-mediated transcription by wild-type p53.Q41553241
Modulation of activity of the promoter of the human MDR1 gene by Ras and p53.Q41643433
Clinical significance of bcl2 and p53 protein expression in diffuse large B-cell lymphoma: a population-based study.Q44427938
A novel form of Epstein-Barr virus latency in normal B cells in vivoQ45789413
The t(14;18) chromosome translocations involved in B-cell neoplasms result from mistakes in VDJ joiningQ48375088
P53 protein expression in lymphomas and reactive lymphoid tissueQ67542214
Multiple recurrent genomic defects in follicular lymphoma. A possible model for cancerQ68918964
Immunohistochemical detection of p53, bcl-2, and retinoblastoma proteins in follicular lymphomaQ71064050
Changes in Bcl-2 and p53 expression in recurrent B-cell lymphomasQ71870877
Heterogeneity in cell proliferation and expression of p53 and bcl-2 during the indolent phase of germinal centre cell lymphoma: an explanation for clinical variabilityQ72046338
Apoptosis and proliferative activity of non-Hodgkin's lymphomas: comparison with expression of bcl-2, p53 and c-myc proteinsQ73192364
Effects of dehydroepiandrosterone and calorie restriction on the Bcl-2/Bax-mediated apoptotic pathway in p53-deficient miceQ73401624
P433issue2
P407language of work or nameEnglishQ1860
P304page(s)240-251
P577publication date2001-01-01
P1433published inOncogeneQ1568657
P1476titleNegative regulation of bcl-2 expression by p53 in hematopoietic cells
P478volume20

Reverse relations

cites work (P2860)
Q41908813A DR4:tBID axis drives the p53 apoptotic response by promoting oligomerization of poised BAX.
Q34584528A genetic variant of p53 restricts the mucous secretory phenotype by regulating SPDEF and Bcl-2 expression.
Q36681959A novel SATB1 binding site in the BCL2 promoter region possesses transcriptional regulatory function
Q42059305A p38MAPK-p53 cascade regulates mesodermal differentiation and neurogenesis of embryonic stem cells
Q36016499A p53 axis regulates B cell receptor-triggered, innate immune system-driven B cell clonal expansion
Q34572898A role for p53 in the frequency and mechanism of mutation
Q38332936A transcriptional regulatory element in the coding sequence of the human Bcl-2 gene.
Q36210284AS1411-Induced Growth Inhibition of Glioma Cells by Up-Regulation of p53 and Down-Regulation of Bcl-2 and Akt1 via Nucleolin
Q40628992Adenovirus 2 E1B-55K protein relieves p53-mediated transcriptional repression of the survivin and MAP4 promoters
Q92891569Alantolactone suppresses human osteosarcoma through the PI3K/AKT signaling pathway
Q51511748Apoptosis and expression of the Bcl-2 family of proteins and P53 in human pancreatic ductal adenocarcinoma.
Q34520432Apoptosis: a link between cancer genetics and chemotherapy
Q35595410Apoptotic pathways activated by histone deacetylase inhibitors: implications for the drug-resistant phenotype
Q37522376BACH1 Promotes Temozolomide Resistance in Glioblastoma through Antagonizing the Function of p53.
Q45050515Bi-directional regulation between tyrosine kinase Etk/BMX and tumor suppressor p53 in response to DNA damage
Q40592113CMV promoter is repressed by p53 and activated by JNK pathway
Q37790163Candidate genes and potential targets for therapeutics in Wilms’ tumour
Q38911126Census and evaluation of p53 target genes.
Q33767881Combination of 9-aminoacridine with Campath-1H provides effective therapy for a murine model of adult T-cell leukemia
Q36642752Combination of galectin inhibitor GCS-100 and BH3 mimetics eliminates both p53 wild type and p53 null AML cells
Q34455157Conditional gene targeting for cancer gene therapy
Q37381120Cyclin-dependent kinase 1 inhibitor RO-3306 enhances p53-mediated Bax activation and mitochondrial apoptosis in AML
Q35752372Cyclooxygenase-2 induction by arsenite through the IKKbeta/NFkappaB pathway exerts an antiapoptotic effect in mouse epidermal Cl41 cells
Q43140225Cytoplasmic sequestration of p53 promotes survival in leukocytes transformed by Theileria
Q37656349DNA damage-binding complex recruits HDAC1 to repress Bcl-2 transcription in human ovarian cancer cells
Q49374158DZNep represses Bcl-2 expression and modulates apoptosis sensitivity in response to Nutlin-3a
Q33761586Dependence of p53-deficient cells on the DHX9 DExH-box helicase
Q39030857Dicoumarol sensitizes renal cell carcinoma Caki cells to TRAIL-induced apoptosis through down-regulation of Bcl-2, Mcl-1 and c-FLIP in a NQO1-independent manner
Q53703877Differential mRNA expression of the main apoptotic proteins in normal and malignant cells and its relation to in vitro resistance.
Q43847020Doxorubicin induces apoptosis and CD95 gene expression in human primary endothelial cells through a p53-dependent mechanism.
Q40612658Effect of haemopoietic growth factors on cancer cell lines and their role in chemosensitivity
Q61447347Ell3 functions as a critical decision maker at the crossroad between stem cell senescence and apoptosis
Q37383705Epidermal growth factor receptor pathway analysis identifies amphiregulin as a key factor for cisplatin resistance of human breast cancer cells
Q42138210Expression of LGI1 Impairs Proliferation and Survival of HeLa Cells
Q40034771Expression of androgen receptor is negatively regulated by p53.
Q33291582Expression of hereditary hemochromatosis C282Y HFE protein in HEK293 cells activates specific endoplasmic reticulum stress responses
Q28584218FGF1 inhibits p53-dependent apoptosis and cell cycle arrest via an intracrine pathway
Q79751169Failure of stress-induced downregulation of Bcl-2 contributes to apoptosis resistance in senescent human diploid fibroblasts
Q37761970Focal adhesion kinase and p53 signal transduction pathways in cancer
Q36921742Focal adhesion kinase and p53 signaling in cancer cells
Q40601158Guanine nucleotide depletion triggers cell cycle arrest and apoptosis in human neuroblastoma cell lines
Q33860585Histone deacetylase inhibitors down-regulate bcl-2 expression and induce apoptosis in t(14;18) lymphomas
Q36346936IPS-1 differentially induces TRAIL, BCL2, BIRC3 and PRKCE in type I interferons-dependent and -independent anticancer activity.
Q36529009Identification of a novel Bcl-2 promoter region that counteracts in a p53-dependent manner the inhibitory P2 region.
Q43084011In vitro anticancer effect of venom from Cuban scorpion Rhopalurus junceus against a panel of human cancer cell lines
Q35131580Insights into the mitochondrial signaling pathway: what lessons for chemotherapy?
Q36249132Interferon regulatory factor 4 binding protein is a novel p53 target gene and suppresses cisplatin-induced apoptosis of breast cancer cells
Q58695202Knockdown of BCL6 Inhibited Malignant Phenotype and Enhanced Sensitivity of Glioblastoma Cells to TMZ through AKT Pathway
Q55669681Luteoloside Inhibits Proliferation and Promotes Intrinsic and Extrinsic Pathway-Mediated Apoptosis Involving MAPK and mTOR Signaling Pathways in Human Cervical Cancer Cells.
Q37710558Lysine-specific demethylase KDM3A regulates ovarian cancer stemness and chemoresistance
Q36218273Mdm2 overexpression and p73 loss exacerbate genomic instability and dampen apoptosis, resulting in B-cell lymphoma
Q36687760Mechanisms of doxorubicin resistance in hepatocellular carcinoma
Q40481710Mechanisms of thymidine kinase/ganciclovir and cytosine deaminase/ 5-fluorocytosine suicide gene therapy-induced cell death in glioma cells.
Q47416965Mechanisms of transcriptional regulation by p53.
Q40399548Mitochondrial localization of p53 during adenovirus infection and regulation of its activity by E1B-19K.
Q33852777Modulation of cellular signaling pathways in P23H rhodopsin photoreceptors
Q40729431NF-kappaB activates Bcl-2 expression in t(14;18) lymphoma cells
Q37981834New frontiers in promoting tumour cell death: targeting apoptosis, necroptosis and autophagy
Q28080158Non-Canonical Cell Death Induced by p53
Q39202885Notch activation inhibits AML growth and survival: a potential therapeutic approach
Q81267242Oct transcription factors mediate t(14;18) lymphoma cell survival by directly regulating bcl-2 expression
Q34132206Oestrogen prevents cardiomyocyte apoptosis by suppressing p38α-mediated activation of p53 and by down-regulating p53 inhibition on p38β
Q37857673One function--multiple mechanisms: the manifold activities of p53 as a transcriptional repressor
Q50093685Orai3 calcium channel and resistance to chemotherapy in breast cancer cells: the p53 connection.
Q47368506PLK4: a link between centriole biogenesis and cancer
Q36961965Pathophysiological Significance of Hepatic Apoptosis
Q24310675Phosphorylation of Pirh2 by calmodulin-dependent kinase II impairs its ability to ubiquitinate p53
Q34372160Plumbagin reduces human colon cancer cell survival by inducing cell cycle arrest and mitochondria-mediated apoptosis
Q87374333Positive immunohistochemical expression of bcl-2 in hormone-independent breast carcinomas is associated with a greater lymph node involvement and poor outcome
Q39188578Pramanicin analog induces apoptosis in human colon cancer cells: critical roles for Bcl-2, Bim, and p38 MAPK signaling.
Q36310873Regulation of anti-apoptotic Bcl-2 family protein Mcl-1 by S6 kinase 2
Q43819783Regulation of the cellular prion protein gene expression depends on chromatin conformation
Q45000475Repression of hsp90beta gene by p53 in UV irradiation-induced apoptosis of Jurkat cells
Q34390964Requirement of p53 targets in chemosensitization of colonic carcinoma to death ligand therapy.
Q24550864SAK, a new polo-like kinase, is transcriptionally repressed by p53 and induces apoptosis upon RNAi silencing
Q92890209Shikonin potentiates paclitaxel antitumor efficacy in esophageal cancer cells via the apoptotic pathway
Q42454028Simultaneous exposure to dietary acrylamide and corn oil developed carcinogenesis through cell proliferation and inhibition of apoptosis by regulating p53-mediated mitochondria-dependent signaling pathway
Q67994576Structured Reviews for Data and Knowledge Driven Research
Q91866899Structured reviews for data and knowledge-driven research
Q37339461Suppression of MicroRNA 200 Family Expression by Oncogenic KRAS Activation Promotes Cell Survival and Epithelial-Mesenchymal Transition in KRAS-Driven Cancer
Q34568607TP53: a key gene in human cancer.
Q37260683Targeting the p53 pathway
Q42008941The BCL-2 5′ Untranslated Region Contains an RNA G-Quadruplex-Forming Motif That Modulates Protein Expression
Q40216814The BCL2 major breakpoint region (mbr) regulates gene expression
Q37455886The i-motif in the bcl-2 P1 promoter forms an unexpectedly stable structure with a unique 8:5:7 loop folding pattern
Q35181974The immunoglobulin heavy chain gene 3' enhancers induce Bcl2 deregulation and lymphomagenesis in murine B cells
Q51583482The immunoglobulin heavy-chain gene 3' enhancers deregulate bcl-2 promoter usage in t(14;18) lymphoma cells.
Q36542788The impact of post-transcriptional regulation in the p53 network
Q39488712The natural diterpene ent-16β-17α-dihydroxykaurane down-regulates Bcl-2 by disruption of the Ap-2α/Rb transcription activating complex and induces E2F1 up-regulation in MCF-7 cells
Q35878526The relative contribution of pro-apoptotic p53-target genes in the triggering of apoptosis following DNA damage in vitro and in vivo
Q39677796The retinoblastoma protein binds the promoter of the survival gene bcl-2 and regulates its transcription in epithelial cells through transcription factor AP-2.
Q91741764The role of microRNA in the resistance to treatment of hepatocellular carcinoma
Q38981518The role of the p53 protein in nitrosative stress-induced apoptosis of PC12 rat pheochromocytoma cells
Q36546440The tissue dependent interactions between p53 and Bcl-2 in vivo
Q24273295The transcription factor p53: not a repressor, solely an activator
Q37181734To kill a tumor cell: the potential of proapoptotic receptor agonists
Q34963231Toll-like receptor 3 (TLR3) induces apoptosis via death receptors and mitochondria by up-regulating the transactivating p63 isoform alpha (TAP63alpha).
Q64265490Transcriptional regulation of Bcl-2 gene by the PR/SET domain family member PRDM10
Q44522476Transcriptional regulation of mitotic checkpoint gene MAD1 by p53.
Q35116644Transcriptional repression mediated by the p53 tumour suppressor
Q37068043Transduction of Recombinant M3-p53-R12 Protein Enhances Human Leukemia Cell Apoptosis
Q40408487TrkA induces apoptosis of neuroblastoma cells and does so via a p53-dependent mechanism
Q34058409Tumor suppressor protein p53 recruits human Sin3B/HDAC1 complex for down-regulation of its target promoters in response to genotoxic stress
Q34202703p53 Isoforms: An Intracellular Microprocessor?
Q34388165p53 acts as a co-repressor to regulate keratin 14 expression during epidermal cell differentiation
Q37602510p53 and E2f: partners in life and death
Q33376888p53 induces distinct epigenetic states at its direct target promoters
Q42457086p53 mediates density-dependent growth arrest.
Q38334966p53 suppresses c-Myb-induced trans-activation and transformation by recruiting the corepressor mSin3A.
Q38366523p53, a translational regulator: contribution to its tumour-suppressor activity.
Q40022446p53-dependent repression of the human MCL-1 gene encoding an anti-apoptotic member of the BCL-2 family: the role of Sp1 and of basic transcription factor binding sites in the MCL-1 promoter

Search more.