Transcriptional repression by the SMRT-mSin3 corepressor: multiple interactions, multiple mechanisms, and a potential role for TFIIB.

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Transcriptional repression by the SMRT-mSin3 corepressor: multiple interactions, multiple mechanisms, and a potential role for TFIIB. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/MCB.18.9.5500
P932PMC publication ID109135
P698PubMed publication ID9710634
P5875ResearchGate publication ID13573948

P2093author name stringC W Wong
M L Privalsky
P2860cites workUnliganded thyroid hormone receptor alpha can target TATA-binding protein for transcriptional repressionQ24310721
Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressorQ24311650
Mad: a heterodimeric partner for Max that antagonizes Myc transcriptional activityQ24320236
Mxi1, a protein that specifically interacts with Max to bind Myc-Max recognition sitesQ24320277
Histone deacetylases and SAP18, a novel polypeptide, are components of a human Sin3 complexQ24320470
Two receptor interaction domains in the corepressor, N-CoR/RIP13, are required for an efficient interaction with Rev-erbA alpha and RVR: physical association is dependent on the E region of the orphan receptorsQ24543959
A transferable silencing domain is present in the thyroid hormone receptor, in the v-erbA oncogene product and in the retinoic acid receptorQ24555696
The tau 4 activation domain of the thyroid hormone receptor is required for release of a putative corepressor(s) necessary for transcriptional silencingQ24646988
Cloning and characterization of a corepressor and potential component of the nuclear hormone receptor repression complexQ24648169
Transcriptional repression by YY1 is mediated by interaction with a mammalian homolog of the yeast global regulator RPD3Q24648290
Sodium butyrate inhibits myogenesis by interfering with the transcriptional activation function of MyoD and myogeninQ41597273
Unliganded thyroid hormone receptor inhibits formation of a functional preinitiation complex: implications for active repressionQ42069854
Coactivator and corepressor regulation of the agonist/antagonist activity of the mixed antiestrogen, 4-hydroxytamoxifen.Q42439064
Protein encoded by v-erbA functions as a thyroid-hormone receptor antagonistQ44537287
The histone deacetylase RPD3 counteracts genomic silencing in Drosophila and yeastQ47072158
Both positive and negative regulators of HO transcription are required for mother-cell-specific mating-type switching in yeastQ57270194
Repression of transcription mediated at a thyroid hormone response element by the v-erb-A oncogene productQ59098062
Activation of the yeast HO gene by release from multiple negative controlsQ68934076
Butyrate and related inhibitors of histone deacetylation block the induction of egg white genes by steroid hormonesQ71432413
Stoichiometric and steric principles governing repression by nuclear hormone receptorsQ73231880
Gene silencing by chicken ovalbumin upstream promoter-transcription factor I (COUP-TFI) is mediated by transcriptional corepressors, nuclear receptor-corepressor (N-CoR) and silencing mediator for retinoic acid receptor and thyroid hormone receptorQ73386741
SMRT corepressor interacts with PLZF and with the PML-retinoic acid receptor alpha (RARalpha) and PLZF-RARalpha oncoproteins associated with acute promyelocytic leukemiaQ24653689
Repression by Ume6 involves recruitment of a complex containing Sin3 corepressor and Rpd3 histone deacetylase to target promotersQ27936998
HDA1 and RPD3 are members of distinct yeast histone deacetylase complexes that regulate silencing and transcriptionQ27937238
Eukaryotic proteins expressed in Escherichia coli: An improved thrombin cleavage and purification procedure of fusion proteins with glutathione S-transferaseQ28131695
An amino-terminal domain of Mxi1 mediates anti-Myc oncogenic activity and interacts with a homolog of the yeast transcriptional repressor SIN3Q28236250
Transcriptional control. Sinful repressionQ28237278
What's up and down with histone deacetylation and transcription?Q28238059
Histone deacetylase activity is required for full transcriptional repression by mSin3AQ28238079
Histone deacetylases associated with the mSin3 corepressor mediate mad transcriptional repressionQ28238089
The partial agonist activity of antagonist-occupied steroid receptors is controlled by a novel hinge domain-binding coactivator L7/SPA and the corepressors N-CoR or SMRTQ28239712
Role of the histone deacetylase complex in acute promyelocytic leukaemiaQ28263534
Rb interacts with histone deacetylase to repress transcriptionQ28263985
A transcriptional co-repressor that interacts with nuclear hormone receptorsQ28289864
Role for N-CoR and histone deacetylase in Sin3-mediated transcriptional repressionQ28513708
A complex containing N-CoR, mSin3 and histone deacetylase mediates transcriptional repressionQ28578229
Two receptor interacting domains in the nuclear hormone receptor corepressor RIP13/N-CoRQ28586882
Nuclear receptor repression mediated by a complex containing SMRT, mSin3A, and histone deacetylaseQ29547913
Fusion proteins of the retinoic acid receptor-alpha recruit histone deacetylase in promyelocytic leukaemiaQ29616211
Epistasis analysis of suppressor mutations that allow HO expression in the absence of the yeast SW15 transcriptional activatorQ33962612
Suppressors of defective silencing in yeast: effects on transcriptional repression at the HMR locus, cell growth and telomere structure.Q33966150
Identification of TRACs (T3 receptor-associating cofactors), a family of cofactors that associate with, and modulate the activity of, nuclear hormone receptorsQ34398024
The corepressor N-CoR and its variants RIP13a and RIP13Delta1 directly interact with the basal transcription factors TFIIB, TAFII32 and TAFII70.Q34669136
Interaction of human thyroid hormone receptor beta with transcription factor TFIIB may mediate target gene derepression and activation by thyroid hormoneQ36556508
Corepressor SMRT binds the BTB/POZ repressing domain of the LAZ3/BCL6 oncoproteinQ36594782
Functional evidence for ligand-dependent dissociation of thyroid hormone and retinoic acid receptors from an inhibitory cellular factorQ36664756
Transcriptional repression in Saccharomyces cerevisiae by a SIN3-LexA fusion proteinQ36676648
RPD3 encodes a second factor required to achieve maximum positive and negative transcriptional states in Saccharomyces cerevisiaeQ36744711
SMRT isoforms mediate repression and anti-repression of nuclear receptor heterodimersQ36813375
The erbA oncogene represses the actions of both retinoid X and retinoid A receptors but does so by distinct mechanismsQ36822461
The centromere and promoter factor, 1, CPF1, of Saccharomyces cerevisiae modulates gene activity through a family of factors including SPT21, RPD1 (SIN3), RPD3 and CCR4.Q38316201
A nuclear hormone receptor corepressor mediates transcriptional silencing by receptors with distinct repression domains.Q38352823
Differential recognition of liganded and unliganded thyroid hormone receptor by retinoid X receptor regulates transcriptional repressionQ40023991
Trichostatin A and trapoxin: novel chemical probes for the role of histone acetylation in chromatin structure and functionQ40547910
Chromatin unfoldsQ41021102
Characterization of receptor interaction and transcriptional repression by the corepressor SMRT.Q41066584
Retinoid X and retinoic acid receptors interact with transcription factor II-B by distinct mechanismsQ41115072
Polarity-specific activities of retinoic acid receptors determined by a co-repressor.Q41284148
Nuclear receptor coactivators and corepressorsQ41447637
Histone acetylation: chromatin in actionQ41468916
P433issue9
P407language of work or nameEnglishQ1860
P304page(s)5500-5510
P577publication date1998-09-01
P1433published inMolecular and Cellular BiologyQ3319478
P1476titleTranscriptional repression by the SMRT-mSin3 corepressor: multiple interactions, multiple mechanisms, and a potential role for TFIIB.
P478volume18

Reverse relations

cites work (P2860)
Q33598783A conserved lysine in the thyroid hormone receptor-alpha1 DNA-binding domain, mutated in hepatocellular carcinoma, serves as a sensor for transcriptional regulation
Q22254089A core SMRT corepressor complex containing HDAC3 and TBL1, a WD40-repeat protein linked to deafness
Q28141676A mechanism of repression by acute myeloid leukemia-1, the target of multiple chromosomal translocations in acute leukemia
Q34144764A novel mechanism involving coordinated regulation of nuclear levels and acetylation of NF-YA and Bcl6 activates RGS4 transcription.
Q46617735AML1B transcriptional repressor function is impaired by the Flt3-internal tandem duplication
Q39576827Aberrant recruitment of the nuclear receptor corepressor-histone deacetylase complex by the acute myeloid leukemia fusion partner ETO.
Q35639785Alternative mRNA splicing of corepressors generates variants that play opposing roles in adipocyte differentiation.
Q34290292Avian erythroleukemia: a model for corepressor function in cancer
Q31875497Cell type-specific roles of histone deacetylase in TR ligand-independent transcriptional repression
Q34678559Chromosomal localization links the SIN3-RPD3 complex to the regulation of chromatin condensation, histone acetylation and gene expression
Q39681319Competitive cofactor recruitment by orphan receptor hepatocyte nuclear factor 4alpha1: modulation by the F domain
Q28284917Components of the SMRT corepressor complex exhibit distinctive interactions with the POZ domain oncoproteins PLZF, PLZF-RARalpha, and BCL-6
Q31078289Corepressor requirement and thyroid hormone receptor function during Xenopus development
Q33632335DNA methylation and chromatin modification.
Q35130222Direct interaction of NRSF with TBP: chromatin reorganization and core promoter repression for neuron-specific gene transcription
Q24514479Domain structure of the NRIF3 family of coregulators suggests potential dual roles in transcriptional regulation
Q36832163Emerging roles of the corepressors NCoR1 and SMRT in homeostasis
Q39092838Epigenetic targets in hepatocellular carcinoma cells: identification of chaperone protein complexes with histone deacetylases
Q52580083Estrogen-induced and TAFII30-mediated gene repression by direct recruitment of the estrogen receptor and co-repressors to the core promoter and its reversal by tamoxifen.
Q34722386FMR1 silencing and the signals to chromatin: a unified model of transcriptional regulation
Q34813109Gene silencing
Q28505345Glucocorticoid receptor (GR)-associated SMRT binding to C/EBPbeta TAD and Nrf2 Neh4/5: role of SMRT recruited to GR in GSTA2 gene repression
Q22253934Histone deacetylase-independent transcriptional repression by methyl-CpG-binding protein 2.
Q33632987Histone deacetylases: transcriptional repression with SINers and NuRDs
Q38298930Identification of a neurorestrictive suppressor element (NRSE) in the human mu-opioid receptor gene
Q39436081Identification of nuclear orphan receptors as regulators of expression of a neurotransmitter receptor gene
Q28141911Ikaros interactions with CtBP reveal a repression mechanism that is independent of histone deacetylase activity
Q28215092Ikaros-CtIP interactions do not require C-terminal binding protein and participate in a deacetylase-independent mode of repression
Q39686347Inhibition of polyomavirus ori-dependent DNA replication by mSin3B
Q30453299Involvement of histone methylation and phosphorylation in regulation of transcription by thyroid hormone receptor
Q34889102Isotype-restricted corepressor recruitment: a constitutively closed helix 12 conformation in retinoic acid receptors beta and gamma interferes with corepressor recruitment and prevents transcriptional repression
Q33630360MeCP2 driven transcriptional repression in vitro: selectivity for methylated DNA, action at a distance and contacts with the basal transcription machinery
Q36902922Molecular antagonism between X-chromosome and autosome signals determines nematode sex.
Q24532232Msx3 protein recruits histone deacetylase to down-regulate the Msx1 promoter
Q40811024Negative regulation of bcl-2 expression by p53 in hematopoietic cells
Q24644926Neural restrictive silencer factor recruits mSin3 and histone deacetylase complex to repress neuron-specific target genes
Q34621596Nuclear receptor-dependent transcription with chromatin. Is it all about enzymes?
Q24290950PSF is a novel corepressor that mediates its effect through Sin3A and the DNA binding domain of nuclear hormone receptors
Q35802815Pharmacology of nuclear receptor-coregulator recognition.
Q34324051Precipitous release of methyl-CpG binding protein 2 and histone deacetylase 1 from the methylated human multidrug resistance gene (MDR1) on activation
Q24302865Recruitment of O-GlcNAc transferase to promoters by corepressor mSin3A: coupling protein O-GlcNAcylation to transcriptional repression
Q24657661Recruitment of SMRT/N-CoR-mSin3A-HDAC-repressing complexes is not a general mechanism for BTB/POZ transcriptional repressors: the case of HIC-1 and gammaFBP-B
Q34444363Regulation of SMRT corepressor dimerization and composition by MAP kinase phosphorylation
Q40898485Resistance to thyroid hormone (RTH) syndrome reveals novel determinants regulating interaction of T3 receptor with corepressor
Q37175201Response of SMRT (silencing mediator of retinoic acid and thyroid hormone receptor) and N-CoR (nuclear receptor corepressor) corepressors to mitogen-activated protein kinase kinase kinase cascades is determined by alternative mRNA splicing
Q37241518Retinoid isomers differ in the ability to induce release of SMRT corepressor from retinoic acid receptor-alpha
Q30440069SMRT and N-CoR corepressors are regulated by distinct kinase signaling pathways
Q40652029Signal-dependent N-CoR Requirement for Repression by the Ski Oncoprotein
Q41013482Signaling by tyrosine kinases negatively regulates the interaction between transcription factors and SMRT (silencing mediator of retinoic acid and thyroid hormone receptor) corepressor
Q28254928Structure-function analysis of the estrogen receptor alpha corepressor scaffold attachment factor-B1: identification of a potent transcriptional repression domain
Q38318863Synergistic effect of histone hyperacetylation and DNA demethylation in the reactivation of the FMR1 gene.
Q21284161TBLR1 regulates the expression of nuclear hormone receptor co-repressors
Q42827376TEL contacts multiple co-repressors and specifically associates with histone deacetylase-3.
Q37284561Targeted chromatin binding and histone acetylation in vivo by thyroid hormone receptor during amphibian development
Q34732688Targeting of N-CoR and histone deacetylase 3 by the oncoprotein v-erbA yields a chromatin infrastructure-dependent transcriptional repression pathway
Q24292959The ErbB3 binding protein Ebp1 interacts with Sin3A to repress E2F1 and AR-mediated transcription
Q34441108The SIN3/RPD3 deacetylase complex is essential for G(2) phase cell cycle progression and regulation of SMRTER corepressor levels
Q28343797The SMRT corepressor is a target of phosphorylation by protein kinase CK2 (casein kinase II)
Q39455172The SMRT corepressor is regulated by a MEK-1 kinase pathway: inhibition of corepressor function is associated with SMRT phosphorylation and nuclear export
Q22253389The adenovirus E1A binding protein BS69 is a corepressor of transcription through recruitment of N-CoR
Q30888959The adenovirus-2 E1B-55K protein interacts with a mSin3A/histone deacetylase 1 complex
Q34313320The biology of human lymphoid malignancies revealed by gene expression profiling.
Q22253387The co-repressor mSin3A is a functional component of the REST-CoREST repressor complex
Q40549870The highly conserved region of the co-repressor Sin3A functionally interacts with the co-repressor Alien
Q28144226The minimal repression domain of MBD2b overlaps with the methyl-CpG-binding domain and binds directly to Sin3A
Q24550992The neuron-restrictive silencer element-neuron-restrictive silencer factor system regulates basal and endothelin 1-inducible atrial natriuretic peptide gene expression in ventricular myocytes
Q34141139The silencing mediator of retinoic acid and thyroid hormone receptors can interact with the aryl hydrocarbon (Ah) receptor but fails to repress Ah receptor-dependent gene expression
Q35089956The thyroid hormone receptor and the insulator protein CTCF: two different factors with overlapping functions
Q34493334Towards understanding the epigenetics of transcription by chromatin structure and the nuclear matrix
Q37241513Transcriptional anti-repression. Thyroid hormone receptor beta-2 recruits SMRT corepressor but interferes with subsequent assembly of a functional corepressor complex
Q39451978Transcriptional repression by blimp-1 (PRDI-BF1) involves recruitment of histone deacetylase
Q33826663Transcriptional repression by nuclear hormone receptors
Q40816966Transcriptional repression by thyroid hormone receptors. A role for receptor homodimers in the recruitment of SMRT corepressor
Q34698342Tzfp represses the androgen receptor in mouse testis
Q24524018mSin3A regulates murine erythroleukemia cell differentiation through association with the TAL1 (or SCL) transcription factor

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