Identification of potential ibrutinib combinations in hematological malignancies using a combination high-throughput screen.

scientific article

Identification of potential ibrutinib combinations in hematological malignancies using a combination high-throughput screen. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1080/10428194.2017.1349899
P698PubMed publication ID28750570

P2093author name stringSriram Balasubramanian
Yang Liu
Michael Schaffer
Jennifer Yang
Shalini Chaturvedi
Matthias Versele
Rongzhen Lu
Cuc Davis
Regina Aquino
Emily Stepanchick
P2860cites workCombination of ibrutinib with ABT-199: synergistic effects on proliferation inhibition and apoptosis in mantle cell lymphoma cells through perturbation of BTK, AKT and BCL2 pathways.Q55070853
Small-molecule inhibition of BRDT for male contraceptionQ24616901
The Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancyQ24633214
Molecular subtypes of diffuse large B-cell lymphoma arise by distinct genetic pathwaysQ24652565
A gene expression-based method to diagnose clinically distinct subgroups of diffuse large B cell lymphomaQ24680233
Distinct types of diffuse large B-cell lymphoma identified by gene expression profilingQ27860529
Cancer statistics, 2013Q27860762
Exploiting synthetic lethality for the therapy of ABC diffuse large B cell lymphomaQ28649793
The NCI60 human tumour cell line anticancer drug screenQ29614975
Targeting BTK with ibrutinib in relapsed chronic lymphocytic leukemiaQ29620690
Targeting BTK with ibrutinib in relapsed or refractory mantle-cell lymphomaQ30371806
High-throughput combinatorial screening identifies drugs that cooperate with ibrutinib to kill activated B-cell-like diffuse large B-cell lymphoma cellsQ30433183
Combination of ibrutinib with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) for treatment-naive patients with CD20-positive B-cell non-Hodgkin lymphoma: a non-randomised, phase 1b studyQ33416593
Ibrutinib combined with bendamustine and rituximab compared with placebo, bendamustine, and rituximab for previously treated chronic lymphocytic leukaemia or small lymphocytic lymphoma (HELIOS): a randomised, double-blind, phase 3 studyQ33428297
Bruton tyrosine kinase inhibitor ibrutinib (PCI-32765) has significant activity in patients with relapsed/refractory B-cell malignanciesQ33893704
Ibrutinib versus ofatumumab in previously treated chronic lymphoid leukemiaQ34052075
Selective BCL-2 inhibition by ABT-199 causes on-target cell death in acute myeloid leukemiaQ34392488
Critical role of PI3K signaling for NF-kappaB-dependent survival in a subset of activated B-cell-like diffuse large B-cell lymphoma cells.Q34472091
IPI-145 antagonizes intrinsic and extrinsic survival signals in chronic lymphocytic leukemia cellsQ34636880
Pharmacoproteomics identifies combinatorial therapy targets for diffuse large B cell lymphomaQ36335846
Constitutive nuclear factor kappaB activity is required for survival of activated B cell-like diffuse large B cell lymphoma cellsQ36369816
Epigenetic gene regulation by Janus kinase 1 in diffuse large B-cell lymphoma.Q37469613
Ibrutinib for B cell malignanciesQ37555418
Targeting pathological B cell receptor signalling in lymphoid malignanciesQ38085501
Ibrutinib versus temsirolimus in patients with relapsed or refractory mantle-cell lymphoma: an international, randomised, open-label, phase 3 studyQ38670952
Initial optimization and series evolution of diaminopyrimidine inhibitors of interleukin-1 receptor associated kinase 4.Q38859723
Targeting B cell receptor signaling with ibrutinib in diffuse large B cell lymphoma.Q40716705
A mutation in MYD88 (L265P) supports the survival of lymphoplasmacytic cells by activation of Bruton tyrosine kinase in Waldenström macroglobulinemia.Q42285217
Pharmacokinetic-pharmacodynamic modeling of tumor growth inhibition and biomarker modulation by the novel phosphatidylinositol 3-kinase inhibitor GDC-0941.Q43031217
Mcl-1 down-regulation potentiates ABT-737 lethality by cooperatively inducing Bak activation and Bax translocationQ44926251
P275copyright licenseCreative Commons Attribution-NonCommercial-NoDerivs 4.0 InternationalQ24082749
P6216copyright statuscopyrightedQ50423863
P433issue4
P921main subjectibrutinibQ5984881
P304page(s)931-940
P577publication date2017-07-28
P1433published inLeukemia & LymphomaQ6534493
P1476titleIdentification of potential ibrutinib combinations in hematological malignancies using a combination high-throughput screen.
P478volume59

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cites work (P2860)
Q91623240Bromodomains: a new target class for drug development
Q90245956Co-inhibition of BET proteins and PI3Kα triggers mitochondrial apoptosis in rhabdomyosarcoma cells
Q90066183Differential expression of N-linked oligosaccharides in methotrexate-resistant primary central nervous system lymphoma cells
Q48169839Direct and indirect approaches to identify drug modes of action.
Q92150213Emerging epigenetic-modulating therapies in lymphoma
Q89767697Ibrutinib plus CIT for R/R mature B-NHL in children (SPARKLE trial): initial safety, pharmacokinetics, and efficacy
Q58790081Recent advances in combinatorial drug screening and synergy scoring
Q94671635Survey of ex vivo drug combination effects in chronic lymphocytic leukemia reveals synergistic drug effects and genetic dependencies

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