FOXD3 is a mutant B-RAF-regulated inhibitor of G(1)-S progression in melanoma cells

scientific article

FOXD3 is a mutant B-RAF-regulated inhibitor of G(1)-S progression in melanoma cells is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1158/0008-5472.CAN-09-3139
P932PMC publication ID2848900
P698PubMed publication ID20332228

P2093author name stringAndrew E Aplin
Ethan V Abel
P2860cites workThe Brn-2 transcription factor links activated BRAF to melanoma proliferationQ24599712
Efficient tumour formation by single human melanoma cellsQ24648938
Isolating human transcription factor targets by coupling chromatin immunoprecipitation and CpG island microarray analysisQ24672892
Mutations of the BRAF gene in human cancerQ27860760
A new mathematical model for relative quantification in real-time RT-PCRQ27860781
WAF1, a potential mediator of p53 tumor suppressionQ27861121
The emerging roles of forkhead box (Fox) proteins in cancerQ28253741
Mutant B-RAF signaling and cyclin D1 regulate Cks1/S-phase kinase-associated protein 2-mediated degradation of p27Kip1 in human melanoma cellsQ28259285
Requirement for Foxd3 in maintaining pluripotent cells of the early mouse embryoQ28506803
Genesis, a winged helix transcriptional repressor with expression restricted to embryonic stem cellsQ28591060
Foxd3 is required in the trophoblast progenitor cell lineage of the mouse embryoQ28592381
BRAF mutation predicts sensitivity to MEK inhibitionQ29614281
Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanomaQ29614282
Identification of a Novel Inhibitor of Mitogen-activated Protein Kinase KinaseQ29616448
Oncogenic BRAF regulates melanoma proliferation through the lineage specific factor MITF.Q33352015
The winged-helix transcription factor FoxD3 is important for establishing the neural crest lineage and repressing melanogenesis in avian embryos.Q33939222
Cyclin D3 expression in melanoma cells is regulated by adhesion-dependent phosphatidylinositol 3-kinase signaling and contributes to G1-S progressionQ34703578
Rescue of neural tube defects in Pax-3-deficient embryos by p53 loss of function: implications for Pax-3- dependent development and tumorigenesisQ35005937
In control of biology: of mice, men and FoxesQ36515335
ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradationQ36647913
BRAF(E600) in benign and malignant human tumoursQ36921234
The making of a melanocyte: the specification of melanoblasts from the neural crestQ37345006
Targeting the RAF-MEK-ERK pathway in cancer therapyQ37393116
colgate/hdac1 Repression of foxd3 expression is required to permit mitfa-dependent melanogenesisQ38295495
Regulation of embryonic stem cell self-renewal and pluripotency by Foxd3Q39957518
AZD6244 (ARRY-142886), a potent inhibitor of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase 1/2 kinases: mechanism of action in vivo, pharmacokinetic/pharmacodynamic relationship, and potential for combination in preclQ40093939
B-RAF and PI-3 kinase signaling protect melanoma cells from anoikisQ40302263
Stimulation of oncogenic metabotropic glutamate receptor 1 in melanoma cells activates ERK1/2 via PKCepsilonQ40348200
The p21(Cip1) and p27(Kip1) CDK 'inhibitors' are essential activators of cyclin D-dependent kinases in murine fibroblastsQ40967344
Mutational analysis of the human p53 gene in malignant melanomaQ41697274
Adhesion-dependent activation of the ERK1/2 cascade is by-passed in melanoma cellsQ42443534
Dissection of the functional interaction between p53 and the embryonic proto-oncoprotein PAX3.Q42819906
SnapShot: p53 posttranslational modificationsQ43118019
FOXD3 regulates the lineage switch between neural crest-derived glial cells and pigment cells by repressing MITF through a non-canonical mechanismQ43130524
Requirement for Foxd3 in the maintenance of neural crest progenitorsQ43139378
High prevalence of BRAF mutations in thyroid cancer: genetic evidence for constitutive activation of the RET/PTC-RAS-BRAF signaling pathway in papillary thyroid carcinomaQ44387406
Raf/MEK/MAPK signaling stimulates the nuclear translocation and transactivating activity of FOXM1cQ45238610
Effectively targeting BRAF in melanoma: a formidable challengeQ46424236
Mutant B-RAF mediates resistance to anoikis via Bad and Bim.Q46774780
An organometallic protein kinase inhibitor pharmacologically activates p53 and induces apoptosis in human melanoma cellsQ47583291
A negative feedback loop of transcription factors that controls stem cell pluripotency and self-renewalQ56067490
Adhesion control of cyclin D1 and p27Kip1 levels is deregulated in melanoma cells through BRAF-MEK-ERK signalingQ58450931
Constitutive mitogen-activated protein kinase activation in melanoma is mediated by both BRAF mutations and autocrine growth factor stimulationQ73013877
Suppression of BRAF(V599E) in human melanoma abrogates transformationQ79074168
Clonally cultured differentiated pigment cells can dedifferentiate and generate multipotent progenitors with self-renewing potentialQ79277701
P433issue7
P407language of work or nameEnglishQ1860
P304page(s)2891-2900
P577publication date2010-03-23
P1433published inCancer ResearchQ326097
P1476titleFOXD3 is a mutant B-RAF-regulated inhibitor of G(1)-S progression in melanoma cells
P478volume70

Reverse relations

cites work (P2860)
Q92642778Adaptive Responses as Mechanisms of Resistance to BRAF Inhibitors in Melanoma
Q35683271Adaptive upregulation of FOXD3 and resistance to PLX4032/4720-induced cell death in mutant B-RAF melanoma cells
Q58606024BRAF Splice Variant Resistance to RAF Inhibitor Requires Enhanced MEK Association
Q41056167BRAF mutation-specific promoter methylation of FOX genes in colorectal cancer
Q38757522Crosstalk signaling in targeted melanoma therapy
Q34742221CtBP2 downregulation during neural crest specification induces expression of Mitf and REST, resulting in melanocyte differentiation and sympathoadrenal lineage suppression
Q38708426Curcumin inhibits prostate cancer by targeting PGK1 in the FOXD3/miR-143 axis
Q35642026Decreased FOXD3 Expression Is Associated with Poor Prognosis in Patients with High-Grade Gliomas
Q37393397Down-regulation of long non-coding RNA FOXD3 antisense RNA 1 (FOXD3-AS1) inhibits cell proliferation, migration, and invasion in malignant glioma cells
Q37587383Downregulation of the transcription factor, FoxD3, is associated with lymph node metastases in invasive ductal carcinomas of the breast
Q36660155Dynamic DNA methylation across diverse human cell lines and tissues
Q47203970ERK-mediated phosphorylation regulates SOX10 sumoylation and targets expression in mutant BRAF melanoma.
Q34389137Effects and interactions of MiR-577 and TSGA10 in regulating esophageal squamous cell carcinoma
Q92642727Enhanced JunD/RSK3 signalling due to loss of BRD4/FOXD3/miR-548d-3p axis determines BET inhibition resistance
Q36468749Establishment and Characterization of Orthotopic Mouse Models for Human Uveal Melanoma Hepatic Colonization
Q36951681FOXD3 Promotes PAX3 Expression in Melanoma Cells
Q38603133FOXD3 Regulates CSC Marker, DCLK1-S, and Invasive Potential: Prognostic Implications in Colon Cancer
Q92659648FOXD3 Regulates VISTA Expression in Melanoma
Q37420182FOXD3 is a novel tumor suppressor that affects growth, invasion, metastasis and angiogenesis of neuroblastoma
Q37706298FOXD3 is a tumor suppressor of colon cancer by inhibiting EGFR-Ras-Raf-MEK-ERK signal pathway
Q42546275FOXD3 modulates migration through direct transcriptional repression of TWIST1 in melanoma
Q33779603FOXD3 regulates anaplastic thyroid cancer progression
Q24633339FOXD3 regulates migration properties and Rnd3 expression in melanoma cells
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Q39084764Foxd3 suppresses interleukin-10 expression in B cells
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Q44447711microRNA regulation of skin pigmentation in fish

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