| Q51726272 | 17β-Estradiol Protects Skeletal Myoblasts From Apoptosis Through p53, Bcl-2, and FoxO Families. |
| Q47784163 | A Rationale for Targeting Extracellular Regulated Kinases ERK1 and ERK2 in Glioblastoma |
| Q35274443 | A benzimidazole derivative exhibiting antitumor activity blocks EGFR and HER2 activity and upregulates DR5 in breast cancer cells |
| Q37379468 | A dual specificity kinase, DYRK1A, as a potential therapeutic target for head and neck squamous cell carcinoma |
| Q24651455 | A new fork for clinical application: targeting forkhead transcription factors in cancer |
| Q46456978 | A novel mouse model of rhabdomyosarcoma underscores the dichotomy of MDM2-ALT1 function in vivo |
| Q33908828 | A pathway from JNK through decreased ERK and Akt activities for FOXO3a nuclear translocation in response to UV irradiation |
| Q89717389 | A small-molecule inhibitor of PCSK9 transcription ameliorates atherosclerosis through the modulation of FoxO1/3 and HNF1α |
| Q35906944 | AMP-Activated Protein Kinase Directly Phosphorylates and Destabilizes Hedgehog Pathway Transcription Factor GLI1 in Medulloblastoma |
| Q34135442 | AMPK reverses the mesenchymal phenotype of cancer cells by targeting the Akt-MDM2-Foxo3a signaling axis |
| Q33858449 | ARHI (DIRAS3) induces autophagy in ovarian cancer cells by downregulating the epidermal growth factor receptor, inhibiting PI3K and Ras/MAP signaling and activating the FOXo3a-mediated induction of Rab7 |
| Q39348735 | Aberrant microRNA-182 expression is associated with glucocorticoid resistance in lymphoblastic malignancies |
| Q53734974 | Acquisition of anoikis resistance promotes alterations in the Ras/ERK and PI3K/Akt signaling pathways and matrix remodeling in endothelial cells. |
| Q45927212 | Activation of CaMKIIγ potentiates T-cell acute lymphoblastic leukemia leukemogenesis via phosphorylating FOXO3a. |
| Q33956177 | Activation of FOXO3a is sufficient to reverse mitogen-activated protein/extracellular signal-regulated kinase kinase inhibitor chemoresistance in human cancer |
| Q88950250 | Activation of FOXO3a reverses 5-Fluorouracil resistance in human breast cancer cells |
| Q35632231 | Activation of FOXO3a suggests good prognosis of patients with radically resected gastric cancer |
| Q89529850 | Activation of Tyrosine Metabolism in CD13+ Cancer Stem Cells Drives Relapse in Hepatocellular Carcinoma |
| Q41575635 | Activation of autophagy by FOXO3 regulates redox homeostasis during osteogenic differentiation |
| Q36896233 | Active Constituents from Liriope platyphylla Root against Cancer Growth In Vitro. |
| Q39328413 | Activity of the selective IκB kinase inhibitor BMS-345541 against T-cell acute lymphoblastic leukemia: involvement of FOXO3a |
| Q30300544 | Adenosine monophosphate activated protein kinase (AMPK), a mediator of estradiol-induced apoptosis in long-term estrogen deprived breast cancer cells |
| Q33688980 | Adjustment for smoking does not alter the FOXO3A association with longevity |
| Q39627333 | Akt-FOXO3a signaling axis dysregulation in human oral squamous cell carcinoma and potent efficacy of FOXO3a-targeted gene therapy |
| Q39149338 | Allium Roseum L. Extract Exerts Potent Suppressive Activities on Chronic Myeloid Leukemia K562 Cell Viability Through the Inhibition of BCR-ABL, PI3K/Akt, and ERK1/2 Pathways and the Abrogation of VEGF Secretion |
| Q34455378 | An Arf-Egr-C/EBPβ pathway linked to ras-induced senescence and cancer |
| Q54978059 | An ERK-Dependent Feedback Mechanism Prevents Hematopoietic Stem Cell Exhaustion. |
| Q34326755 | An aqueous extract of Fagonia cretica induces DNA damage, cell cycle arrest and apoptosis in breast cancer cells via FOXO3a and p53 expression. |
| Q38102998 | Antagonism between FOXO and MYC Regulates Cellular Powerhouse |
| Q36670915 | Anti-HER3 domain 1 and 3 antibodies reduce tumor growth by hindering HER2/HER3 dimerization and AKT-induced MDM2, XIAP, and FoxO1 phosphorylation. |
| Q28749134 | Apoptosis Induction by MEK Inhibition in Human Lung Cancer Cells Is Mediated by Bim |
| Q37605160 | Apoptosis and autophagy: BIM as a mediator of tumour cell death in response to oncogene-targeted therapeutics |
| Q37888960 | Applications of post-translational modifications of FoxO family proteins in biological functions |
| Q33680687 | Arrest-defective-1 protein (ARD1): tumor suppressor or oncoprotein? |
| Q92716043 | Autophagy Deficiency Leads to Impaired Antioxidant Defense via p62-FOXO1/3 Axis |
| Q92324835 | BH3 mimetic ABT-263 enhances the anticancer effects of apigenin in tumor cells with activating EGFR mutation |
| Q36846719 | BRCA1 positively regulates FOXO3 expression by restricting FOXO3 gene methylation and epigenetic silencing through targeting EZH2 in breast cancer |
| Q38965047 | BRCA1-IRIS inactivation sensitizes ovarian tumors to cisplatin |
| Q35803035 | Back to your heart: ubiquitin proteasome system-regulated signal transduction |
| Q35687864 | Baicalein increases the expression and reciprocal interplay of RUNX3 and FOXO3a through crosstalk of AMPKα and MEK/ERK1/2 signaling pathways in human non-small cell lung cancer cells |
| Q34267155 | Bidirectional regulation between WDR83 and its natural antisense transcript DHPS in gastric cancer |
| Q58609660 | Bidirectional regulation of osteogenic differentiation by the FOXO subfamily of Forkhead transcription factors in mammalian MSCs |
| Q33289348 | Bimodal regulation of FoxO3 by AKT and 14-3-3 |
| Q33732534 | Blockade of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase and murine double minute synergistically induces Apoptosis in acute myeloid leukemia via BH3-only proteins Puma and Bim. |
| Q64090129 | Boolean model of growth signaling, cell cycle and apoptosis predicts the molecular mechanism of aberrant cell cycle progression driven by hyperactive PI3K |
| Q41907536 | Breast cancer suppression by aplysin is associated with inhibition of PI3K/AKT/FOXO3a pathway |
| Q36041749 | Butein sensitizes HeLa cells to cisplatin through the AKT and ERK/p38 MAPK pathways by targeting FoxO3a |
| Q39578305 | CCN6 enhances ICAM-1 expression and cell motility in human chondrosarcoma cells |
| Q37184400 | CXCL12 increases human neural progenitor cell proliferation through Akt-1/FOXO3a signaling pathway |
| Q39205831 | Caspase-independent cell death is involved in the negative effect of EGF receptor inhibitors on cisplatin in non-small cell lung cancer cells. |
| Q39375812 | Celecoxib Treatment Alters p53 and MDM2 Expression via COX-2 Crosstalk in A549 Cells |
| Q37403487 | Cellular and molecular mechanisms of memory T-cell survival |
| Q64058283 | Chasing the FOXO3: Insights into Its New Mitochondrial Lair in Colorectal Cancer Landscape |
| Q35989767 | Chemotherapy triggers HIF-1-dependent glutathione synthesis and copper chelation that induces the breast cancer stem cell phenotype |
| Q28476362 | Combination treatment with MEK and AKT inhibitors is more effective than each drug alone in human non-small cell lung cancer in vitro and in vivo |
| Q35865318 | Computational identification and modeling of crosstalk between phosphorylation, O-β-glycosylation and methylation of FoxO3 and implications for cancer therapeutics |
| Q38186677 | Concise review: forkhead pathway in the control of adult neurogenesis |
| Q92542887 | Considering the Role of Murine Double Minute 2 in the Cardiovascular System? |
| Q39332546 | Control of cell death and mitochondrial fission by ERK1/2 MAP kinase signalling. |
| Q60149868 | Critical role of FOXO3a in carcinogenesis |
| Q33797782 | Cross-regulation between oncogenic BRAF(V600E) kinase and the MST1 pathway in papillary thyroid carcinoma |
| Q41526032 | DAF-16/FOXO Transcription Factor in Aging and Longevity |
| Q24322745 | Deacetylation of FOXO3 by SIRT1 or SIRT2 leads to Skp2-mediated FOXO3 ubiquitination and degradation |
| Q35146638 | Deciphering the role of forkhead transcription factors in cancer therapy |
| Q35032514 | Decreased expression of the FOXO3a gene is associated with poor prognosis in primary gastric adenocarcinoma patients |
| Q41923220 | Deregulation of FOXO3A during prostate cancer progression |
| Q37089152 | Direct activation of forkhead box O3 by tumor suppressors p53 and p73 is disrupted during liver regeneration in mice |
| Q37657919 | Direct binding of MEK1 and MEK2 to AKT induces Foxo1 phosphorylation, cellular migration and metastasis |
| Q37687570 | Discovery and clinical introduction of first-in-class imipridone ONC201. |
| Q92581702 | Dissecting mechanisms of resistance to targeted drug combination therapy in human colorectal cancer |
| Q49718088 | Distinct signal transductions in fast- and slow- twitch muscles upon denervation |
| Q91810326 | Downregulation of FOXO3a by DNMT1 promotes breast cancer stem cell properties and tumorigenesis |
| Q41472801 | Dual degradation signals destruct GLI1: AMPK inhibits GLI1 through β-TrCP-mediated proteasome degradation |
| Q35951059 | Dual inactivation of Akt and ERK by TIC10 signals Foxo3a nuclear translocation, TRAIL gene induction, and potent antitumor effects |
| Q26827297 | Dysregulated transcriptional and post-translational control of DNA methyltransferases in cancer |
| Q34634278 | E2F transcription factor 1 regulates cellular and organismal senescence by inhibiting Forkhead box O transcription factors |
| Q35075274 | EPS8 inhibition increases cisplatin sensitivity in lung cancer cells |
| Q46774847 | ERK and MDM2 prey on FOXO3a. |
| Q96640459 | ERK signalling: a master regulator of cell behaviour, life and fate |
| Q39169106 | ERK1/2 activity contributes to gemcitabine resistance in pancreatic cancer cells |
| Q36283231 | Electroacupuncture inhibits apoptosis in annulus fibrosis cells through suppression of the mitochondria-dependent pathway in a rat model of cervical intervertebral disc degradation. |
| Q54976620 | Encoding Growth Factor Identity in the Temporal Dynamics of FOXO3 under the Combinatorial Control of ERK and AKT Kinases. |
| Q53368213 | Epibrassinolide alters PI3K/MAPK signaling axis via activating Foxo3a-induced mitochondria-mediated apoptosis in colon cancer cells. |
| Q35007782 | Epidermal growth factor receptor tyrosine kinase inhibitor reverses mesenchymal to epithelial phenotype and inhibits metastasis in inflammatory breast cancer |
| Q48159049 | Epigallocatechin-3-gallate confers protection against corticosterone-induced neuron injuries via restoring extracellular signal-regulated kinase 1/2 and phosphatidylinositol-3 kinase/protein kinase B signaling pathways. |
| Q89620766 | Epstein-Barr Virus Latent Membrane Protein 1 Regulates Host B Cell MicroRNA-155 and Its Target FOXO3a via PI3K p110α Activation |
| Q35032548 | Epstein-Barr Virus_Encoded LMP1 upregulates microRNA-21 to promote the resistance of nasopharyngeal carcinoma cells to cisplatin-induced Apoptosis by suppressing PDCD4 and Fas-L. |
| Q61449763 | Estrogen Signaling in ERα-Negative Breast Cancer: ERβ and GPER |
| Q35077393 | Evaluating the evidence for targeting FOXO3a in breast cancer: a systematic review |
| Q52746431 | Experimental Therapy of Advanced Breast Cancer: Targeting NFAT1-MDM2-p53 Pathway. |
| Q39861265 | Extracellular signal-regulated kinase 2-dependent phosphorylation induces cytoplasmic localization and degradation of p21Cip1. |
| Q33836475 | Extracellular signal-regulated kinase signaling-mediated induction and interaction of FOXO3a and p53 contribute to the inhibition of nasopharyngeal carcinoma cell growth by curcumin |
| Q52725941 | Extracellular-Regulated Kinases: Signaling From Ras to ERK Substrates to Control Biological Outcomes. |
| Q33767083 | FOXD3 is a mutant B-RAF-regulated inhibitor of G(1)-S progression in melanoma cells |
| Q41377055 | FOXO Signaling Pathways as Therapeutic Targets in Cancer |
| Q26776415 | FOXO factors and breast cancer: outfoxing endocrine resistance |
| Q38674456 | FOXO transcription factors in cancer development and therapy |
| Q26853741 | FOXO transcription factors throughout T cell biology |
| Q26851722 | FOXO transcription factors: key regulators of cellular quality control |
| Q90390938 | FOXO1 degradation via G9a-mediated methylation promotes cell proliferation in colon cancer |
| Q34173809 | FOXO1: a potential target for human diseases |
| Q36659141 | FOXO3 signalling links ATM to the p53 apoptotic pathway following DNA damage |
| Q38742577 | FOXO3a Expression Regulated by ERK Signaling is Inversely Correlated With Y-Box Binding Protein-1 Expression in Prostate Cancer. |
| Q38743209 | FOXO3a and the MAPK p38 are activated by cetuximab to induce cell death and inhibit cell proliferation and their expression predicts cetuximab efficacy in colorectal cancer. |
| Q54506174 | FOXO3a and β-catenin co-localization: double trouble in colon cancer? |
| Q90226885 | FOXO3a from the Nucleus to the Mitochondria: A Round Trip in Cellular Stress Response |
| Q37106118 | FOXO3a inhibits TNF-α- and IL-1β-induced astrocyte proliferation:Implication for reactive astrogliosis |
| Q37672602 | FOXO3a loss is a frequent early event in high-grade pelvic serous carcinogenesis |
| Q39588969 | FOXO3a nuclear localisation is associated with good prognosis in luminal-like breast cancer |
| Q35622770 | FOXO3a-Dependent Mechanism of E1A-Induced Chemosensitization |
| Q103826165 | FOXO3a-driven miRNA signatures suppresses VEGF-A/NRP1 signaling and breast cancer metastasis |
| Q38074598 | FOXOs: signalling integrators for homeostasis maintenance |
| Q35048836 | Fancd2 is required for nuclear retention of Foxo3a in hematopoietic stem cell maintenance |
| Q35870864 | Flavones inhibit breast cancer proliferation through the Akt/FOXO3a signaling pathway |
| Q38121578 | Forkhead box class O transcription factors in liver function and disease |
| Q38116309 | Forkhead box proteins: tuning forks for transcriptional harmony. |
| Q64447846 | Forkhead box transcription factors as context-dependent regulators of lymphocyte homeostasis |
| Q39000854 | Forkhead followed by disordered tail: The intrinsically disordered regions of FOXO3a. |
| Q34552736 | Forkhead transcription factor FOXO3a levels are increased in Huntington disease because of overactivated positive autofeedback loop |
| Q39037983 | Fox transcription factors: from development to disease |
| Q42317507 | FoxO proteins or loss of functional p53 maintain stemness of glioblastoma stem cells and survival after ionizing radiation plus PI3K/mTOR inhibition |
| Q33587373 | FoxO proteins restrain osteoclastogenesis and bone resorption by attenuating H2O2 accumulation |
| Q50137602 | FoxO transcription factors in cancer metabolism |
| Q36663162 | FoxO transcription factors in the maintenance of cellular homeostasis during aging |
| Q34362813 | FoxO, autophagy, and cardiac remodeling |
| Q38795542 | FoxO3 inactivation promotes human cholangiocarcinoma tumorigenesis and chemoresistance through Keap1-Nrf2 signaling |
| Q44208674 | FoxO3a modulation and promotion of apoptosis by interferon-α2b in rat preneoplastic liver. |
| Q42092099 | FoxO3a nuclear localization and its association with β-catenin and Smads in IFN-α-treated hepatocellular carcinoma cell lines. |
| Q36508271 | Foxo3a transcription factor is a negative regulator of Skp2 and Skp2 SCF complex |
| Q36688942 | Foxo3a-mediated overexpression of microRNA-622 suppresses tumor metastasis by repressing hypoxia-inducible factor-1α in ERK-responsive lung cancer |
| Q35565061 | Frequent amplification of PTP1B is associated with poor survival of gastric cancer patients |
| Q33698374 | From basic research to clinical development of MEK1/2 inhibitors for cancer therapy |
| Q33667171 | G protein-coupled receptor kinase 2 (GRK2) modulation and cell cycle progression |
| Q47262684 | Gain-of-function mutant p53 promotes the oncogenic potential of head and neck squamous cell carcinoma cells by targeting the transcription factors FOXO3a and FOXM1. |
| Q36661222 | Gefitinib-resistance is related to BIM expression in non-small cell lung cancer cell lines |
| Q33877608 | Genetic demonstration of a redundant role of extracellular signal-regulated kinase 1 (ERK1) and ERK2 mitogen-activated protein kinases in promoting fibroblast proliferation |
| Q38184928 | Genetics of breast cancer bone metastasis: a sequential multistep pattern |
| Q39206484 | Genome-wide analysis of FOXO3 mediated transcription regulation through RNA polymerase II profiling |
| Q33503255 | Global gene expression profiling of human pleural mesotheliomas: identification of matrix metalloproteinase 14 (MMP-14) as potential tumour target |
| Q37237202 | Glycosylation and stabilization of programmed death ligand-1 suppresses T-cell activity. |
| Q33717222 | High level of AKT activity is associated with resistance to MEK inhibitor AZD6244 (ARRY-142886) |
| Q36065874 | Highly phosphorylated FOXO3A is an adverse prognostic factor in acute myeloid leukemia |
| Q37309204 | How ERK1/2 activation controls cell proliferation and cell death: Is subcellular localization the answer? |
| Q37215023 | Human SNP links differential outcomes in inflammatory and infectious disease to a FOXO3-regulated pathway |
| Q34730816 | IKBKE phosphorylation and inhibition of FOXO3a: a mechanism of IKBKE oncogenic function |
| Q35713747 | IKKα activation of NOTCH links tumorigenesis via FOXA2 suppression |
| Q61809330 | ING4 suppresses hepatocellular carcinoma via a NF-κB/miR-155/FOXO3a signaling axis |
| Q42046431 | IQGAP1 regulates cell proliferation through a novel CDC42-mTOR pathway |
| Q34755828 | Identification of a mechanism underlying regulation of the anti-angiogenic forkhead transcription factor FoxO1 in cultured endothelial cells and ischemic muscle |
| Q47248280 | In retinitis pigmentosa TrkC.T1-dependent vectorial Erk activity upregulates glial TNF-α, causing selective neuronal death. |
| Q88664220 | Increasing Cardiomyocyte Atrogin-1 Reduces Aging-Associated Fibrosis and Regulates Remodeling in Vivo |
| Q37619697 | Inducible nitric oxide synthase enhances disease aggressiveness in pancreatic cancer |
| Q90127314 | Inflammatory macrophage derived TNFα downregulates estrogen receptor α via FOXO3a inactivation in human breast cancer cells |
| Q64054551 | Inhibition of DYRK1A-EGFR axis by p53-MDM2 cascade mediates the induction of cellular senescence |
| Q39396267 | Inhibition of metadherin sensitizes breast cancer cells to AZD6244. |
| Q38982765 | Inhibition of tumor growth by U0126 is associated with induction of interferon-γ production |
| Q38270775 | Insights into a Critical Role of the FOXO3a-FOXM1 Axis in DNA Damage Response and Genotoxic Drug Resistance. |
| Q89478133 | Insulin-like growth factor 1 signaling in motor neuron and polyglutamine diseases: From molecular pathogenesis to therapeutic perspectives |
| Q37994048 | Insulin-like growth factors and insulin: at the crossroad between tumor development and longevity |
| Q64094105 | Insulin/IGF1 signalling mediates the effects of β -adrenergic agonist on muscle proteostasis and growth |
| Q50350755 | Involvement of the FOXO6 transcriptional factor in breast carcinogenesis. |
| Q37467189 | Key signalling nodes in mammary gland development and cancer. Mitogen-activated protein kinase signalling in experimental models of breast cancer progression and in mammary gland development. |
| Q61808203 | Knockdown of FOXO3a induces epithelial-mesenchymal transition and promotes metastasis of pancreatic ductal adenocarcinoma by activation of the β-catenin/TCF4 pathway through SPRY2 |
| Q39050385 | Knockdown of Sec8 promotes cell-cycle arrest at G1/S phase by inducing p21 via control of FOXO proteins |
| Q92423983 | Long noncoding RNA PiHL regulates p53 protein stability through GRWD1/RPL11/MDM2 axis in colorectal cancer |
| Q36977443 | MDM2 E3 ubiquitin ligase mediates UT-A1 urea transporter ubiquitination and degradation |
| Q39868313 | MDM2 acts downstream of p53 as an E3 ligase to promote FOXO ubiquitination and degradation. |
| Q91997757 | MDM2 promotes genome instability by ubiquitinating the transcription factor HBP1 |
| Q37689443 | MDM2 restrains estrogen-mediated AKT activation by promoting TBK1-dependent HPIP degradation |
| Q42156598 | MDM4 expression as an indicator of TP53 reactivation by combined targeting of MDM2 and MDM4 in cancer cells without TP53 mutation |
| Q34036341 | MEK and the inhibitors: from bench to bedside |
| Q37190384 | MEK1 signaling promotes self-renewal and tumorigenicity of liver cancer stem cells via maintaining SIRT1 protein stabilization |
| Q35872321 | MEK1/2 inhibitor selumetinib (AZD6244) inhibits growth of ovarian clear cell carcinoma in a PEA-15-dependent manner in a mouse xenograft model |
| Q54978541 | MPK-1/ERK pathway regulates DNA damage response during development through DAF-16/FOXO. |
| Q52713189 | Major Physiological Signaling Pathways in the Regulation of Cell Proliferation and Survival. |
| Q89782931 | Mdm2 and MdmX RING Domains Play Distinct Roles in the Regulation of p53 Responses: A Comparative Study of Mdm2 and MdmX RING Domains in U2OS Cells |
| Q21092186 | Mdm2 induces mono-ubiquitination of FOXO4 |
| Q47601432 | Mdm2 mediates FMRP- and Gp1 mGluR-dependent protein translation and neural network activity |
| Q37508606 | Mdm2-mediated ubiquitylation: p53 and beyond. |
| Q37276428 | MdmX regulates transformation and chromosomal stability in p53-deficient cells |
| Q36553375 | Measles virus nucleocapsid protein, a key contributor to Paget's disease, increases IL-6 expression via down-regulation of FoxO3/Sirt1 signaling |
| Q53071967 | Mechanisms in cardiac fibroblast growth: an obligate role for Skp2 and FOXO3a in ERK1/2 MAPK-dependent regulation of p27kip1. |
| Q36209138 | Methylation by Set9 modulates FoxO3 stability and transcriptional activity. |
| Q61795842 | MiR-30a regulates cancer cell response to chemotherapy through SNAI1/IRS1/AKT pathway |
| Q46037722 | MiR-629 promotes human pancreatic cancer progression by targeting FOXO3. |
| Q24603354 | MicroRNA-155 regulates cell survival, growth, and chemosensitivity by targeting FOXO3a in breast cancer |
| Q36602853 | MicroRNAs and Glucocorticoid-Induced Apoptosis in Lymphoid Malignancies |
| Q28384629 | Mitochondria and FOXO3: breath or die |
| Q37049122 | Mitotic degradation of yeast Fkh1 by the Anaphase Promoting Complex is required for normal longevity, genomic stability and stress resistance. |
| Q33612153 | Modelling the response of FOXO transcription factors to multiple post-translational modifications made by ageing-related signalling pathways |
| Q38137168 | Molecular mechanisms of the pro-apoptotic actions of melatonin in cancer: a review |
| Q38069375 | Molecular pathways: targeting Mdm2 and Mdm4 in cancer therapy |
| Q38966698 | Molecular signaling cascades involved in nonmelanoma skin carcinogenesis |
| Q97420774 | Mouse Double Minute 2 Homolog-Mediated Ubiquitination Facilitates Forkhead Box P3 Stability and Positively Modulates Human Regulatory T Cell Function |
| Q34488901 | Multiple Scaffolding Functions of β-Arrestins in the Degradation of G Protein-coupled Receptor Kinase 2 |
| Q35930829 | Murine Double-Minute 2 Homolog Single Nucleotide Polymorphisms 285 and 309 in Cervical Carcinogenesis. |
| Q89064775 | Murine double minute 2, a potential p53-independent regulator of liver cancer metastasis |
| Q37660797 | Myocardial protective effect of extracellular superoxide dismutase gene modified bone marrow mesenchymal stromal cells on infarcted mice hearts |
| Q34351264 | Natural product MDM2 inhibitors: anticancer activity and mechanisms of action. |
| Q57496075 | Natural products targeting the p53-MDM2 pathway and mutant p53: Recent advances and implications in cancer medicine |
| Q38779851 | Negative regulation of the FOXO3a transcription factor by mTORC2 induces a pro-survival response following exposure to ultraviolet-B irradiation. |
| Q38963105 | New Insights into Protein Hydroxylation and Its Important Role in Human Diseases. |
| Q37739372 | New insights for FOXO and cell-fate decision in HIV infection and HIV associated neurocognitive disorder |
| Q24300910 | Nodal enhances the activity of FoxO3a and its synergistic interaction with Smads to regulate cyclin G2 transcription in ovarian cancer cells |
| Q38851856 | Novel insights into redox system and the mechanism of redox regulation |
| Q64115578 | Nuclear ERK: Mechanism of Translocation, Substrates, and Role in Cancer |
| Q41535058 | Nuclear Localization Marker of FOXO3a: Can it be Used to Predict Doxorubicin Response? |
| Q59078925 | O-GlcNAcylation mediates metastasis of cholangiocarcinoma through FOXO3 and MAN1A1 |
| Q47748570 | Oncogenic RAS-induced CK1α drives nuclear FOXO proteolysis |
| Q100456052 | Optical control of ERK and AKT signaling promotes axon regeneration and functional recovery of PNS and CNS in Drosophila |
| Q39672517 | Outfoxing FoxO transcription factors: HTLV-1 Tax oncoprotein inactivates FoxO4 via the ubiquitin-proteasome pathway |
| Q39945226 | Overexpression of SSTR2 inhibited the growth of SSTR2-positive tumors via multiple signaling pathways |
| Q37245117 | Oxidative stress in the regulation of normal and neoplastic hematopoiesis |
| Q37688130 | PAX3 is a novel tumor suppressor by regulating the activities of major signaling pathways and transcription factor FOXO3a in thyroid cancer |
| Q26862544 | PI3K-AKT-mTOR-signaling and beyond: the complex network in gastroenteropancreatic neuroendocrine neoplasms |
| Q38644584 | PI3K/AKT Pathway and Its Mediators in Thyroid Carcinomas |
| Q35951377 | PLK1 is a binding partner and a negative regulator of FOXO3 tumor suppressor |
| Q34761941 | PTEN loss confers BRAF inhibitor resistance to melanoma cells through the suppression of BIM expression |
| Q37073648 | PTEN-regulated AKT/FoxO3a/Bim signaling contributes to reactive oxygen species-mediated apoptosis in selenite-treated colorectal cancer cells. |
| Q39373394 | Pachastrissamine from Pachastrissa sp. inhibits melanoma cell growth by dual inhibition of Cdk2 and ERK-mediated FOXO3 downregulation |
| Q26824476 | Pathobiology of Paget's Disease of Bone |
| Q53121718 | Phosphoinositides: Two-Path Signaling in Neuronal Response to Oligomeric Amyloid β Peptide. |
| Q33685068 | Phosphorylation and acetylation modifications of FOXO3a: Independently or synergistically? |
| Q39435517 | Phosphorylation of FOXO3a on Ser-7 by p38 promotes its nuclear localization in response to doxorubicin |
| Q37204077 | Platycodin D induces tumor growth arrest by activating FOXO3a expression in prostate cancer in vitro and in vivo |
| Q38039281 | Post-translational regulation of FOXO. |
| Q38984536 | Pregnancy-associated plasma protein A regulates mitosis and is epigenetically silenced in breast cancer |
| Q33850553 | Prolyl hydroxylation by EglN2 destabilizes FOXO3a by blocking its interaction with the USP9x deubiquitinase |
| Q41287206 | Protecting the genome from mdm2 and mdmx |
| Q33721192 | Protein phosphatase 2A reactivates FOXO3a through a dynamic interplay with 14-3-3 and AKT. |
| Q38720684 | Quantification of growth factor signaling and pathway cross talk by live-cell imaging |
| Q36507466 | Quercetin Attenuates Chronic Ethanol-Induced Hepatic Mitochondrial Damage through Enhanced Mitophagy |
| Q92094415 | RNA Sequence Analyses throughout the Course of Mouse Cardiac Laminopathy Identify Differentially Expressed Genes for Cell Cycle Control and Mitochondrial Function |
| Q48029350 | Rapid Renal Regulation of Peroxisome Proliferator-activated Receptor γ Coactivator-1α by Extracellular Signal-Regulated Kinase 1/2 in Physiological and Pathological Conditions |
| Q36403779 | Ras family small GTPase-mediated neuroprotective signaling in stroke |
| Q55013698 | Ras signaling in aging and metabolic regulation. |
| Q37219345 | RasV12-mediated down-regulation of CCAAT/enhancer binding protein beta in immortalized fibroblasts requires loss of p19Arf and facilitates bypass of oncogene-induced senescence |
| Q26799843 | Redox regulation of FoxO transcription factors |
| Q90223689 | Redox regulation of cell state and fate |
| Q91658182 | Reduced Expression of Sprouty1 Contributes to the Aberrant Proliferation and Impaired Apoptosis of Acute Myeloid Leukemia Cells |
| Q26781203 | Regulation of Bim in Health and Disease |
| Q50057271 | Regulation of FOXO Factors in Mammalian Cells. |
| Q35032366 | Regulation of FOXO protein stability via ubiquitination and proteasome degradation |
| Q37858547 | Regulation of Foxo-dependent transcription by post-translational modifications |
| Q52584355 | Regulation of breast cancer induced bone disease by cancer-specific IKKβ. |
| Q51825137 | Regulation of p38, PKC/Foxo3a/p73 signaling network by GTP during erythroid differentiation in chronic myelogenous leukemia. |
| Q35244124 | Regulation of the tumor suppressor FOXO3 by the thromboxane-A2 receptors in urothelial cancer |
| Q35971560 | Regulation of ubiquitination-mediated protein degradation by survival kinases in cancer |
| Q39893812 | Repression of Gadd45alpha by activated FLT3 and GM-CSF receptor mutants contributes to growth, survival and blocked differentiation |
| Q37687611 | Restoring miR122 in human stem-like hepatocarcinoma cells, prompts tumor dormancy through Smad-independent TGF-β pathway. |
| Q21090846 | RhoC regulates the proliferation of gastric cancer cells through interaction with IQGAP1 |
| Q36288352 | Ribosome biogenesis dysfunction leads to p53-mediated apoptosis and goblet cell differentiation of mouse intestinal stem/progenitor cells |
| Q36899622 | Role of TRPM2 in cell proliferation and susceptibility to oxidative stress |
| Q38120523 | Role of the Crosstalk between Autophagy and Apoptosis in Cancer |
| Q37106652 | Role of the phosphatidylinositol-3-kinase and extracellular regulated kinase pathways in the induction of hypoxia-inducible factor (HIF)-1 activity and the HIF-1 target vascular endothelial growth factor in ovarian granulosa cells in response to fol |
| Q53629703 | SIRT1 Protects Against Oxidative Stress-Induced Endothelial Progenitor Cells Apoptosis by Inhibiting FOXO3a via FOXO3a Ubiquitination and Degradation. |
| Q51701430 | SIRT3 interactions with FOXO3 acetylation, phosphorylation and ubiquitinylation mediate endothelial cell responses to hypoxia. |
| Q34016493 | SOD3 decreases ischemic injury derived apoptosis through phosphorylation of Erk1/2, Akt, and FoxO3a. |
| Q36083385 | STAT3 mediates resistance to MEK inhibitor through microRNA miR-17. |
| Q39023080 | Salicin, an extract from white willow bark, inhibits angiogenesis by blocking the ROS-ERK pathways |
| Q39002205 | Saturated free fatty acids induce cholangiocyte lipoapoptosis. |
| Q37179308 | Serine 574 phosphorylation alters transcriptional programming of FOXO3 by selectively enhancing apoptotic gene expression |
| Q27027778 | Signaling cross-talk in the resistance to HER family receptor targeted therapy |
| Q57165696 | Silencing of uPAR via RNA interference inhibits invasion and migration of oral tongue squamous cell carcinoma |
| Q44492204 | Simvastatin promotes cardiac microvascular endothelial cells proliferation, migration and survival by phosphorylation of p70 S6K and FoxO3a |
| Q34322871 | Skeletal muscle tissue engineering: methods to form skeletal myotubes and their applications |
| Q35957393 | Small-Molecule ONC201/TIC10 Targets Chemotherapy-Resistant Colorectal Cancer Stem-like Cells in an Akt/Foxo3a/TRAIL-Dependent Manner. |
| Q37192083 | Spi-1 and Fli-1 directly activate common target genes involved in ribosome biogenesis in Friend erythroleukemic cells. |
| Q35221809 | Stress-induced alternative splice forms of MDM2 and MDMX modulate the p53-pathway in distinct ways |
| Q34627210 | Subunit 6 of the COP9 signalosome promotes tumorigenesis in mice through stabilization of MDM2 and is upregulated in human cancers |
| Q29614835 | TFEB links autophagy to lysosomal biogenesis |
| Q35903214 | TGF-β converts apoptotic stimuli into the signal for Th9 differentiation |
| Q37387690 | TNFalpha induces HIF-1alpha expression through activation of IKKbeta |
| Q35030217 | Targeting MDM2-p53 interaction for cancer therapy: are we there yet? |
| Q99549077 | Targeting PI3K/Akt/mTOR in AML: Rationale and Clinical Evidence |
| Q38104439 | That which does not kill me makes me stronger; combining ERK1/2 pathway inhibitors and BH3 mimetics to kill tumour cells and prevent acquired resistance. |
| Q36782222 | The C. elegans Ortholog of USP7 controls DAF-16 stability in Insulin/IGF-1-like signaling |
| Q33763059 | The Erk2 MAPK regulates CD8 T cell proliferation and survival |
| Q34013124 | The FoxO family in cardiac function and dysfunction |
| Q34030117 | The Mdm2-p53 relationship evolves: Mdm2 swings both ways as an oncogene and a tumor suppressor |
| Q24616946 | The Ras-ERK and PI3K-mTOR pathways: cross-talk and compensation |
| Q92989510 | The Role of Forkhead Box Proteins in Acute Myeloid Leukemia |
| Q35986310 | The Role of Insulin and Insulin-Like Growth Factor-1/FoxO-Mediated Transcription for the Pathogenesis of Obesity-Associated Dementia |
| Q39296184 | The anti-angiogenic activities of glycyrrhizic acid in tumor progression |
| Q38418344 | The apoptotic effect of simvastatin via the upregulation of BIM in nonsmall cell lung cancer cells |
| Q44760808 | The association of Foxo3a gene polymorphisms with serum Foxo3a levels and oxidative stress markers in vitiligo patients |
| Q37585080 | The cunning little vixen: Foxo and the cycle of life and death |
| Q35067622 | The enhanced in vivo activity of the combination of a MEK and a PI3K inhibitor correlates with [18F]-FLT PET in human colorectal cancer xenograft tumour-bearing mice |
| Q37492303 | The estrogen receptor α is the key regulator of the bifunctional role of FoxO3a transcription factor in breast cancer motility and invasiveness |
| Q46328066 | The expression and significance of pThr32-FOXO3a in human ovarian cancer |
| Q60917471 | The forkhead-box family of transcription factors: key molecular players in colorectal cancer pathogenesis |
| Q93216881 | The high protein expression of FOXO3, but not that of FOXO1, is associated with markers of good prognosis |
| Q35077555 | The human T-cell leukemia virus type 1 oncoprotein tax controls forkhead box O4 activity through degradation by the proteasome |
| Q39023942 | The increase in BIK expression following ERK1/2 pathway inhibition is a consequence of G₁ cell-cycle arrest and not a direct effect on BIK protein stability |
| Q37721158 | The interaction between acetylation and serine-574 phosphorylation regulates the apoptotic function of FOXO3. |
| Q37862125 | The multifaceted roles of USP7: new therapeutic opportunities |
| Q35996498 | The natural compound forskolin synergizes with dexamethasone to induce cell death in myeloma cells via BIM |
| Q35140947 | The novel anti-MEK small molecule AZD6244 induces BIM-dependent and AKT-independent apoptosis in diffuse large B-cell lymphoma |
| Q37599707 | The regulation of MDM2 oncogene and its impact on human cancers |
| Q37596115 | The role of vimentin intermediate filaments in the progression of lung cancer |
| Q42067514 | The transcription of FOXO genes is stimulated by FOXO3 and repressed by growth factors |
| Q101564352 | Therapeutic strategies targeting FOXO transcription factors |
| Q36477693 | Transcriptional factor FOXO3 negatively regulates the expression of nm23-H1 in non-small cell lung cancer |
| Q100465050 | Transcriptional regulators and alterations that drive melanoma initiation and progression |
| Q37803120 | Translating p53 into the clinic. |
| Q34158118 | Trop2 expression contributes to tumor pathogenesis by activating the ERK MAPK pathway. |
| Q38770788 | Tumor-suppressive activity of 1,25-dihydroxyvitamin D3 against kidney cancer cells via up-regulation of FOXO3. |
| Q37290943 | Tumour cell survival signalling by the ERK1/2 pathway |
| Q50315356 | Uncoupling FoxO3A mitochondrial and nuclear functions in cancer cells undergoing metabolic stress and chemotherapy |
| Q35126991 | Unraveling the role of FoxOs in bone--insights from mouse models |
| Q37258559 | Up-regulation of miR-21 by HER2/neu signaling promotes cell invasion. |
| Q39690190 | Upregulation of Id1 by Epstein-Barr virus-encoded LMP1 confers resistance to TGFbeta-mediated growth inhibition |
| Q36532394 | Vitamin D directly regulates Mdm2 gene expression in osteoblasts. |
| Q37204101 | Vitexin attenuates acute doxorubicin cardiotoxicity in rats via the suppression of oxidative stress, inflammation and apoptosis and the activation of FOXO3a |
| Q37797472 | Why Target PIM1 for Cancer Diagnosis and Treatment? |
| Q36739979 | XBP-1u suppresses autophagy by promoting the degradation of FoxO1 in cancer cells |
| Q60044508 | aPKC controls endothelial growth by modulating c-Myc via FoxO1 DNA-binding ability |
| Q33824884 | beta1-Integrin-collagen interaction suppresses FoxO3a by the coordination of Akt and PP2A |
| Q38725204 | cGMP Signaling Increases Antioxidant Gene Expression by Activating Forkhead Box O3A in the Colon Epithelium |
| Q36962884 | eIF4B is a convergent target and critical effector of oncogenic Pim and PI3K/Akt/mTOR signaling pathways in Abl transformants. |
| Q38835327 | hTERT promotes the invasion of gastric cancer cells by enhancing FOXO3a ubiquitination and subsequent ITGB1 upregulation |
| Q37697065 | miR-22 targets YWHAZ to inhibit metastasis of hepatocellular carcinoma and its down-regulation predicts a poor survival |
| Q42760698 | p21-activated kinases in Erbb2-positive breast cancer: A new therapeutic target? |
| Q36742571 | p38 MAP kinase mediates arsenite-induced apoptosis through FOXO3a activation and induction of Bim transcription |
| Q33581359 | p38α MAPK-mediated induction and interaction of FOXO3a and p53 contribute to the inhibited-growth and induced-apoptosis of human lung adenocarcinoma cells by berberine |
| Q38247164 | p53-independent effects of Mdm2. |
| Q55319952 | β-arrestin1-medieated inhibition of FOXO3a contributes to prostate cancer cell growth in vitro and in vivo. |