| scholarly article | Q13442814 |
| P50 | author | Mien-Chie Hung | Q1532952 |
| P2093 | author name string | Jer-Yen Yang | |
| P2860 | cites work | Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor | Q22009126 |
| IkappaB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a | Q24336832 | ||
| IKK beta suppression of TSC1 links inflammation and tumor angiogenesis via the mTOR pathway | Q24337225 | ||
| A conserved MST-FOXO signaling pathway mediates oxidative-stress responses and extends life span | Q24338599 | ||
| Crystal structure of the human FOXO3a-DBD/DNA complex suggests the effects of post-translational modification | Q27648799 | ||
| Functional interaction between beta-catenin and FOXO in oxidative stress signaling | Q28115106 | ||
| TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling | Q28131740 | ||
| Unified nomenclature for the winged helix/forkhead transcription factors | Q28145807 | ||
| FoxO3a transcriptional regulation of Bim controls apoptosis in paclitaxel-treated breast cancer cell lines | Q28207468 | ||
| Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis | Q28246808 | ||
| The emerging roles of forkhead box (Fox) proteins in cancer | Q28253741 | ||
| The FoxO code | Q28275268 | ||
| FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis | Q28285131 | ||
| DYRK1A enhances the mitogen-activated protein kinase cascade in PC12 cells by forming a complex with Ras, B-Raf, and MEK1. | Q28574593 | ||
| FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress | Q29615562 | ||
| Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress | Q29619436 | ||
| FOXO transcription factors at the interface between longevity and tumor suppression | Q29620472 | ||
| Forkhead transcription factor FKHR-L1 modulates cytokine-dependent transcriptional regulation of p27(KIP1). | Q33606105 | ||
| Skp2 inhibits FOXO1 in tumor suppression through ubiquitin-mediated degradation | Q33755125 | ||
| Transcriptional feedback control of insulin receptor by dFOXO/FOXO1. | Q34084120 | ||
| JNK extends life span and limits growth by antagonizing cellular and organism-wide responses to insulin signaling | Q34410199 | ||
| Dual role of transcription factor FoxO1 in controlling hepatic insulin sensitivity and lipid metabolism | Q34945194 | ||
| The many forks in FOXO's road | Q35079447 | ||
| Activating FOXO3a, NF-kappaB and p53 by targeting IKKs: an effective multi-faceted targeting of the tumor-cell phenotype? | Q35836779 | ||
| Multiple roles of FOXO transcription factors in mammalian cells point to multiple roles in cancer | Q36522282 | ||
| ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation | Q36647913 | ||
| Biology of interactions: antiepidermal growth factor receptor agents | Q36935078 | ||
| Epidermal growth factor receptor inhibitors in the treatment of lung cancer: reality and hopes | Q37094889 | ||
| Functional interaction between FOXO3a and ATM regulates DNA damage response | Q37171572 | ||
| Doxorubicin activates FOXO3a to induce the expression of multidrug resistance gene ABCB1 (MDR1) in K562 leukemic cells | Q38292631 | ||
| Phosphorylation of CK1delta: identification of Ser370 as the major phosphorylation site targeted by PKA in vitro and in vivo | Q39253347 | ||
| Cell cycle inhibition by FoxO forkhead transcription factors involves downregulation of cyclin D. | Q39677789 | ||
| The energy sensor AMP-activated protein kinase directly regulates the mammalian FOXO3 transcription factor | Q40091020 | ||
| AZD6244 (ARRY-142886), a potent inhibitor of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase 1/2 kinases: mechanism of action in vivo, pharmacokinetic/pharmacodynamic relationship, and potential for combination in precl | Q40093939 | ||
| FOXO3a induces differentiation of Bcr-Abl-transformed cells through transcriptional down-regulation of Id1. | Q40203404 | ||
| Ionizing radiation activates expression of FOXO3a, Fas ligand, and Bim, and induces cell apoptosis | Q40251813 | ||
| Adenovirus-mediated gene transfer of FKHRL1 triple mutant efficiently induces apoptosis in melanoma cells. | Q40252297 | ||
| Simultaneous inhibition of PDK1/AKT and Fms-like tyrosine kinase 3 signaling by a small-molecule KP372-1 induces mitochondrial dysfunction and apoptosis in acute myelogenous leukemia | Q40296363 | ||
| Mutant Bik expression mediated by the enhanced minimal topoisomerase IIalpha promoter selectively suppressed breast tumors in an animal model | Q40309215 | ||
| Paclitaxel-induced nuclear translocation of FOXO3a in breast cancer cells is mediated by c-Jun NH2-terminal kinase and Akt. | Q40333129 | ||
| Blockade of epidermal growth factor receptors chemosensitizes breast cancer cells through up-regulation of Bnip3L. | Q40372888 | ||
| Direct transcriptional regulation of Bim by FoxO3a mediates STI571-induced apoptosis in Bcr-Abl-expressing cells. | Q40462629 | ||
| Selective activation of ceruloplasmin promoter in ovarian tumors: potential use for gene therapy | Q40583136 | ||
| Stimulation of the Raf/MEK/ERK cascade is necessary and sufficient for activation and Thr-160 phosphorylation of a nuclear-targeted CDK2. | Q40700200 | ||
| Involvement of Foxo transcription factors in angiogenesis and postnatal neovascularization | Q42130997 | ||
| Correlation between FOXO1a (FKHR) and FOXO3a (FKHRL1) binding and the inhibition of basal glucose-6-phosphatase catalytic subunit gene transcription by insulin | Q42498173 | ||
| A chemical genetic screen identifies inhibitors of regulated nuclear export of a Forkhead transcription factor in PTEN-deficient tumor cells | Q44714283 | ||
| Cancer-specific activation of the survivin promoter and its potential use in gene therapy | Q45877856 | ||
| The psammaplysenes, specific inhibitors of FOXO1a nuclear export | Q46449319 | ||
| Sensitizing estrogen receptor-negative breast cancer cells to tamoxifen with OSU-03012, a novel celecoxib-derived phosphoinositide-dependent protein kinase-1/Akt signaling inhibitor | Q46643620 | ||
| Foxo3a is essential for maintenance of the hematopoietic stem cell pool. | Q51960990 | ||
| FOXO1A Is a Candidate for the 13q14 Tumor Suppressor Gene Inhibiting Androgen Receptor Signaling in Prostate Cancer | Q56927880 | ||
| FAT: a novel domain in PIK-related kinases | Q57444244 | ||
| Targeted expression of BikDD eradicates pancreatic tumors in noninvasive imaging models | Q80572869 | ||
| P433 | issue | 3 | |
| P407 | language of work or name | English | Q1860 |
| P304 | page(s) | 752-7 | |
| P577 | publication date | 2009-02-01 | |
| P13046 | publication type of scholarly work | review article | Q7318358 |
| P1433 | published in | Clinical Cancer Research | Q332253 |
| P1476 | title | A new fork for clinical application: targeting forkhead transcription factors in cancer | |
| P478 | volume | 15 |
| Q38715524 | 1α,25(OH) 2D3 Sensitive Cytosolic pH Regulation and Glycolytic Flux in Human Endometrial Ishikawa Cells |
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| Q35781567 | A novel HIF-1α-integrin-linked kinase regulatory loop that facilitates hypoxia-induced HIF-1α expression and epithelial-mesenchymal transition in cancer cells |
| Q39027495 | A novel cyclometallated Pt(II)-ferrocene complex induces nuclear FOXO3a localization and apoptosis and synergizes with cisplatin to inhibit lung cancer cell proliferation. |
| Q35659739 | Acidic Fibroblast Growth Factor Promotes Endothelial Progenitor Cells Function via Akt/FOXO3a Pathway |
| Q37727061 | Acquired and intrinsic BRAF inhibitor resistance in BRAF V600E mutant melanoma |
| Q33956177 | Activation of FOXO3a is sufficient to reverse mitogen-activated protein/extracellular signal-regulated kinase kinase inhibitor chemoresistance in human cancer |
| Q34168448 | Activation of murine double minute 2 by Akt in mammary epithelium delays mammary involution and accelerates mammary tumorigenesis. |
| Q34402211 | Activation of p21(CIP1/WAF1) in mammary epithelium accelerates mammary tumorigenesis and promotes lung metastasis |
| Q39328413 | Activity of the selective IκB kinase inhibitor BMS-345541 against T-cell acute lymphoblastic leukemia: involvement of FOXO3a |
| Q33688980 | Adjustment for smoking does not alter the FOXO3A association with longevity |
| Q39627333 | Akt-FOXO3a signaling axis dysregulation in human oral squamous cell carcinoma and potent efficacy of FOXO3a-targeted gene therapy |
| Q27027207 | An overview on the role of FLT3-tyrosine kinase receptor in acute myeloid leukemia: biology and treatment |
| Q42371219 | Apigenin in cancer therapy: anti-cancer effects and mechanisms of action. |
| Q33680687 | Arrest-defective-1 protein (ARD1): tumor suppressor or oncoprotein? |
| Q33724850 | Association between rs2981582 polymorphism in the FGFR2 gene and the risk of breast cancer in Mexican women |
| Q42754619 | Automated quantitative multiplex immunofluorescence in situ imaging identifies phospho-S6 and phospho-PRAS40 as predictive protein biomarkers for prostate cancer lethality. |
| Q35066071 | BRCA1-IRIS inactivation overcomes paclitaxel resistance in triple negative breast cancers |
| Q27026953 | Beyond NF-κB activation: nuclear functions of IκB kinase α |
| Q39534956 | Blunting Autoantigen-induced FOXO3a Protein Phosphorylation and Degradation Is a Novel Pathway of Glucocorticoids for the Treatment of Systemic Lupus Erythematosus |
| Q41907536 | Breast cancer suppression by aplysin is associated with inhibition of PI3K/AKT/FOXO3a pathway |
| Q26750753 | Cancer drug resistance: redox resetting renders a way |
| Q38047676 | Cancer genetics and genomics of human FOX family genes |
| Q38081076 | Caveolin-1 and polymerase I and transcript release factor: new players in insulin-like growth factor-I receptor signaling. |
| Q39450823 | Caveolin‐1 is essential for metformin inhibitory effect on IGF1 action in non‐small‐cell lung cancer cells |
| Q90165835 | Circ-Foxo3 is positively associated with the Foxo3 gene and leads to better prognosis of acute myeloid leukemia patients |
| Q36238826 | Combination effects of dietary soy and methylselenocysteine in a mouse model of prostate cancer |
| Q35865318 | Computational identification and modeling of crosstalk between phosphorylation, O-β-glycosylation and methylation of FoxO3 and implications for cancer therapeutics |
| Q33940076 | Constitutive phosphorylation of the FOXO1 transcription factor in gastric cancer cells correlates with microvessel area and the expressions of angiogenesis-related molecules |
| Q28475229 | Constitutively nuclear FOXO3a localization predicts poor survival and promotes Akt phosphorylation in breast cancer |
| Q60149868 | Critical role of FOXO3a in carcinogenesis |
| Q35146638 | Deciphering the role of forkhead transcription factors in cancer therapy |
| Q41668059 | Diverse effects of ANXA7 and p53 on LNCaP prostate cancer cells are associated with regulation of SGK1 transcription and phosphorylation of the SGK1 target FOXO3A |
| Q91810326 | Downregulation of FOXO3a by DNMT1 promotes breast cancer stem cell properties and tumorigenesis |
| Q37683036 | EZH2 participates in malignant biological behavior of epithelial ovarian cancer through regulating the expression of BRCA1. |
| Q35032548 | Epstein-Barr Virus_Encoded LMP1 upregulates microRNA-21 to promote the resistance of nasopharyngeal carcinoma cells to cisplatin-induced Apoptosis by suppressing PDCD4 and Fas-L. |
| Q24616117 | Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer |
| Q35609443 | Expression of FOXO1 is associated with GATA3 and Annexin-1 and predicts disease-free survival in breast cancer |
| Q50931079 | Extracellular ATP regulates FoxO family of transcription factors and cell cycle progression through PI3K/Akt in MCF-7 cells |
| Q39385262 | FOXO transcription factors at the interface of metabolism and cancer |
| Q39646423 | FOXO1 is a direct target of EWS-Fli1 oncogenic fusion protein in Ewing’s sarcoma cells |
| Q92538857 | FOXO3 Transcription Factor Regulates IL-10 Expression in Mycobacteria-Infected Macrophages, Tuning Their Polarization and the Subsequent Adaptive Immune Response |
| Q37040688 | FOXO3 expression during colorectal cancer progression: biomarker potential reflects a tumour suppressor role. |
| Q36889384 | FOXO3 gene variants and human aging: coding variants may not be key players |
| Q28384062 | FOXO3 growth inhibition of colonic cells is dependent on intraepithelial lipid droplet density |
| Q38742577 | FOXO3a Expression Regulated by ERK Signaling is Inversely Correlated With Y-Box Binding Protein-1 Expression in Prostate Cancer. |
| Q39588969 | FOXO3a nuclear localisation is associated with good prognosis in luminal-like breast cancer |
| Q103826165 | FOXO3a-driven miRNA signatures suppresses VEGF-A/NRP1 signaling and breast cancer metastasis |
| Q35870864 | Flavones inhibit breast cancer proliferation through the Akt/FOXO3a signaling pathway |
| Q36354217 | Forkhead Box Transcription Factor (FOXO3a) mediates the cytotoxic effect of vernodalin in vitro and inhibits the breast tumor growth in vivo |
| Q39006521 | Forkhead box O3 (FOXO3) transcription factor mediates apoptosis in BCG-infected macrophages |
| Q34362813 | FoxO, autophagy, and cardiac remodeling |
| Q64261664 | FoxO3a inhibiting expression of EPS8 to prevent progression of NSCLC: A new negative loop of EGFR signaling |
| Q28570206 | FoxO3a is activated and executes neuron death via Bim in response to β-amyloid |
| Q36451188 | Foxo3a drives proliferation in anaplastic thyroid carcinoma via transcriptional regulation of cyclin A1: A paradigm shift that impacts current therapeutic strategies |
| Q36508271 | Foxo3a transcription factor is a negative regulator of Skp2 and Skp2 SCF complex |
| Q26829456 | Foxo3a: an integrator of immune dysfunction during HIV infection |
| Q35565061 | Frequent amplification of PTP1B is associated with poor survival of gastric cancer patients |
| Q55519018 | Genetic and cellular sensitivity of Caenorhabditis elegans to the chemotherapeutic agent cisplatin. |
| Q34153531 | Genetic inactivation of the pancreatitis-inducible gene Nupr1 impairs PanIN formation by modulating Kras(G12D)-induced senescence |
| Q36557595 | High casein kinase 1 epsilon levels are correlated with better prognosis in subsets of patients with breast cancer. |
| Q36065874 | Highly phosphorylated FOXO3A is an adverse prognostic factor in acute myeloid leukemia |
| Q34764674 | Histone Methyltransferase EZH2 Induces Akt-Dependent Genomic Instability and BRCA1 Inhibition in Breast Cancer |
| Q61809330 | ING4 suppresses hepatocellular carcinoma via a NF-κB/miR-155/FOXO3a signaling axis |
| Q92350228 | Identification of Crucial Candidate Genes and Pathways in Glioblastoma Multiform by Bioinformatics Analysis |
| Q39521104 | Identification of FOXO3 and PRDM1 as tumor-suppressor gene candidates in NK-cell neoplasms by genomic and functional analyses |
| Q40170713 | In silico, in vitro and in vivo analysis identifies a potential role for steroid hormone regulation of FOXD3 in endometriosis-associated genes |
| Q37416799 | Induction of Akt activity by chemotherapy confers acquired resistance |
| Q38791193 | Inhibition of AKT promotes FOXO3a-dependent apoptosis in prostate cancer |
| Q42249572 | Inhibition of IκB kinase in Notch signaling activates FOXO3a |
| Q38270775 | Insights into a Critical Role of the FOXO3a-FOXM1 Axis in DNA Damage Response and Genotoxic Drug Resistance. |
| Q34208426 | Integrated miRNA and mRNA expression profiling of mouse mammary tumor models identifies miRNA signatures associated with mammary tumor lineage |
| Q37820481 | Intracellular amino acid sensing and mTORC1-regulated growth: new ways to block an old target? |
| Q41925033 | Is redox signaling a feasible target for overcoming multidrug resistance in cancer chemotherapy? |
| Q37168138 | JAK2 mutants (e.g., JAK2V617F) and their importance as drug targets in myeloproliferative neoplasms |
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| Q39291263 | Lineage-specific growth inhibition of NK cell lines by FOXO3 in association with Akt activation status |
| Q53071967 | Mechanisms in cardiac fibroblast growth: an obligate role for Skp2 and FOXO3a in ERK1/2 MAPK-dependent regulation of p27kip1. |
| Q61795842 | MiR-30a regulates cancer cell response to chemotherapy through SNAI1/IRS1/AKT pathway |
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| Q35875424 | ON 01910.Na is selectively cytotoxic for chronic lymphocytic leukemia cells through a dual mechanism of action involving PI3K/AKT inhibition and induction of oxidative stress |
| Q36453502 | Oligodendrocyte regeneration after neonatal hypoxia requires FoxO1-mediated p27Kip1 expression |
| Q38789453 | On a FOX hunt: functions of FOX transcriptional regulators in bladder cancer. |
| Q42137006 | Oral administration of withaferin A inhibits carcinogenesis of prostate in TRAMP model |
| Q37688130 | PAX3 is a novel tumor suppressor by regulating the activities of major signaling pathways and transcription factor FOXO3a in thyroid cancer |
| Q36498165 | PMCA2 regulates HER2 protein kinase localization and signaling and promotes HER2-mediated breast cancer |
| Q35124711 | Phosphoproteomic analysis of apoptotic hematopoietic stem cells from hemoglobin E/β-thalassemia |
| Q39435517 | Phosphorylation of FOXO3a on Ser-7 by p38 promotes its nuclear localization in response to doxorubicin |
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| Q39388968 | Ras-induced ROS upregulation affecting cell proliferation is connected with cell type-specific alterations of HSF1/SESN3/p21Cip1/WAF1pathways |
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| Q36164893 | Targeting Aurora A kinase activity with the investigational agent alisertib increases the efficacy of cytarabine through a FOXO‐dependent mechanism |
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| Q42924738 | The phosphatidylinositol-3-kinase inhibitor NVP-BKM120 overcomes resistance signals derived from microenvironment by regulating the Akt/FoxO3a/Bim axis in chronic lymphocytic leukemia cells |
| Q35138997 | The regulation and function of miR-21-FOXO3a-miR-34b/c signaling in breast cancer |
| Q38714954 | The scaffolding protein NHERF1 regulates the stability and activity of the tyrosine kinase HER2. |
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| Q34158118 | Trop2 expression contributes to tumor pathogenesis by activating the ERK MAPK pathway. |
| Q36689103 | Tumor suppressive effect of PARP1 and FOXO3A in gastric cancers and its clinical implications |
| Q37948470 | Tumor suppressor genes and ROS: complex networks of interactions |
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