Epidermal growth factor receptor tyrosine kinase inhibitor reverses mesenchymal to epithelial phenotype and inhibits metastasis in inflammatory breast cancer

scientific article

Epidermal growth factor receptor tyrosine kinase inhibitor reverses mesenchymal to epithelial phenotype and inhibits metastasis in inflammatory breast cancer is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1158/1078-0432.CCR-09-0951
P932PMC publication ID2783487
P698PubMed publication ID19825949

P50authorMien-Chie HungQ1532952
Gabriel N HortobagyiQ88225186
Massimo CristofanilliQ91695610
P2093author name stringFrancisco J Esteva
Dongwei Zhang
Ping Liu
Naoto T Ueno
Savitri Krishnamurthy
Anthony Lucci
Balraj Singh
Tiffany A LaFortune
P2860cites workMolecular biology of breast cancer metastasis. Inflammatory breast cancer: clinical syndrome and molecular determinantsQ24801016
Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogeneQ27860693
Untangling the ErbB signalling networkQ27860884
Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivoQ28368373
Erlotinib in previously treated non-small-cell lung cancerQ29547546
Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancerQ29547699
Epithelial-mesenchymal transitions in development and pathologiesQ29614986
The ErbB signaling network: receptor heterodimerization in development and cancerQ29617919
Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancerQ29618155
Regulation of transcription by MAP kinase cascadesQ29618477
Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: a phase III trial of the National Cancer Institute of Canada Clinical Trials GroupQ29619344
Epidemiology of inflammatory breast cancer (IBC).Q33781315
Update on the management of inflammatory breast cancerQ35108008
Inflammatory breast cancer: a reviewQ36121844
Prognostic value of ERBB-1, VEGF, cyclin A, FOS, JUN and MYC in patients with squamous cell lung carcinomasQ36291695
Isolation and characterization of a new human breast cancer cell line, KPL-4, expressing the Erb B family receptors and interleukin-6.Q36618907
ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradationQ36647913
Activity of lapatinib is independent of EGFR expression level in HER2-overexpressing breast cancer cellsQ36852254
Sensitivity of breast cancer cells to erlotinib depends on cyclin-dependent kinase 2 activityQ37015793
Epithelial-mesenchymal transition in breast cancer relates to the basal-like phenotypeQ40012189
COX-2 involvement in breast cancer metastasis to boneQ40184738
Expression profiling of epithelial plasticity in tumor progressionQ40625666
Treatment of metastatic melanoma with an orally available inhibitor of the Ras-Raf-MAPK cascadeQ40629608
Ras induces NBT-II epithelial cell scattering through the coordinate activities of Rac and MAPK pathways.Q40727746
Chemosensitization of HER-2/neu-overexpressing human breast cancer cells to paclitaxel (Taxol) by adenovirus type 5 E1A.Q41093419
Epidermal growth factor receptor expression correlates with poor prognosis in non-small cell lung cancer patients with p53 overexpression.Q43586088
Evaluation of biologic end points and pharmacokinetics in patients with metastatic breast cancer after treatment with erlotinib, an epidermal growth factor receptor tyrosine kinase inhibitorQ45000490
Cre-loxP-controlled periodic Aurora-A overexpression induces mitotic abnormalities and hyperplasia in mammary glands of mouse modelsQ45103581
Phase II and tumor pharmacodynamic study of gefitinib in patients with advanced breast cancer.Q46531450
Combination treatment with erlotinib and pertuzumab against human tumor xenografts is superior to monotherapyQ46610633
Phase II study of predictive biomarker profiles for response targeting human epidermal growth factor receptor 2 (HER-2) in advanced inflammatory breast cancer with lapatinib monotherapyQ46796554
Antitumor activity of erlotinib in combination with capecitabine in human tumor xenograft modelsQ46857082
Inflammatory breast carcinoma incidence and survival: the surveillance, epidemiology, and end results program of the National Cancer Institute, 1975-1992.Q46901734
Epidermal growth factor receptors in lung tumoursQ69426534
Inflammatory breast cancer: the experience of the surveillance, epidemiology, and end results (SEER) programQ69833744
Epidermal growth factor receptor in human breast cancer comparison with steroid receptors and other prognostic factorsQ70872137
Prospective study of the prognostic significance of epidermal growth factor receptor in primary breast cancerQ70997826
Matrix metalloproteinase 9 and the epidermal growth factor signal pathway in operable non-small cell lung cancerQ73937563
Expression of growth factor and chemokine receptors: new insights in the biology of inflammatory breast cancerQ79918235
P433issue21
P407language of work or nameEnglishQ1860
P921main subjectphenotypeQ104053
inflammatory breast cancerQ5922406
P304page(s)6639-6648
P577publication date2009-10-13
P1433published inClinical Cancer ResearchQ332253
P1476titleEpidermal growth factor receptor tyrosine kinase inhibitor reverses mesenchymal to epithelial phenotype and inhibits metastasis in inflammatory breast cancer
P478volume15

Reverse relations

cites work (P2860)
Q37211807-216G/T (rs712829), a functional variant of the EGFR promoter, is associated with the pleural metastasis of lung adenocarcinoma
Q36962901A function-blocking CD47 antibody suppresses stem cell and EGF signaling in triple-negative breast cancer
Q24626194A phase II trial to assess efficacy and safety of afatinib in extensively pretreated patients with HER2-negative metastatic breast cancer
Q36795486A view on EGFR-targeted therapies from the oncogene-addiction perspective.
Q33770856AZD8931, an equipotent, reversible inhibitor of signaling by epidermal growth factor receptor (EGFR), HER2, and HER3: preclinical activity in HER2 non-amplified inflammatory breast cancer models
Q90429851An In Vitro Model of Triple-Negative Breast Cancer
Q35829855Anoikis evasion in inflammatory breast cancer cells is mediated by Bim-EL sequestration
Q36359519Antitumor Activity of KW-2450 against Triple-Negative Breast Cancer by Inhibiting Aurora A and B Kinases
Q35558027Breast cancer growth and metastasis: interplay between cancer stem cells, embryonic signaling pathways and epithelial-to-mesenchymal transition
Q55322297CSF-1/CSF-1R axis is associated with epithelial/mesenchymal hybrid phenotype in epithelial-like inflammatory breast cancer.
Q42735675Cancer stem cell subsets and their relationships
Q33760216Challenging a Misnomer? The Role of Inflammatory Pathways in Inflammatory Breast Cancer
Q28554790Clonal Evolutionary Analysis during HER2 Blockade in HER2-Positive Inflammatory Breast Cancer: A Phase II Open-Label Clinical Trial of Afatinib +/- Vinorelbine
Q34456201Comparative analysis of dynamic cell viability, migration and invasion assessments by novel real-time technology and classic endpoint assays
Q37690619Comparison of molecular subtype distribution in triple-negative inflammatory and non-inflammatory breast cancers
Q49124045Conditioned Medium from Adipose-Derived Stem Cells (ADSCs) Promotes Epithelial-to-Mesenchymal-Like Transition (EMT-Like) in Glioma Cells In vitro
Q36706840Development and characterization of two human triple-negative breast cancer cell lines with highly tumorigenic and metastatic capabilities
Q92153761E2F1 Drives Breast Cancer Metastasis by Regulating the Target Gene FGF13 and Altering Cell Migration
Q36824370EGFR Gene Amplification and Protein Expression in Invasive Ductal Carcinoma of the Breast
Q39111192EGFR inhibition promotes an aggressive invasion pattern mediated by mesenchymal-like tumor cells within squamous cell carcinomas
Q36360133EGFR regulates the development and microarchitecture of intratumoral angiogenic vasculature capable of sustaining cancer cell intravasation
Q42243028EGFR signaling promotes inflammation and cancer stem-like activity in inflammatory breast cancer
Q37362586EZH2 knockdown suppresses the growth and invasion of human inflammatory breast cancer cells
Q39167876Early clinical development of epidermal growth factor receptor targeted therapy in breast cancer
Q37270040Effect of intermittent dosing regimens of erlotinib on methylnitrosourea-induced mammary carcinogenesis
Q33927493ErbB/EGF signaling and EMT in mammary development and breast cancer
Q38862668Establishment of a multimarker qPCR panel for the molecular characterization of circulating tumor cells in blood samples of metastatic breast cancer patients during the course of palliative treatment
Q39727786Evaluation of a CXCR4 antagonist in a xenograft mouse model of inflammatory breast cancer
Q36657315Ganoderma lucidum Combined with the EGFR Tyrosine Kinase Inhibitor, Erlotinib Synergize to Reduce Inflammatory Breast Cancer Progression
Q34287510Highly adaptable triple-negative breast cancer cells as a functional model for testing anticancer agents
Q44586994How do I treat inflammatory breast cancer?
Q64228655Identification of Biologically Active Compounds and Synthesis of Improved Derivatives That Confer Anti-cancer Activities
Q36356354Identification of epidermal growth factor receptor and its inhibitory microRNA141 as novel targets of Krüppel-like factor 8 in breast cancer
Q38555670Immune Targeting of Tumor Epithelial-Mesenchymal Transition via Brachyury-Based Vaccines.
Q63366138Inflammatory breast cancer biology: the tumour microenvironment is key
Q37642845Ink4a/Arf(-/-) and HRAS(G12V) transform mouse mammary cells into triple-negative breast cancer containing tumorigenic CD49f(-) quiescent cells.
Q35983594Local iontophoretic administration of cytotoxic therapies to solid tumors
Q35313206Mesenchymal stem cells mediate the clinical phenotype of inflammatory breast cancer in a preclinical model
Q42513445Metalloprotease-dependent activation of EGFR modulates CD44+/CD24- populations in triple negative breast cancer cells through the MEK/ERK pathway.
Q30528547Microfluidics separation reveals the stem-cell-like deformability of tumor-initiating cells
Q91783003Perspectives on Inflammatory Breast Cancer (IBC) Research, Clinical Management and Community Engagement from the Duke IBC Consortium
Q39693833Preneoplastic changes persist after IGF-IR downregulation and tumor regression
Q53312576Quantification of epidermal growth factor receptor (EGFR) in canine mammary tumours by ELISA assay: clinical and prognostic implications.
Q54976875RIPK2: New Elements in Modulating Inflammatory Breast Cancer Pathogenesis.
Q39426062RNAi-mediated knockdown of ERK1/2 inhibits cell proliferation and invasion and increases chemosensitivity to cisplatin in human osteosarcoma U2-OS cells in vitro
Q47100005Risk Factors and Preventions of Breast Cancer
Q37320346Role of epidermal growth factor receptor in breast cancer
Q63366144Safety and Efficacy of Panitumumab Plus Neoadjuvant Chemotherapy in Patients With Primary HER2-Negative Inflammatory Breast Cancer
Q45916506Scientific Summary from the Morgan Welch MD Anderson Cancer Center Inflammatory Breast Cancer (IBC) Program 10th Anniversary Conference.
Q28730146Selection of metastatic breast cancer cells based on adaptability of their metabolic state
Q34711378Silencing kinase-interacting stathmin gene enhances erlotinib sensitivity by inhibiting Ser¹⁰ p27 phosphorylation in epidermal growth factor receptor-expressing breast cancer
Q64890079Stapled EGFR peptide reduces inflammatory breast cancer and inhibits additional HER-driven models of cancer.
Q36430004Strategies to target molecules that control the acquisition of a mesenchymal-like phenotype by carcinoma cells
Q53090999TIG1 promotes the development and progression of inflammatory breast cancer through activation of Axl kinase.
Q58117324Targeted Nanomedicine to Treat Bone Metastasis
Q34117454Targeted therapy in inflammatory breast cancer
Q42766317Targeting EGFR in Triple Negative Breast Cancer
Q42369599The Third International Inflammatory Breast Cancer Conference
Q34419629The role of inflammation in inflammatory breast cancer.
Q36900976Thrombin stimulation of inflammatory breast cancer cells leads to aggressiveness via the EGFR-PAR1-Pak1 pathway

Search more.